Adult HIV/AIDS patients are more likely to experience anxiety symptoms by Zakir Abdu, Wondwossen Belayneh, Aman Dule, Solomon Seyife Alemu, Lema Fikadu Wedajo, Mohammedamin Hajure, Gebremeskel Mulatu Tesfaye, Yadeta Alemayehu Workneh, Wubishet Gezimu, Mustefa Adem Hussen, Bilisumamulifna Tefera, Sadik Habib

“…Based on these findings, timely intervention is recommended to enhance the overall well-being and quality of life for people living with HIV (PLWH), leading to better health outcomes, reducing the burden of mental health issues, and supporting more holistic, patient-centered care.…”
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NIFTy: near-infrared fluorescence (NIRF) imaging to prevent postsurgical hypoparathyroidism (PoSH) after thyroid surgery—a phase II/III pragmatic, multicentre randomised controlled... by Deborah D Stocken, Maureen Twiddy, Hisham Mehanna, Jonathan Wadsley, Neil Corrigan, Katie Gordon, Julie Croft, Neil Sharma, Anna Perry, Mark Strachan, Gemma Ainsworth, Elizabeth Glenister, Sabapathy Prakash P Balasubramanian

“…Phase III secondary outcomes include protracted hypoparathyroidism, hypercalcaemia, complications, length of stay, readmissions and patient reported quality of life using the Short Form 36 Health Survey Questionnaire and Hypoparathyroid Patient Questionnaire instruments.Ethics and dissemination NIFTy is funded by National Institute for Health and Care Research Efficacy and Mechanism Evaluation Programme (Grant Ref: 17/11/27) and approved by a Research Ethics Committee (reference: 21/WA/0375) and Health Research Authority (HRA). …”
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Efficacy and safety of glycyrrhizic acid and essential phospholipids (Phosphogliv) combination for alcoholic liver disease: results of the double-blind randomized placebo-controlle... by I. G. Bakulin, N. A. Bokhan, P. O. Bogomolov, N. I. Geyvandova, M. V. Matsiyevich, M. A. Vinnikova, V. G. Morozov, O. M. Khromtsova, G. S. Soldatova, O. Yu. Shiryayev, R. D. Ilyuk, K. V. Rybakova, A. G. Katkovskaya, S. V. Teplykh, A. A. Bagretsova, M. V. Krasnova, Ye. V. Alekseyeva, A. V. Anipchenko, Ye. V. Baskakov

“…The dynamics of serum alanine transaminase (ALT), aspartate transaminase (AST), liver scores by noninvasive FibroMax test was applied to assess the treatment efficacy and safety, along with change in quality of life of patients. Results. In 24 wks in group A in comparison to the group B significantly lower mean ALT level was found: 35,2±29,4 U/l vs 48,4±36,1 U/l (р =0,044), AST level became normal in higher rate of patients: 69,4% vs 47,7% (р =0,034), that had more prominent decrease in gamma-glutamyltranspeptidase (GGT) level - 47,4±36,5% vs 25,1±63,9% (р =0,039), the rate of patients with Aktitest A2-A3 range decreased - 8,5% vs 21,4% (p…”
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Descemet Endothelial Thickness Comparison Trial 1 (DETECT 1): outcome masked, placebo-controlled trial comparing two types of corneal transplant surgeries and effect of rho kinase... by Thomas M Lietman, Jennifer Rose-Nussbaumer, Bennie H Jeng, Benjamin F Arnold, Winston Chamberlain, Charles C Lin, Jennifer Y Li, William Gensheimer, Jameson Clover, Nicole Varnado, Sarah Abdelrahman

“…Secondary outcomes include visual acuity at different time points, vision-related quality of life, endothelial cell morphology and cost-effectiveness.Results The study outcomes will be analysed using mixed effects linear regression models, taking into account the treatment arms and relevant covariates. …”
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Characterization of adult T-cell leukemia/lymphoma patients with specific skin lesions in a tertiary dermatological service in Brazil by Mariana Valente, José Antonio Sanches, Youko Nukui, Jade Cury-Martins, Bruno Castro Souza, Juliana Pereira, Denis Miyashiro

“…Description of clinical, pathology, laboratory, and follow-up data, and factors associated with poorer survival is essential to provide better care and to improve the quality of life of these patients.…”
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Traditional Chinese Mind and Body Exercises for Neck Pain: A Meta-Analysis of Randomized Controlled Trials by Yu-Hua Xie, Man-Xia Liao, Mao-Yuan Wang, W. C. Hewith A. Fernando, Yue-Ming Gu, Xue-Qiang Wang, Lin-Rong Liao

“…Neck pain is common and can have a significant impact on patients’ physical functionality, mobility, and quality of life (QOL). In clinical practice, traditional Chinese mind and body exercise (TCMBE) is a combination of different types of exercise based on traditional Chinese medicine, including qigong, tai chi, the 12-words-for-life-nurturing exercise, and so on, and many studies have found that it is safe and effective at helping patients with neck pain. …”
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Psoriasis severity in moderate to severe psoriatic Greek patients routinely treated with systemic treatment: a cross-sectional and retrospective chart review study (CRYSTAL-Greece) by Dimitrios Rigopoulos, J. Katsantonis, O. Neofotistou, V. Chasapi, E. Lazaridou, A. V. Roussaki-Schulze, M. Papakonstantis, C. Angelakopoulos, P. Rigatos, P. Aronis, C. Zeglinas, A. Kyriakakis, T. Heatta-Speicher, A. Kollia, K. Antachopoulou, E. Papadavid

“…Most affected EQ-5D-5L dimensions were anxiety/depression (58.6%) and pain/discomfort (28.6%).Conclusion A considerable proportion of patients still do not achieve complete or almost complete skin clearance, while one fifth of the population experience at least moderate impairment of quality of life.…”
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The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise T... by Magdalena Dudek, Marta Kałużna-Oleksy, Filip Sawczak, Agata Kukfisz, Aleksandra Soloch, Jacek Migaj, Maciej Lesiak, Ewa Straburzyńska-Migaj

“…<b>Background/Objectives</b>: Heart failure (HF) constitutes a complex clinical syndrome that is highly prevalent worldwide, comprises a serious prognosis, and results in a reduced quality of life. Exercise capacity is one of the most significant parameters involved in the prognosis in HF patients. …”
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Catheter ablation versus antiarrhythmic drugs with risk factor modification for treatment of atrial fibrillation: a protocol of a randomised controlled trial (PRAGUE-25 trial) by Stepan Havranek, Jiri Jarkovsky, Otakar Jiravský, Pavel Osmancik, Veronika Bulková, Jan Chovančík, Tomáš Roubíček, Dalibor Heřman, Zuzana Čarná, Vladimír Tuka, Martin Matoulek, Martin Fiala, Sylvie Stregl-Hruskova, Adam Latiňák, Jiřina Kotryová

“…The secondary endpoints include AF burden, clinical endpoints associated with AF reoccurrence, changes in the quality of life assessed using dedicated questionnaires, changes in cardiorespiratory fitness and metabolic endpoints. …”
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Chemotherapy plus therapeutic plasmapheresis with 4% human albumin solution in multiple myeloma patients with acute kidney injury: a prospective, open-label, proof-of-concept study by Tianzhi Wu, Dandan Liu, Shangqin Liu, Hui Xiao, Bei Xiong, Yi Zhou, Yafen Xiong, Qin Cui, Jiang Wu, Minghui Liu, Hongli Liu, Yiming Li, Meixin Wang, Xueqin Bao, Ye Li, Fuling Zhou

“…In conclusion, in MM patients with AKI, plasma-free plasmapheresis with 4% human ALB solution and bortezomib-based chemotherapy effectively alleviated light chain damage to kidney function while improving patient quality of life.…”
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Enhancing balance and auditory function in bilateral vestibulopathy through otolithic vestibular stimulation: insights from a pilot study on cochlea-vestibular implant efficacy by Ángel Ramos-de-Miguel, Ángel Ramos-de-Miguel, Morgana Sluydts, Juan Carlos Falcón, Raquel Manrique-Huarte, Isaura Rodriguez, Andrzej Zarowski, Maurizio Barbara, Manuel Manrique, Silvia Borkoski, Joan Lorente, Marc Leblanc, Antonin Rambault, Erika Van Baelen, Carl Van Himbeeck, Alicia Huarte, Ángel Ramos Macías, Ángel Ramos Macías

“…Residual balance gains after device deactivation suggest neural adaptation, and placebo tests confirmed cochleovestibular stimulation specificity.DiscussionCVI effectively restores auditory and vestibular function, with improvements in hearing, balance, and quality of life. Neural plasticity likely supports long-term benefits. …”
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The work-related well-being of social service workers post COVID-19 pandemic: The psychosocial impact of remote vs in-person work by Venusia COVELLI, Morena TAFFARELLO, Marina Angela VISCO, Francesco CHIRICO, Pietro CRESCENZO, Luca COPPETA, Kavita BATRA, Alessandra MARELLI

“…Comparing working in-person with remote working, the quality of life and satisfaction with one’s health do not change. …”
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Internalizing and externalizing symptoms in individuals with neurofibromatosis type 1: a systematic review and meta-analysis by Dan Liu, Liyan Yu, Xian Wu, Julia Moreira, Benjamin Felipe Mujica, Elora Shelly Mukhopadhyay, Angelena Novotney, André B. Rietman, Yang Hou

“…This hinders the overall attendance of their psychosocial needs and has a major impact on their quality of life. Thus, this systematic review and meta-analysis was conducted to synthesize existing findings on the degree to which individuals with NF1 experience internalizing and externalizing symptoms, compared with the unaffected population, and explore moderators of the group disparities. …”
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Physiology and Pathophysiology of Marathon Running: A narrative Review by Lorin Braschler, Pantelis T. Nikolaidis, Mabliny Thuany, Daniela Chlíbková, Thomas Rosemann, Katja Weiss, Matthias Wilhelm, Beat Knechtle

“…As such, it improves cardiovascular risk factors, leads to favorable cardiac adaptations, enhances lung function, and improves quality of life in chronic kidney disease patients. It also enhances gastrointestinal mobility and reduces the risk of specific tumors such as colorectal cancer and hepatocellular carcinoma. …”
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Safety profiles of IDH inhibitors: a pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database by Ximu Sun, Han Zhou, Yanming Li, Yanhui Luo, Qixiang Guo, Yixin Sun, Chenguang Jia, Bin Wang, Maoquan Qin, Peng Guo

“…Promptly monitoring and intervention in specific organ systems depending on the type of IDH inhibitor may improve the overall survival or enhance the quality of life. In the future, it will be necessary to validate our findings in prospective large-scale studies and to investigate the underlying mechanisms.…”
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Exploring the Psychological and Physiological Insights Through Digital Phenotyping by Analyzing the Discrepancies Between Subjective Insomnia Severity and Activity-Based Objective... by Ji Won Yeom, Hyungju Kim, Seung Pil Pack, Heon-Jeong Lee, Taesu Cheong, Chul-Hyun Cho

“… BackgroundInsomnia is a prevalent sleep disorder affecting millions worldwide, with significant impacts on daily functioning and quality of life. While traditionally assessed through subjective measures such as the Insomnia Severity Index (ISI), the advent of wearable technology has enabled continuous, objective sleep monitoring in natural environments. …”
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Osilodrostat treatment in patients with Cushing’s disease of Asian or non-Asian origin: a pooled analysis of two Phase III randomized trials (LINC 3 and LINC 4) by Akira Shimatsu, Beverly MK Biller, Maria Fleseriu, Rosario Pivonello, Eun Jig Lee, Rattana Leelawattana, Jung Hee Kim, Rama Walia, Yerong Yu, Zhihong Liao, Andrea Piacentini, Alberto M Pedroncelli, Peter J Snyder

“…Improvements in cardiovascular and metabolic-related parameters, physical manifestations of hypercortisolism, and quality of life were similar in both groups. Most common adverse events (AEs) were adrenal insufficiency (44.6%) in Asian and nausea (45.5%) in non-Asian patients. …”
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Real-World Life Analysis of a Continuous Glucose Monitoring and Smart Insulin Pen System in Type 1 Diabetes: A Cohort Study by Paola Pantanetti, Giovanni Cangelosi, Sara Morales Palomares, Gaetano Ferrara, Federico Biondini, Stefano Mancin, Gabriele Caggianelli, Mauro Parozzi, Marco Sguanci, Fabio Petrelli

“…Advances in diabetes management, such as continuous glucose monitoring (CGM), insulin pumps (IP), and, more recently, smart multiple dose injection (MDI) pens, have significantly enhanced glycemic control and improved patients’ quality of life. Aim: This study aims to evaluate the baseline characteristics of patients switching from MDI therapy to the Medtronic Smart MDI system [composed of a smart insulin pen (InPenTM) and a connected CGM Medtronic SimpleraTM sensor] and to assess its impact on glycemic outcomes over different time periods (14, 30, and 90 days). …”
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Hydrogen-oxygen mixture inhalation as an adjunctive treatment to home-based exercise in older patients with knee osteoarthritis: an open-label, blinded-endpoint, randomized control... by Chenhui Wang, Mengwei Yan, Yuru Li, Lei Han, Hongqian Wang, Shufeng Jia, Xingchen Liu, Yang Liu, Fan Wu, Baoguo Wang

“…ObjectiveKnee osteoarthritis (KOA) is a degenerative joint condition, leading to disability and diminished quality of life. Molecular hydrogen has been proven to have antioxidant and anti-inflammatory properties, but few studies have investigated its effects on osteoarthritis. …”
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Clinical efficacy of a virtual reality tool for the treatment of obesity: study protocol of a randomised controlled trial by Dimitra Anastasiadou, Jose Antonio Ramos-Quiroga, Mel Slater, Bernhard Spanlang, Desiderio Cano Porras, Marta Comas, Andreea Ciudin, Gemma Parramon Puig, Julia Vázquez-De Sebastián, Pilar Lusilla-Palacios

“…Readiness to change, BMI, eating habits and physical activity, psychological well-being, body image satisfaction, quality of life in relation to body image, and weight bias internalisation will be assessed at baseline, post intervention, 1-week and 4-week follow-up. …”
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