Organophosphate esters inhibit enzymatic proteolysis through non-covalent interactions by Zeming Wang, Wei Zhang, Xiaojie Hu, Yanzheng Gao

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The Emerging Role of Proteolysis in Mitochondrial Quality Control and the Etiology of Parkinson’s Disease by Riya Shanbhag, Guang Shi, Jarungjit Rujiviphat, G. Angus McQuibban

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Theoretical investigation on models of circadian rhythms based on dimerization and proteolysis of PER and TIM by Jifa Jiang, Qiang Liu, Lei Niu

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Zinc Metalloproteinases and Amyloid Beta-Peptide Metabolism: The Positive Side of Proteolysis in Alzheimer's Disease by Mallory Gough, Catherine Parr-Sturgess, Edward Parkin

“…It is the role of zinc metalloproteinases in this “positive side of proteolysis in Alzheimer's disease” that is discussed in the current paper.…”
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Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation by Guliang Yang, Haiyan Zhong, Xinxin Xia, Zhiwen Qi, Chengzhang Wang, Shiming Li

“…However, the direct identification of a targeted protein remains unexplored for natural occurring compounds. Proteolysis targeting chimera (PROTAC) is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway. …”
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Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

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Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production by Parnian Arafi, Sujan Devkota, Emily Williams, Masato Maesako, Michael S Wolfe

Subjects: “…proteolysis…”
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Cartilage Oligomeric Matrix Protein (COMP)-Mediated Cell Differentiation to Proteolysis Mechanism Networks from Human Normal Adjacent Tissues to Lung Adenocarcinoma by Lin Wang, Juxiang Huang, Minghu Jiang, Haizhen Diao, Huilei Zhou, Xiaohe Li, Qingchun Chen, Zhenfu Jiang, Haitao Feng, Stefan Wolfl

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miR-26a-5p/ADAM17-Mediated Proteolysis of TREM2 Regulates Neuroinflammation in Hypertensive Mice Following Lead Exposure by Yuran Wang, Zeming Wang, Han Hao, Yuwei Zhao, Jian Wang, Weixuan Wang

“…This decline in TREM2 expression was associated with increased proteolysis of TREM2 by a disintegrin and metalloproteases 10 (ADAM10) as well as a disintegrin and metalloproteases 17 (ADAM17), in which ADAM17 was verified as the main cleavage enzyme in terms of TREM2 proteolytic cleavage in hypertensive mice following Pb exposure. …”
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Formyl Met-Leu-Phe-Stimulated FPR1 Phosphorylation in Plate-Adherent Human Neutrophils: Enhanced Proteolysis but Lack of Inhibition by Platelet-Activating Factor by Algirdas J. Jesaitis, Jeannie Gripentrog, Jovanka M. Voyich

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Regulatory mechanism of Reelin activity: a platform for exploiting Reelin as a therapeutic agent by Mitsuharu Hattori

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Classification of Slovenian Dry-Cured Ham – Kraški pršut – According to Texture Profile by Mateja Lušnic Polak, Tomaž Polak, Mojca Kuhar, Iva Zahija Jazbec, Tadej Kaltnekar, Lea Demšar

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Effect of marination with broccoli (Brassica oleracea var. italica) juice and soy sauce on physicochemical, structural and oxidative properties of beef steak by Ashkan Jebelli Javan, Fatemeh Mirhaj, Nasim Khorshidian, Mehrdad Mohammadi

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Effect of Dry Aging on Beef Muscle Proteins by Galina V. Gurinovich, Irina S. Patrakova, Vladislav A. Khrenov, Marina V. Patshina, Antonina I. Shevchenko

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Non-enzymatic protein targeting agents as a promising strategy for cancer treatment by Madison Ambrose, Jeremy Lee, Aleem Syed, Zamal Ahmed, Guang Peng

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Role of calpain system in meat tenderness: A review by Z.F. Bhat, James D. Morton, Susan L. Mason, Alaa El-Din A. Bekhit

“…Keywords: Aging, Tenderness, Calpains, Proteolysis, Calpain activity, Factors…”
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A Cellular Potts model simulating cell migration on and in matrix environments by Marco Scianna, Luigi Preziosi, Katarina Wolf

“…Our modelprovides a strong correlation of the directionality of migrationwith the topological extracellular matrix distribution and abiphasic dependence of migration on the matrix structure, density,adhesion, and stiffness, and, moreover, simulates that celllocomotion in highly constrained fibrillar obstacles requires thedeformation of the cell's nucleus and/or the activity ofcell-derived proteolysis. In conclusion, we here propose amathematical modeling approach that serves to characterize cellmigration as a biological phenomenon in healthy and diseased tissuesand in engineering applications.…”
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The Importance of Ubiquitination and Deubiquitination in Cellular Reprogramming by Bharathi Suresh, Junwon Lee, Kye-Seong Kim, Suresh Ramakrishna

“…There are two switches: an E3 ubiquitin ligase enzyme that tags ubiquitin molecules to the target proteins for proteolysis and a second enzyme, the deubiquitinating enzyme (DUBs), that performs the opposite action, thereby preventing proteolysis. …”
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Does Branched-Chain Amino Acids Supplementation Modulate Skeletal Muscle Remodeling through Inflammation Modulation? Possible Mechanisms of Action by Humberto Nicastro, Claudia Ribeiro da Luz, Daniela Fojo Seixas Chaves, Luiz Roberto Grassmann Bechara, Vanessa Azevedo Voltarelli, Marcelo Macedo Rogero, Antonio Herbert Lancha

“…The proinflammatory status of muscle cells, observed in pathological conditions such as cancer, aging, and sepsis, can directly modulate protein translation initiation and muscle proteolysis, contributing to negative protein turnover. …”
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The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs by Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty

“…Classically, elevated levels of TIMPs are suggested to result in ECM accumulation leading to fibrosis, whereas loss of TIMP responses leads to enhanced matrix proteolysis. Here, we outline the known roles of the most abundant TIMP, TIMP2, in pulmonary diseases but also discuss future perspectives in TIMP2 research that could impact the lungs. …”
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