Innovative models of healthcare delivery: an umbrella review of reviews by Frances Rapport, Jeffrey Braithwaite, Yvonne Zurynski, Peter D Hibbert, Kate Churruca, Louise A Ellis, Chiara Pomare, Robyn Clay-Williams, Stephanie Best, Janet C Long, Gaston Arnolda, Bróna Nic Giolla Easpaig, Zeyad Mahmoud, Mitchell N Sarkies, Hoa Mi Nguyen, Karen Hutchinson, Gilbert Thomas Knaggs, Katherine Maka, Elizabeth E Austin, Diana Fajardo Pulido, Sarah Hatem, Natalie Roberts, Emilie Francis Auton, Genevieve Dammery, Isabelle Meulenbroeks, Ann Carrigan, Mai-Tran Nguyen

“…Common outcomes evaluated across reviews were clinical indicators and mortality, healthcare utilisation, self-care and self-management, patient knowledge, quality of life and cost-effectiveness. The findings indicate that the innovative models of healthcare we identified in this review may be effective in managing patients with a range of acute and chronic conditions. …”
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Beneficial and harmful effects of duloxetine versus placebo, ‘active placebo’ or no intervention for adults with major depressive disorder: a systematic review with meta-analysis a... by Christian Gluud, Marija Barbateskovic, Joanna Moncrieff, Faiza Siddiqui, Janus C Jakobsen, Mathias Maagaard, Sophie Juul, Johanne Juul Petersen, Caroline Barkholt Kamp, Mark Abie Horowitz, Kiran Kumar Katakam

“…Meta-analyses showed evidence of a beneficial effect of duloxetine on depressive symptoms (mean difference −1.81, Hamilton Depression Rating Scale (HDRS-17) points; 95% CI −2.34 to −1.28; heterogeneity I2=0.0%; 12 trials) and quality of life (mean difference −3.79 points, 95% CI −5.11 to −2.46; I2=0.0%; three trials), but the effect sizes were below our predefined minimal clinically important differences. …”
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Deep immunophenotyping of circulating immune cells in major depressive disorder patients reveals immune correlates of clinical course and treatment response by Fabiola Stolfi, Claudio Brasso, Davide Raineri, Virginia Landra, Camilla Barbero Mazzucca, Ali Ghazanfar, Lorenza Scotti, Riccardo Sinella, Vincenzo Villari, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti

“…We studied the associations between immunophenotype and depressive symptoms, social and working functioning, and subjective quality of life during the acute phase and after three months of treatment. …”
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Vibration therapy as an intervention for trochanteric hip fractures – A randomized double-blinded, placebo-controlled trial by Ronald Man Yeung Wong, Pui Yan Wong, Chaoran Liu, Chun Sing Chui, Wing Hong Liu, Ning Tang, James Griffith, Ning Zhang, Wing Hoi Cheung

“…Secondary outcome assessments were clinical and functional outcomes with quadriceps muscle strength, balancing ability, handgrip strength, Time Up and Go (TUG) test, quality of life outcomes, pain, falls, and mortality. …”
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Feasibility, Usability, and Pilot Efficacy Study of a Software-Enabled, Virtual Pulmonary Rehabilitation with Remote Therapeutic Monitoring by Flynn S, Mosher CL, Cornelison S, Rao E, Metzler KA, Pu W, Davies J, Paladenech C, Doyle D, MacIntyre N, Ohar J

“…Efficacy was evaluated with the 6 minute Walk Test (6MWT) and various functional performance and patient-centered health-related quality of life (HRQoL) questionnaires.Results: Forty-eight participants were enrolled, and 40 (83.3%) completed the intervention, n=17 in the C-PR group and n=23 in the V-PR group. …”
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Recurrent adenoid cystic carcinoma of the left upper palate accompanied by massive maxillary hemorrhage: a case report and literature review by ZHANG Wangru, CHEN Yuanyuan, LI Zhiping, MENG Jian

“…With the addition of radiotherapy and immune-targeted drug treatment, tumor progression was effectively controlled, leading to an improved quality of life for the patient, who successfully survived for 129 months with the tumor by July 2024. …”
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The Role of Butirprost^® as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial by Felice Crocetto, Armando Calogero, Michele Santangelo, Agostino Fernicola, Filippo Varlese, Benito Fabio Mirto, Fabio Machiella, Alfonso Falcone, Giovanni Pagano, Fabrizio Dinacci, Gaetano Giampaglia, Domenico Varriale, Francesco Trama, Salvatore Iaconis, Francesco Del Giudice, Gian Maria Busetto, Matteo Ferro, Francesco Lasorsa, Giuseppe Lucarelli, Ciro Imbimbo, Biagio Barone

“…It affects young and older men bimodally and impacts quality of life (QoL) significantly. <i>Background and Objectives</i>: Treatment typically involves antibiotics, but a multimodal approach with additional nutraceuticals may enhance outcomes. …”
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Bevacizumab Demonstrates Prolonged Disease Stabilization in Patients with Heavily Pretreated Metastatic Renal Cell Carcinoma: A Case Series and Review of the Literature by Nicole M. Agostino, Rebecca Gingrich, Joseph J. Drabick

“…These heavily pretreated patients sustained very prolonged periods of stable disease (median of 12 months) with very little toxicity and excellent quality of life. The activity of this agent in patients who had failed prior therapies directed against the VEGFR and mTOR suggests that therapy targeting the ligand, VEGF, is still a viable approach in these patients and deserves further study.…”
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Hemochromatosis Patients as Voluntary Blood Donors by Tara E Power, Paul C Adams

“…Despite the fact that in May 2001 the Canadian Blood Services, in collaboration with the Canadian Hemochromatosis Society, began a promotion campaign to encourage hemochromatosis patients to become voluntary blood donors, the present study found that 15% of the respondents reported having been refused from the voluntary blood donation service due to the diagnosis of hemochromatosis. With respect to quality of life, it was found that individuals who donate blood were generally healthier with respect to physical functioning and bodily pain, however, these findings may indicate that hemochromatosis patients who are healthier are better able to donate at public blood banks, rather than that voluntary blood donation has an effect on the donors' physical functioning over phlebotomy clinic users. …”
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Results from 10 Years of a CBT Pain Self-Management Outpatient Program for Complex Chronic Conditions by Kathryn A. Boschen, Edward Robinson, Kent A. Campbell, Sarah Muir, Elvina Oey, Kristen Janes, Samantha R. Fashler, Joel Katz

“…Cognitive Behavioural Therapy (CBT) and physical exercise (PE) are empirically supported treatments that can reduce pain and improve quality of life. Objectives. To examine the outcomes of a pain self-management outpatient program based on CBT and PE at a rehabilitation hospital in Toronto, Ontario. …”
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The Patient’s Experience of the Psychosocial Process That Influences Identity following Stroke Rehabilitation: A Metaethnography by E. Hole, B. Stubbs, C. Roskell, A. Soundy

“…Patient experience is increasingly being recognised as a key health outcome due to its positive correlation with quality of life and treatment compliance. The aim of this study was to create a model of how patient’s experiences of rehabilitation after stroke influence their outcome. …”
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Influence Factors of Reproductive Organ Maintenance Among Adolescent Girls in Coastal Areas by Armyla Eka Wahyu Yuliani, Lu'lu Nafisah, Bambang Hariyadi

“…This may further impact adolescents' quality of life and productivity. Adolescents in coastal areas tend to have limited sources of information, parental support, and inadequate health facilities related to adolescent reproductive health. …”
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From Bench to Bedside to Bug: An Update of Clinically Relevant Advances in the Care of Persons with Helicobacter pylori Associated Diseases by N Chiba, ABR Thomson, P Sinclair

“…New clinical trials of H pylori treatment show symptom relief and improvement in the quality of life of persons with functional dyspepsia, especially in those with ulcer-like or reflux-like dyspepsia. …”
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Comparison of Globus Pallidus Interna and Subthalamic Nucleus in Deep Brain Stimulation for Parkinson Disease: An Institutional Experience and Review by Shazia Mirza, Umar Yazdani, Richard Dewey III, Neepa Patel, Richard B. Dewey, Svjetlana Miocinovic, Shilpa Chitnis

“…Currently, the Globus Pallidus Interna (GPi) and Subthalamic Nucleus (STN) are both viable targets for DBS, and the choice of site should focus on the constellation of symptoms, both motor and nonmotor, which are key determinants to quality of life. Our article sheds light on the specific advantages and drawbacks of the two sites, highlighting the need for matching the inherent properties of a target with specific desired effects in patients. …”
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Determination of Physical Activity Levels of Karabük University Students by Serkan Revan, Mert Aydogmus, Yılmaz Yüksel, Numan Kayışoğlu

“…Health-related behaviors that an individual gains early in his life affect the individual's quality of life in adulthood. The purpose of this study was to examine the physical activity (PA) levels of students studying at Karabük University according to the variables of gender, the program attended and body mass index (BMI). …”
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The Association of COPD Exacerbations with New Onset Type 2 Diabetes among Medicare Patients by Joseph S. Marino, Cynthiya Ruban, Christopher M. Blanchette

“…**Objective:** Chronic obstructive pulmonary disease (COPD) is highly prevalent in the elderly population and typically reduces overall quality of life. Exacerbations of COPD are commonly treated with corticosteroids, a class of drug known to cause insulin resistance. …”
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Time Savings and Surgery Task Load Reduction in Open Intraperitoneal Onlay Mesh Fixation Procedure by Sanjoy Roy, Jeffrey Hammond, Jessica Panish, Pullen Shnoda, Sandy Savidge, Mark Wilson

“…Mechanical fixation with ETHICON SECURESTRAPTM Open demonstrated a significant reduction in fixation time and surgeon stress, which may translate into improved operating efficiency, improved performance, improved surgeon quality of life, and reduced overall costs of the procedure.…”
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Risk factors for lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: a systematic review and meta-analysis by Ziyue Chen, Dajian Zhu

“…A comprehensive evaluation of these risk factors and imaging findings is recommended to tailor personalized treatment strategies that optimize survival outcomes and improve quality of life.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42024581891.…”
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Analysis and Optimization of the Spatial Patterns of Commercial Service Facilities Based on Multisource Spatiotemporal Data and Graph Neural Networks: A Case Study of Beijing, Chin... by Yihang Xiao, Cunzhi Li, Zhiwu Zhou, Dongyang Hou, Xiaoguang Zhou

“…As a crucial component of urban economic activities, the layout and optimization of urban commercial spaces directly influence the economic prosperity and quality of life of residents. Therefore, comprehensively and accurately characterizing the distribution characteristics and evolutionary patterns of urban commercial spaces is essential for improving the efficiency of urban spatial allocation and achieving scientific spatial planning and governance. …”
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Oral Rehabilitation of Oral Cancer Patients Using Zygomatic Implant-Supported Maxillary Prostheses with Magnetic Attachment: Three Case Reports by Hisashi Ozaki, Hiromasa Sakurai, Yukie Yoshida, Hideyuki Yamanouchi, Mitsuyoshi Iino

“…These findings show that quality of life (QOL) and oral function were improved.…”
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