-
421
An updated reference genome of Barbatula barbatula (Linnaeus, 1758)
Published 2025-01-01“…We identified 23270 protein-coding genes, and the proteome exhibited high completeness with BUSCO (93.1%) and OMArk (90.81%). …”
Get full text
Article -
422
BIOINFORMATIC ANALYSIS OF THE GENOME OF THE Geobacillus stearothermophilus 22 STRAIN ISOLATED FROM THE GARGA HOT SPRING, BAIKAL REGION
Published 2015-01-01“…Nucleotide sequences (contigs) of the strain were found to be similar to the genome of the thermophilic strain G. kaustophilus Y412MC52. The proteome of the new strain was analyzed. Fragments associated with hemicellulases (endoxylanase, beta xylosidase, and arabinofuranosidase) and the endoxylanase enzyme were detected.…”
Get full text
Article -
423
Protein Glycation in Diabetes as Determined by Mass Spectrometry
Published 2013-01-01“…The development of mass spectrometric techniques able to give highly specific and reliable results in proteome field is of wide interest for physicians, giving them new tools to monitor the disease progression and the possible complications related to diabetes, as well as the effectiveness of therapeutic treatments. …”
Get full text
Article -
424
The Occurrence of Sequences Identical with Epitopes from the Allergen Pen a 1.0102 Among Food and Non-Food Proteins
Published 2015-03-01“…The work presented is the first survey concerning global distribution of epitopes from Pen a 1.0102 in universal proteome. In the group of known tropomyosin epitopes, the fragment with the sequence ESKIVELEEEL was found in the sequence of channel catfish (Ictalurus punctatus) tropomyosin. …”
Get full text
Article -
425
Don't die like me: Which proteins are responsible for the selective neuronal vulnerability within the substantia nigra?
Published 2024-01-01“…For this purpose, the neurons from the ventral as well as dorsal tier of the substantia nigra were specifically isolated out of neuropathologically unremarkable human substantia nigra sections with laser microdissection. Following, their proteome was analyzed by data independent acquisition mass spectrometry. …”
Get full text
Article -
426
Characterization of the Protective HIV-1 CTL Epitopes and the Corresponding HLA Class I Alleles: A Step towards Designing CTL Based HIV-1 Vaccine
Published 2014-01-01“…High mutation rate in the viral genome underlying the antigenic variability of the viral proteome is the major hindrance as far as the antibody based vaccine development is concerned. …”
Get full text
Article -
427
Why cutting respiratory CO2 loss from crops is possible, practicable, and prudential
Published 2023-03-01“…Conceptual and technical advances, particularly in protein turnover and directed enzyme evolution, have now opened ways to trim the large fraction of respiration that fuels proteome maintenance by lowering the breakdown and resynthesis rates of enzymes and other proteins. …”
Get full text
Article -
428
Effects of Acyclovir and IVIG on Behavioral Outcomes after HSV1 CNS Infection
Published 2017-01-01“…Female, but not male, PBS-treated mice were cognitively impaired, and unexpectedly, ACV was protective, while the inclusion of IVIG surprisingly antagonized ACV’s beneficial effects. Distinct serum proteomic profiles were observed for male and female mice, and the antagonistic effects of ACV and IVIG on behavior were paralleled by similar changes in the serum proteome of ACV- and ACV + IVIG-treated mice. …”
Get full text
Article -
429
Drug Target Identification and Elucidation of Natural Inhibitors for : An Study
Published 2016-12-01“…In this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of B. petrii DSM 12804 (accession No. …”
Get full text
Article -
430
Cross-trait multivariate GWAS confirms health implications of pubertal timing
Published 2025-01-01“…We find 266 independent variants in 197 loci, including 18 novel variants. Transcriptomic, proteome imputation and fine-mapping analyses reveal genes causal for pubertal timing, including KDM4C, LEPR, CCNC, ACP1, and PCSK1. …”
Get full text
Article -
431
Vitamin D sensitizes cervical cancer to radiation-induced apoptosis by inhibiting autophagy through degradation of Ambra1
Published 2025-01-01“…We examined conventional radiation-induced cell death, such as DNA damage and cell cycle arrest, in vitamin D–treated cells to detect the underlying mechanism, but no association was observed between them. Subsequently, our proteome analysis exhibited that autophagy was reduced in irradiated CCs treated with vitamin D, and apoptosis displayed the opposite effect. …”
Get full text
Article -
432
SIRT5 Contributes to Colorectal Cancer Growth by Regulating T Cell Activity
Published 2020-01-01“…In this work, we found that Sirt5 knockout mice were resistant to AOM and DSS-induced colitis-associated colorectal tumorigenesis and the level of IFN-γ in their tumor microenvironment was higher. Additionally, proteome and network analysis revealed that SIRT5 was important in the T cell receptor signaling pathway. …”
Get full text
Article -
433
Elucidation of peptide screen for targeted identification of Yersinia pestis by nano-liquid chromatography tandem mass spectrometry
Published 2025-01-01“…We employed a shotgun proteomic approach using nano-liquid chromatography-tandem mass spectrometry (nLC-MS/MS) to discover Y. pestis-specific peptides. …”
Get full text
Article -
434
Identifying optimal substrate classes of membrane transporters.
Published 2024-01-01“…Identifying all membrane transporters within a (meta-)proteome, along with their specific substrates, provides important information for various research fields, including biotechnology, pharmacology, and metabolomics. …”
Get full text
Article -
435
Altering the redox status of Chlamydia trachomatis directly impacts its developmental cycle progression
Published 2025-01-01“…EBs and RBs have distinctive characteristics that distinguish them, including their size, infectivity, proteome, and transcriptome. Intriguingly, they also differ in their overall redox status as EBs are oxidized and RBs are reduced. …”
Get full text
Article -
436
VEIKIANTIS GENOMAS - VISUMINIS POŽYMIS: DABARTIES ŽVILGSNIS Į GENETIKĄ
Published 2003-01-01“…Keywords: genome, genomics, DNA microarrays, proteome. …”
Get full text
Article -
437
Transcription factor TCF4: structure, function, and associated diseases
Published 2024-11-01“…The biological role of approximately 20 % of human proteins has not been established yet, and the molecular functions of the known part of the proteome remain poorly understood. This hinders progress in basic and applied biological and medical sciences, especially in treating hereditary diseases, which are caused by mutations and polymorphic variants in individual genes. …”
Get full text
Article -
438
Overexpression of PLCG2 and TMEM38A inhibit tumor progression in clear cell renal cell carcinoma
Published 2025-01-01“…We further analyzed proteome and single-cell data and selected PLCG2 and TMEM38A for the following experiments. …”
Get full text
Article -
439
Applying the Concept of Peptide Uniqueness to Anti-Polio Vaccination
Published 2015-01-01“…Proteins from poliovirus type 1, strain Mahoney, were analyzed for amino acid sequence identity to the human proteome at the pentapeptide level, searching for sequences that (1) have zero percent of identity to human proteins, (2) are potentially endowed with an immunologic potential, and (3) are highly conserved among poliovirus strains. …”
Get full text
Article -
440
The molecular view of mechanical stress of brain cells, local translation, and neurodegenerative diseases
Published 2021-03-01“…In further consideration of the role of the local translation system in the development of neuropsychic and neurodegenerative diseases, an original hypothesis was put forward that one of the possible causes of synaptopathies is impaired proteome stability associated with mTOR hyperactivity and formation of complex dynamic modes of de novo protein synthesis in response to synapse-stimulating factors, including chronic mechanical stress.…”
Get full text
Article