Drug-Drug Interactions Between HIV Antivirals and Concomitant Drugs in HIV Patients: What We Know and What We Need to Know by Emanuela De Bellis, Danilo Donnarumma, Adele Zarrella, Salvatore Maria Mazzeo, Annarita Pagano, Valentina Manzo, Ines Mazza, Francesco Sabbatino, Graziamaria Corbi, Pasquale Pagliano, Amelia Filippelli, Valeria Conti

“…Protease inhibitors, followed by nonnucleoside reverse transcriptase inhibitors and integrase inhibitors have been recognized as the main players in DDIs with antivirals used to control co-infection, such as Hepatitis C virus, or with drugs commonly used to treat HIV comorbidities, such as lipid-lowering agents, proton pump inhibitors and anticancer drugs. However, the studies do not seem to be consistent with regard to sample size and follow-up, the drugs involved, or the results obtained. …”
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V-ATPase in glioma stem cells: a novel metabolic vulnerability by Alessandra Maria Storaci, Irene Bertolini, Cristina Martelli, Giorgia De Turris, Nadia Mansour, Mariacristina Crosti, Maria Rosaria De Filippo, Luisa Ottobrini, Luca Valenti, Elisa Polledri, Silvia Fustinoni, Manuela Caroli, Claudia Fanizzi, Silvano Bosari, Stefano Ferrero, Giorgia Zadra, Valentina Vaira

“…Abstract Background Glioblastoma (GBM) is a lethal brain tumor characterized by the glioma stem cell (GSC) niche. The V-ATPase proton pump has been described as a crucial factor in sustaining GSC viability and tumorigenicity. …”
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Perforated Carcinoma in the Gastric Remnant: A Case of Conservative Treatment Prior to Successful Curative R0 Resection by Ken Yuu, Hiroshi Kawashima, Sho Toyoda, Satoshi Okumura, Kansuke Yamamoto, Naoto Mizumura, Aya Ito, Hiromitsu Maehira, Atsuo Imagawa, Masao Ogawa, Masayasu Kawasaki, Masao Kameyama

“…Conservative medical management was selected, including nasogastric tube insertion, antibiotics, and proton pump inhibitors, because his peritonitis was limited to his epigastrium and his general condition was stable. …”
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Effects of water stably-enriched with oxygen as a novel method of tissue oxygenation on mitochondrial function, and as adjuvant therapy for type 2 diabetes in a randomized placebo-... by Joan Khoo, Christoph E Hagemeyer, Darren C Henstridge, Sumukh Kumble, Ting-Yi Wang, Rong Xu, Linsey Gani, Thomas King, Shui-Boon Soh, Troy Puar, Vanessa Au, Eberta Tan, Tunn-Lin Tay, Carmen Kam, Eng-Kiong Teo

“…The high-glucose environment induced a greater mitochondrial proton leak in cells cultured in ELO water compared to cells cultured in control medium at similar glucose concentration. …”
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Diagnostic Accuracy of EndoFaster® and Narrow-Band Imaging Endoscopy in Patients with Impaired Gastric Acid Secretion: A Real-Time Prospective Study by M. Cazzato, G. Esposito, G. Galli, E. Pilozzi, E. Lahner, V. D. Corleto, A. Zullo, E. Di Giulio, B. Annibale

“…Patients in therapy with proton pump inhibitors, previous gastric surgery, and/or known gastric neoplasia were excluded. …”
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Awake brain MRSI reveals anesthetic sensitivity and regional aging effects on [13C]bicarbonate metabolism in mice by Maiko Ono, Rena Kono, Kosei Hirata, Kosei Hirata, Keita Saito, Motonao Nakao, Yoichi Takakusagi, Rikita Araki, Akira Sumiyoshi, Yuhei Takado

“…Abnormalities and alterations in the glycolytic pathway in the pathology of neurodegenerative diseases and brain aging have received much attention, as clinical applications of proton-based magnetic resonance spectroscopy (MRS) have recently illuminated the elevation of lactate concentrations in the brains of patients with neurodegenerative diseases, including Alzheimer’s disease. …”
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Simultaneous Determination of Multiple Acid-Suppressing Drugs by UPLC-MS/MS Method and Application for Pharmacokinetics Study by Li X, Liu S, Yu M, Xi W, Wu X, Liu D, Liu A, Wang H

“…Xiuqi Li,1,* Shupeng Liu,1,* Mengyang Yu,1 Wanlin Xi,1 Xiaofei Wu,1 Dan Liu,2 Aijing Liu,1 Hongyun Wang1 1Clinical Pharmacology Research Center, Peking Union Medical College Hospital, NMPA Key Laboratory for Clinical Research and Evaluation of Drug, Beijing Key Laboratory of Clinical PK & PD Investigation for Innovative Drugs, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People’s Republic of China; 2School of Life Science and Biopharmaceuticals, Shenyang Pharmaceutical University, Shenyang, Liaoning, 110000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongyun Wang, Email wanghy@pumch.cnBackground: Proton pump inhibitors (PPIs) and potassium competitive acid blockers (P-CABs) are widely used to treat acid-related diseases (ARDs). …”
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Advantages of alginate and PPI combination in relief of heartburn and regurgitation during the first days of treatment of gastroesophageal reflux disease by D. S. Bordin, O. B. Yanova, O. I. Berezina, Ye. V. Treyman

“…To estimate advantages of combined intake of proton pump inhibitor (PPI) and alginate in comparison to monotherapy by PPI in terms of symptom relief in the first days of gastroesophageal reflux disease (GERD) treatment.Material and methods. …”
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Recommendations of the Russian Gastroenterological Association in Diagnosis and Treatment of Gastroesophageal Reflux Disease by V. T. Ivashkin, I. V. Maev, A. S. Trukhmanov, T. L. Lapina, O. A. Storonova, O. V. Zayratyants, O. B. Dronova, Yu. A. Kucheryavyy, S. S. Pirogov, R. G. Sayfutdinov, Yu. P. Uspenskiy, A. A. Sheptulin, D. N. Andreev, D. E. Rumyantseva

“…Patients should be conclusively performed esophageal 24-hour pH-metry or pH-impedance monitoring, high-resolution manometry to thoroughly examine functionality of esophagus, esophagogastric junction and assess disease prognosis and therapy outcomes.Treatment of GERD should be personalised accounting for clinical manifestations and severity, as well as aimed at symptom improvement, lesion healing in erosive esophagitis, averting complications, Barrett's esophagus progression, dysplasia and esophageal adenocarcinoma.Proton pump inhibitors (PPIs) are most effective agents in primary (4-8 weeks) and maintenance anti-GERD therapy. …”
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Tracing the change of the volatile compounds of soy sauce at different fermentation times by PTR-TOF-MS, E-nose and GC–MS by Qixin Kan, Longbipei Cao, Liping He, Peipei Wang, Guangdie Deng, Jun Li, Jiangyan Fu, Qingrong Huang, Chi-Tang Ho, Yunqi Li, Chunhui Xie, Yong Cao, Linfeng Wen

“…Proton-transfer reaction time-of-flight mass spectrometry (PTR-TOF-MS), combined with electronic nose (E-nose), was first used to track the change of volatile organic compounds (VOCs) in soy sauce in this study. …”
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Rapid identification of high-temperature Daqu Baijiu with the same aroma type by UV-VIS sensor of HBT combined with Zn2+ by Yanmei Zhu, Yuanyuan Su, Yipeng Cang, Hengye Chen, Wanjun Long, Wei Lan, Xue Jiang, Haiyan Fu

“…The specific mechanism of light signal change was mainly based on the competitive coordination effect of pyrazines and other nitrogen-containing compounds in high-temperature Daqu Baijiu and small molecular probe HBT on Zn2+ and the excited state intramolecular proton transfer (ESIPT) mechanism of HBT itself. Results: The random forest results showed that the prediction set classification accuracy was improved from 62.37% to 100%. …”
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Nissen-Sleeve procedure versus laparoscopic Roux-en-Y gastric bypass in patients with morbid obesity and gastro-oesophageal reflux disease: protocol for a non-inferiority randomise... by Jan A Apers, Martin Dunkelgrun, Ivonne Leeuwenburgh, Judith W H 't Hart, Bo J Noordman, Laser U Biter

“…Secondary outcome measures are long-term GORD improvement; failure rate of procedure; health-related quality of live; weight loss; proton pump inhibitor use; postoperative complications <30 days and >30 days; length of hospital stay; duration of primary surgery; effect on comorbidities; presence and grade of oesophagitis (grade A–D) and/or presence of Barrett’s oesophagus and cost-effectiveness.Ethics and dissemination The protocol was approved by the Medical Research Ethics Committees United (MEC-U), Nieuwegein, on 15 September 2021. …”
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A Study of Volatile Organic Compounds in Patients with Obstructive Sleep Apnea by Chuan Hao Gui, Zhunan Jia, Zihao Xing, Fuchang Zhang, Fang Du, Alex Chengyao Tham, Ming Yann Lim, Yaw Khian Chong, Agnes Si Qi Chew, Khai Beng Chong

“…<b>Objectives</b>: This study explores the potential of proton-transfer-reaction mass spectrometry (PTR-MS) in identifying volatile organic compound (VOC) biomarkers for the non-invasive detection of OSA. …”
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Machine learning-based plasma metabolomics for improved cirrhosis risk stratification by Jingru Song, Ziwei Gao, Liqun Lai, Jie Zhang, Binbin Liu, Yi Sang, Siqi Chen, Jiachen Qi, Yujun Zhang, Huang Kai, Wei Ye

“…Methods This study used proton nuclear magnetic resonance (1 H-NMR) serum metabolomics data from the UK Biobank (UKB) and employed elastic net-regularized Cox proportional hazards models to explore the role of metabolomics in cirrhosis risk stratification in patients with CLD. …”
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Effects of Nicotinamide Riboside Supplementation on Postmortem Mitochondrial Functionality and Apoptotic Activation by Chen Zhu, Luke A. Whitcomb, Adam J. Chicco, Morgan E. Gravely, Hanna M. Alcocer, Daniela A. Alambarrio, John M. Gonzalez, Colton L. Smith, Mahesh N. Nair, Huey Yi Loh, Terry E. Engle, Arya Niraula, Chaoyu Zhai

“…Results: NR-supplemented muscle exhibited lower proton leak-associated respiration at 45 min postmortem (<i>p</i> < 0.05), followed by a slower accumulation of mitochondrial outer membrane permeabilization (MOMP; <i>p</i> < 0.05) and a slower loss of mitochondrial integral function (<i>p</i> < 0.05) from 45 min to 24 h postmortem. …”
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Shining light on the dark sector: search for axion-like particles and other new physics in photonic final states with FASER by The FASER collaboration, Roshan Mammen Abraham, Xiaocong Ai, John Anders, Claire Antel, Akitaka Ariga, Tomoko Ariga, Jeremy Atkinson, Florian U. Bernlochner, Emma Bianchi, Tobias Boeckh, Jamie Boyd, Lydia Brenner, Angela Burger, Franck Cadoux, Roberto Cardella, David W. Casper, Charlotte Cavanagh, Xin Chen, Eunhyung Cho, Dhruv Chouhan, Andrea Coccaro, Stephane Débieux, Monica D’Onofrio, Ansh Desai, Sergey Dmitrievsky, Radu Dobre, Sinead Eley, Yannick Favre, Deion Fellers, Jonathan L. Feng, Carlo Alberto Fenoglio, Didier Ferrere, Max Fieg, Wissal Filali, Elena Firu, Edward Galantay, Ali Garabaglu, Stephen Gibson, Sergio Gonzalez-Sevilla, Yuri Gornushkin, Carl Gwilliam, Daiki Hayakawa, Michael Holzbock, Shih-Chieh Hsu, Zhen Hu, Giuseppe Iacobucci, Tomohiro Inada, Luca Iodice, Sune Jakobsen, Hans Joos, Enrique Kajomovitz, Hiroaki Kawahara, Alex Keyken, Felix Kling, Daniela Köck, Pantelis Kontaxakis, Umut Kose, Rafaella Kotitsa, Susanne Kuehn, Thanushan Kugathasan, Lorne Levinson, Ke Li, Jinfeng Liu, Yi Liu, Margaret S. Lutz, Jack MacDonald, Chiara Magliocca, Toni Mäkelä, Lawson McCoy, Josh McFayden, Andrea Pizarro Medina, Matteo Milanesio, Théo Moretti, Mitsuhiro Nakamura, Toshiyuki Nakano, Laurie Nevay, Ken Ohashi, Hidetoshi Otono, Lorenzo Paolozzi, Brian Petersen, Titi Preda, Markus Prim, Michaela Queitsch-Maitland, Hiroki Rokujo, André Rubbia, Jorge Sabater-Iglesias, Osamu Sato, Paola Scampoli, Kristof Schmieden, Matthias Schott, Anna Sfyrla, Davide Sgalaberna, Mansoora Shamim, Savannah Shively, Yosuke Takubo, Noshin Tarannum, Ondrej Theiner, Eric Torrence, Oscar Ivan Valdes Martinez, Svetlana Vasina, Benedikt Vormwald, Di Wang, Yuxiao Wang, Eli Welch, Yue Xu, Samuel Zahorec, Stefano Zambito, Shunliang Zhang

“…Abstract The first FASER search for a light, long-lived particle decaying into a pair of photons is reported. The search uses LHC proton-proton collision data at s $$ \sqrt{s} $$ = 13.6 TeV collected in 2022 and 2023, corresponding to an integrated luminosity of 57.7 fb −1. …”
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Emergency medicine pharmacists’ interventions in the tertiary hospitals’ emergency departments in Malaysia by Hock Peng Koh, Haliza Ab Jalal, Yee Ping Koo, Mary Siew Yng Chen, Manimegahlai Selvaratanam, Anaanthan Bhuvanendran Pillai, Wai Kit Wong, Xin Nee Guee, Sherene Su Ann Tan, Shirlyn Tan, Lih Jiuan Teh, Rosalind Guen Lin Sia

“…Antimicrobials, antihypertensives, and proton pump inhibitors were the commonest drug intervened under the categories of inappropriate drug intervention. …”
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Diagnostics and treatment of exocrine pancreatic insufficiency: clinical guidelines of the Russian gastroenterological Association by V. T. Ivashkin, I. V. Mayev, A. V. Okhlobystin, S. A. Alekseyenko, Ye. V. Beloborodova, Yu. A. Kucheryavy, T. L. Lapina, A. S. Trukhmanov, I. B. Khlynov, M. V. Chikunova, A. A. Sheptulin, O. S. Shifrin

“…Digestive enzymes should be taken at the beginning of food intake, to increase treatment efficacy PERT should be accompanied by prescription of proton pump inhibitors. Patient’s diet quantity and content should be adjusted with participation of nutritionist. …”
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Clostridium difficile-associated disease in versatile hospital patient population and risk factors for its development by Ya. N. Yarushina, G. B. Kolotova, V. A. Rudnov, V. A. Bagin

“…Predictors of C. difficile-associated diarrhea risk were following: the age over 65 years (OR=3.43; 95%CI 1.06-11.08; р=0.0409), Charlson comorbidity index over 2 points (OR=2,92, 95%CI 1.33-6.44; р=0.0114), presence of anemia (OR=4,35, 95%CI 1.98-9.54; р=0.0003), admission to intensive care unit with staying for more than 1 day (OR=10.59; 95%CI 2.35-47.69; р=0.0002) and in surgical departments (OR=2.46; 95%CI 1.16-5.20; р=0.0276), surgical intervention (OR=3.06; 95%CI 1.33-7.04; р=0.0120), hospital stay for 5 days (OR=3.87; 95%CI 1.87-8.01; р=0.0004), chronic dialysis at chronic renal failure (OR=8.56; 95% of CI 1,05-69,69; р=0,0210), installation of an urethral catheter (OR=3,43; 95% of CI 1.06-11.08; р=0.0409), proton pump inhibitors (PPI) therapy for over 7 days (OR=7.76; 95% CI 1.69-35.53; р=0.0032), antibacterial therapy for over 5 days (OR=4.10; 95%CI 1.93-8.68; р=0.0003), more than one course} of antibacterial treatment (OR=5.31; 95% CI 1.12-25.03; р=0.0365), ceftriaxone therapy (OR=3.21; 95%CI 1.51-6.82; р=0.0036). …”
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Analytical Methods for Atmospheric Carbonyl Compounds: A Review by Xiaoshuai Gao, Xin Zhang, Yan Nie, Jiemeng Bao, Junling Li, Rui Gao, Yunfeng Li, Wei Wei, Xiaoyu Yan, Yongxin Yan, Hong Li

“…For multiple carbonyl compounds, offline detection results were greatly influenced by detectors coupled with chromatography, whereas online monitoring techniques were applicable to all types of volatile organic compounds (VOCs), including some carbonyl compounds, providing higher temporal resolution and improved isomer identification with the development of online mass spectrometry. The combined use of proton transfer reaction-mass spectrometry (PTR-MS) and liquid chromatography-mass spectrometry (GC-MS) was suitable for the detection of carbonyl compounds in atmospheric photochemical smog chamber simulation studies. …”
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