Oncogenic PIK3CA corrupts growth factor signaling specificity by Ralitsa R Madsen, Alix Le Marois, Oliwia N Mruk, Margaritis Voliotis, Shaozhen Yin, Jahangir Sufi, Xiao Qin, Salome J Zhao, Julia Gorczynska, Daniele Morelli, Lindsay Davidson, Erik Sahai, Viktor I Korolchuk, Christopher J Tape, Bart Vanhaesebroeck

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The expression landscape and clinical significance of methyltransferase-like 17 in human cancer and hepatocellular carcinoma: a pan-cancer analysis using multiple databases by Yezhou Ding, Mingyang Feng, Wanqing Chi, Xiaoyin Wang, Baoyan An, Kehui Liu, Shike Lou, Xiaolin Wang, Hui Wang

“…Abstract Background Methyltransferase-like (METTL) family protein plays a crucial role in the progression of malignancies. …”
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TIGIT inhibitor M6223 as monotherapy or in combination with bintrafusp alfa in patients with advanced solid tumors: a first-in-human, phase 1, dose-escalation trial by Wei Gao, Ping Hu, Aung Naing, Meredith McKean, Anthony Tolcher, Lillian L Siu, Keyvan Tadjalli-Mehr, Anja Victor, Emilia Richter, Marco A F Nogueira Filho, Thomas Kitzing, Stephan Gleicher, Daniel Holland

“…Bintrafusp alfa (BA) is a bifunctional fusion protein that simultaneously blocks nonredundant immunosuppressive TGF-β and PD-(L)1 pathways.Methods This first-in-human, dose-escalation study in patients with advanced solid tumors (N=58; aged ≥18 years, ECOG PS≤1) evaluated M6223 alone (Part 1A, n=40; M6223 10–2400 mg every 2 weeks, n=32; M6223 2400 mg every 3 weeks, n=8) or with BA (Part 1B, n=18; M6223 300–1600 mg with BA 1200 mg; both every 2 weeks, intravenous). …”
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Long-Term Analysis of Recurrence Beyond Milan Criteria Following Ablation of Solitary Early-Stage Hepatocellular Carcinoma ≤3 cm in Potentially Transplantable Patients: A Over 1... by Chen S, Qi H, Tan H, Cao F, Xie L, Huang T, Wu Y, Wen C, Wang Y, Shen L, Fan W

“…Multivariable analysis identified older age, C-reactive protein(CRP)≥ 1.81 mg/L, and platelet(PLT)≤ 80× 109/L as independent risk factors for TRBM. …”
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Effect of HUFA in Enriched Artemia on Growth Performance, Biochemical and Fatty Acid Content, and Hepatopancreatic Features of Penaeus vannamei Postlarvae from a Commercial Shrimp... by Marina Martínez Soler, Gercende Courtois de Vicose, Javier Roo Filgueira, José Zambrano Sánchez, Edwin Yugcha Oñate, Magaly Montachana Chimborazo, Walter Intriago Díaz, Eduardo Reyes Abad, Juan Manuel Afonso López

“…Biochemical composition of postlarvae (lipids, ash, and protein content) did not present differences between the three treatments. …”
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The m6A modification regulates the composition of myofiber types in chicken skeletal muscle by Yanju Shan, Yifan Liu, Ming Zhang, Lichuan Pang, Gaige Ji, Xiaojun Ju, Yunjie Tu, Jingting Shu

“…It is exciting we found that the expression level of ALKBH5 mRNA and protein, was closely related to the composition of myofiber types. …”
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Low versus high initial oral glucocorticoid dose for lupus nephritis: a pooled analysis of randomised controlled clinical trials by Amit Saxena, Peter Izmirly, Jill P Buyon, Cristina Sorrento, Janine Sullivan, Monica Gamez-Perez, Jammie Law, Howard Michael Belmont

“…Complete renal response requiring urine protein-creatinine ratio <0.5 mg/mg (CRR 0.5), CRR or partial renal response (PRR), serious adverse events (SAE) and SAE due to infections at 12 months of treatment were compared between groups.Results 417 patients from SOC arms of five studies were exposed to low-dose initial GC after intravenous pulse, while 521 patients from four studies were treated with high-dose oral GC. …”
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Selected cannabis cultivars modulate glial activation: in vitro and in vivo studies by Sigal Fleisher-Berkovich, Nitzan Sharon, Yvonne Ventura, Valeria Feinshtein, Jonathan Gorelick, Nirit Bernstein, Shimon Ben-Shabat

“…Materials and methods In vitro experiments were performed with lipopolysaccharide (LPS)-activated BV-2 microglia and primary glial cells to evaluate the effect of different cannabis cultivars on nitric oxide (NO) and inflammatory cytokines, as well as inducible nitric oxide synthase (iNOS) protein expression. An in vivo experiment using the experimental autoimmune encephalomyelitis (EAE) MS model was conducted using Myelin oligodendrocyte glycoprotein (MOG) as the activating peptide. …”
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Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions by Martin Škandík, Lara Friess, Guillermo Vázquez-Cabrera, Lily Keane, Kathleen Grabert, Mireia Cruz De los Santos, Mercedes Posada-Pérez, Austeja Baleviciute, Mathilde Cheray, Bertrand Joseph

“…Microglial purine sensing and motility capacities, regulated by P2RY12/P2RY13, displayed age-related alterations. Remarkably, protein analysis in human brain tissue validated the observed upregulation of MCT4 and downregulation of P2RY12 in aged microglia. …”
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Family Rehabilitation Training by Jinyun Rehabilitation Platform in Patients with Ankylosing Spondylitis Treated by Chinese Medicine Fumigation Combined with Muscle Energy Technolo... by Longbin SHEN, Hui OUYANG, Dongling WU, Wenhao XIE

“…After treatment, the visual analogue score (VAS), rang of motion (ROM), muscle strength, Bath AS disease activity index (BASDAI), Bath AS functional index (BASFI), Schober test score, erythrocyte sedimentation rate (ESR) and C reactive protein (CRP) were compared between the two groups.Results:Before treatment, there was no significant difference in VAS, ROM, muscle strength, BASDAI, BASFI, Schober score, ESR and CRP between the two groups (<italic>P</italic>&gt; 0.05). …”
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Impaired pulmonary function increases the risk of gout: evidence from a large cohort study in the UK Biobank by Zijian Kang, Jianzheng Zhang, Chen Zhu, Ying Zhu, Hanlei Jiang, Qiang Tong, Sheng-Ming Dai

“…Mediation analysis revealed that urate levels (49.1% mediation proportion), C-reactive protein (CRP) levels (6.62%), monocyte counts (1.33%), and neutrophil counts (4.85%) significantly mediated the relationship between pulmonary function and the risk of gout. …”
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Effects of Stocking Density on Fatty Acid and Amino Acid Composition in Muscle, Serum Cortisol, Stress and Immune Response in Large Yellow Croaker (<i>Larimichthys crocea</i>) by Youbin Yu, Liang Wang, Wenyun Huang, Duo Yu, Qiaoxuan Sun, Mingcao Cui

“…Levels of cortisol in serum, superoxide dismutase (SOD) and catalase (CAT) in liver, Na⁺-K⁺ ATPase and Na⁺-K⁺ ATPase gene in gills, and heat shock protein (HSP70/90) genes and glutathione S-transferase (GST) genes in the liver significantly increased under HD treatment. …”
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Effects of deoxynivalenol contaminated corn distiller's dried grains with solubles on growth performance, body composition, immunological response, and gastrointestinal health in y... by Deependra Paneru, Milan K. Sharma, Hanyi Shi, Doyun Goo, Venkata S.R. Choppa, Ishwari Gyawali, Revathi Shanmugasundaram, Woo K. Kim

“…Gut health was compromised as gut permeability increased linearly with increasing DDGS inclusion (linear, P = 0.043), aligning with significant alterations in the expression of the tight junction protein occludin (OCLN; P = 0.007). Antioxidant responses in the liver showed increased superoxide dismutase (SOD) activity in early exposure (day 13, P = 0.038), followed by decreased SOD activity (P = 0.001) and reduced glutathione (GSH) levels (P < 0.001) by day 28. …”
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Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender by Nicoletta Luciano, Elisa Barone, Enrico Brunetta, Alessio D’Isanto, Maria De Santis, Angela Ceribelli, Marta Caprioli, Giacomo M. Guidelli, Daniela Renna, Carlo Selmi

“…Results Seventy-one/458 (16%) patients fulfilled the 2021 EULAR criteria for D2T-RA with no significant differences for age (median 62 years interquartile range -IQR- 58- 65 vs. 62 IQR 60 – 63 in non-D2T), gender prevalence (23% in both groups) and positivity rates for rheumatoid factors (62% vs. 62% in non-D2T) and Anti-Citrullinated Protein Antibodies (ACPA) (69% vs. 61% in non-D2T). …”
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Waning neutralizing antibodies through 180 days after homologous and heterologous boosters of inactivated COVID-19 vaccine by Zhifei Chen, Fangqin Xie, Hairong Zhang, Dong Li, Suhan Zhang, Mengping Zhang, Junrong Li, Jianfeng Xie, Lina Zhang, Xiuhui Yang, Dongjuan Zhang

“…This cohort study involved 320 healthy individuals, who were randomly assigned to four groups, to receive boosters with inactivated vaccine (COVac and BIBP), the adenovirus type-5-vectored vaccine (Convidecia), and the recombinant protein-based vaccine (Zifivax), respectively, all the vaccines studied had the Wuhan variant as their parental variant. …”
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Differentiations in Illness Duration, Thyroid-Stimulating Hormone, Glucose and P300 Latency Between Drug-Na&iuml;ve Unipolar and Bipolar Depression: A Comparative Cross-Sectional S... by Li C, Yang L, Zhang Q, Zhang Y, Li R, Jia F, Wang L, Ma X, Yao K, Tian H, Liu Z, Zhuo C

“…Fasting serum levels of free triiodothyronine (FT3), free thyroxine (FT4), thyroid-stimulating hormone (TSH), as well as fasting plasma glucose (FPG), lipid, C-reactive protein (CRP), and uric acid (UA) indicators were measured.Results: Patients with BD had longer illness duration and P300 latency and lower FT3 levels, but higher levels of TSH and FPG than patients with UD (all P< 0.05). …”
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The Usefulness of Soluble ST2 Concentration in Heart Failure with Reduced Ejection Fraction to Predict Severe Impairment in Exercise Capacity Assessed in Cardiopulmonary Exercise T... by Magdalena Dudek, Marta Kałużna-Oleksy, Filip Sawczak, Agata Kukfisz, Aleksandra Soloch, Jacek Migaj, Maciej Lesiak, Ewa Straburzyńska-Migaj

“…<b>Conclusions</b>: The concentration of sST2 protein is substantially associated with the clinical severity of heart failure with reduced left ventricular ejection fraction assessed by functional capacity through CPET.…”
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大鼠缺血缺氧过程脑皮质神经化学物质的变化

“…同时采用免疫组织化学的方法,对该脑皮质区域内的胶质纤维酸性蛋白(glial fibrillary acidic protein, GFAP)的变化进行观察?【结果】 与对照组相比较,所检测的实验组大鼠脑皮质的主要神经化学物质中(mmol/kg)Lac(10.97 ± 1.07)?…”
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Effect of Processed Coffee Husk on Feed Intake, Nutrient Digestibility, Body Weight Changes and Economic Feasibility of Bonga Sheep Fed on Natural Pasture Hay as a Basal Diet by Lidya Marew, Fentahun Meheret, Bimrew Asmare

“…The chemical compositions of the CM had maximum crude protein (22%), followed by boiled coffee husk (14.74%), which was higher than natural pasture hay (6.91%) and raw coffee husk (12.4%). …”
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Diagnostic value of the MZXBTCH scoring system for acute complex appendicitis by Tianyi Ma, Qian Zhang, Hongwei Zhao, Peng Zhang

“…Multivariate logistic regression analysis identified preoperative body temperature (odds ratio (OR) = 1.104; 95% confidence interval (CI) 1.067–1.143; P < 0.001), preoperative C-reactive protein (CRP) level (OR = 1.002; 95% CI 1.001–1.002; P < 0.001), lymphocyte percentage (OR = 0.994; 95% CI 0.990–0.996; P < 0.001), appendiceal fecal stones (OR = 1.127; 95% CI 1.068–1.190; P < 0.001), periappendiceal fat stranding (OR = 1.133; 95% CI 1.072–1.198; P < 0.001), and appendix diameter (OR = 1.013; 95% CI 1.004–1.022; P < 0.001) as independent risk factors for complex appendicitis. …”
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