ROS-Induced Oxidative Damage and Mitochondrial Dysfunction Mediated by Inhibition of SIRT3 in Cultured Cochlear Cells by Lingjun Zhang, Zhengde Du, Lu He, Wenqi Liang, Ke Liu, Shusheng Gong

“…Furthermore, the expression of SIRT3, FOXO3A, and SOD2 proteins declined, except for an initial elevation of SIRT3 between 0 and 0.75 mM H2O2. …”
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CRYβB2 alters cell adhesion to promote invasion in a triple-negative breast cancer cell line by Amr A. Waly, London Harper, Jodie M. Fleming, Lindsey M. Costantini

“…These findings provide a novel link between a previously identified differentially expressed gene, CRYβB2, in driving breast cancer phenotypes by modulating a class of adhesion proteins.…”
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Impact of modulating leptin sensitivity on the transcriptomic profile of adult-derived hypothalamic mouse neurons by Ewa Ocłoń, Artur Gurgul, Tomasz Szmatoła, Igor Jasielczuk, Miroslaw Kucharski, Joanna Zubel-Łojek, Dorota Anna Zieba

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High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy. by Yu Zhao, Yuteng Jiang, Fengmei Wang, Li Sun, Mengyuan Ding, Liyuan Zhang, Beibei Wu, Xiaoliang Zhang

“…Immunofluorescence and Western blot analyses were used to detect the expression of autophagy-related proteins (LC3 and Beclin-1), M1 markers (iNOS and CD11c) and M2 markers (MR and CD206).…”
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Perilipin2-dependent lipid droplets accumulation promotes metastasis of oral squamous cell carcinoma via epithelial-mesenchymal transition by Jiayu Zhang, Jianmin Peng, Siyu Wang, Li Wang, Yutong Sun, Juan Xia, Bin Cheng, Qinchao Hu

“…Possible mechanisms of these biological effects were clarified by detecting the levels of epithelial-mesenchymal transition (EMT) markers and phosphatidylinositol 3-kinase (PI3K) pathway proteins as well as conducting various bioinformatics analyses. …”
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Loss of BRCA1 Spontaneously Induces the Tumorigenesis in Lacrimal Gland by Sun Eui Kim, Hye Jung Baek, Eun Jung Park, Sung Chul Lim, Sang Soo Kim

“…Tumors also exhibited rearrangement of cytoskeletal proteins, including β-catenin, keratin 5, and vimentin, depending on tumor progression. …”
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Nanomechanical characterization of soft nanomaterial using atomic force microscopy by Chi-Dat Lam, Soyeun Park

“…Atomic force microscopy (AFM) is a promising method for generating high-spatial-resolution images, providing insightful perspectives on the nanomechanical attributes of soft matter, including cells, bacteria, viruses, proteins, and nanoparticles. AFM is widely used in biological and pharmaceutical sciences because it can scrutinize mechanical properties under physiological conditions. …”
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Acute hepatitis of non-specified etiology by Ye. V. Tsyganova, O. O. Znoyko, N. D. Yushchuk, K. R. Dudina, M. G. Isagulyants, N. V. Petrakova, T. V. Petrova, M. I. Mikhaylov

“…Investigation of patients with acute hepatitis of non-specified etiology included clinical, epidemiologic, routine laboratory, serological methods; molecular biological method (RNA of hepatitis A, C, Е, G viruses; DNA of hepatitis B virus, TTV, CMV, EBV, HHV of 1, 2, 6 and 8 types, PV B-19, NV-f – qualitative analysis); method of immunofluorescence (assessment of antimitochondrial and antinuclear antibodies); immunologic methods (laboratory diagnostic methods) – independent assessment of specific antibodies for individual HCV antigens spectrum, including structural and unstructural proteins and compound peptides, representing the whole HCV polyprotein (overall 38 antigens: 34 HCV antigens and 4 control antigens) in blood serum by EIA method; investigation of Т-cellular immune response to HCV antigens by blast-cell lymphocytes transformation method under stimulation by HCV antigens with quantitative evaluation of cytokine secretion; instrumental method – ultrasound investigation of abdominal organs.Conclusions. …”
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Molecular mechanisms and enhanced functions of Hibiscus sabdariffa L—nanoliposomes as an emerging therapeutic strategy in UV and galactosamine skin aging-induced model by Eptehal Nassar, Mai Rady, Heba Handousa

“…Moreover, the Bcl-2/Bax proteins were determined via ELISA, and MMP-1, MMP-2, MMP-9, and TIMP-1 expression was determined via RT‒qPCR in the study groups. …”
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Decoding Vitellogenin Subtype Responses: A Molecular Approach to Biomarkers of Endocrine Disruption in <i>Scatophagus argus</i> by Meiqin Wu, Jun Zhang, Di Wu, Amina S. Moss, Weilong Wang

“…Vitellogenins (Vtgs) are key yolk precursor proteins in fish, serving as critical indicators of gonadal maturation in females and reliable biomarkers for detecting xeno-oestrogenic pollution, particularly through their expression in juveniles or males. …”
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The impact of signaling pathways on the desmosome ultrastructure in pemphigus by Thomas Schmitt, Julia Huber, Julia Pircher, Enno Schmidt, Enno Schmidt, Jens Waschke

“…Dsgs are clustered by plaque proteins and linked to the keratin cytoskeleton by desmoplakin (Dp). …”
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N6-Methyladenosine in RNA and DNA: An Epitranscriptomic and Epigenetic Player Implicated in Determination of Stem Cell Fate by Pengfei Ji, Xia Wang, Nina Xie, Yujing Li

“…The mRNA m6A modification has been characterized biochemically, molecularly, and phenotypically, including elucidation of its methyltransferase complexes (m6A writer), demethylases (m6A eraser), and direct interaction proteins (readers), while limited information on the DNA m6dA is available. …”
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A Nodulation-Proficient Nonrhizobial Inhabitant of Pueraria phaseoloides by W. M. M. Wedage, A. H. M. N. R. Aberathne, I. N. Harischandra, D. Gunawardana

“…Sub1 secreted a pair of enzymes to the extracellular medium to degrade cellulose and milk proteins. The Sub1 bacterium showed biofilm formation and secreted into the extracellular medium, indole acetic acid. …”
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Efficiency comparison of natural coagulants (Cactus pads and Moringa seeds) for treating textile wastewater (in the case of Kombolcha textile industry) by Getahun Demeke Worku, Shimeles Nigussie Abate

“…Moringa seeds and cactus pad consist of proteins (cationic and dimeric) which help in neutralizing and absorbing colloidal charges in water containing suspended solids. …”
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Four MES genes from calamondin (Citrofortunella microcarpa) regulated citrus bacterial canker resistance through the plant hormone pathway by Yu-Xiong Xiao, Cui Xiao, Zhu Tong, Xiu-Juan He, Ze-Qiong Wang, Hai-Yue Zhang, Wen-Ming Qiu

“…Subcellular localization analysis showed that the four MES-encoding proteins were localized in the cytoplasm. Overexpression of CmMES1.1 and CmMES1.5 from calamondin (Citrofortunella microcarpa) significantly enhanced CBC resistance and increased the salicylic acid (SA) content in calamondin. …”
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Vascular Endhothelial Growth Factor levels in medium-intensity versus low-intensity exercise with blood flow restriction in elderly women by Nanda Aulya Ramadhan, Damayanti Tinduh, Nuniek Nugraheni, Imam Subadi, Inggar Narasinta, Soenarnatalina Melaniani

“… Introduction and Objective: The decrease in muscle mass in the elderly occurs due to molecular changes related to regeneration and degeneration of muscle proteins. Vascular Endothelial Growth Factor has a role in angiogenesis and increasing muscle mass through increasing the number and function of satellite cells. …”
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Expressions and Clinical Significance of Met and YAP in Gastric Cancer Tissue Microarray by Jinxia Li, Xinyun Zhang, Ying Liu, Jinyong Zhou, Li Shen, Guangxin Yue

“…Bioinformatics analysis demonstrated a significant correlation between the expressions of Met and YAP; both proteins were highly expressed in gastric cancer patients accompanied by markedly reduced survival time. …”
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The helper strategy in vector-transmission of plant viruses by Di Mattia, Jérémy, Zeddam, Jean-Louis, Uzest, Marilyne, Blanc, Stéphane

“…HCs are virus-encoded non-structural proteins produced in infected plant cells that are mandatory for the transmission success. …”
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Protective Effect of Exercise Preconditioning on Myocardial Ischemia-Reperfusion Injury in Rats Based on Autophagy by Qiang TANG, Jiyao ZHANG, Hongyu LI, Xue WANG, Xia YIN, Xuedong WANG, Zichen MU, Luwen ZHU

“…The ultrastructure and autophagic bodies of rat cardiac myocytes were observed by transmission electron microscopy, the infarct size was measured by Evans blue-TTC double staining, and the expression ofPI3K-Akt-mTOR signal pathway related proteins was detected by Western blot.Results:In the Sham group, the nuclear membrane was intact and continuous, the myofibrillar bundles arranged orderly, the structure of mitochondria was intact and no edema, the morphology of myocardial cells was normal, and no autophagic bodies were found; in the MIRI group, the myofibrillar bundles were loose and disordered with interstitial edema, mitochondria and myocardial cells were damaged seriously, the structure of cells was disordered, and autophagy was observed in the field of vision; in the EP group, some of sarcoplasmic reticulum was edema and expanding, mitochondrial structure was more complete with slight edema, myocardial cell was less damaged, and autophagy was less. …”
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NRF2 Exerts Anti-Inflammatory Effects in LPS-Induced gEECs by Inhibiting the Activation of the NF-κB by Hongchu Bao, Qinglan Qu, Wei Zhang, Xinrong Wang, Jianye Fang, Jinwen Xue, Zhenteng Liu, Shunzhi He

“…NRF2 knockout (KO) not only increased the expression of LPS-induced proinflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-8) but also increased the expression of TLR4, p-IκBα/IκBα, and p-p65/p65 proteins. Immunoprecipitation experiments showed that NRF2 directly binds to p65 in the nucleus and inhibits the binding of p65 to downstream target genes (TNF-α, IL-1β, IL-6, and IL-8). …”
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