Neurocognitive impact of different irradiation modalities for patients with grade I-II skull base meningioma: a prospective multi-arm cohort study (CANCER COG) by Paul Lesueur, Florence Joly, Benedicte Clarisse, Justine Lequesne, Dinu Stefan, Jacques Balosso, Marie Lange, Sebastien Thureau, Aurelie Capel, Marie Castera, Berenice Legrand, Nicolas Goliot, Jean Michel Grellard, Thomas Tessonier, Helene Castel, Samuel Valable

“…The rate of clinical symptomatology improvement over time after irradiation, the evolution of health-related quality-of-life, anxiety/depression, fatigue, over time after irradiation, the tumoral local control after irradiation, the progression-free survival (PFS), the professional reintegration for working-age patients will also be assessed. …”
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Spectrum and trends of cancer among HIV patients in Southwestern Uganda. by Raymond Atwine, Mitala Yekosani, Abraham Birungi, Brian Ssenkumba, Barbra Tuhamize, Richard Ezinga, Keneth Male, Taseera Kabanda

“…<h4>Background</h4>Antiretroviral therapy (ART) restores cellular immunity, significantly reducing AIDS-related mortality and morbidity thus improving the quality of life among People living with HIV (PLHIV). …”
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The relationship between activities of daily living and speech impediments based on evidence from statistical and machine learning analyses by Liu Jun, Hongguo Li, Yu Mao, Lan Hu, Dan Wu

“…Machine learning algorithms (Support Vector Machine, Decision Tree, and Logistic Regression) were employed to validate the findings and elucidate the underlying relationship between ADL and SI.BackgroundSI poses significant challenges to the health and quality of life of middle-aged and older adults, increasing the demands on community-based and home care services. …”
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Effect of ticagrelor combined with metoprolol extended-release tablets on cardiac function and clinical prognosis in elderly patients with acute coronary syndrome after percutaneou... by Lili Wang, Linlin Gao, Qin Chen, Li Chen, Hui Xu, Ling Sun, Youbin Hu

“…The incidence of adverse prognostic events in the OG was significantly lower at 8.89%, compared to 37.78% in the CG (P &lt; 0.05).ConclusionTicagrelor combined with metoprolol extended-release tablets can significantly improve cardiac function, motor performance, and quality of life in ACS patients after PCI. Additionally, it effectively increases myocardial injury markers and reduces serum inflammatory factor levels.…”
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CHANGE IN TESTOSTERONE LEVELS IN ENDOSCOPIC OPERATIONS ON THE PROSTATE GLAND by E. A. Efremov, S. Yu. Shekhovtsov, D. S. Merinov, A. O. Butov, Yu. V. Kastrikin, T. I. Garaev

“…Preoperative diagnosis and correction of testosterone deficiency is an important component that allows minimizing the number of risks and complications resulting from surgical interventions, as well as improving the quality of life and accelerating post-operative rehabilitation of patients.…”
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Spinal CRH facilitates the micturition reflex via the CRH2 receptor in rats with normal bladder and bladder outlet obstruction by Risa Shinoki, Ryosuke Jikuya, Takuma Nirei, Takeshi Fukazawa, Hiroki Takizawa, Mari Hioki, Sachi Kawaura, Tomoyuki Tatenuma, Go Noguchi, Daiki Ueno, Yusuke Ito, Mitsuru Komeya, Kentaro Muraoka, Hisashi Hasumi, Kazuki Kobayashi, Masahito Takiguchi, Kengo Funakoshi, Kazuhide Makiyama, Naoki Aizawa, Hiroki Ito

“…Abstract Lower urinary tract symptoms (LUTS) significantly affect patient quality of life. Treatment options for bladder outlet obstruction (BOO) due to benign prostatic hyperplasia (BPH) (a common cause of LUTS) are insufficient to relieve discomfort. …”
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Catastrophizing as a Predictor for Pain Perception and Disability Among Patients Undergoing Spinal Cord Stimulation by Juan Vicente-Mampel, Felipe Hernández-Zaballos, Francisco Javier Falaguera-Vera, David Sánchez-Poveda, Eloy Jaenada-Carrilero, Borja Huertas-Ramírez, Francisco Jose Sánchez-Montero

“…PSPS-type 2 is characterized by pain and significant disability, affecting quality of life. Spinal cord stimulation has proven effective in treating this syndrome, although the role of psychological factors, such as pain catastrophizing and central sensitization, remain unclear. …”
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USC-Derived Small Extracellular Vesicles-Functionalized Scaffolds Promote Scarless Vaginal Defect Repair via Delivery of Decorin and DUSP3 Proteins by Xu Y, Li J, Qiu Y, Wu F, Xue Z, Liu B, Fan H, Zhou Y, Wu Q

“…Compared to skin scars, vaginal scars can lead to pain during intercourse and urinary difficulties, severely impacting quality of life. Small extracellular vesicles (sEVs) encapsulate diverse bioactive components, making them potential therapeutic agents. …”
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Healthcare trajectories of aging individuals during their last year of life: application of process mining methods to administrative health databases by Delphine Bosson-Rieutort, Alexandra Langford-Avelar, Juliette Duc, Benjamin Dalmas

“…Abstract Context World is aging and the prevalence of chronic diseases is raising with age, increasing financial strain on organizations but also affecting patients’ quality of life until death. Research on healthcare trajectories has gained importance, as it can help anticipate patients’ needs and optimize service organization. …”
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Tumor aggression-defense index–a novel indicator to predicts recurrence and survival in stage II-III colorectal cancer by Tong Wu, Lin Fang, Yuli Ruan, Mengde Shi, Dan Su, Yue Ma, Ming Ma, Bojun Wang, Yuanyu Liao, Shuling Han, Xiaolin Lu, Chunhui Zhang, Chao Liu, Yanqiao Zhang

“…Therefore, precise predictive models and research on postoperative treatments are crucial for enhancing patient survival and improving quality of life. Methods This retrospective study analyzed 1051 pMMR CRC patients who underwent radical resection and were randomly assigned to training (n = 736) and validation (n = 315) groups. …”
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Prevalence, predictors, and economic burden of mental health disorders among asylum seekers, refugees and migrants from African countries: A scoping review. by Wael Osman, France Ncube, Kamil Shaaban, Alaa Dafallah

“…According to this randomized controlled trial, intervention to reduce psychological impairment can help young people stay in school, improve their quality-adjusted life year (QALY), and earn an incremental cost-effectiveness ratio (ICER) of $7260 for each QALY gained.…”
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Medication patterns and potentially inappropriate medication in patients with metastatic breast cancer: results of the BRE-BY-MED study by Lilly Sophia Brandstetter, Anna Grau, Peter U. Heuschmann, Max Müller-Reiter, Jessica Salmen, Stefan Störk, Achim Wöckel, Jens-Peter Reese

“…Abstract Background The treatment of metastatic breast cancer (mBC) focuses on prolonging patient survival, providing adequate symptom management, and maintaining quality of life (QoL). This includes supportive therapy to prevent or treat potential side effects and handle comorbidities. …”
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Influence of religion and spirituality on head and neck cancer patients and their caregivers: a protocol for a scoping review by Maheeka Seneviwickrama, Ruwan Jayasinghe, Kehinde Kazeem Kanmodi, Simon N. Rogers, Su Keill, Sakuntha Ratnapreya, Sriyani Ranasinghe, Sashini Shehana Denagamagei, Irosha Perera

“…Conclusions/discussion This review will aim to explore existing literature and summarize the findings of studies that examine the influence of religion and spirituality among HNC patients and their caregivers and vice versa over a range of physical, psychological, and social outcomes including quality of life. We also aim to identify existing research gaps. …”
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Intervening to eliminate the centre-effect variation in home dialysis use: protocol for Inter-CEPt—a sequential mixed-methods study designing an intervention bundle by Sarah Damery, Kerry Allen, Lisa Dikomitis, Harry Hill, David Coyle, Maatla Tshimologo, Mark Lambie, Simon J Davies, Iestyn Williams, James Fotheringham, Louise Phillips-Darby, Ivonne Solis-Trapala

“…This will inform a contemporary economic evaluation of modality cost-effectiveness that will quantify how modification of factors facilitating home dialysis, identified from the ethnography and survey, might yield the greatest improvements in costs, quality of life and numbers on home therapies. Selected from these factors, using the capability, opportunity and motivation for behaviour change framework (COM-B) for intervention design, the optimal intervention bundle will be developed through workshops with patients and healthcare professionals to ensure acceptability and feasibility. …”
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Clinical results of autologous fat transfer for basal thumb arthritis with a minimum of three years’ follow-up by Elisabeth M. Haas-Lützenberger, Iana Emelianova, Moritz C. Bader, Sinan Mert, Nicholas Moellhoff, Wolfram Demmer, Ursula Berger, Riccardo Giunta

“…Patients with a minimum three-year post-procedure period were assessed for pain level (numerical rating scale), quality of life (Mental Health Quotient (MHQ)), the abbreviated version of the Disabilities of Arm, Shoulder and Hand questionnaire (QuickDASH)), and grip and pinch strength, as well as their overall impression of the treatment. …”
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The design and rationale of the cardiac REHABilitation to improve metabolic health in Hypertrophic CardioMyopathy (REHAB-HCM) Study by Matthew Cheung, Nathaniel Moulson, Jinelle C. Gelinas, Ali Daraei, Sarah M. Bradwell, Carolyn Taylor, Neil D. Eves, Graeme J. Koelwyn, Thomas M. Roston

“…., major adverse events and exercise-related harms), and efficacy pertaining to long term improvements in physical activity levels, metabolic health, cardiorespiratory fitness, quality of life, and systemic and cellular markers of inflammation. …”
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Branched-chain amino acids levels associated with risk of erectile dysfunction: A Mendelian randomization analysis by Yijian Deng, Liying Zeng, Yigui Lai, Shuai Ji, Baizhao Peng, Hanqi Lu, Ming Wang, Hiu Yee Kwan, Qi Wang, Xiaoshan Zhao

“…Background: Erectile dysfunction (ED) is a prevalent male sexual dysfunction that remarkably impacts patients' quality of life and is also recognized as a precursor to cardiovascular disease (CVD) events. …”
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CtBP1 is essential for epigenetic silencing of μ-opioid receptor genes in the dorsal root ganglion in spinal nerve ligation-induced neuropathic pain by Cheng-Yuan Lai, Ming-Chun Hsieh, Chou-Ming Yeh, Tzer-Bin Lin, Dylan Chou, Hsueh-Hsiao Wang, Kuan-Hung Lin, Jen-Kun Cheng, Po-Sheng Yang, Hsien-Yu Peng

“…Neuropathic pain poses a significant public health challenge, greatly impacting patients' quality of life. Emerging evidence underscores the involvement of epigenetics in dorsal root ganglion (DRG) neurons relevant to pain modulation. …”
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Genetic Biomarkers and Circulating White Blood Cells in Osteoarthritis: A Bioinformatics and Mendelian Randomization Analysis by Yimin Pan, Xiaoshun Sun, Jun Tan, Chao Deng, Changwu Wu, Georg Osterhoff, Nikolas Schopow

“…<b>Background</b>: Osteoarthritis (OA) is a prevalent degenerative joint disease that causes disability and diminishes quality of life. The pathogenesis of OA remains poorly understood, creating an urgent need for biomarkers to aid research, diagnosis, and treatment. …”
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Disparities in anxiety and related factors among Chinese older adults across different aged-care models: a comparison of two cross-sectional studies by Xin Zheng, Ziwen Xu, Jiajie Zhao, Sanyuan Hao, Fuqin Xu, Shuo Ding, Guoqing Liu, Shufan Yang, Benjamin Otsen, Wen Zhu, Zhongliang Bai, Jie Yang, Ren Chen

“…Abstract Background Anxiety disorders in older adults have become a prominent public health problem due to their concomitant chronic conditions, reduced quality of life and even death. However, fewer studies have been conducted on differences in anxiety among older individuals in different aged-care models, and the interactive relationship between the influencing factors on anxiety remains unclear. …”
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