Duodenal Aspirates for Small Intestine Bacterial Overgrowth: Yield, PPIs, and Outcomes after Treatment at a Tertiary Academic Medical Center by Diana L. Franco, Molly B. Disbrow, Allon Kahn, Laura M. Koepke, Lucinda A. Harris, M. Edwyn Harrison, Michael D. Crowell, Francisco C. Ramirez

“…Duodenal aspirates are not commonly collected, but they can be easily used in detection of small intestinal bacterial overgrowth (SIBO). Proton pump inhibitor (PPI) use has been proposed to contribute to the development of SIBO. …”
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Uninvestigated Dyspepsia and Heartburn Overlap Syndrome at Industrial Hub of Eastern Siberia by V. V. Tsukanov, A. V. Vasiutin, J. L. Tonkikh, E. V. Kasparov, O. V. Smirnova

“…Among total patients with the heartburn/uninvestigated dyspepsia overlap syndrome, only 33.3% systemically had proton pump inhibitors, and only 17.4% had a prokinetic therapy.Conclusion. …”
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APT imaging of hepatocellular carcinoma signals an effective therapeutic response in advance of tumor shrinkage by Xiaojing Wang, Keisuke Ishimatsu, Junjie Li, Xiaodong Wen, Weijun Ou, Arnida Anwar, Jaideep Chaudhary, Masaya Takahashi, A Dean Sherry, Ian R Corbin

“…Aim: The aim of this study was to assess the utility of weighted amide proton transfer (APTw) MRI in three different rodent models of hepatocellular carcinoma (HCC).Methods: APTw MRI was evaluated in models of diethylnitrosamine (DEN) induced HCC, N1S1 syngeneic orthotopic xenograft and human HepG2 ectopic xenograft.Results: All models of HCC showed a higher APTw signal over the surrounding normal tissues. …”
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Non-acid reflux and sleep apnea: the importance of drug induced sleep endoscopy by Carlos O’Connor-Reina, Jose Maria Ignacio Garcia, Peter Baptista, Maria Teresa Garcia-Iriarte, Carlos Casado Alba, Monica Perona, Paz Francisca Borrmann, Laura Rodriguez Alcala, Guillermo Plaza

“…Conventional digestive tests such as esophagoscopy and simple- and double-channel 24-h pH-metry suggested mild GERD. Conventional proton-pump inhibitor treatment with pantoprazole (40 mg daily) was started without any improvement in his sleep. …”
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Efficacy of dietary modifications and mucosal protectors in the treatment of laryngopharyngeal reflux: a multicenter study by Matteo Gelardi, Rossana Giancaspro, Christian Fiorentino, Stefano Patruno, Jacopo Marroni, Alessandro D’Avino, Letizia Neri, Michele Cassano, Giampiero Neri

“…There is currently no standardized treatment protocol for LPR. The use of proton pump inhibitors (PPIs) is widely established in common practice and derives from the standard approach of using PPIs to treat patients with gastroesophageal reflux disease (GERD). …”
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Effect of cold rolling rates on microstructure and corrosion behavior of selective laser melted 316L austenitic stainless steel bipolar plates by Zhiyue Shi, Rui Wang, Jin Qin, Yan Kang, Zhiqiang Yu, Zhijie Yan, Shaohua Zhang, Wei Zhang

“…In contrast, the increase of dislocation density and the martensite phase resulting from high-speed deformation negatively impact corrosion resistance of SLMed 316L ASS in the simulated cathodic environment of proton exchange membrane fuel cells (PEMFCs). In addition, different cold deformation rates correspond to different compositions of passive films, with the low-speed deformed sample showing a greater proportion of chromium oxides and O2−/OH− ratio compared to both the un-deformed and high-speed deformed samples.…”
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Monocarboxylate Transporters: Role and Regulation in Corneal Diabetes by Pawan Shrestha, Amy E. Whelchel, Sarah E. Nicholas, Wentao Liang, Jian-Xing Ma, Dimitrios Karamichos

“…Monocarboxylate transporters (MCTs) are a family of proton-linked plasma membrane transporters that carry monocarboxylates across plasma membranes. …”
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Constraining Solar Wind Transport Model Parameters Using Bayesian Analysis by Mark A. Bishop, Sean Oughton, Tulasi N. Parashar, Yvette C. Perrott

“…The TTMs analyzed are essentially the 1D steady-state ones presented in Breech et al. that describe the radial evolution of the energy, correlation length, and normalized cross helicity of the fluctuations, together with the proton temperature, in prescribed background solar wind fields. …”
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Clinical audit of current Helicobacter pylori treatment outcomes in Singapore by Tiing Leong Ang, Kim Wei Lim, Daphne Ang, Yu Jun Wong, Malcolm Tan, Andrew Siang Yih Wong

“…First-line therapies include 14-day PAC (proton pump inhibitor [PPI], amoxicillin, clarithromycin) and PBMT (PPI, bismuth, metronidazole, tetracycline). …”
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A DFT Study of Structural and Bonding Properties of Complexes Obtained from First-Row Transition Metal Chelation by 3-Alkyl-4-phenylacetylamino-4,5-dihydro-1H-1,2,4-triazol-5-one a... by Hubert Jean Nono, Désiré Bikélé Mama, Julius Numbonui Ghogomu, Elie Younang

“…The significant reduction of the proton affinity (PA) observed when passing from ligands to complexes in gas-phase confirms the notable enhancement of antioxidant activities of neutral ligands.…”
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Nano-Azo Ligand and Its Superhydrophobic Complexes: Synthesis, Characterization, DFT, Contact Angle, Molecular Docking, and Antimicrobial Studies by Gehad G. Mohamed, Walaa H. Mahmoud, Ahmed M. Refaat

“…The IR spectra revealed the binding of the azo ligand to the metal ions via two azo nitrogen atoms and protonated carboxylate O in a neutral tetradentate manner. …”
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New Prospects of Cytoprotection in the Treatment and Prevention of Gastric and Intestinal Diseases (Resolution of an Expert Council and Literature Review) by A. I. Martynov, A. A. Sheptulin, I. V. Mayev, A. N. Kazyulin, A. Ye. Karateev, A. V. Melekhov, L. K. Pal’gova, K. L. Raikhel’son

“…In the treatment of gastroesophageal reflux disease, Rebamipide is recommended for patients refractory to therapy with proton pump inhibitors (PPIs) and for those with non-acid reflux. …”
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Impact of glycolysis inhibitor (2-DG) and oxidation and phosphorylation uncoupler (2,4-DNP) on brain metabolites by O. B. Shevelev, M. P. Moshkin

“…Some clinical studies using proton nuclear magnetic resonance spectroscopy (1H NMR spectroscopy) revealed metabolic changes in brain tissue in patients with neurodegenerative diseases. …”
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Duodenal Eosinophilia in Functional Dyspepsia by A. S. Silaeva, E. L. Bueverova, Yu. O. Shulpekova

“…In addition to dietary restrictions, treatment courses with a proton pump inhibitor, itopride, and S-methylmethionine sulfonium chloride, which has an antihistamine effect, were recommended for periods of worsening dyspepsia.Conclusion. …”
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A Comprehensive 10-Year Nationwide Pharmacovigilance Surveillance on Antibacterial Agents in Korea: Data Mining for Signal Detection of Trends and Seriousness of Adverse Events by Seon Hu Mo, Soo Hyeon Lee, Chang-Young Choi, Yongjun Sunwoo, Sooyoung Shin, Yeo Jin Choi

“…The predictors may include age (OR 1.05), the number of concomitant medications (OR 1.44), concomitant proton pump inhibitors (OR 1.46) and non-steroidal anti-inflammatory drugs (OR 1.38) use, and specific antibacterial classes, while multiple antibacterial therapy was associated with lower serious ADE risks. …”
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In-situ biophysical characterization of high-concentration protein formulations using wNMR by Jing Song, Marc Taraban, Y. Bruce Yu, Lynn Lu, Pallavi Guha Biswas, Wei Xu, Hanmi Xi, Akhilesh Bhambhani, Guangli Hu, Yongchao Su

“…In this study, we introduce a novel application of water proton nuclear magnetic resonance (wNMR) to evaluate the aggregation propensity of a high-concentration drug product, Dupixent® (dupilumab), under stress conditions. wNMR results demonstrate a concentration-dependent, reversible association of dupilumab in the commercial formulation, as well as irreversible aggregation when exposed to accelerated thermal stress, but gradually reversible aggregation when exposed to freeze and thaw cycles. …”
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A comprehensive pan-cancer analysis of RNF187 in human tumors by Xuezhong Zhang, Xuebin Zhang, Tonggang Liu, Kaihui Sha

“…GO enrichment and KEGG pathway analyses suggested that RNF187 may play a role in the pathogenesis of cancer through processes such as "bounding membrane of organelle," "macroautophagy," "proton-transporting V-type ATPase complex," "autophagy," "Ubiquitin mediated proteolysis," "Ferroptosis," "Phagosome," and etc. …”
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Current Pharmacological Management of Gastroesophageal Reflux Disease by Yao-Kuang Wang, Wen-Hung Hsu, Sophie S. W. Wang, Chien-Yu Lu, Fu-Chen Kuo, Yu-Chung Su, Sheau-Fang Yang, Chiao-Yun Chen, Deng-Chyang Wu, Chao-Hung Kuo

“…A variety of medications have been used in GERD treatment, and acid suppression therapy is the mainstay of treatment for GERD. Although proton pump inhibitor is the most potent acid suppressant and provides good efficacy in esophagitis healing and symptom relief, about one-third of patients with GERD still have persistent symptoms with poor response to standard dose PPI. …”
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Influence of Hydroxypropyl-β-Cyclodextrin on the Photostability of Fungicide Pyrimethanil by Carlos Fernandes, Igor Encarnação, Alexandra Gaspar, Jorge Garrido, Fernanda Borges, E. Manuela Garrido

“…In this study, the inclusion complex of pyrimethanil with HP-β-CD has been prepared and characterized by proton nuclear magnetic resonance spectroscopy. The formation of the pyrimethanil/HP-β-CD inclusion complex increased the aqueous solubility of this fungicide around five times. …”
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Evaluating the predictive potential of RSM and ANN models in treatment of greywater-syrup mixture using Ekowe clay-PEM microbial fuel cell by Livinus A. Obasi, Cornelius O. Nevo

“…The response variables (power density generation (mW/m2) and chemical oxygen demand (COD) removal efficiency (%)) were measured against four process input variables: mass of the clay component of the proton exchange membrane (PEM) (g), PEM preparation temperature (PPT), anolyte pH, and concentration. …”
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