Genetic Algorithm-Enhanced Direct Method in Protein Crystallography by Ruijiang Fu, Wu-Pei Su, Hongxing He

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Severe deviation in protein fold prediction by advanced AI: a case study by Jacinto López-Sagaseta, Alejandro Urdiciain

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The activation of Chlamydomonas reinhardtii alpha amylase 2 by glutamine requires its N‐terminal aspartate kinase–chorismate mutase–tyrA (ACT) domain by Lisa Scholtysek, Ansgar Poetsch, Eckhard Hofmann, Anja Hemschemeier

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Structural Analysis of Inhibitor Binding to Enterovirus-D68 3C Protease by Vincent N. Azzolino, Ala M. Shaqra, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer

“…Here, we characterize a series of 3C inhibitors against EV68-3C protease through enzyme inhibition, protein crystallography, and structural analysis. We have determined and analyzed three high-resolution inhibitor-bound crystal structures of EV68-3C protease, which revealed possible sites of resistance mutations, a key structural water molecule conserved during ligand binding, and the conformational flexibility of the catalytic histidine H40. …”
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