Effect of physical activity on structural asymmetry of mouse hippocampus by T. A. Zapara, A. V. Romashchenko, A. L. Proskura, A. S. Ratushnyak

“…The reconstruction and analysis of protein­protein interactions that ensure the survival of a large number of new neurons and their integration into existing neural networks in the hippocampus have been carried out. …”
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Modulation of Long Non-coding RNA FAS-AS1/FAS/Caspase3 Axis in Endometriosis: A Cross-sectional Study by Amir Hossein Shayanfard, Zivar Salehi, Farhad Mashayekhi, Ziba Zahiri

“…Furthermore, in silico analyses were performed to investigate protein–protein interactions as well as molecular function and cellular location of selected proteins. …”
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Determination of Dissociation Constants for the Interaction of Myosin-5a with its Cargo Protein Using Microscale Thermophoresis (MST) by Rui Zhou, Jiabin Pan, Xiang-Dong Li

“…We then intend to obtain the dissociation constant between Myo5a-MTD and Mlph-ABD using isothermal titration calorimetry (ITC) or microscale thermophoresis (MST), both of which are two commonly used methods for determining quantitative data on protein interactions. The advantages of MST over ITC include less protein usage, shorter operation time, and higher sensitivity. …”
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Halo-RPD: searching for RNA-binding protein targets in plants by A. O. Shamustakimova

“…Study of RNA-protein interactions and identification of RNA targets are among the key aspects of under-standing RNA biology. …”
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dotears: Scalable and consistent directed acyclic graph estimation using observational and interventional data by Albert Xue, Jingyou Rao, Sriram Sankararaman, Harold Pimentel

“…In real data, differential expression tests and high-confidence protein-protein interactions validate dotears-inferred edges with higher precision and recall than others.…”
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Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis by Rui-Qi Wei, Wen-Mei Zhang, Zhe Liang, Chunmei Piao, Guangfa Zhu

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed and visualized by R and Cytoscape software. Protein-protein interactions (PPI) of DEGs were analysed based on the NetworkAnalyst online tool. …”
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Residue-resolved insights into the stabilization of therapeutic proteins by excipients: A case study of two monoclonal antibodies with arginine and glutamate by Tobias M. Prass, Patrick Garidel, Lars V. Schäfer, Michaela Blech

“…Protein formulation development relies on the selection of excipients that inhibit protein–protein interactions preventing aggregation. Empirical strategies involve screening many excipient and buffer combinations by physicochemical characterization using forced degradation or temperature-induced stress, mostly under accelerated conditions. …”
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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13 by Shang-Jung Cheng, Temitope Gafaar, Jijin R. A. Kuttiyatveetil, Aleksandr Sverzhinsky, Carla Chen, Minghui Xu, Allison Lilley, John M. Pascal, Anthony K. L. Leung

“…Overall, our study uncovers the important role of PAR-protein interactions in stress granule dynamics and maturation, mediated through PARP13.…”
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Ion channel traffic jams: the significance of trafficking deficiency in long QT syndrome by Gema Mondéjar-Parreño, Ana I. Moreno-Manuel, Juan Manuel Ruiz-Robles, José Jalife

“…We examine the concept of “interactome mapping” and illustrate by example the multiple protein–protein interactions an ion channel may undergo throughout its lifetime. …”
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Serum Glycoproteomics and Identification of Potential Mechanisms Underlying Alzheimer’s Disease by Naphatthakarn Kerdsaeng, Sittiruk Roytrakul, Suwannee Chanprasertyothin, Piangporn Charernwat, Sirintorn Chansirikarnjana, Piyamitr Sritara, Jintana Sirivarasai

“…Functions and pathways associated with protein-protein interactions were identified in AD. Significant changes in these proteins can indicate the molecular mechanisms involved in the pathogenesis of AD, and they have the potential to serve as AD biomarkers. …”
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Investigation of the physicochemical properties and pharmacokinetics of the active compounds in Quercus infectoria gall extract by Roohallah Yousefi

“…Ellagic acid, a polyphenol with antioxidant and anticancer properties, has complex pharmacokinetics due to conjugate formation and protein interactions. Gallic acid may impact its distribution, while phlorizin is being studied for its potential to inhibit glucosidase in diabetes management. …”
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Changes in RNA Splicing: A New Paradigm of Transcriptional Responses to Probiotic Action in the Mammalian Brain by Xiaojie Yue, Lei Zhu, Zhigang Zhang

“…The Lacidofil^® altogether altered 2941 differential splicing events, predominantly, skipped exon (SE) and mutually exclusive exon (MXE) events. Protein–protein interactions and a KEGG analysis of differentially spliced genes (DSGs) revealed consistent enrichment in the spliceosome and vesicle transport complexes, as well as in pathways related to neurodegenerative diseases, synaptic function and plasticity, and substance addiction across brain regions. …”
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A multiscale functional map of somatic mutations in cancer integrating protein structure and network topology by Yingying Zhang, Alden K. Leung, Jin Joo Kang, Yu Sun, Guanxi Wu, Le Li, Jiayang Sun, Lily Cheng, Tian Qiu, Junke Zhang, Shayne D. Wierbowski, Shagun Gupta, James G. Booth, Haiyuan Yu

“…Two distinct methodologies—one analyzing mutation clustering within protein sequences and 3D structures, the other leveraging protein-protein interaction network topology—offer complementary strengths. …”
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Identification of crucial pathways and genes linked to endoplasmic reticulum stress in PCOS through combined bioinformatic analysis by Yan Zhang, Xiujuan Chen, Yuan Lin, Xiaoqing Liu, Xiumei Xiong

“…Networks for protein-protein interactions, transcription factor-target genes, miRNA-target genes, and drug-target genes were constructed and visualized using Cytoscape to identify key hub gene nodes. …”
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CDC40 suppression induces CDCA5 splicing defects and anti-proliferative effects in lung cancer cells by Die Hu, Brigitte L. Thériault, Vida Talebian, Laurent Hoffer, Julie Owen, Justin Lim, Benjamin J. Blencowe, Evelyne Lima-Fernandes, Punit Saraon, Richard Marcellus, Rima Al-awar

“…Additionally, protein–protein interactions of CDC40 were explored and spliceosome components were found to be its main binding partners, further highlighting the role of CDC40 in splicing. …”
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Extraction, GC-MS analysis, cytotoxic, anti-inflammatory and anticancer potential of Cannabis sativa female flower; in vitro, in vivo and in silico by Waqas Safir, Arif Malik, Arif Malik, Haleema Saadia, Ayesha Zahid, Jinyao Li

“…The bioinformatics analysis of molecular docking proved significant ligand-protein interactions of CBD, THC, and humulene with cancer-associated proteins such as PD-1/PD-L1, TNF-α, and MMP-9. …”
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Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism by Hee-Jin Jun, Thomas W. Gettys, Ji Suk Chang

“…These findings show that differences in inhibitory protein-protein interactions of PGC-1α and NT-PGC-1α with Twist-1 lead to differential regulation of their function by Twist-1.…”
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Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes by E. L. Mishchenko, V. A. Ivanisenko

“…This review will encompass current, modern studies on the properties and complexes of individual non-structural subunits of the RTC, the structures of individual coronavirus RTC subunits, domain organization and functions of subunits, protein-protein interactions, properties and architectures of subunit complexes, the effect of mutations, and the identif ication of mutations affecting the viability of the virus in cell culture.…”
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Networking Salt Inducible Kinase 1 Regulatory Perturbations on Type 2 Diabetes- Breast Cancer Co-Morbidity Associated Molecular Bridge by Durrani I.A., John P., Bhatti A.

“…Gene mutations, and transcription factors (TF), hub proteins and microRNA (miRNA) associated with SIK1 and its protein-protein interactions (PPIs) were extracted from MuTarget and EnrichR, respectively. …”
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Effect of Pea Resistant Starch on Emulsion Gel Properties and in Vitro Digestibility of Myofibrillar Proteins by CHEN Jinyu, HU Fangyang, JI Zhirui, WU Zijian

“…The addition of pea RS3 significantly decreased the surface hydrophobicity (P < 0.05) while increasing the fluorescence intensity of MP, indicating enhanced protein-protein interactions. The addition of pea RS3 resulted in improved stability of MP emulsions, as manifested by higher absolute values of zeta potential, smaller droplet sizes and reduced creaming index. …”
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