Exercise‐Activated mPFC Tri‐Synaptic Pathway Ameliorates Depression‐Like Behaviors in Mouse by Tian Lan, Ye Li, Xiao Chen, Wenjing Wang, Changmin Wang, Haiyan Lou, Shihong Chen, Shuyan Yu

“…With this pathway, initial inputs from neurons within the dorsal root ganglia (DRG) project to excitatory neurons in the gracile nucleus (GR), which in turn connect with 5‐HTergic neurons in the dorsal raphe nucleus (DRN), eventually coursing to excitatory pyramidal neurons within the medial prefrontal cortex (mPFC). …”
Get full text

Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice by Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo

“…Iron-loaded mice have reduced hippocampal CA3 pyramidal neurons and significant iron accumulation in blood vessels, with no increase in neuronal iron levels. …”
Get full text

Noradrenergic inputs from the locus coeruleus to anterior piriform cortex and the olfactory bulb modulate olfactory outputs by Chi Geng, Ruochen Li, Shan Li, Penglai Liu, Yuxin Peng, Changyu Liu, Zhen Wang, Hongxing Zhang, Anan Li

“…By using pharmacological and optogenetic manipulations in vitro and in vivo, we found that NE reduces the excitability of aPC pyramidal neurons directly via α2 receptors and that it bidirectionally regulates the activity of OB mitral cells via modulation of inhibitory inputs. …”
Get full text

Investigation on the microstructure evolution and deformation behavior of Mg–2Zn-0.5Mn-0.2Ca-xNd/yLa alloy by in-situ tensile by Jie Mi, Shengquan Liang, Shiyu Luan, Qianlong Ren, Xin Che, Peipeng Jin

“…The microstructure evolution and deformation behavior analyzed by in-situ SEM and EBSD show that the basal texture intensity of alloy A is larger, which promotes more prismatic slip during the tensile process, resulting in higher tensile load, while alloy B with higher Nd content produces more pyramidal slip in the later stage of deformation, which contributes to higher plasticity. …”
Get full text

Hyaluronidase-induced matrix remodeling contributes to long-term synaptic changes by Rostislav Sokolov, Rostislav Sokolov, Viktoriya Krut', Viktoriya Krut', Vsevolod Belousov, Vsevolod Belousov, Vsevolod Belousov, Vsevolod Belousov, Andrey Rozov, Andrey Rozov, Irina V. Mukhina, Irina V. Mukhina

“…Spontaneous action potential firing frequency increased rapidly after ECM destruction in interneurons, but not pyramidal neurons. Hyaluronidase-dependent calcium entry can be blocked by a selective antagonist of N-methyl-D-aspartate (NMDA) receptors, revealing these receptors as the main player in the observed phenomenon. …”
Get full text

Le lieu-dit des « Trois-Piliers » : un ensemble à caractère monumental du iiie s. apr. J.-C. dans la périphérie nord-est de Reims/Durocortorum ? by Philippe Rollet, Émilie Jouhet

“…The cladding is composed of small, very neat units, mounted in opus vittatum, with calibrated pyramidal shaped fragments of limestone. And while the cladding courses are perfectly horizontal, the internal blocking is composed of small limestone fragments, bound with a tile mortar. …”
Get full text

Chronic Rapamycin Prevents Electrophysiological and Morphological Alterations Produced by Conditional Pten Deletion in Mouse Cortex by Jason S. Hauptman, Joseph Antonios, Gary W. Mathern, Michael S. Levine, Carlos Cepeda

“…In the present study, we used a conditional mouse model with a deletion of the phosphatase and tensin homologue (Pten^-/-, a negative regulator of mTOR) from cortical pyramidal neurons (CPNs). Whole-cell patch clamp recordings in ex vivo slices examined the intrinsic and synaptic membrane properties of layer II/III CPNs in normal mice treated with rapamycin for four weeks, and Pten^-/- mice with and without chronic treatment with rapamycin. …”
Get full text

The Effect of Repetitive Transcranial Magnetic Stimulation on Motor Symptoms in Hereditary Spastic Paraplegia by J. Antczak, J. Pera, M. Dąbroś, W. Koźmiński, M. Czyżycki, K. Wężyk, M. Dwojak, M. Banach, A. Slowik

“…Hereditary spastic paraplegia (HSP) is a heterogeneous group of inherited disorders affecting predominantly the motor cortex and pyramidal tract, which results in slowly progressing gait disorders, as well as spasticity and weakness of lower extremities. …”
Get full text

L’aqueduc du Gier : étude des ponts-siphons du Garon à Brignais et Chaponost (Rhône) et de Beaunant à Sainte-Foy-lès-Lyon (Métropole de Lyon) by Kilian Blanc, Laurie Danielou

“…The two venter bridges were made using the opus reticulatum mixtum technique, where square-headed pyramidal rubble stones are arranged at an angle of 45° in alternation with double layers of brick. …”
Get full text

Human Detection and Action Recognition for Search and Rescue in Disasters Using YOLOv3 Algorithm by B. Valarmathi, Jain Kshitij, Rajpurohit Dimple, N. Srinivasa Gupta, Y. Harold Robinson, G. Arulkumaran, Tadesse Mulu

“…The proposed work shows that existing models are inadequate for critical applications like search and rescue, which convinces us to propose a model raised by a pyramidal component extracting SSD in human localization and action recognition. …”
Get full text

FOXP2-immunoreactive corticothalamic neurons in neocortical layers 6a and 6b are tightly regulated by neuromodulatory systems by Guanxiao Qi, Danqing Yang, Fernando Messore, Arco Bast, Felipe Yáñez, Marcel Oberlaender, Dirk Feldmeyer

“…It is expressed specifically in a subset of corticothalamic (CT) pyramidal cells (PCs) in layer 6 (L6) of the neocortex. …”
Get full text

CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model by Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

“…A tauopathy mouse model also had the significantly reduced expression of GABA-related genes, as well as the diminished GABAergic synaptic transmission in PFC pyramidal neurons. To elevate endogenous Gad1 levels, we used the CRISPR/Cas9-based epigenome editing technology to recruit histone acetyltransferase p300 to Gad1. …”
Get full text

Single-nucleotide polymorphism analysis accurately predicts multiple impairments in hippocampal activity and memory performance in a murine model of idiopathic autism by Isabel Barón-Mendoza, Luis A. Márquez, Aliesha González Arenas, Jessica Guzmán-Condado, Vladimir A. Martínez-Rojas, Johaly Anguiano-Buenfil, Montserrat Mejía-Hernández, Jorge Luis Almazán, Leonor Pérez-Martínez, Gustavo Pedraza-Alva, Emilio J. Galván, Angélica Zepeda

“…Additionally, several electrophysiological properties of CA3 pyramidal cells and hippocampal communication were altered. …”
Get full text

Electroacupuncture Involved in Motor Cortex and Hypoglossal Neural Control to Improve Voluntary Swallowing of Poststroke Dysphagia Mice by Shuai Cui, Shuqi Yao, Chunxiao Wu, Lulu Yao, Peidong Huang, Yongjun Chen, Chunzhi Tang, Nenggui Xu

“…Four main conclusions can be drawn from our study: (i) EA may enhance the local field potential in noninfarction area of M1, activate the swallowing-related neurons (pyramidal cells), and increase the motor conduction of noninfarction area in voluntary swallowing; (ii) EA may improve the blood flow in both M1 on the healthy side and deglutition muscles and relieve PSD symptoms; (iii) EA could increase the motor conduction velocity (MCV) in hypoglossal nerve, enhance the EMG of mylohyoid muscle, alleviate the paralysis of swallowing muscles, release the substance P, and restore the ability to drink water; and (iv) EA can boost the functional compensation of M1 in the noninfarction side, strengthen the excitatory of hypoglossal nerve, and be involved in the voluntary swallowing neural control to improve PSD. …”
Get full text

Abnormal cytoskeletal remodeling but normal neuronal excitability in a mouse model of the recurrent developmental and epileptic encephalopathy-susceptibility KCNB1-p.R312H variant by Alessandro Bortolami, Elena Forzisi Kathera-Ibarra, Anastasia Balatsky, Mansi Dubey, Rusheel Amin, Srinidi Venkateswaran, Stefania Dutto, Ishan Seth, Adam Ashor, Angel Nwandiko, Ping-Yue Pan, David P. Crockett, Federico Sesti

“…Surprisingly, the electrical properties of Kcnb1 R312H(+/+) pyramidal neurons are similar to those of WT neurons, indicating that the arginine to histidine replacement does not affect the conducting properties of the mutant channel. …”
Get full text

Aging Alters Olfactory Bulb Network Oscillations and Connectivity: Relevance for Aging-Related Neurodegeneration Studies by A. Ahnaou, D. Rodriguez-Manrique, S. Embrechts, R. Biermans, N. V. Manyakov, S. A. Youssef, W. H. I. M. Drinkenburg

“…Specifically, we measured the long-term potentiation of high-frequency stimulation (HFS-LTP) at the Shaffer-Collateral CA1 pyramidal synapses. Next, local field potential (LFP) spectra, phase-amplitude theta-gamma coupling (PAC), and connectivity through coherence were assessed in the olfactory bulb, frontal and entorhinal cortices, CA1, and amygdala circuits. …”
Get full text

Subchronic cyanuric acid treatment impairs spatial flexible behavior in female adolescent rats through depressing GluN2B-dependent neuronal and synaptic function by Wei Sun, Haiyang Yu, Xiaoliang Li, Yiwen Wan, Yazi Mei, Yang Yang, Lei An

“…Hippocampal synaptic function at Schaffer collaterals-CA1 synapses and excitatory postsynaptic currents (EPSCs) in CA1 pyramidal neurons was evaluated. Meanwhile, the glutamate transport inhibitor DL-threo-β-benzyloxyaspartate (DL-TBOA) was infused into hippocampal CA1 region to certify the underlying mechanism. …”
Get full text

Apallic syndrome of toxic origin: the diagnostic criteria by N.V. Kurdil, A.O. Volosovets, O.V. Ivashchenko, V.S. Lisovska, H.M. Balan, O.M. Rozhkova, V.V. Andriushchenko

“…Forensic and histological studies of the cerebral cortex revealed diffuse loss of neurons, neuronophagia, satellitosis, deformed pyramidal neurons with apical dendrites and manifestations of homogenising necrosis, angiomatosis microfoci and neuropil vacuolation, mineralization of the tissue and a moderate glial reaction around the petrifications. …”
Get full text

Larvicidal activity of Bacillus thuringiensis strains against Aedes aegypti and Culex quinquefasciatus mosquitoes by Prakai Rajchanuwong, Sawaporn Peaboon, Ratchadawan Ngoen-Klan, Atsalek Rattanawannee, Atirat Noosidum, Boonhiang Promdonkoy, Jariya Chanpaisaeng, Theeraphap Chareonviriyaphap

“…Scanning electron microscopy revealed that JC690, JC691, and JC699 are rod-shaped, have oval spores, and produce bi-pyramidal crystal proteins. Protein profile analysis using SDS-PAGE demonstrated distinct differences between these Thailand strains (JC690, JC691, and JC699) and the reference Bti strain. …”
Get full text

DNMT3a Downregulation Ttriggered Upregulation of GABAA Receptor in the mPFC Promotes Paclitaxel‐Induced Pain and Anxiety in Male Mice by Lixia Tian, Xu‐Hui Li, Yu‐Long Zhao, Hui‐Yuan Yi, Xue‐Ru Liu, Rongrong Yao, Xue‐Mei Hou, Xuan Zhu, Fu‐Quan Huo, Tao Chen, Lingli Liang

“…Additionally, it reverses the PTX‐induced increase in inhibitory synaptic transmission in the pyramidal neurons of the mPFC. Mechanistically, the upregulation of GABAARβ1 in the mPFC is linked to the reduced expression of DNMT3a and DNA hypomethylation at the promoter region of the Gabrb1 gene. …”
Get full text