Viral replication modulated by hallmark conformational ensembles: how AlphaFold-predicted features of RdRp folding dynamics combined with intrinsic disorder-mediated function enabl... by Rachid Tahzima, Rachid Tahzima, Rachid Tahzima, Rachid Tahzima, Justine Charon, Adrian Diaz, Kris De Jonghe, Sebastien Massart, Thierry Michon, Wim Vranken, Wim Vranken, Wim Vranken, Wim Vranken

“…Key examples illustrate how biophysical-encoded preferences of generic sequence–ensemble relationships can help estimate the global RdRp structural diversity and RNA virus discovery. The quantitative perception we present also highlights the challenging magnitude of the emergent sequence-to-conformations relationships of proteins and illustrates more robust and accurate annotations of novel or divergent RdRps. …”
Get full text