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14961
Synthesis, in silico and antimicrobial activity study of substituted aromatic imines and their corresponding amines
Published 2025-01-01“…Furthermore, binding energy calculations revealed that compounds 1 and 3 exhibited binding energies of −3.9, −4.1, and −3.8, −3.9 kcal/mol with respect to P. agglomerans and P. aeruginosa candidate proteins, respectively. This underscores the strong interaction between the synthesized compounds and the bacterial strains, further supporting their potential as potent antimicrobial agents. …”
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14962
Optimization of the DNA isolation procedure for assessing the genetic diversity of essential oil roses (<i>Rosa</i> L.)
Published 2024-10-01“…Besides, DNA extracts were effectively purified from proteins without phenol or mercaptoethanol, due to double rinsing with a chloroform/isoamyl alcohol (24 : 1) mixture. …”
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14963
Encapsulation of a Pediocin PA-1 producer Pediococcus acidilactici and its impact on enhanced survival and gut microbiota modulation
Published 2024-06-01“…Encapsulation was carried out using alginate, and capsules were then coated with whey proteins using the lyophilized extrusion method. A Scanning Electron Microscope (SEM) was used to study the surface and core structure of capsules. …”
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14964
Coupling of alternative splicing and alternative polyadenylation
Published 2024-12-01“…Those 3′-end processing factors can also interact with different RNA-binding proteins (RBPs) to exert their effects on AS. The length of 3′ untranslated region (3′ UTR) can affect the splicing of upstream exons. …”
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14965
Early mucosal sensing of SIV infection by paneth cells induces IL-1β production and initiates gut epithelial disruption.
Published 2014-08-01“…However, immunohistological analysis revealed the disruption of the gut epithelium manifested by decreased expression and mislocalization of tight junction proteins. Correlating with epithelial disruption was a significant induction of IL-1β expression by Paneth cells, which were in close proximity to SIV-infected cells in the intestinal crypts. …”
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14966
Serological diagnosis of soil-transmitted helminth (Ascaris, Trichuris and hookworm) infections: A scoping review.
Published 2024-04-01“…Almost all records targeted antibodies as analytes, employing proteins and peptides as analyte detection agents. …”
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14967
Comparative Genomics of the First and Complete Genome of “Actinobacillus porcitonsillarum” Supports the Novel Species Hypothesis
Published 2018-01-01“…The 2,263,191 bp circular genome of 9953L55 consisted of 2168 and 2033 predicted genes and proteins, respectively. The lipopolysaccharide cluster resembled the genetic organization of A. pleuropneumoniae serotypes 1, 9, and 11, possibly explaining the positive reactions observed previously in serotyping tests. …”
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14968
Cytogenetic impact of gamma radiation and its effects on growth, yield and drought tolerance of maize (Zea mays L.)
Published 2025-02-01“…The study also investigates the sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS-PAGE) banding patterns of proteins in grains yielded under the influence of gamma radiation and drought treatments. …”
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14969
Ammonium Transporter 1 (<i>AMT1</i>) Gene Family in Pomegranate: Genome-Wide Analysis and Expression Profiles in Response to Salt Stress
Published 2025-01-01“…This study evaluated the isoelectric point, hydropathicity, conserved domains, motifs, and synteny of the PgAMT1 proteins. Phylogenetic analysis confirmed the homology of <i>PgAMT1</i> genes with previously reported <i>AMT</i> in Arabidopsis and tomato. …”
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14970
Expression of cytokeratin 19 in prostatic adenocarcinoma: a systematic review
Published 2025-01-01“…Abstract Background Cytokeratins are intracellular proteins known as diagnostic biomarkers or prognostic factors for certain cancers. …”
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14971
Distribution and frequency of genetic mutations in three insecticide targets in field populations of Culex tritaeniorhynchus in Mianyang City, Sichuan Province, China
Published 2025-02-01“…Overall, the prevalent co-existence of resistance-conferring mutations in multiple insecticide target proteins in Cx. tritaeniorhynchus populations in Mianyang City indicates a worrying status of insecticide resistance, and suggests that it is highly required to monitor the phenotypic resistance of Cx. tritaeniorhynchus on a regular basis.…”
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14972
In silico study of Sambiloto (Andrographis paniculata) compounds from GC-MS and LC-MS/MS as alpha-glucosidase and DPP-4 enzyme inhibitor
Published 2024-11-01“…The crystal structures of the target proteins used were those with PDB ID 5NN8 for alpha-glucosidase and 2QOE for DPP-4. …”
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14973
A De Novo Mutation in ACTC1 and a TTN Variant Linked to a Severe Sporadic Infant Dilated Cardiomyopathy Case
Published 2024-01-01“…Computational 3D modeling of the mutated proteins showed electrostatic and conformational shifts of cardiac actin compared to wild-type version, as well as changes in the stability of the compact/folded states of titin that normally contributes to avoid mechanic damage. …”
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14974
Sakuranetin Prevents Acetaminophen-Induced Liver Injury via Nrf2-Induced Inhibition of Hepatocyte Ferroptosis
Published 2025-01-01“…Serum transaminase levels, histological changes, inflammatory mediators, oxidative stress, ferroptosis-related markers and Nrf2 signaling pathway proteins were analyzed.Results: Sakuranetin significantly reduced serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST), as well as inflammatory factor; increased HepG2 activity and decreased cell death; inhibited ROS production, increased glutathione (GSH) content, expression of Glutathione Peroxidase 4 (GPX4) and Solute Carrier Family 7 Member 11 (SLC7A11), and decreased malondialdehyde and Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) expression in mice and HepG2 cells after APAP treatment. …”
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14975
RETROSPECTIVE STUDY OF THE EFFICACY OF LONG-TERM TREATMENT OF FELINE IDIOPATHIC CYSTITIS
Published 2025-01-01“…Felines in group A receive food supplements (hydrolysed milk proteins, corn silk, D-mannose, Cosequin®, N-acetyl glucosamine) in 53.57% of cases compared to 42.86% of cases in group B. …”
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14976
Organic Glass-Forming Liquids and the Concept of Fragility
Published 2023-08-01“…An important category of glass-forming materials is organic; it includes molecular liquids, polymers, solutions, proteins that can be vitrified by cooling the liquid under standard conditions or after special thermal treatments. …”
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14977
Using the Sleeping Beauty Transposon System for Doxycycline-inducible Gene Expression in RAW264.7 Macrophage Cells to Study Phagocytosis
Published 2025-02-01“…Finally, using the doxycycline-promoter allows for low near endogenous expression of proteins or robust overexpression.…”
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14978
Pivotal roles of biglycan and decorin in regulating bone mass, water retention, and bone toughness
Published 2025-01-01“…Abstract Proteoglycans, key components of non-collagenous proteins in the bone matrix, attract water through their negatively charged glycosaminoglycan chains. …”
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14979
Comparative Analysis of the Therapeutic Effects of MSCs From Umbilical Cord, Bone Marrow, and Adipose Tissue and Investigating the Impact of Oxidized RNA on Radiation-Induced Lung...
Published 2024-01-01“…Ionizing radiation exerts both direct and indirect detrimental effects on cellular macromolecules, including DNA, RNA and proteins, but the impact of oxidized RNA in RILI remains inadequately explored. …”
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14980
Resistance mechanisms involved in complex immunity of wheat against rust diseases
Published 2019-08-01“…There are three types of resistance in cereals: (1) basal resistance provided by plasma membrane-localized receptors proteins; (2) racespecific resistance provided by intracellular immune R-receptors; (3) partial resistance conferred by quantitative gene loci. …”
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