Mutational Analysis of Extranodal NK/T-Cell Lymphoma Using Targeted Sequencing with a Comprehensive Cancer Panel by Seungkyu Choi, Jai Hyang Go, Eun Kyung Kim, Hojung Lee, Won Mi Lee, Chun-Sung Cho, Kyudong Han

“…The recent technological advancements in next-generation sequencing (NGS) have made DNA sequencing cost- and time-effective, with more reliable results. Using the Ion Proton Comprehensive Cancer Panel, we sequenced 409 cancer-related genes to identify somatic mutations in five NKTCL tissue samples. …”
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A retrospective clinical study on the influencing factors of Clostridium difficile infection in elderly patients by Yang Chen, Yingjun Gong, Cui Li, Huan Li, Jia Chen, Hui Su, Xiaoming Wang, Xiaoxuan Ning

“…[Results] The use rate of proton pump inhibitors, antibiotics and glucocorticoids in the positive group was higher than that in the negative group (P<0.05), the hemoglobin, alanine aminotransferase, aspartate aminotransferase, albumin, alkaline phosphatase and γ-glutamyl transferase and vitamin D levels in the positive group were lower than those in the negative group (P < 0.05), and the serum creatinine level in the positive group was higher than that in the negative group(P<0.05).Multivariate binary logistic regression analysis showed that hemoglobin, albumin, and vitamin D were protective factors for Clostridium difficile infection (P < 0.05), and antibiotic use and serum creatinine were independent risk factors for Clostridium difficile infection(P<0.05). …”
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Quality Characteristics and Moisture Mobility of Giant Salamander (Andrias davidianus) Jerky during Roasting Process by Wengang Jin, Xiaohua Chen, Jingzhang Geng, Jing Jin, Jinjin Pei, Ruichang Gao, Dejing Chen

“…The mobility of the immobilized moisture and free moisture were shrunk dramatically during roasting. The proton density weighted images also exhibited the moisture shrinkage during roasting. …”
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SARS-CoV-2 ORF3a accessory protein is a water-permeable channel that induces lysosome swelling by Antonio Michelucci, Luigi Sforna, Riccardo Focaia, Maria Vittoria Leonardi, Angela Di Battista, Giorgia Rastelli, Simone Vespa, Simona Boncompagni, Manlio Di Cristina, Luigi Catacuzzeno

“…Preliminary structural analyses and patch-clamp recordings in HEK293 cells rule out ORF3a functioning as either viroporin or proton (H+) channel. Conversely, videoimaging experiments demonstrate that ORF3a mediates the transmembrane transport of water. …”
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Risk factors for hepatocellular carcinoma: an umbrella review of systematic review and meta-analysis by Jie Wang, Kaijie Qiu, Songsheng Zhou, Yichao Gan, Keting Jiang, Donghuan Wang, Haibiao Wang

“…Medications like metformin, glucagon-like peptide-1 receptor agonists (GLP-1 RAs), aspirin, statins, and selective serotonin reuptake inhibitors reduce HCC risk, while acid suppressive agents, particularly proton pump inhibitors, elevate it. Blood type O reduces the risk of HCC, while male gender and older age increase the risk.Conclusions HBV and HCV are major HCC risk factors, with risk mitigation through antiviral treatments. …”
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Determination of the degree of sulfonation in cross-linked and non-cross-linked Poly(ether ether ketone) using different analytical techniques by Abdul G. Al Lafi, Mohammed S. Rihawy, Abdul W. Allaf, Ali Alzier, Reem Hasan

“…In this work, the DS of sulfonated poly (ether ether ketone) (SPEEK) was evaluated using a combination of analytical techniques, including titration, back titration, Fourier Transform Infrared (FTIR), Ultra-Violet (UV) and proton nuclear magnetic resonance (1H NMR) spectroscopies, Thermogravimetric analysis (TGA), Rutherford backscattering (RBS) and particle induced X-ray emission (PIXE) analysis. …”
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2-, 3-, 4-Bromo Azaflavanonların Amino Kalkonlardan Katı Faz Ortamında Mikrodalga Destekli Sentezi, Antimikrobiyal ve Antioksidan Aktivitelerinin Tayini by Nurettin Yaylı, İsmail Demir, Seda Fandaklı, Tayyibe Beyza Yücel

“…Sentezlenen bileşikler spektroskopik olarak 1Hidrojen, 13Karbon, Bağlanmış Proton Testi (APT) NMR, Fourier Dönüşümlü Kızılötesi Spektroskopisi (FT-IR) Infrared ve Sıvı kromatografi-kütle spektrometresi/kütle spektrometresi (LC-MS/MS)yöntemleriyle karakterize edildi. …”
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Investigating PFAS emissions of light- and heavy-duty fuel cell electric vehicles by T. Lange, M. Dietrich, H. Schlottmann, V. Valkov, V. Mackert, I. Radev, H. Hoster

“…This also includes applications that are used in key components of the hydrogen economy using proton exchange membranes, e.g. PEM fuel cells. This study analyzes PFAS concentrations in product water from two light- and one heavy-duty fuel cell electric vehicles (FCEV), identifying two to five distinct PFAS (including 6:2 FTS, PFBuA, PFHpA, PFHxA, PFOA, HFPO-DA, and PFPeA) in each sample. …”
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Study of defect formation mechanisms in Li2ZrO3/MgLi2ZrO4 ceramics using EPR spectroscopy by Dmitriy I. Shlimas, Ainagul A. Khametova, Artem L. Kozlovskiy, Maxim V. Zdorovets

“…The article presents the results of experimental studies of the effect of the stabilizing MgO dopant using the electron spin resonance (ESP) method on enhancement of the stability of Li2ZrO3 ceramics to defect formation processes and accumulation of radiolysis products in the near-surface layer in the case of high-dose irradiation with protons simulating the hydrogenation effects characteristic of processes associated with tritium production. …”
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Quantum chemical study of molecular properties of small branched-chain amino acids in water by Roman Boča, Žofia Rádiková, Juraj Štofko, Beata Vranovičová, Cyril Rajnák

“…According to thermodynamic data, the SPLET mechanism of the electron-proton coupled transfer is favored over the alternative SET-PT mechanism. …”
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Astrocytic Acid-Sensing Ion Channel 1a Contributes to the Development of Epileptic Cognitive Impairment by Wen Li, Huimin Zhou, Xiaona Li, Gengyao Hu, Dong Wei

“…Reactive astrogliosis and acidosis, common features of epileptogenic lesions, express a high level of astrocytic acid-sensing ion channel-1a (ASIC1a), a proton-gated cation channel and key mediator of responses to neuronal injury. …”
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Early Diagnosis of Helicobacter pylori Infection in Vietnamese Patients with Acute Peptic Ulcer Bleeding: A Prospective Study by Duc Trong Quach, Mai Ngoc Luu, Toru Hiyama, Thuy-HuongThi To, Quy Nhuan Bui, Tuan Anh Tran, Binh Duy Tran, Minh-Cong Hong Vo, Shinji Tanaka, Naomi Uemura

“…Groups A and B had no differences in demographic characteristics, bleeding severity, endoscopic findings, and proton pump inhibitor use. H. pylori-positive rate in group A was significantly higher than that in group B (98.2% versus 86.7%, p=0.004). …”
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Adverse drug reactions, multimorbidity and polypharmacy: a prospective analysis of 1 month of medical admissions by Girvan Burnside, Munir Pirmohamed, Rostam Osanlou, Dyfrig A Hughes, Lauren Walker

“…Drugs most commonly implicated were diuretics, steroid inhalers, anticoagulants and antiplatelets, proton pump inhibitors, chemotherapeutic agents and antihypertensives. 40.4% of ADRs were classified avoidable or possibly avoidable. …”
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Biochemistry of the Thrombin-Like TLBpic and Its Purification from Bothrops pictus “Jergon de la Costa” (Reptilia: Viperidae) by Victor Ludgardo Álvarez Tohalino, Hugo Guillermo Jiménez Pacheco, Juan Raúl Jesús Zumaran Farfán, Pavel Kewin Delgado Sarmiento, Paulino Rodolfo Zegarra Panca

“…The ESI (electrospray ionisation), corresponding to the electrophoresis of proteins in polyacrylamide gels and to their denaturing solubilization in the presence of the SDS ionic detergent, uniting the proteins, breaking hydrophobic interactions, showing a molecular mass of ∼30 kDa, demonstrating high molecular homogeneity that exists in this family of proteins, is a soft ionization method, in which the samples were ionized by the addition or removal of a proton, with very little extra energy to cause fragmentation of the produced ions. …”
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The Role of Duodenogastroesophageal Reflux in the Progression of Gastroesophageal Reflux Disease: From Esophagitis to Adenocarcinoma by O. A. Storonova, A. V. Paraskevova, A. A. Makushina

“…The basic therapy for GERD is proton pump inhibitors (PPIs), but up to 40 % of patients do not fully respond to PPI monotherapy, which indicates the need to consider, among the factors in the pathogenesis of GERD, the persistence of weakly acidic and weakly alkaline refluxes, the presence of which can be diagnosed by performing 24-hour impedance-pH monitoring. …”
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ClC-3 Expression and Its Association with Hyperglycemia Induced HT22 Hippocampal Neuronal Cell Apoptosis by Feiyan Fan, Tao Liu, Xin Wang, Dongni Ren, Hui Liu, Pengxing Zhang, Zhen Wang, Nan Liu, Qian Li, Yanyang Tu, Jianfang Fu

“…With respect to this, the present work aims to study the variation in chloride/proton exchanger ClC-3 expression and its association with HT22 hippocampal neuronal apoptosis under hyperglycemic condition in vitro. …”
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Does therapy with immunosuppressive drugs improve gastrointestinal symptoms in patients with systemic sclerosis? by Oliver Distler, Cosimo Bruni, Suzana Jordan, Carina Mihai, Muriel Elhai, Rucsandra Dobrota, Alexandru Garaiman, Mike Oliver Becker, Lea Stamm, Sherif Ismail, Norina Zampatti, Aurora Maria Tatu

“…Of these, 71 were exposed to immunosuppressive therapy during the observation period, and, compared with unexposed patients, had overall more severe SSc and a higher prevalence of treatment with proton pump inhibitors. In multivariable linear regression, immunosuppressive therapy during the period of observation and lower baseline GIT scores were significantly associated with lower (better) GIT scores at follow-up.Conclusion Immunosuppressive treatment was associated with lower GIT scores in our cohort, which suggests the potential effects of immunosuppressants on GI manifestations in patients with SSc, requiring confirmation in prospective randomised clinical trials.…”
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Study on the influence of working environment on the insulation of fuel cell by Ji Pu, Qianya Xie, Kang Li, Jun Li, Mengmeng Zhang, Chen Ge, Lichang Zhang

“…Based on the improvement of insulation in previous studies, this study uses multi-stack proton exchange membrane(PEM) fuel cells used in commercial vehicles as an example to analyze the influence of ambient relative humidity(RH) on the insulation of fuel cells through a combination of tests and fluid simulations. …”
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Association between magnesium depletion score and prevalence of hyperuricemia in American adults: a study based on NHANES 2007-2018 by Yongchun Xiao, Yong Mou, Yong Mou, Ping Wu, Ke Wang, Tianjun Chen, Zhiwan Chen, Hongsheng Lin, Hua Yang, Zhisheng Ji

“…The MDS was derived by integrating multiple risk factors associated with magnesium depletion: the use of diuretics and proton pump inhibitors (PPI), estimated glomerular filtration rate (eGFR), and alcohol consumption exceeding recommended thresholds. …”
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Characterizing Industrial VOC Hotspots in One of Eastern China’s Largest Petrochemical Parks Using Mobile PTR–ToF–MS Measurements by Jie Fang, Zihang Zhang, Zeye Liang, Ming Wang, Yunjiang Zhang, Xinlei Ge

“…In this study, we employed mobile proton transfer reaction–time-of-flight–mass spectrometry (PTR–ToF–MS) to identify and characterize industrial VOC hotspots in a petrochemical park in eastern China, from June to September 2021. …”
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