Directed disruption of IL2 aggregation and receptor binding sites produces designer biologics with enhanced specificity and improved production capacity by Amy Dashwood, Ntombizodwa Makuyana, Rob van der Kant, Arman Ghodsinia, Alvaro R. Hernandez, Stephanie Lienart, Oliver Burton, James Dooley, Magda Ali, Lubna Kouser, Francisco Naranjo, Matthew G. Holt, Frederic Rousseau, Joost Schymkowitz, Adrian Liston

Subjects: Get full text

Cytokine Couture: Designer IL2 Molecules for the Treatment of Disease by Dashwood A, Ghodsinia AA, Dooley J, Liston A

Subjects: Get full text

Applications of Artificial Intelligence in Biotech Drug Discovery and Product Development by Yuan‐Tao Liu, Le‐Le Zhang, Zi‐Ying Jiang, Xian‐Shu Tian, Peng‐Lin Li, Pei‐Huang Wu, Wen‐Ting Du, Bo‐Yu Yuan, Chu Xie, Guo‐Long Bu, Lan‐Yi Zhong, Yan‐Lin Yang, Ting Li, Mu‐Sheng Zeng, Cong Sun

Subjects: Get full text

Recent trends in the identification and engineering of halogenases by Huibin Wang, Ikuro Abe

Subjects: Get full text

Design of cross-reactive antigens with machine learning and high-throughput experimental evaluation by Chelsy Chesterman, Thomas Desautels, Luz-Jeannette Sierra, Kathryn T. Arrildt, Adam Zemla, Edmond Y. Lau, Shivshankar Sundaram, Jason Laliberte, Lynn Chen, Aaron Ruby, Mark Mednikov, Sylvie Bertholet, Dong Yu, Kate Luisi, Enrico Malito, Corey P. Mallett, Matthew J. Bottomley, Robert A. van den Berg, Daniel Faissol

Subjects: Get full text

Bacterial expression of a designed single‐chain IL‐10 prevents severe lung inflammation by Ariadna Montero‐Blay, Javier Delgado Blanco, Irene Rodriguez‐Arce, Claire Lastrucci, Carlos Piñero‐Lambea, Maria Lluch‐Senar, Luis Serrano

Subjects: Get full text

Application of a Rational Crystal Contact Engineering Strategy on a Poly(ethylene terephthalate)-Degrading Cutinase by Brigitte Walla, Anna-Maria Dietrich, Edwin Brames, Daniel Bischoff, Stefanie Fritzsche, Kathrin Castiglione, Robert Janowski, Dierk Niessing, Dirk Weuster-Botz

Subjects: “…protein engineering…”
Get full text

VenusMutHub—A benchmark for protein mutation effect prediction by Junlin Yu, Guobo Li

Subjects: “…Protein engineering…”
Get full text

Advances in genetically engineered microorganisms: Transforming food production through precision fermentation and synthetic biology by Seyed Mehrdad Mirsalami, Mahsa Mirsalami

Subjects: Get full text

Enhanced Genome Editing Activity with Novel Chimeric ScCas9 Variants in Rice by Zhen Liang, Yuqing Wu, Shuke Deng, Sha Wei, Kai Zhang, Yingjie Guo

Subjects: Get full text

Biocatalytic β-glucosylation/β-galactosylation of Rebaudioside C by glycosynthases by Ye-Yang Yu, Si-Yu Zhang, Jia-Hui Sun, Yu-Yang Li, Yao-Yao Zhang, Ai-Min Lu, Li Liu, Josef Voglmeir

Subjects: Get full text

Functional improvement of natural Saccharomyces cerevisiae yeast strains by cell surface molecular engineering by Sara Granuzzo, Monica Rossetto, Lucio Zennaro, Francesca Righetto, Paolo Antoniali, Raffaele Lopreiato

Subjects: Get full text

Thermostability Improvement of the Chitinase from <i>Bacillus circulans</i> for Efficient Chitin Oligosaccharide Production via Computational Design by Jingwei Liu, Jie Xie, Si Wang, Hong Feng, Ganggang Wang

Subjects: Get full text

SsDiHal: discovery and engineering of a novel tryptophan dihalogenase by Hassan Sher, Haley Hardtke, Wenzhu Tang, Jie Ren, Hayat Ullah, Xudong Zhou, Y. Jessie Zhang, Jixun Zhan

Subjects: Get full text

Rational protein engineering of thermostable heparinase Ⅰ from Bacteroides thetaiotaomicron for highly efficient heparin degradation by Chuan Zhang, Ruohan Zhao, Leilei Yu, Qixiao Zhai, Jianxin Zhao, Hao Zhang, Xuegang Luo, Fengwei Tian, Wei Chen

Subjects: Get full text

Affinity-induced covalent protein-protein ligation via the SpyCatcher-SpyTag interaction by Jacob O. Fierer, Omar E. Tovar-Herrera, Jonathan Y. Weinstein, Amaranta Kahn, Sarah Moraïs, Itzhak Mizrahi, Edward A. Bayer

Subjects: Get full text

Reprogramming FGF1 from the natural growth factor to the engineered heparan sulphate biosensor by Krzysztof Ciura, Olimpia Sobota, Aleksandra Chorążewska, Daniel Krowarsch, Natalia Porębska, Łukasz Opaliński

Subjects: Get full text

Network of nicotinamide mononucleotide biosynthesis: substrate tracking, rate-limiting enzyme, and regulatory strategy by Puyue Zhang, Ziru Ye, Zhong Tian, Qing Liu, Yong Huang

Subjects: Get full text

Engineered Protein Fibers with Reinforced Mechanical Properties Via β‐Sheet High‐Order Assembly by Ming Li, Dawen Qin, Jing Chen, Bo Jia, Zheng Wei, Yi Zhang, Wenhao Cheng, Qianqian Liu, Fan Wang, Jingjing Li, Hongjie Zhang, Kai Liu

Subjects: Get full text

Functional and structural insights into a thermostable (S)-selective amine transaminase and its improved substrate scope by protein engineering by Stefania Patti, Simone A. De Rose, Michail N. Isupov, Ilaria Magrini Alunno, Sergio Riva, Erica Elisa Ferrandi, Jennifer A. Littlechild, Daniela Monti

Subjects: Get full text