Profiling the Secretome of Glioblastoma Cells Under Histone Deacetylase Inhibition Using Mass Spectrometry by Aline Menezes, Yara Martins, Fábio Nogueira, Denise De Abreu Pereira, Katia Carneiro

“…A label-free, mass spectrometry–based quantitative proteomics has been developed to identify and characterize proteins that are differentially expressed in GBM to gain a better understanding of the interactions and functions that lead to the pathological state focusing on the extracellular matrix (ECM). …”
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Profiling Proteins in the Hypothalamus and Hippocampus of a Rat Model of Premenstrual Syndrome Irritability by Mingqi Qiao, Peng Sun, Yang Wang, Sheng Wei, Xia Wei, Chunhong Song, Fushun Wang, Jibiao Wu

“…This study employed two-dimensional gel electrophoresis (2DE) for proteomic map analysis of the hypothalamus and hippocampus of rat models of premenstrual syndrome (PMS) irritability. …”
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Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection by Chen Zou, Minjie Zhao, Jingjing Yu, Dandan Zhu, Yunzhi Wang, Xinping She, Yanan Hu, Zhi Zheng

“…Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR treated with (IVC group; n=9) and without (PDR group; n=8) preoperative IVC. …”
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Unlocking biological complexity: the role of machine learning in integrative multi-omics by Ravindra Kumar, Rajrani Ruhel, Andre J. van Wijnen

“…Integrative multi-omics approaches use multi-layered datasets such as genomic, transcriptomic, proteomic, and metabolomic data to understand biological processes much more comprehensively compared to the single-omics analysis and to provide a comprehensive view of cellular and molecular processes. …”
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A high coverage reference transcriptome assembly of pea (<i>Pisum sativum</i> L.) mycorrhizal roots by A. M. Afonin, I. V. Leppyanen, O. A. Kulaeva, O. Y. Shtark, I. A. Tikhonovich, E. A. Dolgikh, V. A. Zhukov

“…As transcriptomic and proteomic approaches are being implemented for studying the mutualistic symbioses of pea, a need for a reference transcriptome of genes expressed under these specific conditions for increasing the resolution and the accuracy of other methods arose. …”
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A ribosome-associating chaperone mediates GTP-driven vectorial folding of nascent eEF1A by Ibrahim M. Sabbarini, Dvir Reif, Kibum Park, Alexander J. McQuown, Anjali R. Nelliat, Charlotte Trejtnar, Volker Dötsch, Eugene I. Shakhnovich, Andrew W. Murray, Vladimir Denic

“…Here, we use AlphaPulldown to identify Ypl225w (also known as Chp1, Chaperone 1 for eEF1A) as a conserved yeast protein predicted to stabilize the N-terminal, GTP-binding (G) domain of eEF1A against its misfolding propensity, as predicted by computational simulations and validated by microscopy analysis of ypl225wΔ cells. Proteomics and biochemical reconstitution reveal that Ypl225w functions as a co-translational chaperone by forming dual interactions with the eEF1A G domain nascent chain and the UBA domain of ribosome-bound nascent polypeptide-associated complex (NAC). …”
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Identification of Proteins and Genes Associated with Hedgehog Signaling Pathway Involved in Neoplasm Formation Using Text-Mining Approach by Nadezhda Yu. Biziukova, Sergey M. Ivanov, Olga A. Tarasova

“…Systematic accumulation of various types of biological data, including interactions between proteins, regulation of genes transcription, proteomics, and metabolomics experiments results, allows the application of computational analysis of these big data for identification of key molecular mechanisms of certain diseases and pathologies and promising therapeutic targets. …”
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Antimicrobial proteins from oyster hemolymph improve the efficacy of conventional antibiotics. by Kate Summer, Qi Guo, Lei Liu, Bronwyn Barkla, Sarah Giles, Kirsten Benkendorff

“…Effective HPE concentrations are comparable to AMPPs currently approved for use or in clinical trials pipelines. Proteomics analysis of HPE identified a number of proteins including abundant known AMPPs. …”
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RECQL4 affects MHC class II‐mediated signalling and favours an immune‐evasive signature that limits response to immune checkpoint inhibitor therapy in patients with malignant melan... by Sara Egea‐Rodriguez, Renáta Váraljai, Thierry M. Nordmann, Restuan Lubis, Manuel Philip, Florian Rambow, Alexander Roesch, Michael Flaig, Susanne Horn, Raphael Stoll, Fang Zhao, Annette Paschen, Bert Klebl, Ian D. Hickson, Dirk Schadendorf, Matthias Mann, Iris Helfrich

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Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes by Luca Pangrazzi, Andreas Meryk

“…We will examine the current understanding of immunosenescence at the genomic, epigenomic, and proteomic levels, and discuss how various lifestyle factors can potentially mitigate or partially reverse aspects of immune aging. …”
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Prediction of inhibitory peptides against E.coli with desired MIC value by Nisha Bajiya, Nishant Kumar, Gajendra P. S. Raghava

“…Additionally, we screened anti-E. coli proteins in the proteomes of three probiotic bacterial strains and created a web-based platform, “EIPpred”, enabling users to design peptides with desired MIC values ( https://webs.iiitd.edu.in/raghava/eippred ).…”
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Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories. by Shaghayegh Navabpour, Morgan B Patrick, Nour A Omar, Shannon E Kincaid, Yeeun Bae, Jennifer Abraham, Jacobi McGrew, Madeline Musaus, W Keith Ray, Richard F Helm, Timothy J Jarome

“…Despite this, using unbiased proteomics, we found that indirectly acquired fear memories have distinct protein degradation profiles in the amygdala and anterior cingulate cortex (ACC) relative to directly acquired fear memories and pseudoconditioning, which further differed significantly by sex. …”
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Secretion of One Adipokine Nampt/Visfatin Suppresses the Inflammatory Stress-Induced NF-κB Activity and Affects Nampt-Dependent Cell Viability in Huh-7 Cells by Yi-Ching Lin, Hui-Chung Wu, Chen-Chung Liao, Yi-Chih Chou, Shwu-Fen Pan, Chi-Ming Chiu

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Unveiling immune cell response disparities in human primary cancer-associated fibroblasts between two- and three-dimensional cultures. by Jian-Ping Yang, Nikhil Nitin Kulkarni, Masashi Yamaji, Tsubasa Shiraishi, Thang Pham, Han Do, Nicole Aiello, Michael Shaw, Toshihiro Nakamura, Akiko Abiru, Narender R Gavva, Shane R Horman

“…Using single-nucleus RNA sequencing (snRNAseq) and Proteomics' Proximity Extension Assays, we characterized CAF transcriptomic profiles and cytokine levels. …”
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Histopathological characterization of skin and muscle lesions induced by lionfish (Pterois volitans) venom in a murine experimental model by Cecilia Díaz, Arturo Chang-Castillo, Natalia Ortiz

“…Methods: In this study, we characterized the 24-hour histopathological effects of lionfish venom in a mouse experimental model by testing the main fractions obtained by size exclusion-HPLC. By partial proteomics analysis, we also correlated these in vivo effects with the presence of some potentially toxic venom components. …”
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Current Uses of Poly(lactic-co-glycolic acid) in the Dental Field: A Comprehensive Review by Maria Justina Roxana Virlan, Daniela Miricescu, Alexandra Totan, Maria Greabu, Cristiana Tanase, Cristina M. Sabliov, Constantin Caruntu, Bogdan Calenic

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First identification report for amino acid composition of red algae Gracilaria spp. obtained from Central Java, Indonesia by Klara Kharisma Bunga Chandra, Tri Rini Nuringtyas, Tri Joko Raharjo

“…The unique protein expressions have never been analyzed using a proteomic approach, and no reports are available on Gracilaria spp. amino acid sequences in Central Java. …”
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Tracing the paths of modular evolution by quantifying rearrangement events of protein domains by Abdulbaki Coban, Erich Bornberg-Bauer, Carsten Kemena

“…Therefore, these events can be used to characterize and reconstruct major events of molecular adaptation by comparing large data sets of proteomes. Results Here we determine, at unprecedented completeness, the rates of fusion, fission, emergence and loss of domains in five eukaryotic clades (monocots, eudicots, fungi, insects, vertebrates). …”
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Growth Differentiation Factor 15 and Risk of Death in Haemodialysis Patients by Christelle Calen, Seraina Von Moos, Pietro Cippà, Alexandre Mebazaa, Mattia Arrigo

“…Measurements were performed using the Proseek Multiplex Cardiovascular disease panels (Olink Proteomics AB) and validated using the Elecsys GDF-15 electrochemiluminescence immunoassay on a Cobas E801 analyzer (Roche Diagnostics). …”
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Isovitexin targets SIRT3 to prevent steroid-induced osteonecrosis of the femoral head by modulating mitophagy-mediated ferroptosis by Yinuo Fan, Zhiwen Chen, Haixing Wang, Mengyu Jiang, Hongduo Lu, Yangwenxiang Wei, Yunhao Hu, Liang Mo, Yuhao Liu, Chi Zhou, Wei He, Zhenqiu Chen

“…In this study, we analyzed clinical samples obtained from SIONFH patients using proteomic and bioinformatic approaches. We found an imbalance in mitochondrial homeostasis and ferroptosis-induced impairment of osteogenic capacity in SIONFH. …”
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