Functionalized Nanomaterials In Pancreatic Cancer Theranostics And Molecular Imaging by Yoghalakshmi Nagarajan, Natarajan Chandrasekaran, Venkatachalam Deepa Parvathi

“…Surface modification of nanocarriers with antibodies or proteins will enable to attain multifunctionality which increases the efficiency of pancreatic cancer therapy.…”
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Proximity extension assay revealed novel inflammatory biomarkers for follicular development and ovarian function: a prospective controlled study combining serum and follicular flui... by Chong Wang, Ying Feng, Yu Chen, Xianhua Lin, Xiangjuan Li

“…Olink proteomic proximity extension assay (PEA) technology was used to compare the differentially expressed proteins (DEPs), and patients were divided into two subgroups—the normal ovarian reserve (NOR) group and the DOR group—for further bioinformatics analysis and verification by enzyme-linked immunosorbent assay (ELISA).ResultsIn total, 16 DEPs were detected between the mature group and the immature group (FF), and 11 DEPs were detected between the ovulation group and the menstruation group (serum). …”
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Oxyberberine alleviates lipopolysaccharide-induced intestinal barrier disruption and inflammation in human colonic Caco-2 cells in vitro by Cailan Li, Cailan Li, Cailan Li, Jiahao Wang, Hongmei Yang, Shuang Luo, Qiang Lu

“…The transepithelial electrical resistance (TEER), paracellular permeability, and the distribution and expression of tight- and adherent junction proteins were determined to assess barrier integrity. …”
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Optimizing Microwave-Assisted Extraction of Carbohydrate from Scenedesmus sp. Cultivated in Domestic Wastewater by Yeong Hwang Tan, Mee Kin Chai, Ling Shing Wong, Mei Yin Ong, Ranjithkumar Rajamani

“…Microalgae including Scenedesmus sp. are gaining significant attention due to the rapid growth conditions, high biomass production, and significant content of valuable biomolecules such as proteins, lipids, and carbohydrates. Among these biomolecules, carbohydrates extracted from Scenedesmus sp. biomass has the potential to be used in biofuel, food, and pharmaceutical industries. …”
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Protective effects of Notoginsenoside R2 on reducing lipid accumulation and mitochondrial dysfunction in diabetic nephropathy through regulation of c-Src by Xieyi Guo, Liu Yang, Xiaoning An, Maofang Hu, Yilan Shen, Niansong Wang, Youhua Xu, Dingkun Gui

“…The expression of associated proteins was measured using immunohistochemistry and western blot. …”
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Genetic insight into dissecting the immunophenotypes and inflammatory profiles in the pathogenesis of Sjogren syndrome by Jingyi Xu, Shucheng Si, Yijun Han, Lin Zeng, Jinxia Zhao

“…A total of 4 inflammatory cytokines and 7 circulating proteins exhibited potential causal relationships with SS despite no significant result achieved after FDR correction. …”
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Tumor tissue samples collection for scientific research in morphology and molecular oncology by O. R. Khabarov, B. D. Seferov, K. A. Aliev, D. V. Zima, E. P. Golubinskaya, E. Yu. Zyablitskaya

“…We studied the molecular markers of cell cycle regulation, apoptosis, oncogenesis and angiogenesis, the expression of proteins that regulate inflammation and tumor infiltrate cells in biocollections of verified tumors of common localizations: e. g. thyroid cancer, colorectal cancer, breast cancer, prostate adenocarcinoma, endometrioid adenocarcinoma. …”
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Diagnostic potential of CDK1 and STAT1 in acute kidney injury associated with gastrointestinal cancers: a bioinformatics-based study by Qiuwan Wei, Yiqing Shen, Yiren Tian, Yunzhi Ling

“…The expression of DEGs proteins in cancerous and adjacent tissues was assessed using immunohistochemical scoring (H scores). …”
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Prognostic values of intracellular cell-related genes in esophageal cancer and their regulatory mechanisms by Wei Cao, Dacheng Jin, Weirun Min, Haochi Li, Rong Wang, Jinlong Zhang, Yunjiu Gou

“…Prognostic gene expression validation demonstrated significant differences between the disease and normal groups in both datasets. The proteins corresponding to the three prognostic genes interacted with gefitinib and osimertinib. …”
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Exclusive Breastfeeding Knowledge, Intention to Practice and Predictors among Primiparous Women in Enugu South-East, Nigeria by Chikaodili N. Ihudiebube-Splendor, Chinyelu B. Okafor, Agnes N. Anarado, Nonyelum N. Jisieike-Onuigbo, Anthonia U. Chinweuba, Ada C. Nwaneri, Joyce C. Arinze, Paulina C. Chikeme

“…Breastfeeding is considered as the most complete nutritional source for infants because breast milk contains the essential carbohydrates, fats, proteins, and immunological factors needed for infants to thrive and resist infection in the formative first year of life. …”
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BMSC-Derived Exosomes Ameliorate Osteoarthritis by Inhibiting Pyroptosis of Cartilage via Delivering miR-326 Targeting HDAC3 and STAT1//NF-κB p65 to Chondrocytes by Honggang Xu, Bin Xu

“…Incubation with BMSC-Exos could significantly improve the survival rate, migration ability, and chondrocyte-specific genes (COL2A1, SOX9, Agg, and Prg4) and miR-326 expression of OA chondrocytes and significantly inhibit pyroptosis of chondrocytes by downregulation of the levels of inflammatory cytokines, Caspase-1 activity, and pyroptosis-related proteins such as GSDMD, NLRP3, ASC, IL-1β, and IL-18 (P<0.01). …”
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Blast‐Overpressure Induced Modulation of PARP‐SIRT‐NRF2 Axis in Stress Signaling of Astrocytes and Microglia by Vijaya Prakash Krishnan Muthaiah, Kathiravan Kaliyappan, Ramkumar Thiayagarajan, Supriya Mahajan, Krishnamoorthy Gunasekaran

“…PARP over‐activation forms ADP polymers on several nuclear proteins, known as trans‐PARylation, by consuming nicotinamide adenine dinucleotide (NAD+) and ATP. …”
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Comparative analysis of NR and NiR gene families reveals nitrite formation mechanisms in two Toona species by Yi Wei, Jianhua Dai, Yanru Fan, Hengfu Yin, Jun Liu, Xiaojiao Han

“…Through comprehensive genome-wide analysis, we identified two TsNRs and two TsNiRs in T. sinensis, compared to one TcNiR and two TcNiRs in T. ciliata, suggesting an expansion of NR members in T. sinensis relative to T. ciliata. The NR and NiR proteins in T. sinensis and T. ciliata share high sequence similarity and exhibit close genetic relationships with their counterparts in Populus trichocarpa and Salix purpurea. …”
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Regulatory factor X‐5/SCL/TAL1 interruption site axis promotes aerobic glycolysis and hepatocellular carcinoma cell stemness by Zhi‐Zhong Zhang, Zi‐Ming Wang, Hao‐Wen Zhang, Yan‐Xin Gong, Hao‐Ran Sun, Wei Zhang

“…The expression levels of the stem cell markers SOX2, Oct‐4, CD133, CD44, the glycolysis‐related proteins LDHA, HK2, AKT, p‐AKT, and β‐catenin were assessed by Western blot. …”
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Identification of tacrolimus-related genes in familial combined hyperlipidemia and development of a diagnostic model using bioinformatics analysis by Yuan Xu, Hongfei He, Haiyang Li

“…Finally, we examined the regulatory network of screened key genes that interact with RNA-binding proteins, potential drugs, small-molecule compounds, and transcription factors. …”
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In silico design of an epitope-based vaccine ensemble for fasliolopsiasis by Ruchishree Konhar, Ruchishree Konhar, Kanhu Charan Das, Kanhu Charan Das, Aiboklang Nongrum, Rohan Raj Samal, Shailesh Kumar Sarangi, Devendra Kumar Biswal, Devendra Kumar Biswal

“…Finding successful vaccination antigen combinations from these huge number of genes/proteins in the available omics datasets is the key in combating these neglected tropical diseases. …”
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Molecular Epidemiology and Genetic Evolution of Porcine Reproductive and Respiratory Syndrome Virus in Northern China During 2021–2023 by Na Yuan, Zuofeng Yang, Fengxia Lv, Lina Dou, Xiangqing Li, Baokai Zhao, Shishan Dong

“…The predominant recombination modes were L1.8 + L8.7 + L1.5/L3, with L1.5 and L3.5 generally yielding GP2~GP6 structural proteins. Recombination hotspots were primarily located within the ranges of 780~2200 (Nsp1~Nsp2), 5400~6200 (Nsp3~Nsp4), 7800~9000 (Nsp9), and 12,200~14,800 (ORF2~ORF6). …”
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Carvacrol acetate activated Nrf2 modulates mitophagy for the treatment of neurocyte oxidative stress induced by chlorpyrifos by Hong-Ling Zhou, Bei-Bei Wang, Xu-Li Fan, Xiao-Min Zhang, Ying Song

“…Western blot analysis showed that the expression of Tfam, Beclin1, and LC3II/LC3I proteins in the CAA group decreased significantly after Nrf2 inhibition. …”
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Gene Mining and Genetic Effect Analysis Reveal Novel Loci, <i>TaZn-2DS</i> Associated with Zinc Content in Wheat Grain by Zhuangzhuang Hong, Zhankui Zeng, Jiaojiao Li, Xuefang Yan, Junqiao Song, Qunxiang Yan, Qiong Li, Yue Zhao, Chang Liu, Xueyan Jing, Chunping Wang

“…Zinc is an essential microelement of enzymes and proteins in wheat grains and humans. A deficiency in zinc content can lead to decreased wheat yield and low zinc content in grains, which in turn leads to insufficient dietary zinc intake. …”
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Physical Fruit Traits, Proximate Composition, Antioxidant Activity, and Profiling of Fatty Acids and Minerals of Wild Jujube (Ziziphus lotus L. (Desf.)) Fruits from Eleven Moroccan... by Hasna Ait Bouzid, El Hassan Sakar, Laila Bijla, Mohamed Ibourki, Ahmed Zeroual, Jamila Gagour, Jamal Koubachi, Khalid Majourhat, Saïd Gharby

“…Our outcomes revealed significant differences (p<0.05) among different origins for the measured fruit traits including ash (1.69–2.31%), moisture (2.56–5.69%), proteins (2.63–4.64%), oil (1.59–2.91%) and carbohydrates (86.82–89.20%). …”
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