Vaccarin suppresses diabetic nephropathy through <?A3B2 pi6?>inhibiting the EGFR/ERK1/2 signaling pathway by Zhu Xuexue, Meng Xinyu, Du Xinyao, Zhao Chenyang, Ma Xinyu, Wen Yuanyuan, Zhang Shijie, Hou Bao, Cai Weiwei, Du Bin, Han Zhijun, Xu Fei, Qiu Liying, Sun Haijian

“…The levels of malondialdehyde (MDA) and reactive oxygen species (ROS), as well as the content of glutathione peroxidase (GSH-Px), are measured. The protein expressions of collagen I, TGF-β1, α-SMA, E-cadherin, Nrf2, catalase, SOD3, SOD2, SOD1, p-ERK, p-EGFR (Y845), p-EGFR (Y1173), p-NFκB P65, t-ERK, t-EGFR and t-NFκB P65 are detected by western blot analysis. …”
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Unraveling the immunological landscape and gut microbiome in sepsis: a comprehensive approach to diagnosis and prognosisResearch in context by Yali Luo, Jian Gao, Xinliang Su, Helian Li, Yingcen Li, Wenhao Qi, Xuling Han, Jingxuan Han, Yiran Zhao, Alin Zhang, Yan Zheng, Feng Qian, Hongyu He

“…A combined diagnostic model incorporating B.salyersia, NK cells in CD45+ leukocytes, and C-reactive protein (CRP) demonstrated high accuracy in distinguishing sepsis from non-sepsis (area under the receiver operating characteristic curve, AUC = 0.950, 95% CI: 0.811–1.000). …”
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Reproductive performance of female largemouth bass (Micropterus salmoides) broodstock was enhanced by dietary small peptides by Jie Wei, Mingwei Tao, Jiaming Huang, Hangxian Zhou, Qiyou Xu

“…The mRNA expression levels of vgr (1.90 ± 0.29), insulin-like growth factor-1 (1.53 ± 0.67), steroidogenic acute regulatory protein (2.59 ± 0.78), fshr (1.97 ± 0.35) and cyp17a (2.78 ± 1.32) in gonad were up-regulated in the HS group (P < 0.05). …”
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Seroprevalence against SARS-CoV-2 after booster vaccination in a prison in Alicante (Spain) by Ana C. Montagud, Raul Moragues, Nancy Vicente-Alcalde, Nancy Vicente-Alcalde, Emilia Montagud, José Antonio Hurtado-Sánchez, José Antonio Hurtado-Sánchez, José Tuells, José Tuells

“…The aim of this study is to asses the prevalence of antibodies against the Spike protein of SARS-CoV-2 in vaccinated prisoners and staff at a specific prison in Alicante.MethodsA cross-sectional epidemiological study was designed for the population in scope using a rapid lateral flow immunochromatography serological test, conducted on July 27, 2023. …”
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Effect of dietary microalgae on growth performance and health in meat-type quails by Samar M. Mohamed, Mahmoud Alagawany, Mohamed S. El-Kholy, Mohamed M. El-Mekkawy, Ayman S. Salah, Youssef A. Attia, Rashed A. Alhotan, Alessandro Di Cerbo, Antonia Lestingi

“…Liver and kidney function markers were affected by the supplements, and DsAp2 group recorded the highest levels of total protein and albumin. The DsAp1 group significantly (P=0.003) presented the lowest level of alanine aminotransferase (ALT) and the DsAp2 group significantly (P<0.001) presented the lowest levels of aspartate aminotransferase (AST) and urea. …”
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TILTomorrow today: dynamic factors predicting changes in intracranial pressure treatment intensity after traumatic brain injury by Shubhayu Bhattacharyay, Florian D. van Leeuwen, Erta Beqiri, Cecilia A. I. Åkerlund, Lindsay Wilson, Ewout W. Steyerberg, David W. Nelson, Andrew I. R. Maas, David K. Menon, Ari Ercole, the CENTER-TBI investigators and participants

“…The most important predictors of day-to-day changes in ICP management included preceding treatments, age, space-occupying lesions, ICP, metabolic derangements, and neurological function. Serial protein biomarkers were also important and may serve a useful role in the clinical armamentarium for assessing therapeutic needs. …”
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Retinoblastoma. Part 1. Clinical presentations and diagnostic tools by S.V. Ivanova, S.A. Kuleva, N.N. Sadovnikova, M.I. Komissarov, M.N. Chistyakova, A.V. Khokhlova, N.A. Shchegoleva

“…Mutations in the RB1 gene result in the complete inactivation of retinoblastoma protein expression and, therefore, uncontrolled cell proliferation and generation of tumor cell clone. …”
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汉麻仁抗血栓活性肽的制备工艺优化 "Preparation process optimization of hemp kernel antithrombotic active peptide" by 石杰，张正海，魏连会，杨庆丽，李国巍，董艳，姬妍茹 "SHI Jie, ZHANG Zhenghai, WEI Lianhui, YANG Qingli, LI Guowei, DONG Yan, JI Yanru"

“…In order to obtain hemp kernel polypeptide with antithrombotic activity, hemp kernel protein powder was used as raw material to obtain hemp kernel antithrombotic active peptide by enzymatic hydrolysis, and it was purified by ultrafiltration. …”
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Cerebrospinal fluid β2-microglobulin promotes the tau pathology through microglia–astrocyte communication in Alzheimer's disease by Zehu Sheng, Lanyang Wang, Ming Chen, Fuxin Zhong, Shijing Wu, Shuyu Liang, Jiaqi Song, Lihua Chen, Yingxi Chen, Shiyu Chen, Weihua Yu, Yang Lü

“…Methods In this study, 211 participants from the Alzheimer’s disease Neuroimaging Initiative (ADNI) with CSF and Plasma β2M, CSF glial fibrillary acidic protein (GFAP), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), Aβ42, phosphorylated-tau (P-tau) and total tau (T-tau) were divided into four groups, stage 0, 1, 2, and suspected non-AD pathology (SNAP) based on the National Institute on Aging- Alzheimer’s Association (NIA-AA) criteria. …”
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Diagnosis of tuberculosis in buffaloes in Argentina: intradermoreaction, compatible lesions and bacteriological culture by Emilia Irina Martínez, Fabiana Cipolini Galarza, Nolly María Monzón, Ana Gabriela Espasandin, José Luis Konrad, Elvira Falzoni, Soledad Barandiaran, Jimena Marfil, Marcela Martínez Vivot, Diana Elina Martínez

“…In Argentina, bovine and buffalo cattle are under a tuberculosis control and eradication program, which includes tuberculin purified protein derivative bovine (PPDB) diagnosis and slaughter of positive reagents. …”
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Comparative Genomics Reveals Evidence of the Genome Reduction and Metabolic Potentials of <i>Aliineobacillus hadale</i> Isolated from Challenger Deep Sediment of the Mariana Trench by Shaofeng Yang, Jie Liu, Yang Liu, Weichao Wu, Jiahua Wang, Yuli Wei

“…In addition, the reduced number of paralogous genes in strain Lsc_1132^T, together with its high protein-coding gene density, may further contribute to streamlining its genome and enhancing its genomic efficiency. …”
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CHARACTERISTICS OF CYTOPROTECTIVE EFFECT ON THE GASTRIC MUCOSA OF CRYOPRESERVED PLACENTA EXTRACT UNDER WATER-IMMOBILIZATION STRESS by Illia Koshurba, Fedir Hladkykh, Mykola Chyzh

“…The study of the activity of constitutive (cNOS) and inducible (iNOS) isoforms of NOS showed that at the pathobiochemical level against the background of stress-induced ulcerogenesis in the tissues of the central nervous system there is a statistically significant (p<0.001) increase in iNOS activity in 5.2 times was 0.89±0.01 NADPH2/min´g protein. According to the degree of modulation of the activity of both total NOS and its individual isoforms, the study showed that preventive five-day administration of esomeprazole is inferior to the effectiveness of CEP. …”
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Comprehensive treatment of the macular edema in patients with retinal vein occlusion and hemostasis system disturbances by T.V. Shelkovnikova, Kh.P. Takhchidi, G.V. Vavin, N.Yu. Barkova, N.Yu. Shishlyannikova

“…<br> <b>Results</b>: in all patients with RVO and ME before and after comprehensive treatment, deviations from the normal hemostasis parameters and endothelial dysfunction of von Willebrand factor, activated protein C, VIII factor, VEGF were detected. LA was found in 23.6% of cases in patients with RVO. …”
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Poly (ADP-ribose) (PAR) levels in Peripheral Blood Mononuclear Cells (PBMC) during peri-implantation and early pregnancy in buffalo cows by Giovanna De Matteis, Anna Reale, Michele Zampieri, Emanuela Rossi, Federica Signorelli, Olimpia Barbato, Vittoria Lucia Barile

“… Poly(ADP-ribosyl)ation (PAR) is a reversible post-translational protein modification catalyzed by enzyme  members of the poly(ADP-ribose) polymerases (PARPs) family. …”
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Cocktail of Ropivacaine, Morphine, and Diprospan Reduces Pain and Prolongs Analgesic Effects after Total Knee Arthroplasty: A Prospective Randomized Controlled Trial by Zhenyu Luo, Weinan Zeng, Xi Chen, Qiang Xiao, Anjing Chen, Jiali Chen, Haoyang Wang, Zongke Zhou

“…The primary outcomes were the levels of inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6), pain visual analog scale (VAS) scores, opioid consumption, range of motion (ROM), functional tests, and sleeping quality. …”
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Farm-to-fork changes in poultry microbiomes and resistomes in Maputo City, Mozambique by Natalie Olson, Frederica Lamar, Hermógenes Mucache, José Fafetine, Joaquim Saíde, Amélia Milisse, Denise R. A. Brito, Kelsey J. Jesser, Karen Levy, Matthew C. Freeman, Maya L. Nadimpalli

“…These results indicate markets are an important site of exposure to potentially pathogenic bacteria and high-risk ARGs.IMPORTANCEWhile chicken eggs and meat are a critical protein source in low-income settings, antibiotics are routinely fed to chickens with consequences for selection of antimicrobial resistance. …”
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The predictive role of the hs-CRP/HDL-C ratio for long-term mortality in the general population: evidence from a cohort study by Yifeng Wang, Li Wang, Zongquan Zhao, Song Yin, Xuejun Tang, Kerui Zhang

“…Abstract Background The high-sensitivity C-reactive protein (hs-CRP) to high-density lipoprotein cholesterol (HDL-C) ratio, a composite marker of low-grade inflammation and lipid metabolism, is reportedly associated with the occurrence of new cardiovascular diseases (CVDs) in certain people. …”
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Probiotics Can Boost the Antitumor Immunity of CD8+T Cells in BALB/c Mice and Patients with Colorectal Carcinoma by Jie Mao, Shu-Ze Zhang, Peng Du, Zhi-Bin Cheng, Huan Hu, Shi-Yao Wang

“…It was also found that probiotic feeding could upregulate the expression of T-cell immunoglobulin mucin receptor 1(TIM-1) in CD8+T cells of mice and also found that probiotic feeding could downregulate the expression of programmed cell death protein 1 (PD-1) in CD8+T cells of mice, compared with the nonfeeding group; the difference was statistically significant (P=0.045 for TIM-1 and P=0.02 for PD-1, respectively). …”
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Physiological impact of Trichoderma viride agents on the quality and production of melon that is grown on soils continuously cropped to melon by Jingyi Liu, Hua Lian, Jingwei Dou, Jingjing Li, Guangliang Zhu, Jiatong Wang, Guangshu Ma, Mei Li

“…The amount of soluble solids, vitamin C, soluble protein, soluble sugar, and sugar acid ratio also increased. …”
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Effect of sun dry brewer spent yeast on chemical composition, in vitro digestibility, and ruminal degradation kinetics of wheat straw by Geberemariyam Terefe, Mulugeta Walelgne, Dereje Fekadu, Getu Kitaw, Mesfin Dejene, Aeimro Kehaliu, Bethlehem Mekonnen, Yohannse Habteyesus

“…Abstract Background Dry brewer spent yeast (DBSY) has high crude protein (CP) (43.2%) and metabolizable energy (14.3 MJ/kg) contents and it is an alternative animal feed for the improvement of the productive and reproductive performance of the animals. …”
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