Molecular basis and genetics of hypohidrotic ectodermal dysplasias by V. A. Kovalskaia, T. Cherevatova, A. V. Polyakov, O. P. Ryzhkova

“…The domain structures of the corresponding proteins are considered, as well as the molecular genetic pathways in which they are involved. …”
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Genetic approaches to the investigation of serotonergic neuron functions in animals by U. S. Drozd, E. V. Shaburova, N. N. Dygalo

“…The selective cell control is possible due to the genetic determinism of their functions. Proteins that determine the uniqueness of the cell type are expressed under the regulation of cell-specific promoters. …”
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Assessment of Ocriplasmin Effects on the Vitreoretinal Compartment in Porcine and Human Model Systems by Bart Jonckx, Michael Porcu, Aurelie Candi, Isabelle Etienne, Philippe Barbeaux, Jean H. M. Feyen

“…Histological analysis of extracellular matrix (ECM) proteins such as laminin, fibronectin, and collagen IV indicated no retinal ocriplasmin-induced ECM distribution changes. …”
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Underutilized wild edible fungi and their undervalued ecosystem services in Africa by Gudeta W. Sileshi, Donatha D. Tibuhwa, Alec Mlambo

“…Wild edible mushrooms provide food that is high in digestible proteins, antioxidants and fibre but low in fats. They are also sources of income for rural populations. …”
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A minimal mathematical model for the initial molecular interactions of death receptor signalling by Christian Winkel, Simon Neumann, Christina Surulescu, Peter Scheurich

“…Typical for most members of the whole family, death ligands form homotrimeric proteins, capable to bind up to three of their respective receptor molecules. …”
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Alone or in combination, hyaluronic acid and chondroitin sulfate alleviate ECM degradation in osteoarthritis by inhibiting the NF-κB pathway by Yiran Ma, Xin Yang, Min Jiang, Wangjuan Ye, Hong Qin, Songwen Tan

“…Inflammatory factors were measured by ELISA, and ECM-related proteins were detected by immunohistochemistry, immunofluorescence, and Western blotting. …”
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Mechanism by Which Laser Irradiation Combined with Spirulina platensis Enhances FeSO4-Induced Ferroptosis in Salmonella Typhimurium and Listeria monocytogenes by SUN Jinyue, PAN Jianeng, CHEN Yiying, LIU Rencheng, ZHOU Wenwen

“…Additionally, the Fe + SP + L treatment led to increased lipid peroxidation and ROS production and decreased proportion of GSH, thereby damaging the integrity of the cell membrane, increasing the permeability of the cell membrane, decreasing the membrane potential, increasing the leakage of intracellular nucleic acids and proteins, and ultimately resulting in the death of bacteria. …”
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Advances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches by Ayyaz Khan, Zakirullah, Shahid Wahab, Seong-Tshool Hong

“…It also highlights recent advances in antiviral strategies targeting host factors such as lipid metabolism, ion channels, and proteasomes, as well as viral targets like NS2B-NS3 proteases and nonstructural proteins. Additionally, it explores immunomodulatory therapies to enhance antiviral responses and emphasizes the potential of drug repurposing, bioinformatics, artificial intelligence, and deep learning in identifying novel antiviral candidates. …”
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The Impact of Modifiable Risk Factors on the Endothelial Cell Methylome and Cardiovascular Disease Development by Hashum Sum, Alison C. Brewer

“…Further, the potential mechanisms whereby such risk factors might impact upon the activities and/or specificities of the epigenetic writers and erasers which determine the methylome [the DNA methyl transferases (DNMTs) and Ten Eleven translocases (TETs)] are considered here. Notably, the TET proteins are members of the 2-oxoglutarate-dependent dioxygenase superfamily which require molecular oxygen (O2) and α-ketoglutarate (α-KG) as substrates and iron-2+ (Fe II) as a cofactor. …”
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Knockout of the ING5 epigenetic regulator confirms roles in stem cell maintenance and tumor suppression in vivo. by Buthaina Al Shueili, Arthur Dantas, Etienne Mahe, Tak Ho Chu, Yang Yang, Elodie Labit, Eren Kutluberk, Nicolas Lasaleta, Anand Masson, Hiba Omairi, Kenichi Ito, Roman J Krawetz, Rajiv Midha, Gregory Cairncross, Karl Riabowol

“…INhibitor of Growth (ING1-5) proteins are epigenetic readers that target histone acetyltransferase (HAT) or histone deacetylase (HDAC) complexes to the H3K4Me3 mark of active transcription. …”
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Research review and transcriptomic insights into Benzalkonium chloride inhalation and disease association by Jun Woo Kim, Min Seok Kim, Ha Ryong Kim

“…Our study also examined the systemic effects of BKC by analysing the secreted proteins, suggesting possible cardiovascular implications. …”
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Age-Dependent Loss of Mitochondrial Function in Epithelial Tissue Can Be Reversed by Coenzyme Q10 by Daniel Schniertshauer, Daniel Gebhard, Jörg Bergemann

“…The accumulation of reactive oxygen species damaged mitochondrial DNA and proteins can induce mitochondrial dysfunction within the electron transport chain. …”
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New treatment options for generalized myasthenia gravis by Antanas Vaitkus, J. Čiauškaitė, M. Malakauskaitė, M. Baublytė

“…Myasthenia gravis is an autoimmune disease in which autoantibodies against the postsynaptic membrane proteins of the neuromuscular junction disrupt impulse transmission thus causing pathological muscle weakness and fatigue that worsens throughout the day. …”
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Cbf11 and Mga2 function together to activate transcription of lipid metabolism genes and promote mitotic fidelity in fission yeast. by Anna Marešová, Michaela Grulyová, Miluše Hradilová, Viacheslav Zemlianski, Jarmila Princová, Martin Převorovský

“…In S. pombe, the Cbf11 and Mga2 proteins are transcriptional activators of non-sterol lipid metabolism genes, with Cbf11 also known as a cell cycle regulator. …”
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How to Translate Basic Knowledge into Clinical Application of Biologic Therapy in Spondyloarthritis by Chung-Tei Chou

“…Drugs (anti-IL6R or anti-IL6) which can reduce the binding of IL6 and IL6R to the cell surface may be beneficial in SpA. Many proteins are implicated in the new bone formation (syndesmophyte) or ankylosis in AS or SpA. …”
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Solvent‐Based and Matrix‐Matched Calibration Methods on Analysis of Ceftiofur Residues in Milk and Pharmaceutical Samples Using a Novel HPLC Method by Saniye Özcan, Serkan Levent, Nafiz Öncü Can

“…Because milk has a complex matrix, which is rich in fats, proteins and many other compounds, the determination of CEF in milk products deals with issues of trueness. …”
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Classification, Processing Procedures, and Market Demand of Chinese Biscuits and the Breeding of Special Wheat for Biscuit Making by Xin Hu, Lejia Hu, Jing Zheng, Junkang Rong

“…Biscuits are composed of four main ingredients, which are flour, fat/oil, sugar, and water, whereas several secondary ingredients also are important sources of high molecular carbohydrates, plant proteins, vitamins, and minerals for human beings. …”
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Optogenetic regulation of endogenous gene transcription in mammals by E. S. Omelina, A. V. Pindyurin

“…The factors include zinc finger proteins, transcription activator-like effectors (TALEs), and the CRISPR/Cas9 technology. …”
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Bridging Molecular Docking to Molecular Dynamics to Enlighten Recognition Processes of Tailored D-A/D-A-D Types' AIEgens with HSA/BSA by Harun Nalçakan, Gülbin Kurtay

“…In this scope, we performed a detailed molecular dock-ing study of Donor (D)-Acceptor (A) or D-A-D type luminogens with two blood proteins; namely bovine serum albumin (BSA) and human serum albumin (HSA), which appeared as robust carriers of several pharmaceuticals against preliminary cancer diseases. …”
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Rad3 decorates critical chromosomal domains with gammaH2A to protect genome integrity during S-Phase in fission yeast. by Sophie Rozenzhak, Eva Mejía-Ramírez, Jessica S Williams, Lana Schaffer, Jennifer A Hammond, Steven R Head, Paul Russell

“…Here, we use ChIP-on-chip analysis to map genomic loci decorated by phosphorylated histone H2A (gammaH2A), a Rad3 substrate that establishes a chromatin-based recruitment platform for Crb2 and Brc1 DNA repair/checkpoint proteins. Unexpectedly, gammaH2A marks a diverse array of genomic features during S-phase, including natural replication fork barriers and a fork breakage site, retrotransposons, heterochromatin in the centromeres and telomeres, and ribosomal RNA (rDNA) repeats. gammaH2A formation at the centromeres and telomeres is associated with heterochromatin establishment by Clr4 histone methyltransferase. …”
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