Prediction of Deleterious Nonsynonymous Single-Nucleotide Polymorphism for Human Diseases by Jiaxin Wu, Rui Jiang

“…As a typical type of genetic variation, nonsynonymous single-nucleotide polymorphisms (nsSNPs) occurring in protein coding regions may alter the encoded amino acid, potentially affect protein structure and function, and further result in human inherited diseases. …”
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A Biomimetic Approach for the Creation of Two-Dimensional Microscale Surface Patterns: Creation of Isolated Immunological Synapses by Eric Stern, David J. Mooney, Tarek M. Fahmy

“…We demonstrate our approach with a biomimetic structure inspired by the immunological synapse, a cell-cell interfacial structure characterized by two concentric rings of proteins: an outer adhesion protein structure and an inner recognition ligand core. …”
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Physical Aspects of Viral Membrane Fusion by Laura Wessels, Keith Weninger

“…Here we focus our discussion on the key dynamical aspects of fusion protein structure, along with some of the experimental and computational techniques presently being used to investigate viral-mediated membrane fusion.…”
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Bioinformatics Interpretation of Exome Sequencing: Blood Cancer by Jiwoong Kim, Yun-Gyeong Lee, Namshin Kim

“…By comparing with previous somatic mutation profiles, we had concluded that the provided data originated from acute myeloid leukemia. Protein structure modeling showed that somatic mutations in IDH2, RASGEF1B, and MSH4 can affect protein structures.…”
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Using In Silico Methods to Identify Protein Tyrosine Kinase A (PtkA) Homolog in Non-Tuberculous Mycobacteria (NTM) by Swati Jaiswal, Sanjay Kumar

“…In this article, we have employed tools like BLAST (Basic Local Alignment Search Tool), protein structure databases, and the NTM database to identify PtkA homologs in NTM genomes, providing a foundation for further studies.…”
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Enhanced sampling of protein conformational changes via true reaction coordinates from energy relaxation by Huiyu Li, Ao Ma

“…Furthermore, our method uses a single protein structure as input, enabling predictive sampling of conformational changes. …”
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An outlook on structural biology after AlphaFold: tools, limits and perspectives by Serena Rosignoli, Maddalena Pacelli, Francesca Manganiello, Alessandro Paiardini

“…AlphaFold and similar groundbreaking, AI‐based tools, have revolutionized the field of structural bioinformatics, with their remarkable accuracy in ab‐initio protein structure prediction. This success has catalyzed the development of new software and pipelines aimed at incorporating AlphaFold's predictions, often focusing on addressing the algorithm's remaining challenges. …”
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Towards a Molecular Understanding of the Fanconi Anemia Core Complex by Charlotte Hodson, Helen Walden

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Signal integrator function of CXXC5 in Cancer by Zihao An, Jiepu Wang, Chengzuo Li, Chao Tang

“…CXXC5 acts as a regulator in various physiological processes, and abnormalities in its protein structure or function have been linked to multiple pathological processes. …”
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Structure-Based Approaches for Protein–Protein Interaction Prediction Using Machine Learning and Deep Learning by Despoina P. Kiouri, Georgios C. Batsis, Christos T. Chasapis

“…This work summarizes the recent advances in computational approaches leveraging protein structure information for PPI prediction, focusing on machine learning (ML) and deep learning (DL) techniques. …”
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Selected Mechanisms of Action of Bacteriophages in Bacterial Infections in Animals by Renata Urban-Chmiel, Ewelina Pyzik

“…Due to their complex protein structure, phages can also directly or indirectly modulate immune processes, including innate immunity, by modulating phagocytosis and cytokine reactions, as well as acquired immunity, by producing antibodies and activating effector cells. …”
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Evolutionary plasticity and functional repurposing of the essential metabolic enzyme MoeA by Daniela Megrian, Mariano Martinez, Pedro M. Alzari, Anne Marie Wehenkel

“…We use phylogenetic inference and protein structure analyses to study its diversity and evolutionary history. …”
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Senyawa Fucodiphlorethol Dan Phloroglucinol Alga Coklat Sebagai Inhibitor Lipase Secara In Silico by Yohanes Bare, Dewi Ratih Tirto Sari, Marsiana Coo Mogi, Maria Marcelina Dua Nurak

“…Therefore, we predicted that both of fucodiphlorethol and phloroglucinol inhibit lipase allosterically by altering the protein structure conformations. molecular docking analysis suggested that fucodiphlorethol and phloroglucinol have potential antiobesity effect by inhibiting lipase. …”
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Improved Stability of Liquid Milk Based on the Structure of the Milk Fat Globule Membrane: A Review on the Mechanism of Milk Fat Globule Membrane Construction by WANG Xin, YU Jinghua, ZHAO Tingting, LIU Xiaohui

“…Additionally, thermal treatment alters protein structure and induces the lateral separation of lipid domains in the membrane. …”
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Immobilization of α-Chymotrypsin on the Surface of Magnetic/Gold Core/Shell Nanoparticles by Mahmoud Kamal Ahmadi, Manouchehr Vossoughi

“…Next, the enzyme was immobilized on the surface of synthesized nanoparticles by covalent bonding of Au shell with thiol and amine groups present in the protein structure (e.g., cysteine and histidine residues). …”
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STRUCTURAL AND DYNAMIC PROPERTIES OF MUTANTS OF THE SOD1 PROTEIN ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS by N. A. Alemasov, N. V. Ivanisenko, V. A. Ivanisenko

“…Molecular dynamics simulations were conducted to estimate frequencies of hydrogen bond occurrence in the protein structure. It was shown that the regression model based on frequencies of hydrogen bond occurrence significantly better correlated with patients’ survival time (R = 0.89, p < 0.00001) than the estimation based on thermodynamic stability analysis of mutant SOD1 proteins.…”
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Activation of Macrophages by Oligomeric Proteins of Different Size and Origin by Indrė Dalgėdienė, Asta Lučiūnaitė, Aurelija Žvirblienė

“…Data on the impact of protein structure during inflammation are evident; however, some separate steps of this process involving changes in macrophage phenotype are not fully understood. …”
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Cryo-electron tomography pipeline for plasma membranes by Willy W. Sun, Dennis J. Michalak, Kem A. Sochacki, Prasanthi Kunamaneni, Marco A. Alfonzo-Méndez, Andreas M. Arnold, Marie-Paule Strub, Jenny E. Hinshaw, Justin W. Taraska

“…Abstract Cryo-electron tomography (cryoET) provides sub-nanometer protein structure within the dense cellular environment. …”
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The effect of protein oxidation on the formation of advanced glycation end products after chicken myofibrillar protein glycation by Zongshuai Zhu, Anthony Pius Bassey, Ming Huang, Iftikhar Ali Khan

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A Structural Bioinformatics-Guided Study of Adenosine Triphosphate-Binding Cassette (ABC) Transporters and Their Substrates by Iqra Younus, Robert C. Ford, Stephen M. Prince

“…We discuss the efficiency of such bioinformatics approaches and make suggestions for their improvement and wider application in membrane protein-structure determination.…”
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