Immunotargeting of Integrin αβ for Single-Photon Emission Computed Tomography and Near-Infrared Fluorescence Imaging in a Pancreatic Cancer Model by Winn Aung MBBS, PhD, Atsushi B. Tsuji PhD, Hitomi Sudo PhD, Aya Sugyo M.Ed, Takako Furukawa PhD, Yoshinori Ukai PhD, Yoshikazu Kurosawa PhD, Tsuneo Saga MD, PhD

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Immediate Respiratory Warm-Up Effect on Dynamic Inspiratory Muscle Strength in Cardiac Surgery Candidates by Bahareh Mehregan Far, Sedigheh Sadat Naimi, Mohsen Abedi, Seyed Ahmad Raeissadat, Mahmood Beheshti Monfared, Alireza Akbarzadeh Baghban

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Human milk and bronchopulmonary dysplasia have a dose-dependent effect: a cohort study by Jiaxin Li, Chuanzhong Yang, Jiaming Yang, Huiyan Wang, Xueyu Chen, Liga ChaoMu, Aifen Cao, Xiaoyun Xiong

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Is the convergence insufficiency symptom survey applicable to elderly individuals? by Saeid Abdi, Haleh Kangari, Saeed Rahmani, Alireza Akbarzadeh Baghban, Zahra Kamary Rad

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C9ORF72 poly-PR induces TDP-43 nuclear condensation via NEAT1 and is modulated by HSP70 activity by Diksha Agnihotri, Chi-Chang Lee, Po-Chao Lu, Ruei-Yu He, Yung-An Huang, Hung-Chih Kuo, Joseph Jen-Tse Huang

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Exploring the functional diversity and metabolic activities of the human gut microbiome in Thai adults in response to a prebiotic diet by Amornthep Kingkaw, Preecha Patumcharoenpol, Narissara Suratannon, Massalin Nakphaichit, Sittiruk Roytrakul, Wanwipa Vongsangnak

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Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A. Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G. Karlsson, Anne Marie Lynge Pedersen

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Uncovering genetic determinants of antioxidant properties in Thai landrace rice through genome-wide association analysis by Putut Rakhmad Purnama, Pipob Suwanchaikasem, Supaporn Junbuathong, Somsong Chotechuen, Peerapon Moung-Ngam, Waraluk Kasettranan, Chanita Paliyavuth, Monnat Pongpanich, Sittiruk Roytrakul, Luca Comai, Teerapong Buaboocha, Supachitra Chadchawan

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Immunomodulatory effects of thymol and cinnamaldehyde in chicken cell lines by C. Shen, L.G. Christensen, S.Y. Bak, N. Christensen, K. Kragh

“…The expression of cytokines, chemokines and pattern recognition receptors by HD-11 monocytes/macrophages was measured by RT-PCR and by proteomic analysis. TCB was well tolerated by both cell lines (cell viability >90% after co-culture with TCB at 100 ng/ml for 48 h with or without LPS). …”
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2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment by Minzhen Xie, Siqi Gu, Yan Liu, Haolin Yang, Yuqi Wang, Wei Yin, Yang Hong, Wanying Lu, Chengbing He, Lin Li, Limin Zhao, Jianjia Zhang, Heng Liu, Tian Lan, Shuijie Li, Qi Wang

“…A combination of behavioral, proteomic, and molecular biology approaches was used to explore specific regulatory mechanisms and identify potential pharmacological targets. …”
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Collection of microorganisms of ICG SB RAS as a genetic resource for biotechnology by A. V. Bryanskaya, Y. E. Uvarova, A. S. Rozanov, N. M. Slynko, V. N. Shlyakhtun, K. V. Starostin, E. A. Demidov, E. V. Lazareva, O. P. Taran, S. E. Peltek

“…The value of the collection of microorganisms of the FRC ICG SB RAS as a genetic resource for biotechnology and bioengineering is determined not only by the species diversity of its strains, but also by a wide range of their area isolation and by the depth of their characterization using the widest arsenal of both classical and modern methods (including methods of genomics, proteomics, transcriptomics and bioinformatics).…”
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Identification of CENPM as a key gene driving adrenocortical carcinoma metastasis via physical interaction with immune checkpoint ligand FGL1 by Cunru Zou, Yu Zhang, Chengyue Liu, Yaxin Li, Congjie Lin, Hao Chen, Jiangping Hou, Guojun Gao, Zheng Liu, Qiupeng Yan, Wenxia Su

“…The impact of CENPM on metastasis behaviour was verified in ACC (H295R and SW‐13) cells and xenograft NPG mice. DIA quantitative proteomics analysis, western blot, immunofluorescence, and co‐immunoprecipitation assay were performed to identify the downstream target of CENPM. …”
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Disturbed shear stress promotes atherosclerosis through TRIM21‐regulated MAPK6 degradation and consequent endothelial inflammation by Feng Wang, Shu‐Yu Wang, Yue Gu, Shuai Luo, Ai‐Qun Chen, Chao‐Hua Kong, Wen‐Ying Zhou, Li‐Guo Wang, Zhi‐Mei Wang, Guang‐Feng Zuo, Xiao‐Fei Gao, Jun‐Jie Zhang, Shao‐Liang Chen

“…Methods In vitro and in vivo experiments, RNA‐seq, CO‐IP and proteomic analysis, combined with single‐cell RNA‐seq datasets were used to reveal the upstream and downstream mechanisms involved. …”
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PPARα suppresses growth of hepatocellular carcinoma in a high-fat diet context by reducing neutrophil extracellular trap release by Banglun Pan, Zhu Zhang, Dongjie Ye, Xiaoxia Zhang, Yuxin Yao, Yue Luo, Haijie Hong, Xinran Cai, Yanling Chen, Nanhong Tang

“…Methods: In this study, the molecular mechanism of NET release and the potential beneficial effects of PPARα agonists on the HCC microenvironment were explored through proteomics, metabolomics, tissue microarray, immunofluorescence, flow cytometry, western blot, and dual-luciferase reporter gene assays (n = 6 per group). …”
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Aspergillus fumigatus extract modulates human eosinophils via NOD2 and oxidative stress by Hisashi Sasaki, Jun Miyata, Yusuke Kawashima, Ryo Konno, Masaki Ishikawa, Yoshinori Hasegawa, Ryuta Onozato, Yo Otsu, Emiko Matsuyama, Keeya Sunata, Katsunori Masaki, Hiroki Kabata, Yoshifumi Kimizuka, Tomoe Abe, Shigeharu Ueki, Koichiro Asano, Akihiko Kawana, Koichi Fukunaga

“…Multi-omics analysis, comprising transcriptomic and proteomic analyses, was performed. The expression of specific factors was evaluated using quantitative real-time polymerase chain reaction and flow cytometry. …”
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Targeting MYCN upregulates L1CAM tumor antigen in MYCN-dysregulated neuroblastoma to increase CAR T cell efficacy by Laura Grunewald, Lena Andersch, Konstantin Helmsauer, Silke Schwiebert, Anika Klaus, Anton G. Henssen, Teresa Straka, Marco Lodrini, Sebastian G. Wicha, Steffen Fuchs, Falk Hertwig, Frank Westermann, Alice Vitali, Carlotta Caramel, Gabriele Büchel, Martin Eilers, Kathy Astrahantseff, Angelika Eggert, Uta E. Höpken, Johannes H. Schulte, Thomas Blankenstein, Kathleen Anders, Annette Künkele

“…RNA sequencing datasets characterizing the model were compared to publicly available RNA/proteomic datasets. MYCN-directed L1CAM regulation was explored using public ChIP-sequencing datasets. …”
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Multi-omic biomarker panel in pancreatic cyst fluid and serum predicts patients at a high risk of pancreatic cancer development by Laura E. Kane, Gregory S. Mellotte, Eimear Mylod, Paul Dowling, Simone Marcone, Caitriona Scaife, Elaine M. Kenny, Michael Henry, Paula Meleady, Paul F. Ridgway, Finbar MacCarthy, Kevin C. Conlon, Barbara M. Ryan, Stephen G. Maher

“…Here, we extensively profile the proteome and transcriptome of patient pancreatic cyst fluid (PCF) (n = 32) and serum (n = 68), before integrating matched omic and biofluid data, to identify biomarkers of pancreatic cancer risk. …”
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Natural killer cells occupy unique spatial neighborhoods in HER2- and HER2+ human breast cancers by Femke A. I. Ehlers, Katie E. Blise, Courtney B. Betts, Shamilene Sivagnanam, Loes F. S. Kooreman, E. Shelley Hwang, Gerard M. J. Bos, Lotte Wieten, Lisa M. Coussens

“…This study establishes the utility of quantitative mIHC to evaluate NK cells at the single-cell spatial proteomics level and illustrates how spatial characteristics of NK cell neighborhoods vary within the context of HER2- and HER2+ breast cancers.…”
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Lipoxin A4 yields an electrophilic 15-oxo metabolite that mediates FPR2 receptor-independent anti-inflammatory signaling by Adolf Koudelka, Gregory J. Buchan, Veronika Cechova, James P. O’Brien, Emily R. Stevenson, Crystal E. Uvalle, Heng Liu, Steven R. Woodcock, Steven J. Mullett, Cheng Zhang, Bruce A. Freeman, Stacy L. Gelhaus

“…Rather, if present in sufficient concentrations, LXA4 and other mono- and poly-hydroxylated unsaturated fatty acids synthesized by macrophages would be readily oxidized to electrophilic α,β-unsaturated ketone products that modulate the redox-sensitive cysteine proteome via G-protein coupled receptor-independent mechanisms.…”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…Methods Multiple omics data from RNA-seq, proteomics and spatial transcriptome analyses of HNSCC samples were integrated to analyze the spatial heterogeneity of glucose deficiency. …”
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