Signal integrator function of CXXC5 in Cancer by Zihao An, Jiepu Wang, Chengzuo Li, Chao Tang

“…CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or function have been linked to multiple pathological processes. …”
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Towards a Quantitative Description of Proteolysis: Contribution of Demasking and Hydrolysis Steps to Proteolysis Kinetics of Milk Proteins by Mikhail M. Vorob’ev

“…The two-step proteolysis model is regarded, which includes demasking of peptide bonds as a result of opening of the protein structure at the first stage, then hydrolysis of the demasked peptide bonds. …”
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Structure-Based Approaches for Protein–Protein Interaction Prediction Using Machine Learning and Deep Learning by Despoina P. Kiouri, Georgios C. Batsis, Christos T. Chasapis

“…This work summarizes the recent advances in computational approaches leveraging protein structure information for PPI prediction, focusing on machine learning (ML) and deep learning (DL) techniques. …”
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Heat stable and intrinsically sterile liquid protein formulations by Atip Lawanprasert, Harminder Singh, Sopida Pimcharoen, Mariangely González Vargas, Arshiya Dewan, Girish S. Kirimanjeswara, Scott H. Medina

“…This generates non-aqueous, fluorine-based liquid protein formulations that biochemically rigidify protein structure to yield thermally stable biologics at extreme temperatures (up to 90 °C). …”
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Selected Mechanisms of Action of Bacteriophages in Bacterial Infections in Animals by Renata Urban-Chmiel, Ewelina Pyzik

“…Due to their complex protein structure, phages can also directly or indirectly modulate immune processes, including innate immunity, by modulating phagocytosis and cytokine reactions, as well as acquired immunity, by producing antibodies and activating effector cells. …”
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Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA by Daniela Megrian, Mariano Martinez, Pedro M. Alzari, Anne Marie Wehenkel

“…We use phylogenetic inference and protein structure analyses to study its diversity and evolutionary history. …”
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Senyawa Fucodiphlorethol Dan Phloroglucinol Alga Coklat Sebagai Inhibitor Lipase Secara In Silico by Yohanes Bare, Dewi Ratih Tirto Sari, Marsiana Coo Mogi, Maria Marcelina Dua Nurak

“…Therefore, we predicted that both of fucodiphlorethol and phloroglucinol inhibit lipase allosterically by altering the protein structure conformations. molecular docking analysis suggested that fucodiphlorethol and phloroglucinol have potential antiobesity effect by inhibiting lipase. …”
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Improved Stability of Liquid Milk Based on the Structure of the Milk Fat Globule Membrane: A Review on the Mechanism of Milk Fat Globule Membrane Construction by WANG Xin, YU Jinghua, ZHAO Tingting, LIU Xiaohui

“…Additionally, thermal treatment alters protein structure and induces the lateral separation of lipid domains in the membrane. …”
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Immobilization of α-Chymotrypsin on the Surface of Magnetic/Gold Core/Shell Nanoparticles by Mahmoud Kamal Ahmadi, Manouchehr Vossoughi

“…Next, the enzyme was immobilized on the surface of synthesized nanoparticles by covalent bonding of Au shell with thiol and amine groups present in the protein structure (e.g., cysteine and histidine residues). …”
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STRUCTURAL AND DYNAMIC PROPERTIES OF MUTANTS OF THE SOD1 PROTEIN ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS by N. A. Alemasov, N. V. Ivanisenko, V. A. Ivanisenko

“…Molecular dynamics simulations were conducted to estimate frequencies of hydrogen bond occurrence in the protein structure. It was shown that the regression model based on frequencies of hydrogen bond occurrence significantly better correlated with patients’ survival time (R = 0.89, p < 0.00001) than the estimation based on thermodynamic stability analysis of mutant SOD1 proteins.…”
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Activation of Macrophages by Oligomeric Proteins of Different Size and Origin by Indrė Dalgėdienė, Asta Lučiūnaitė, Aurelija Žvirblienė

“…Data on the impact of protein structure during inflammation are evident; however, some separate steps of this process involving changes in macrophage phenotype are not fully understood. …”
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Cryo-electron tomography pipeline for plasma membranes by Willy W. Sun, Dennis J. Michalak, Kem A. Sochacki, Prasanthi Kunamaneni, Marco A. Alfonzo-Méndez, Andreas M. Arnold, Marie-Paule Strub, Jenny E. Hinshaw, Justin W. Taraska

“…Abstract Cryo-electron tomography (cryoET) provides sub-nanometer protein structure within the dense cellular environment. …”
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The effect of protein oxidation on the formation of advanced glycation end products after chicken myofibrillar protein glycation by Zongshuai Zhu, Anthony Pius Bassey, Ming Huang, Iftikhar Ali Khan

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A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates by Iqra Younus, Robert C. Ford, Stephen M. Prince

“…We discuss the efficiency of such bioinformatics approaches and make suggestions for their improvement and wider application in membrane protein-structure determination.…”
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Identification of Viral Taxon-Specific Genes (VTSG): Application to by Shinduck Kang, Young-Chang Kim

“…First, based on the dogma “protein structure determines its function,” we hypothesized that the specific sequence can be identified by the specific structure. …”
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Molecular Modeling and Simulation Analysis of Antimicrobial Photodynamic Therapy Potential for Control of COVID-19 by Maryam Pourhajibagher

“…In this in silico study, SARS-CoV-2-SG was selected as a novel target for curcumin as a photosensitizer during aPDT to exploit its physicochemical properties, molecular modeling, hierarchical nature of protein structure, and functional analysis using several bioinformatics tools and biological databases. …”
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The structural landscape and diversity of Pyricularia oryzae MAX effectors revisited. by Mounia Lahfa, Philippe Barthe, Karine de Guillen, Stella Cesari, Mouna Raji, Thomas Kroj, Marie Le Naour-Vernet, François Hoh, Pierre Gladieux, Christian Roumestand, Jérôme Gracy, Nathalie Declerck, André Padilla

“…Combining experimental protein structure determination and in silico structure modeling we validated the presence of the conserved MAX effector core domain in 77 out of 94 groups of orthologs (OG) identified in a previous population genomic study. …”
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Artificial intelligence driven innovations in biochemistry: A review of emerging research frontiers by Mohammed Abdul Lateef Junaid

“…AI-driven tools like AlphaFold, which have significantly advanced protein structure prediction, are evaluated alongside AI’s role in expediting drug discovery. …”
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Expression and Characterization of the Novel Gene fr47 during Freezing in the Wood Frog, Rana sylvatica by Katrina J. Sullivan, Kyle K. Biggar, Kenneth B. Storey

“…De novo analysis of FR47 protein structure revealed a likelihood of membrane associated function and possible GRB2 association. …”
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Conformational Dynamics of Mitochondrial Inorganic Pyrophosphatase hPPA2 and Its Changes Caused by Pathogenic Mutations by Ekaterina Bezpalaya, Svetlana Kurilova, Nataliya Vorobyeva, Elena Rodina

“…The results of this work allow for deeper insight into the structural basis of PPase function and the possible effects of pathogenic mutations on the protein structure and function.…”
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