Noninvasive Demonstration of Dual Coronary Artery Fistulas to Main Pulmonary Artery with 64-Slice Multidetector-Computed Tomography: A Case Report by Yoshiki Noda, Ryo Matsutera, Yoshinori Yasuoka, Haruhiko Abe, Hidenori Adachi, Susumu Hattori, Ryo Araki, Takahiro Imanaka, Motohiro Kosugi, Tatsuya Sasaki

“…We report here a 58-year-old woman with dual fistulas originating from the left anterior descending coronary artery and right coronary sinus to the main pulmonary artery, demonstrating noninvasively with multidetector-computed tomography (MDCT) and transthoracic echocardiography (TTE).…”
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Transition from Intravenous Epoprostenol to Oral or Subcutaneous Therapy in Pulmonary Arterial Hypertension: A Retrospective Case Series and Systematic Literature Review by Kirily Park, David Ostrow, Robert D Levy, John Swiston

“…BACKGROUND: Intravenous epoprostenol, a prostaglandin analogue, has been a mainstay of therapy for patients with advanced pulmonary arterial hypertension (PAH) since the early 1990s. …”
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Serum-Free Thyroxine Levels Were Associated with Pulmonary Hypertension and Pulmonary Artery Systolic Pressure in Euthyroid Patients with Coronary Artery Disease by Bingjie Wu, Jingjing Jiang, Minghui Gui, Lin Liu, Qiqige Aleteng, Shanshan Wang, Xiaojing Liu, Yan Ling, Xin Gao

“…The aim of this study was to evaluate the association between thyroid hormone levels, pulmonary hypertension (PH), and pulmonary artery systolic pressure (PASP) in euthyroid patients with coronary artery disease (CAD). …”
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STAT6 deficiency mitigates the severity of pulmonary arterial hypertension caused by chronic intermittent hypoxia by suppressing Th2-inducing cytokines by Pan Jiang, Huai Huang, Zilong Liu, Guiling Xiang, Xiaodan Wu, Shengyu Hao, Shanqun Li

“…The immune response contributes to pulmonary artery remodeling and OSA-related diseases. The immunologic factors linked to OSA-induced PH are not well understood. …”
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A study on blocking store-operated Ca2+ entry in pulmonary arterial smooth muscle cells with xyloketals from marine fungi by Zhou Jie-Bin, Sun Ying-Ying, Zheng Ying-Lin, Yu Chu-Qin, Lin Hua-Qing, Pang Ji-Yan

“…In this study, the effect of four xyloketals 1-4 on store-operated calcium entry (SOCE) was investigated in primary distal pulmonary arterial smooth muscle cells (PASMCs) isolated from mice. …”
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Sacubitril/valsartan on right ventricular-pulmonary artery coupling and albumin-bilirubin score in heart failure in Chinese patients with reduced ejection fraction by Yanan Shi, Chuanyu Gao, Yu Xu, Fang Yuan

“…Abstract Objective Impaired right ventricular (RV)-pulmonary arterial (PA) coupling, calculated by measuring the tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP), can be used as an early indicator of right ventricular dysfunction (RVD) in patients with heart failure with a reduced ejection fraction (HFrEF). …”
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Psychological counselling interventions to improve perceived quality of life and counter anxiety and depression in pulmonary-arterial-hypertension patients: A clinical trial by Emilia TARANTINO, Pietro CRESCENZO, Maria CAMPOBASSO, Francesca D’ALESSANDRO, Paola ARGIENTO, Emanuele ROMEO, Stefano GHIO, Patrizio VITULO, Francesco PARISI, Massimiliano MULÈ, Carlo ALBERA, Carmine Dario VIZZA, Michele D’ALTO

Subjects: “…anxiety; counselling psychology; depression; eq-vas; eq-5d; pulmonary arterial hypertension; quality of life.…”
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MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension by Yi Tang, Xiaowei Huo, Junyu Liu, Yijin Tang, Min Zhang, Wenlin Xie, Zhaofen Zheng, Jin He, Jiayan Lian

“…Background. Pulmonary arterial hypertension (PAH) usually causes right ventricular dysfunction, which is closely related to cardiac fibrosis. …”
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Metastatic Non-Small-Cell Lung Cancer in the Setting of Unilateral Agenesis of the Left Pulmonary Artery: A Case Report and Comprehensive Literature Review by John Agzarian, Jakub Kadlec, Lori Whitehead, Yaron Shargall

“…Unilateral absence of the pulmonary artery (UAPA) represents a rare condition that is often associated with cardiac congenital abnormalities but can also be relatively asymptomatic and indolent. …”
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Anomalous Left Coronary Artery Connected to the Pulmonary Artery in a 15-Year-Old Girl: Case Report and Discussion on Secondary Prevention of Sudden Death by Jérémy Laïk, Virginie Fouilloux, Philippe Aldebert, Linda Koutbi, Jérôme Hourdain, Philippe De Swardt, Fabrice Tiger, Anne Bellemain-Appaix, François Bernasconi, Laurent Jacq

“…Anomalous left coronary artery connected to the pulmonary artery (ALCAPA) is a rare congenital heart disease. …”
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Using Real World Evidence to Describe Pulmonary Arterial Hypertension Treatment Patterns, Healthcare Resource Utilization, and Costs Associated with PDE-5 Inhibitor Monotherapy by George Ruiz, Jason Yeaw, Cassandra A. Lickert, Ajita P. De, Rolin L. Wade, Janis Pruett, William Drake

“…**Background:** Pulmonary arterial hypertension (PAH) is described by proliferation of small pulmonary arteries leading to increased pulmonary vascular resistance, right ventricular failure, and death. …”
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Comparison of Healthcare Encounters and Drug Persistence in Patients With Pulmonary Arterial Hypertension Receiving Oral Selexipag, Inhaled Iloprost, or Parenteral Treprostinil: A Retrospective Database Analysis by Ci Song, Peter Kunovszki, Amélie Beaudet

“…**Background:** Agents targeting the prostacyclin (PGI~2~) pathway are important in managing pulmonary arterial hypertension (PAH). No head-to-head clinical trials have compared outcomes between the 3 different PGI~2~-pathway drugs most commonly available in countries with advanced healthcare: oral selexipag, inhaled iloprost, and parenteral (subcutaneous or intravenous) treprostinil. …”
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Reducing TRPC1 Expression through Liposome-Mediated siRNA Delivery Markedly Attenuates Hypoxia-Induced Pulmonary Arterial Hypertension in a Murine Model by Cheuk-Kwan Sun, Yen-Yi Zhen, Hung-I Lu, Pei-Hsun Sung, Li-Teh Chang, Tzu-Hsien Tsai, Jiunn-Jye Sheu, Yung-Lung Chen, Sarah Chua, Hsueh-Wen Chang, Yi-Ling Chen, Fan-Yen Lee, Hon-Kan Yip

“…We tested the hypothesis that Lipofectamine siRNA delivery to deplete transient receptor potential cation channel (TRPC) 1 protein expression can suppress hypoxia-induced pulmonary arterial hypertension (PAH) in mice. Adult male C57BL/6 mice were equally divided into group 1 (normal controls), group 2 (hypoxia), and group 3 (hypoxia + siRNA TRPC1). …”
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Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-bli... by Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama Dabbagh

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Loss of Type 2 Bone Morphogenetic Protein Receptor Activates NOD‐Like Receptor Family Protein 3/Gasdermin E‐Mediated Pyroptosis in Pulmonary Arterial Hypertension by Xiao‐ting Tian, Zhou‐yang‐fan Peng, Yu‐si Wu, Yuan‐yuan Cao, Xue‐chun Li, Ying Li, Si‐Yuan Tang, Alex F. Chen, Xiao‐hui Li

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Peak steps to measure ‘‘capacity for activity’’: Actigraphy in the ADAPT registry with oral treprostinil by Daniel Lachant, DO, James Gagermeier, MD, Scott Seaman, PhD, Andrew Wang, MPH, Meredith Broderick, PharmD, JD, R. James White, MD, PhD

Subjects: “…pulmonary arterial hypertension…”
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Profile of Endothelin-1, Nitric Oxide, and Prostacyclin Levels in Pulmonary Arterial Hypertension Related to Uncorrected Atrial Septal Defect: Results from a Single Center Study in Indonesia by Lucia Kris Dinarti, Anggoro Budi Hartopo, Dyah Wulan Anggrahini, Ahmad Hamim Sadewa, Budi Yuli Setianto, Abdus Samik Wahab

“…Background and Objectives. Pulmonary arterial hypertension (PAH) pathomechanism involves an increased plasma level of endothelin-1 and a reduced plasma level of prostacyclin and nitric oxide. …”
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Rationale and design of the CardioMEMS Post‐Market Multinational Clinical Study: COAST by Martin R. Cowie, Pascal deGroote, Scott McKenzie, Marie‐Elena Brett, Philip B. Adamson, the CardioMEMS Post‐Market Study Investigators

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Circulating miRNA-486 as a novel diagnostic biomarker for right ventricular remodeling by Huiling Cai, Huiling Cai, Cheng Yu, Xiuchuan Li, Xuenan Wang, Xuenan Wang, Yongjian Yang, Yongjian Yang, Yongjian Yang, Cong Lan, Cong Lan

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Cardiopulmonary Exercise Testing: Deciphering Cardiovascular Complications in Systemic Sclerosis by Ailia Giubertoni, Mattia Bellan, Luca Cumitini, Giuseppe Patti

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