CRISPR/Cas9-mediated genomic insertion of functional genes into Lactiplantibacillus plantarum WCFS1 by Kamilla Wiull, Lisa K. Haugen, Vincent G. H. Eijsink, Geir Mathiesen

“…All the knock-in strains produced the target protein, although with lower yields than strains with plasmid-encoded expression.IMPORTANCEGenetic engineering of lactic acid bacteria, such as Lactiplantibacillus plantarum, has proven to be difficult. This study presents an inducible two-plasmid CRISPR/Cas9-system for inserting genes into the chromosome of Lactiplantibacillus plantarum. …”
Get full text

The Anti-Inflammatory Effect of Chenopodium Murale in Comparison to Salvia Frigida on Atopic Eczema by Zahraa Y. Hassan, Tuka Y. Hassan, Ahmed Y. Kanany

“…Chenopodium murale is clinically proven for treating many medical conditions, such as AD, due to its easy application and efficacy. …”
Get full text

Photovoltaic Farm Production Forecasting: Modified Metaheuristic Optimized Long Short-Term Memory-Based Networks Approach by Aleksandar Stojkovic, Bosko Nikolic, Miodrag Zivkovic, Nebojsa Bacanin

“…Machine learning models have proven to be a prospective resolution due to their ability to process large datasets and capture intricate patterns within the data. …”
Get full text

Psychometric accuracy of the Dutch Child and Adolescent Trauma Screener by Lieke H. Kooij, Irma M. Hein, Cedric Sachser, Samantha Bouwmeester, Madelief Bosse, Ramón J. L. Lindauer

“…The ROC-curve analysis has proven a good accuracy (AUC = .81; n = 106).Discussion and conclusion: This study demonstrates the psychometric accuracy of the KJTS in a Dutch clinical population. …”
Get full text

Efficacy and Safety of Immunosuppressive Therapy for PBC–AIH Overlap Syndrome Accompanied by Decompensated Cirrhosis: A Real-World Study by Xiaoli Fan, Yongjun Zhu, Ruoting Men, Maoyao Wen, Yi Shen, Changli Lu, Li Yang

“…This cohort study was performed between October 2013 and June 2017 and included 28 biopsy-proven patients diagnosed according to the Paris criteria. …”
Get full text

The Role of Therapeutic Anticoagulation in COVID-19 by Ruth McGovern, Patrick Conway, Isabell Pekrul, Omar Tujjar

“…Coagulopathy has proven to be a common complication of the novel coronavirus SARS-CoV-2, with evidence of elevated D-dimers and fibrin degradation products associated with an increased incidence of thromboembolism. …”
Get full text

INTEGRATION OF UKRAINIAN CHILDREN AND YOUTH USING DIGITAL TOOLS IN THE EDUCATIONAL ENVIRONMENT OF SLOVAKIA by Nelly Nychkalo, Nataliia Muranova, Olena Voliarska, Maria Matulcikova

“…It has been established that Slovak teachers use such digital tools as Microsoft Teams, Cisco Webex Meetings, Google Classroom, Zoom to integrate Ukrainian students into the educational environment. It has been proven that Slovakian society faces the problem of accelerating the integration of Ukrainian children, pupils and students by means of digital tools. …”
Get full text

Oxidative Stress, Lipid Peroxidation, and Loss of Hyaluronic Acid in the Human Vitreous Affected by Synchysis Scintillans by Loredana Bergandi, Oleksii A Skorokhod, Rosalba La Grotta, Evelin Schwarzer, Raffaele Nuzzi

“…The data consistently show that synchisis scintillans is accompanied by a redox imbalance with increased oxidative modifications of 4-HNE proteins and loss of HA, both of likely importance for remote damages of the retina. It remains to be proven whether a therapeutic strategy which targets oxidative stress may be effective in the treatment of synchysis patients.…”
Get full text

Criteria for the admissibility of digital (electronic) evidence in criminal proceedings by V. V. Romaniuk, S. Ye. Ablamskyi

“…This is due to the fact that digital (electronic) evidence contains abstract technical and mathematical models, characterized by specific conditions of origin, existence, copying and storage, which significantly differ from other types of evidentiary information. It has been proven that when determining digital (electronic) evidence, such a mandatory feature as relevance to a certain criminal proceeding should be displayed. …”
Get full text

A reproducible representation of healthy tibiofemoral kinematics during stair descent using REFRAME – part I: REFRAME foundations and validation by Ariana Ortigas-Vásquez, William R. Taylor, Barbara Postolka, Pascal Schütz, Allan Maas, Matthias Woiczinski, Thomas M. Grupp, Adrian Sauer

“…Exacerbated by numerous difficulties to consistently define joint coordinate frames, the influence of local frame orientation and position on the characteristics of the resultant kinematic signals has been previously proven to be a major limitation. Consequently, for consistent interpretation of joint motion (especially direct comparison) to be possible, differences in local frame position and orientation must first be addressed. …”
Get full text

Pengukuran Niat Penggunaan Virtual Reality sebagai Alat Simulasi Pelatihan by Riski Arifin, Adithya Sudiarno

“…Abstract Virtual Reality is a technology that describes a virtual environment, the virtual reality continues to show a massive increase of usage over the years ranging from a gaming application to a simulation tool for education and training, which proven to provide better understanding of the learning subject compared to the conventional training. …”
Get full text

The antihypertensive efficacy of a quadruple single-pill combination in patients with resistant hypertension: study protocol for a randomized, open-label, crossover trial by Yuanyuan Yao, Xin Zhang, Runyu Ye, Shanshan Jia, Xiangyu Yang, Xiaoping Chen

“…Compound reserpine and triamterene tablets, a traditional Chinese quadruple single-pill combination, have been proven to have good antihypertensive effects as well as safety, and are promising effective antihypertensive drugs for treating RH. …”
Get full text

Ginkgetin delays the progression of osteoarthritis by inhibiting the NF-κB and MAPK signaling pathways by Liang Zhu, Yanchi Bi, Ting Liang, Po Zhang, Xiao Xiao, Tengbo Yu

“…Ginkgetin (GK), a natural non-toxic chemical, has proven anti-inflammatory, antioxidant, anti-tumor, and neuroprotective effects. …”
Get full text

hucMSC-Ex Alleviates IBD-Associated Intestinal Fibrosis by Inhibiting ERK Phosphorylation in Intestinal Fibroblasts by Yifei Wang, Yaqin Zhang, Bing Lu, Jianbo Xi, Dickson Kofi Wiredu Ocansey, Fei Mao, Donglin Hao, Yongmin Yan

“…Mesenchymal stem cell-derived exosomes have been proven to exert inhibitory and reversal effects in IBD and other organ fibrosis. …”
Get full text

SYNERGISTIC EFFECT OF QUERCETIN AND EPIGALLOCATECHIN-3-GALLATE AS AGENTS TO PREVENT CONNECTIVE TISSUE DISINTEGRATION IN THE PERIODONTIUM OF RATS UNDER SYSTEMIC AND LOCAL ADMINISTR... by A.M. Yelins’ka, V.O. Kostenko

“…Thus, the co-administration of water-soluble form of quercetin and epigallocatechin-3-gallate under systemic and local introducing of S. typhi lipopolysaccharide has been proven to be more effective means for preventing and correcting periodontal connective tissue disruption than this occurs at separate administration of each of the polyphenols.…”
Get full text

INNOVATIVE MECHANISMS FOR IMPLEMENTING STATE ECONOMIC POLICY FOR POST-WAR RECONSTRUCTION OF UKRAINE: QUANTUM TRANSFORMATIONS AS A DRIVER OF DEVELOPMENT by Oleksiy Shkuratov, Liudmila Antonova, Roman Dzyuba

“…It is justified that, exhausted by the full-scale invasion of Russian aggressors, Ukraine currently does not have the necessary financial resources for the development and introduction of quantum technologies. It has been proven that it is possible to improve the situation only if a balanced state investment policy for quantum transformation of the country is developed and implemented. …”
Get full text

Symptomatic vigabatrin‐associated MRI toxicity is associated with simultaneous hormonal therapy among patients with infantile spasms by Rujuta Sathe, Gyaneshwar Shrestha, Aria Terango, David Tabibzadeh, Rajsekar R. Rajaraman, Hiroki Nariai, Shaun A. Hussain

“…However, we have not proven that combination therapy actually causes sVABAM. …”
Get full text

Effects of removing reimbursement restrictions on targeted therapy accessibility for non-small cell lung cancer treatment in Taiwan: an interrupted time series study by Jason C Hsu, Chen-Fang Wei, Szu-Chun Yang

“…Interventions Targeted therapies have been proven to provide clinical benefits to patients with metastatic non-small cell lung cancer (NSCLC). …”
Get full text

Business Development of The Ecotourism of Javan Gibbon: A Marketing Mix Strategy at Gede Pangrango National Park by Fandawa Saputra, Tutut Sunarminto, Harnios Arief, Khairiyah Kamilah

“…Results: Findings indicate that tourists have a positive perception of Javan gibbon ecotourism, proven by the score given by local tourist and foreign tourists are 5.7 and 5.9 in a row. …”
Get full text

Preliminary Numerical Modeling of CO2 Geological Storage in the Huangcaoxia Gas Reservoir in the Eastern Sichuan Basin, China by Hongwu Lei, Qian Zhang, Xiaochun Li

“…Depleted gas reservoirs are important potential sites for CO2 geological sequestration due to their proven integrity and safety, well-known geological characteristics, and existing infrastructures and wells built for natural gas production. …”
Get full text