Predictive, preventive and personalized project of vascular cognitive impairment in China (P3): Study design and interim baseline patient characteristics of a Nationwide multicente... by Linlin Wang, Jiwei Jiang, Yanli Wang, Gaifen Liu, Wenyi Li, Qiwei Ren, Shirui Jiang, Min Zhao, Huiying Zhang, Tianlin Jiang, Shiyi Yang, Mei Cui, Qiang Dong, Jun Xu

“…Through multidimensional analysis of clinical information, radiomics, proteomics, metabolomics, microbiomics, and genetics, provide a more comprehensive understanding of VCI trajectories and individual variability, enhancing early detection and prognosis management.…”
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AKT1-Mediated NOTCH1 phosphorylation promotes gastric cancer progression via targeted regulation of IRS-1 transcription by Lingshan Zhou, Yuan Yang, Qian Qiao, Yingying Mi, Yuling Gan, Ya Zheng, Yuping Wang, Min Liu, Yongning Zhou

“…Methods The study utilized databases such as PhosphositePlus, TRANSFAC, CHEA, GPS 5.0, and TCGA, along with experimental techniques including Western Blot, co-IP, in vitro kinase assay, construction of lentiviral overexpression and silencing vectors, immunoprecipitation, modified proteomics, immunofluorescence, ChIP-PCR, EdU assay, Transwell assay, and scratch assay to investigate the effects of AKT1-induced Notch1 phosphorylation on cell proliferation, invasion and migration in vitro, as well as growth and epithelial-mesenchymal transition (EMT) in vivo. …”
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A cohort-based multi-omics identifies nuclear translocation of eIF5B /PD-L1/CD44 complex as the target to overcome Osimertinib resistance of ARID1A-deficient lung adenocarcinoma by Dantong Sun, Helei Hou, Feiyue Feng, Weizheng Wu, Jingyu Tan, Tongji Xie, Jiayu Liu, Jinsong Wang, Haili Qian, Junling Li, Puyuan Xing

“…Methods Spatial transcriptomic and proteomic analyses were utilized to investigate the mechanisms of Osimertinib resistance. …”
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The Synthesis, Crystal Structure, Modification, and Cytotoxic Activity of α-Hydroxy-Alkylphosphonates by Zsuzsanna Szalai, Anna Sára Kis, Angéla Takács, László Kőhidai, Konstantin Karaghiosoff, Mátyás Czugler, László Drahos, György Keglevich

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A graph neural network approach for hierarchical mapping of breast cancer protein communities by Xiao Zhang, Qian Liu

“…Results Using a large amount of publicly available proteomics data, we created a hierarchical tree for breast cancer protein communities using a novel hierarchical graph neural network, with the supervision of gene ontology terms and assistance of a pre-trained deep contextual language model. …”
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Sensory Diet Program Through In-Person and Tele-Occupationa Therapy in Children with Autism Spectrum Disorder: A Single-Blind Randomized Controlled Trial by Simin Dehghani, Marzieh Pashmdarfard, Zahra Pashazadeh Azari, Alireza Akbarzadeh Baghban, Sima Dehghani, Navid Mirzakhani Araghi

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Circulating CD3+HLA-DR+ Extracellular Vesicles as a Marker for Th1/Tc1-Type Immune Responses by Ryutaro Oba, Motomichi Isomura, Akira Igarashi, Kinya Nagata

“…To establish T cell subset-specific biomarkers, we performed proteomic analysis with Th1- and Th2-derived EVs and identified HLA-DR as a Th1-dominated EV membrane protein. …”
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Analysis of Bacterial Diversity in Different Heavy Oil Wells of a Reservoir in South Oman with Alkaline pH by Biji Shibulal, Saif N. Al-Bahry, Yahya M. Al-Wahaibi, Abdulkadir E. Elshafie, Ali S. Al-Bemani, Sanket J. Joshi

“…Molecular approaches like proteomic and genomic characterization of the isolates are replacing the traditional method of identification with systemic classification. …”
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Innovative applications and future trends of multiparametric PET in the assessment of immunotherapy efficacy by Tingting Qiao, Tingting Qiao, Zhaoping Cheng, Yanhua Duan

“…The integration of multi-omics data (including genomics and proteomics) with PET imaging enhanced the sensitivity and accuracy of efficacy prediction. …”
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Addressing genome scale design tradeoffs in Pseudomonas putida for bioconversion of an aromatic carbon source by Deepanwita Banerjee, Javier Menasalvas, Yan Chen, Jennifer W. Gin, Edward E. K. Baidoo, Christopher J. Petzold, Thomas Eng, Aindrila Mukhopadhyay

“…In this study glutamine is then converted to indigoidine, an alternative sustainable pigment and a model heterologous product that is commonly used to colorimetrically quantify glutamine concentration. Through proteomics, promoter-variation, and growth characterization of a fully implemented gene deletion design, we provide evidence that aromatic catabolism in the completed design is rate-limited by fumarase hydratase (FUM) enzyme activity in the citrate cycle and requires careful optimization of another fumarate hydratase protein (PP_0897) expression to achieve growth and production. …”
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Regulation of interferon alpha production by the MAGUK-family protein CASK under H5N1 infection by Jing-Ying Huang, Jing-Ying Huang, Pei-Shan Sung, Shie-Liang Hsieh, Shie-Liang Hsieh, Shie-Liang Hsieh, Shie-Liang Hsieh

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Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis by Yuanshan Cui, Zhongbao Zhou, Yumeng Chai, Yong Zhang

“…The Human Protein Atlas and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) were used to assess the protein expression of GSDMB. …”
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Prioritization of potato genes involved in the formation of agronomically valuable traits using the SOLANUM TUBEROSUM knowledge base by P. S. Demenkov, O. V. Saik, T. V. Ivanisenko, N. A. Kolchanov, A. V. Kochetov, V. A. Ivanisenko

“…The development of highly efficient technologies in genomics, transcriptomics, proteomics and metabolomics, as well as new technologies in agriculture has led to an “information explosion” in plant biology and crop production, including potato production. …”
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Encapsulated LyeTx III Peptide: Cytotoxic Agent Isolated from <i>Lycosa erythrognatha</i> Spider Venom by Daniel Moreira dos Santos, Livia Ramos Santiago, Nayara Araújo dos Santos, Wanderson Romão, Jarbas Magalhães Resende, Maria Elena de Lima, Márcia Helena Borges, Rosy Iara Maciel de Azambuja Ribeiro

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Seed priming and abiotic stress tolerance in carrot: Unraveling the mechanisms of improved germination. by Marcin Nowicki, Marzena Nowakowska, Katarzyna Nowak, Wojciech Szczechura, Piotr Kaminski

“…., transcriptomics, proteomics, metabolomics) will provide deeper insights into the molecular mechanisms that regulate stress tolerance, to aid in the development of more resilient carrot varieties suitable for cultivation under adverse environmental conditions.…”
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Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament by Emmajay Sutherland, Christopher J. Harding, Tancrède du Monceau de Bergendal, Gordon J. Florence, Katrin Ackermann, Bela E. Bode, Silvia Synowsky, Ramasubramanian Sundaramoorthy, Clarissa Melo Czekster

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Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…With the advances in genomic and proteomic technologies, new opportunities have emerged to explore the molecular biology of N. fowleri and its host response. …”
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Serial Paediatrics Omics Tracking in Myalgic Encephalomyelitis (SPOT-ME): protocol paper for a multidisciplinary, observational study of clinical and biological markers of paediatr... by Adam Scheinberg, Natalie Thomas, Katherine Huang, Paul R Gooley, Elisha K Josev, Tracey Chau, Darcy Tantanis, Sarah J Knight, Christopher W Armstrong

“…ME/CFS patients aged 12–19 years and controls will donate biosamples of urine, blood, and peripheral blood mononuclear cells for an in-depth omics profiling analysis (whole-genome sequencing, metabolomics and quantitative proteomics) while being assessed by gold-standard clinical and neuropsychological measures. …”
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MSC-sEVs exacerbate senescence by transferring bisecting GlcNAcylated GPNMB by Yihan Ma, Chongfu Zhao, Jingjing Feng, Junjie Gou, Enci Kang, Feng Guan, Qiong Wu, Xiang Li

“…We employed advanced proteomic analysis to quantify the expression levels of GPNMB in both BMMSCs and sEVs. …”
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Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…Our results indicated that noise-exposed mice exhibited accelerated age-related hearing loss spanning from high to low frequencies. Proteomics analysis revealed an upregulation in the receptor for the advanced glycation end-products (RAGE) signaling pathway, which was associated with an activated inflammatory response, vascular injury, and mitochondrial and synaptic dysfunction. …”
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