Association of PPAR Alpha Intron 7 G/C, PPAR Gamma 2 Pro12Ala, and C161T Polymorphisms with Serum Fetuin-A Concentrations by Bernadett Márkus, Krisztián Vörös, Dorina Supák, Zsolt Melczer, Károly Cseh, László Kalabay

“…Both peroxisome activator proteins (PPARs) and fetuin-A play a role in lipid and glucose metabolism. …”
Get full text

INFORMACINIS GENOMAS, INDIVIDO IR POPULIACIJOS GENOMAI by Jonas Rubikas

“…Information genome is the DNA or RNA molecule carrying information for the beginning of replication (plasmid), for the replication of enzymes and other proteins and structures connected with the replication (viruses). …”
Get full text

Long-Term Salinity-Responsive Transcriptome in Advanced Breeding Lines of Tomato by Monther T. Sadder, Ahmad Abdelrahim Mohamed Ali, Abdullah A. Alsadon, Mahmoud A. Wahb-Allah

“…However, both genotypes showed the up-regulation of ROS-detoxifying enzymes and ROS-scavenging proteins under salinity stress. Therefore, L56 was more effective in conveying the stress message downstream along all available regulatory pathways. …”
Get full text

RED light promotes flavonoid and phenolic accumulation in Cichorium spp. callus culture as anti-candida agent by Sayeda Abdelrazek Abdelhamid, Alaa I. Marzouk, Mohsen S. Asker, Hattem M. El Shabrawi

“…The antifungal activity was assessed by determining the effects on acid-soluble phosphorus, total lipids, and soluble proteins in the Candida cells. Our results demonstrate that the red LED light-exposed Cichorium endive Supp. …”
Get full text

Molecular mechanisms and therapeutic strategies of Naegleria fowleri Carter (1970): a review of the fatal brain-eating amoeba by N. Datta

“…By identifying the genes and proteins involved in key processes such as adhesion, motility, and immune evasion, researchers can design targeted therapies to disrupt these essential functions and prevent or treat infection. …”
Get full text

Allelic state of prolamin-coding loci in the new oat cultivar ‘Tobolyak’ by A. V. Lyubimova, M. N. Fomina, D. I. Eremin, V. S. Mamaeva, V. S. Mishechkina, N. A. Bragin, S. A. Belousov, M. V. Bragina

“…High efficiency was shown by the method of electrophoresis of seed storage proteins – prolamins. The aim of this study was to assess the biotype composition and allelic state of the prolamin-coding loci in the new spring oat cultivar ‘Tobolyak’ for its further use in initial seed production.Materials and methods. …”
Get full text

Genetic mechanisms of the influence of light and phototransduction on Drosophila melanogaster lifespan by I. A. Solovev, M. V. Shaposhnikov, A. A. Moskalev

“…In the present paper, basic transducers of light and other signals, such as the family of TRP receptors, G proteins, phospholipase C, and others, are considered in the context of aging and longevity. …”
Get full text

Determination of indicators for tests of polysept (polyhexamethylene guanidine hydrochloride) for flocculation properties by M. N. Guseva, M. I. Doronin, M. A. Shevchenko, D. V. Mikhalishin, Y. M. Gochmuradov, V. V. Mikhalishin, Y. S. El’kina

“…In vaccine production, it is particularly important to purify the virus-containing suspension in order to remove ballast proteins and fats, which, when present in high concentrations, are responsible for depression or allergic reactions in animals. …”
Get full text

Decreased SynMuv B gene activity in response to viral infection leads to activation of the antiviral RNAi pathway in C. elegans. by Ashwin Seetharaman, Himani Galagali, Elizabeth Linarte, Mona H X Liu, Jennifer D Cohen, Kashish Chetal, Ruslan Sadreyev, Alex J Tate, Taiowa A Montgomery, Gary Ruvkun

“…Many synMuv B genes encode dREAM complex chromatin-regulatory proteins found in nearly all animals and plants. We show that mRNAs which are highly induced in synMuv B mutants are congruent with those induced by Orsay RNA virus infection, suggesting that the enhanced RNAi of synMuv B mutants may also be triggered by down-regulation of synMuvB gene activity in an Orsay virus infection of wild type. …”
Get full text

Therapeutic Effects of the Combination of Alpha-Lipoic Acid (ALA) and Coenzyme Q10 (CoQ10) on Cisplatin-Induced Nephrotoxicity by Eman Aly Khalifa, Ahmed Nabil Ahmed, Khalid Shaaban Hashem, Ahmad Gad Allah

“…Renal function tests and urinary proteins were significantly higher within group II compared with other groups (P value <0.001). …”
Get full text

Mother-fetus immunogenetic dialogue as a factor of progeny immune system development by L. A. Gerlinskaya, A. V. Varlachev, G. I. Krotov, G. V. Kontsevaya, M. P. Moshkin

“…Since breast milk contains large amounts of various immunoactive components, including proteins, cytokines, hormones, immunoglobulins, exosomes containing micro-RNA, and viable immune cells, the immunomodulating effects of breast milk persist even after elimination of maternal immunoglobulins from the blood of the offspring, up to maturation. …”
Get full text

Taxonomic and ecophysiological characteristics of actinobacteria in soils of the dry steppe zone of the Selenga Highlands (Western Transbaikalia) by E. P. Nikitina, L. B. Buyantueva, E. Yu. Abidueva, C. H. Sun

“…The isolated strains were capable of using both organic (proteins and amino acids) and inorganic (ammonium salts and nitrates) compounds as nitrogen sources. …”
Get full text

Theoretical Study of Sphingomyelinases from <i>Entamoeba histolytica</i> and <i>Trichomonas vaginalis</i> Sheds Light on the Evolution of Enzymes Needed for Survival and Colonizati... by Fátima Berenice Ramírez-Montiel, Sairy Yarely Andrade-Guillen, Ana Laura Medina-Nieto, Ángeles Rangel-Serrano, José A. Martínez-Álvarez, Javier de la Mora, Naurú Idalia Vargas-Maya, Claudia Leticia Mendoza-Macías, Felipe Padilla-Vaca, Bernardo Franco

“…Additionally, the structural models of the aSMase6 of <i>E. histolytica</i> showed a loop that is absent from the rest of the aSMases, suggesting that it may be involved in hemolytic activity, as demonstrated experimentally using the recombinant proteins of aSMase4 and aSMase6. <i>Trichomonas vaginalis</i> enzymes show a putative transmembrane domain and seem functionally different from <i>E. histolytica</i>. …”
Get full text

Intelligent diagnosis and prediction of pregnancy induced hypertension in obstetrics and gynecology teaching by integrating GA by Xiaolan Li, Xiaolan Li, Xiaolan Li, Fen Kang, Fen Kang, Fen Kang, Xiaojing Li, Xiaojing Li, Xiaojing Li

“…The objective of this model is to maximize the utility of medical data and enhance treatment quality.ResultsThe refined intelligent feature selection approach identified several significant indicators of pregnancy-related hypertension, such as phosphor dehydrogenase deficiency, body mass index, gestational urinary proteins, vascular endothelial growth factor receptor 1, placental growth factor, thalassemia, and a familial history of diabetes mellitus or hypertension. …”
Get full text

The Role of Nutrients in Supporting The Immune System Against Viral Infection; Newly Emerged Coronavirus (COVID19): A Narrative Review by Halgord Ali Farag, Hardi Rafat Baqi, Yousif Taha Hussein, Osama Hamid Shareef, Syamand Ahmed Qadir, Amany El Afifi, Abdel Hamid El Bilbeisi

“…The macronutrients such as carbohydrates, lipids, and proteins are essential for cells to generate energy and participate in immune function as well. …”
Get full text

Cyclopiazonic acid suppresses the function of Leydig cells in prepubertal male rats by disrupting mitofusin 1-mediated mitochondrial function by Hang Lin, Ming Su, He Zhu, Yang Yu, Jianmin Sang, Yiyan Wang, Qiqi Zhu, Yang Zhu, Xiaoheng Li, Xingwang Li, Ren-Shan Ge, Huitao Li

“…The qPCR and Western blotting analyses revealed significant alterations in the expression of genes and proteins pertinent to PLC function, such as Scarb1, Star, Cyp11a1, and Cyp17a1. …”
Get full text

Cryoablation combined with dual immune checkpoint blockade enhances antitumor efficacy in hepatocellular carcinoma model mice by Jun Gu, Zepeng Yu, Xiangxiang Tang, Wenying Chen, Xuedong Deng, Xiaoli Zhu

“…The expression of apoptosis-related proteins was detected by Western blot (WB) assay. The percentages of immune cells and immunosuppressive cells were analyzed by flow cytometry. …”
Get full text

Isolation and identification of novel casein-derived bioactive peptides and potential functions in fermented casein with Lactobacillus helveticus by Mengzhu Fan, Tingting Guo, Wanru Li, Jing Chen, Fushuo Li, Chao Wang, Yi Shi, David Xi-an Li, Shaohui Zhang

“…Intracellular peptides are much larger in quantity and more complex in composition than extracellular peptides, between which the correlation reveals proteolytic and metabolic mechanisms.In addition, totally 241 different peptide sequences were identified by Nano LC–MS/MS from casein (212) and Lactobacillus helveticus proteins (29). These casein-derived peptides mostly originated from β-casein, followed by αS1-casein, κ-casein, and αS2-casein, and came from extracell (69) and intracell (143), in which common peptides have a total of 27. …”
Get full text

Identification and characterization of multiple novel viruses in fecal samples of cormorants by Li Ji, Li Ji, Ran Zhao, Yifei Pei, Yijie Sun, Xiaoyi Sun, Likai Ji, Xiaochun Wang, Yuwei Liu, Quan Shen, Shixing Yang, Yan Wang, Wen Zhang

“…Similar to other known picornaviruses, the conserved NTPase, proteinase, and polymerase motifs are presented in the 2C, 3C, and 3D proteins separately. Based on the phylogenetic analysis and amino acid sequence alignment, the CormhepaE may be assigned to a new picornavirus genus. …”
Get full text

Genome analysis of Bifidobacterium adolescentis and investigation of its effects on inflammation and intestinal barrier function by Bo Li, Bo Li, Haoyu Wang, Haoyu Wang, Haoyu Wang, Mengmeng Wang, Mengmeng Wang, Hewei Liang, Hewei Liang, Hewei Liang, Tongyuan Hu, Tongyuan Hu, Tongyuan Hu, Jinlong Yang, Jinlong Yang, Jinlong Yang, Shangyong Li, Xinbi You, Xinbi You, Xinbi You, Binbin Xia, Binbin Xia, Binbin Xia, Yue Yuan, Yue Yuan, Yuanqiang Zou, Yuanqiang Zou, Yinglei Miao, Yinglei Miao, Yang Sun, Yang Sun, Yang Sun

“…The restoration of tight junction proteins ZO-1, occludin, and claudin-2 by B. adolescentis AF91-08b2A demonstrated its capacity to safeguard the intestinal epithelial barrier. …”
Get full text