Secretion of S100A8, S100A9, and S100A12 by Neutrophils Involves Reactive Oxygen Species and Potassium Efflux by Mélanie R. Tardif, Julie Andrea Chapeton-Montes, Alma Posvandzic, Nathalie Pagé, Caroline Gilbert, Philippe A. Tessier

“…S100A8/A9 (calprotectin) and S100A12 proinflammatory mediators are found at inflammatory sites and in the serum of patients with inflammatory or autoimmune diseases. These cytoplasmic proteins are secreted by neutrophils at sites of inflammation via alternative secretion pathways of which little is known. …”
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Replication kinetics, pathogenicity and virus-induced cellular responses of cattle-origin influenza A(H5N1) isolates from Texas, United States by Ahmed Mostafa, Ramya S. Barre, Anna Allué-Guardia, Ruby A. Escobedo, Vinay Shivanna, Hussin Rothan, Esteban M. Castro, Yao Ma, Anastasija Cupic, Nathaniel Jackson, Mahmoud Bayoumi, Jordi B. Torrelles, Chengjin Ye, Adolfo García-Sastre, Luis Martinez-Sobrido

“…Still, variations in the PA and NA proteins didn’t affect their antiviral susceptibility to PA and NA inhibitors. …”
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Acer palmatum thumb. Ethanol Extract Alleviates Interleukin-6-Induced Barrier Dysfunction and Dextran Sodium Sulfate-Induced Colitis by Improving Intestinal Barrier Function and Re... by Kwang-Youn Kim, Tae-Woo Oh, Hyun Ju Do, Ju-Hye Yang, In Jun Yang, Yong Hyun Jeon, Young-Hoon Go, Soon-Cheol Ahn, Jin-Yeul Ma, Kwang-Il Park

“…We investigated the effect of Acer palmatum thumb. ethanol extract (KIOM-2015E) on the expression of tight junction proteins and the levels of inflammation in the cell model induced with interleukin-6- (IL-6-) and mouse model of dextran sodium sulfate (DSS) induced with acute colitis. …”
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Association Analysis of the Genomic and Functional Characteristics of Halotolerant <i>Glutamicibacter endophyticus</i> J2-5-19 from the Rhizosphere of <i>Suaeda salsa</i> by Longhao Sun, Shanshan Sun, Tianyang Liu, Xinmin Lei, Ruiqi Liu, Junyi Zhang, Shanshan Dai, Jing Li, Yanqin Ding

“…Moreover, this work presented the first whole-genome of <i>Glutamicibacter endophyticus</i>, revealing that <i>G. endophyticus</i> J2-5-19 resisted salt stress by expelling sodium ions and taking up potassium ions through Na⁺/H⁺ antiporters and potassium uptake proteins, while also accumulating compatible solutes such as betaine, proline, and trehalose. …”
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NaP-TRAP reveals the regulatory grammar in 5’UTR-mediated translation regulation during zebrafish development by Ethan C. Strayer, Srikar Krishna, Haejeong Lee, Charles Vejnar, Nils Neuenkirchen, Amit Gupta, Jean-Denis Beaudoin, Antonio J. Giraldez

“…Through this approach we identified general and developmentally dynamic cis-regulatory elements, as well as potential trans-acting proteins. We find that U-rich motifs are general enhancers, and upstream ORFs and GC-rich motifs are global repressors of translation. …”
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Functional hydrogel empowering 3D printing titanium alloys by Weimin Zhang, Jiaxin Zhang, He Liu, Yang Liu, Xiao Sheng, Sixing Zhou, Tiansen Pei, Chen Li, Jincheng Wang

“…Hydrogels composed of three-dimensional networks of hydrophilic polymers can effectively simulate the extracellular matrix of natural bone and are capable of loading bioactive molecules such as proteins, peptides, growths factors, polysaccharides, or nucleotides for localized release within the human body, by directly participating in biological processes. …”
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NSUN2 lactylation drives cancer cell resistance to ferroptosis through enhancing GCLC-dependent glutathione synthesis by Kaifeng Niu, Zixiang Chen, Mengge Li, Guannan Ma, Yuchun Deng, Ji Zhang, Di Wei, Jiaqi Wang, Yongliang Zhao

“…Lactate-mediated lactylation on target proteins is recently identified as the novel posttranslational modification with profound biological functions. …”
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Development of an analytical method for the simultaneous determination of 22 Polycyclic Aromatic Hydrocarbons (PAHs) in maternal and umbilical cord blood by Swiha, Stéphanie, Pichon, Valérie, Fournier, Thierry, Gil, Sophie, Delaunay, Nathalie

“…Then, to break any interactions between PAHs and serum proteins, a precipitation step prior to solid-phase extraction was optimized using a design of experiments. …”
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Screening for transcriptomic associations with Swine Inflammation and Necrosis Syndrome by Katharina Gerhards, Sabrina Becker, Josef Kuehling, Mirjam Lechner, Hermann Willems, Robert Ringseis, Gerald Reiner

“…The primarily endogenous syndrome is based on vasculitis, thrombosis, and intimal proliferation, involving defence cells, interleukins, chemokines, and acute phase proteins and accompanied by alterations in clinical chemistry, metabolome, and liver transcriptome. …”
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Bilayer 3D co‐culture platform inducing the differentiation of normal fibroblasts into cancer‐associated fibroblast like cells: New in vitro source to obtain cancer‐associated fibr... by Yeon Ju Kim, Hyeon Song Lee, Dohyun Kim, Hwa Kyung Byun, Woong Sub Koom, Won‐Gun Koh

“…Proteomic analysis identified upregulated proteins associated with CAFs, further confirming the transformation of normal fibroblasts into CAF within the proposed 3D co‐culture platform. …”
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Differential expression and localization of expansins in Arabidopsis shoots: implications for cell wall dynamics and drought tolerance by Darina Balkova, Katerina Mala, Jan Hejatko, Jan Hejatko, Klara Panzarova, Lamis Abdelhakim, Barbora Pleskacova, Marketa Samalova, Marketa Samalova

“…Expansins are cell wall-modifying proteins implicated in plant growth and stress responses. …”
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Advances in growth factor-containing 3D printed scaffolds in orthopedics by Longwen Zhan, Yigui Zhou, Ruitang Liu, Ruilong Sun, Yunfei Li, Yongzheng Tian, Bo Fan

“…This paper aims to summarize the research progress of 3D printed scaffolds containing growth factors in orthopedics in recent years and summarize the use of different growth factors in 3D scaffolds, including bone morphogenetic proteins, platelet-derived growth factors, transforming growth factors, vascular endothelial growth factors, etc. …”
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Advanced Copper Oxide Chemical and Green Synthesis: Characterization and Antibacterial Evaluation by Ecaterina Magdalena Modan, Adriana-Gabriela Schiopu, Sorin Georgian Moga, Denis Aurelian Negrea, Daniela Istrate, Ion Ciuca, Mihai Oproescu

“…SEM illustrated various morphologies, such as flakes, microspheres, and irregular polyhedra, influenced by the presence of proteins and organic acids. Antibacterial tests demonstrated the effective inhibition of <i>Escherichia coli</i> and <i>Enterococcus faecalis</i>, confirming the potential of CuO as a promising antibacterial agent. …”
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Platycodon grandiflorum-derived extracellular vesicles suppress triple-negative breast cancer growth by reversing the immunosuppressive tumor microenvironment and modulating the gu... by Min Yang, Jia Guo, Jinxian Li, Shuyue Wang, Yuan Sun, Ying Liu, Yinghua Peng

“…The PGEVs were isolated by ultracentrifugation and sucrose gradient centrifugation method and contained adequate functional components such as proteins, lipids, RNAs and active molecules. PGEVs exhibited remarkable stability, tolerating acidic digestion and undergoing minimal changes in simulated gastrointestinal fluid. …”
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Long-term copper exposure induced pyroptosis and inflammation of rat spleen through intestinal-splenic axis by Jinwen Quan, Xiaoyue Chang, Siying Liu, Ting He, Gaolong Zhong, Zhonghua Liu, Wenlan Yu

“…Our results demonstrated that under copper exposure, the structural integrity of the intestinal epithelium was compromised, resulting in a significant downregulation of genes and proteins expression levels related to the intestinal barrier (Zonula occludens-1, Claudin-1 and Occludin). …”
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PLGA confers upon conventional nonfluorescent molecules luminescent properties to trigger 1O2-induced pyroptosis and immune response in tumors by Lan Zou, Rujing Wang, Mengnan Zhao, Yuke Li, Chen Sun, Jinjin Xie, Yan Chen, Qian Jing, Dandan Mi, Sanjun Shi

“…Abstract Pyroptosis, a recently identified cellular demise regulated by gasdermin family proteins, is emerging as a promising avenue in cancer immunotherapy. …”
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The role of adipose and muscle tissue breakdown on interorgan energy substrate fluxes in a Pseudomonas aeruginosa induced sepsis model in female pigs by Ryan Morse, Gabriella A. M. Ten Have, John J. Thaden, Marielle P. K. J. Engelen, Sarah Rice, Martin Hagve, Nicolaas E. P. Deutz

“…In the acute phase of sepsis, we hypothesize an important role of altered intestinal amino acid metabolism and breakdown of muscle proteins, but not of glycolysis to support gluconeogenesis.…”
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Sodium Lactate Accelerates M2 Macrophage Polarization and Improves Cardiac Function after Myocardial Infarction in Mice by Jialiang Zhang, Fangyang Huang, Li Chen, Guoyong Li, Wenhua Lei, Jiahao Zhao, Yanbiao Liao, Yijian Li, Changming Li, Mao Chen

“…Macrophage phenotype was detected via qPCR, flow cytometry, and immunofluorescence. Signaling proteins were measured by Western blotting. Results. …”
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Effects of P1G10 against UVB-induced damage: Reduction of antioxidant stress, inflammation and cell proliferation by Kátia M. Freitas, Emerson S. Veloso, Ênio Ferreira, Marcelo V. Caliari, Carlos E. Salas, Miriam T.P. Lopes

“…Pathways involved in the inflammatory process and in UVB-induced production of free radicals were also affected, revealing that P1G10 application reduced phosphorylation of MAP kinase proteins (JNK and P38) and Akt, as well as MMP-9 activity. …”
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A novel 4-(1,3,4-thiadiazole-2-ylthio)pyrimidine derivative inhibits cell proliferation by suppressing the MEK/ERK signaling pathway in colorectal cancer by Li Weiwei, Yang Zhifu, Ding Likun, Wang Ying, Zhao Xian, Chu Jian Jie, Ji Qing, Yao Minna, Wang Jingwen

“…And compound 4 yielded the same effects as the MEK inhibitor U0126 on cell apoptosis and MEK/ERK-related proteins. These findings suggested that compound 4 inhi bited cell proliferation and growth, and induced cell apoptosis, indicating its use as a novel and potent anticancer agent against CRC via the MEK/ERK signaling pathway.…”
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