Genetic Analysis Reveals A Missense Mutation In Reactivation Gene-2 Causing Severe Combined Immunodeficiency Disease In A Pakistani Family by Shahida Awais, Lubna Siddique, Nida Shafi, Sobia Humerah, Summyah Niazi, Wafa Omer

“…Conclusion: In human reactivation gene 1 and 2 encode proteins with endonuclease activity which are involved in V(D)J rearrangement to generate variety of different types of T- and B- cell receptors. …”
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Role of PPARs in Progression of Anxiety: Literature Analysis and Signaling Pathways Reconstruction by Olga I. Rudko, Artemii V. Tretiakov, Elena A. Naumova, Eugene A. Klimov

“…Current study revealed 14 PPAR-regulated proteins linked to anxiety. Possible mechanism of PPAR involvement in neuroinflammation protection is proposed. …”
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Sensitization to nsLTP: A Retrospective Study in An Italian Pediatric Population over the Last Decade by Cristiana Indolfi, Giulio Dinardo, Angela Klain, Marcella Contieri, Giuseppina Rosaria Umano, Fabio Decimo, Salvatore Abbadessa, Carolina Vitulano, Giorgio Ciprandi, Michele Miraglia del Giudice

“…Food allergy is common in the Mediterranean, especially concerning lipid transfer proteins (LTPs) allergy. LTPs are widespread plant food allergens in fruits, vegetables, nuts, pollen, and latex. …”
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Chromatin remodeling in oligodendrogenesis by E. V. Antontseva, N. P. Bondar

“…Mutations in the genes encoding proteins of the remodeling complexes are often accompanied by serious disorders at early stages of embryogenesis and are frequently identified in various cancers. …”
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Effects of feeding different proportions of steam-flaked corn-based starter on growth performance, immunity and serum metabolism of pre-weaned Simmental calves by Kangyu Yao, Yu Gao, Liang Yang, Min Yang, Xiuyu Wu, Xinyu Zhang, Zhengke Lv, Wei Shao, Yong Wei, Wanping Ren

“…Compared to control, 31 metabolites differed in SFC33 group, mostly up-regulated, including glycerophospholipids, linoleic/arachidonic acid metabolism, cholesterol pathway molecules, L-glutamine in multiple pathways, and mannose in fructose/mannose metabolism.DiscussionIn summary, feeding 33% steam-flaked corn-based starter can improve the growth performance, enhance immunity, and improve sugars, lipids, and proteins metabolism of pre-weaned Simmental calves.…”
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Autoantibody to MDM2: A Potential Serological Marker of Systemic Lupus Erythematosus by Yuan Liu, Liping Dai, Weihong Liu, Guixiu Shi, Jianying Zhang

“…Since abnormally expressed proteins can induce autoimmune response, anti-MDM2 autoantibody was examined in SLE patients. …”
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Pseudomonas evades immune recognition of flagellin in both mammals and plants. by Bart W Bardoel, Sjoerd van der Ent, Michiel J C Pel, Jan Tommassen, Corné M J Pieterse, Kok P M van Kessel, Jos A G van Strijp

“…In order to prevent immune activation and thus favor survival in the host, bacteria secrete many proteins that hamper such recognition. In our search for Toll like receptor (TLR) antagonists, we screened bacterial supernatants and identified alkaline protease (AprA) of Pseudomonas aeruginosa as a TLR5 signaling inhibitor as evidenced by a marked reduction in IL-8 production and NF-κB activation. …”
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MicroRNAs secreted by the parasitic nematode Brugia malayi disrupt lymphatic endothelial cell integrity. by Hailey Johnson, Stephanie Banakis, Matthew Chung, Elodie Ghedin, Denis Voronin

“…We then measured the effect of these miRNAs on the regulation of proteins necessary for cell integrity, demonstrating downregulation leading to a significant increase in the permeability of the endothelium monolayer. …”
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The Use of SenseWear Armband for Assessment of Daily Energy Expenditure and the Relation to Body Fat Distribution and Nutritional Intake in Lean Women with Polycystic Ovary Syndrom... by Gulcan Arusoglu

“…Energy percentage of proteins (%12.73 ± 1.98, p=0.008) was statistically lower in subjects versus the control group. …”
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Label-Free Detection of Human Serum Using Surface-Enhanced Raman Spectroscopy Based on Highly Branched Gold Nanoparticle Substrates for Discrimination of Non-Small Cell Lung Cancer by Xiaowei Cao, Zhenyu Wang, Liyan Bi, Jie Zheng

“…The difference spectra among different types of NSCLC were compared, and analysis result revealed their intrinsic difference in types and contents of nucleic acids, proteins, carbohydrates, amino acids, and lipids. SERS spectra were analyzed by principal component analysis (PCA), which was able to distinguish different types of NSCLC. …”
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Autoimmune sensorineural hearing loss/Meniere’s disease possibly triggered by neurocysticercosis: a case report by Hamza Arman Lateef, Evan Davies, Alidad Arabshahi

“…Laboratory work-up revealed a positive result for the anti-heat shock proteins antibody and abnormal electrocochleography, more prominent on the left than the right. …”
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Inhibition of the SARS-CoV-2 Main Protease by Isoquercitrin γ-Cyclodextrin Inclusion Complex Formulations: A Biochemical and In Silico Study by Martin Wurtele, Camila Coelho, Gloria Gallo, Claudia Campos, Leon Hardy, Yunierkis Perez Castillo, Masamitsu Moriwaki, Mahendra P. Kapoor, Damião Pergentino de Sousa

“…Since the targeted proteases are essential for viral activity, the delivery isoquercitrin-cyclodextrin inclusion complex formulations could be of great interest for the development of future antiviral drugs to target intracellular virus proteins or other components.…”
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VARIABILITY OF RACIAL COMPOSITION OF SUNFLOWER BROOMRAPE (ОROBANCHE CUMANA WALLR.) AND NEW STRATEGIES FOR PROTECTION FROM THE PARASITE by S. G. Hablak, Y. A. Abdullaeva, I. S. Riabovol

“…It causes systemic resistance to bacterial, fungal and viral diseases, induces the synthesis of PR proteins, and also activates the protective reactions of sunflower to the introduction of broomrape and leads to lignification of the endoderm and inhibition of haustoria of the broomrape seeds through the cell wall of the root cells.…”
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Establishment and Mechanism Study of a Primary Ovarian Insufficiency Mouse Model Using Lipopolysaccharide by Si-Ji Lv, Shu-Hui Hou, Lei Gan, Jing Sun

“…Western blotting was performed to measure the levels of inflammation-, fibrosis-, and apoptosis-related proteins in the mouse ovaries. Like CTX, both low- and high-dose LPS significantly impaired ovarian functions in mice, as evidenced by extended lengths of estrous cycles, reduced counts of primordial follicles, and alterations in the levels of serum hormones. …”
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Essential and recurrent roles for hairpin RNAs in silencing de novo sex chromosome conflict in Drosophila simulans. by Jeffrey Vedanayagam, Marion Herbette, Holly Mudgett, Ching-Jung Lin, Chun-Ming Lai, Caitlin McDonough-Goldstein, Stephen Dorus, Benjamin Loppin, Colin Meiklejohn, Raphaëlle Dubruille, Eric C Lai

“…Finally, using tagged transgenes of Dox and PDox2, we provide the first experimental evidence Dox family genes encode proteins that are strongly derepressed in cognate hpRNA mutants. …”
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Effect of thymol and propolis extract on genotoxicity, biochemical activities and expression profile of some genes on honey bee, Apis mellifera, infected with Vairimorpha (Nosema)... by Salwa I. Sebak, Heba A. S. Elelimy, Heba Seyam, Soad A. Elkenawy

“…The collected samples were used in studying the genotoxicity effect, the concentration of oxidative enzymes (superoxide-dismutases, glutathione S transferase, catalase and malondialdehyde (MDA)), measuring the relative expression of antimicrobial genes and hypopharyngeal glands genes major royal proteins 1 & 2 (MJRP1 and MJRP2). Results The results show that thymol and propolis extract decreased genotoxicity effect, increased expression of antimicrobial genes, increased expression levels of MJRP1 and MJRP2 genes and decreased activities of oxidative enzymes when applied to Nosema-infected bees. …”
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Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli. by Danelle S Eto, Tiffani A Jones, Jamie L Sundsbak, Matthew A Mulvey

“…Uropathogenic Escherichia coli (UPEC), the primary causative agent of urinary tract infections, typically express filamentous adhesive organelles called type 1 pili that mediate both bacterial attachment to and invasion of bladder urothelial cells. Several host proteins have previously been identified as receptors for type 1 pili, but none have been conclusively shown to promote UPEC entry into host bladder cells. …”
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Role of inflammatory aging in the development of age-related macular degeneration by A.S. Khalatyan, Yu. Yusef

“…The pathogenesis of AMD begins with the thickening of Bruch's membrane caused by the accumulation of lipids and proteins, resulting in the formation of subretinal deposits called drusen. …”
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Exploring the role and mechanisms of MAGEA4 in tumorigenesis, regulation, and immunotherapy by Weijian Zhu, Qiang Yi, Zheng Chen, Jiaqi Wang, Kui Zhong, Xinting Ouyang, Kuan Yang, Bowei Jiang, Jianing Zhong, Jinghua Zhong

“…MAGEA4 interacts with proteins including Miz-1, p53, and RAD18, participating in gene transcription regulation and DNA damage repair. …”
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Amylin: Localization, Effects on Cerebral Arteries and on Local Cerebral Blood Flow in the Cat by Lars Edvinsson, Peter J. Goadsby, Rolf Uddman

“…With RT-PCR and Real-Time�PCR we revealed the presence of mRNA for calcitonin receptor-like receptor (CLRL) and receptor-activity-modifying proteins (RAMPs) in cat cerebral arteries. In vitro studies revealed that amylin, adrenomedullin, and CGRP relaxed ring segments of the cat middle cerebral artery. …”
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