Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain by Chae-Jeong Lee, Seung Hyun Jang, Jiwoo Lim, Hyunju Park, So-Hee Ahn, Seon Young Park, Hyangmi Seo, Soo-Jin Song, Jung-A Shin, Chulhee Choi, Heon Yung Gee, Youn-Hee Choi

“…Exosomes are potent therapeutics or drug delivery vehicles for various materials, including proteins and regulatory genes, to target cells. In the present study, we evaluated the therapeutic efficacy of exosomes loaded with a nondegradable form of IκB (Exo-srIκB), which inhibits the nuclear translocation of NF-κB to suppress age-related neuroinflammation. …”
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Nonviral targeted mRNA delivery: principles, progresses, and challenges by Xi He, Guohong Li, Letao Huang, Haixing Shi, Sha Zhong, Siyu Zhao, Xiangyu Jiao, Jinxiu Xin, Xiaoling Yin, Shengbin Liu, Zhongshan He, Mengran Guo, Chunli Yang, Zhaohui Jin, Jun Guo, Xiangrong Song

“…Due to the inherent nuclease‐instability and negative charge of mRNA, delivery systems are developed to protect the mRNA from degradation and facilitate its crossing cell membrane to express functional proteins or peptides in the cytoplasm. However, the deficiency in transfection efficiency and targeted biological distribution are still the major challenges for the mRNA delivery systems. …”
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MAGI2-AS3 hypermethylated in promoter region promotes migration and invasion of head and neck squamous cell carcinoma via miRNA-31-5p/AR axis by Kai Yue, Ting Zhang, Huanhuan Wang, Bo Wang, Yalin Mu, Hui Li

“…Molecular regulatory mechanism of MAGI2-AS3 in HNSCC is not yet mature.In this study, we analyzed the methylation level of MAGI2-AS3 promoter and its downstream miR-31-5p/AR axis by bioinformatics methods. qRT-PCR was used to detect the mRNA expression level of each gene, and western blot was used to detect the expression level of AR proteins in tissues and cells. CCK-8, colony formation, wound healing, and cellular invasion assays were used to detect the HNSCC cell proliferation, migration, and invasion. …”
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Direct conversion of peptides into diverse peptidomimetics using a transformer-based chemical language model by Atsushi Yoshimori, Jürgen Bajorath

“…The design of pharmaceutically relevant compounds that mimic bioactive peptides or secondary structure elements in proteins is an important task in medicinal chemistry. …”
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Textural Analysis of Nuclear Mitotic Apparatus Antigen (NuMA) Spatial Distribution in Interphase Nuclei from Human Drug-Resistant CEM Lymphoblasts by Naima Rafki‐Beljebbar, Françoise Liautaud‐Roger, Dominique Ploton, Jean Dufer

“…Moreover, Optical Densities measurements indicate that MDR cells seem to contain less NuMA, a datum confirmed by immunoblotting of nuclear proteins. In conclusion, chromatin changes observed by image cytometry in drug‐resistant human leukemic CEM cells appear associated with modifications of the nuclear matrix structure.…”
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Hypovitaminosis D3, Leukopenia, and Human Serotonin Transporter Polymorphism in Anorexia Nervosa and Bulimia Nervosa by Anna Tasegian, Francesco Curcio, Laura Dalla Ragione, Francesca Rossetti, Samuela Cataldi, Michela Codini, Francesco Saverio Ambesi-Impiombato, Tommaso Beccari, Elisabetta Albi

“…We choose 18 patients with a normal blood test profile such as thyroid hormones, hepatic and renal parameters, triglycerides, proteins, vitamin B12, and folic acid. Among these emerged the case of a woman with long-term anorexia nervosa and the case of a woman with long-term bulimia nervosa both complicated by anxiety and depression, severe hypovitaminosis D3, decrease of vitamin D receptor, leukopenia, and 5-hydroxytryptamine transporter linked polymorphic region short allele. …”
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Role of sirtuins in obesity and osteoporosis: molecular mechanisms and therapeutic targets by Yikuan Du, Yuying Huo, Yujia Yang, Peiqi Lin, Wuzheng Liu, Ziqin Wang, Wenqi Zeng, Jiahui Li, Zhonghan Liang, Chenyue Yuan, Jinfeng Zhu, Ziyi Luo, Yi Liu, Chunling Ma, Chun Yang

“…Among the various research avenues exploring the potential of sirtuins, the effects of these proteins on obesity and OP have garnered significant attention from numerous researchers. …”
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The role of Mitofusin-1 and Mitofusin-2 in periodontal disease: a comprehensive review by Sudhir R. Varma, Sudhir R. Varma, Omar H. A. A. Ani, Jayaraj K. Narayanan, Jayaraj K. Narayanan, Asok Mathew, Asok Mathew

“…Decreased levels of these proteins were related to elevated oxidative stress, inflammation, and increased mitochondrial dysfunction in periodontal tissues. …”
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Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4 signaling by Lixuan Chen, Yingnan Wu, Tiying Lv, Rui Tuo, Yang Xiao

“…Lipid peroxidation levels, iron deposition and mitochondrial morphology were detected. The genes and proteins of Keap1/Nrf2/GPX4 signaling were examined.Results Salidroside and MSCs were found to inhibit cell death of GCs by reducing peroxidation and intracellular ferrous. …”
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CHD6 has poly(ADP-ribose)- and DNA-binding domains and regulates PARP1/2-trapping inhibitor sensitivity via abasic site repair by Luc Provencher, Wilson Nartey, Peter M. Brownlee, Austin W. Atkins, Jean-Philippe Gagné, Lou Baudrier, Nicholas S. Y. Ting, Cortt G. Piett, Shujuan Fang, Dustin D. Pearson, Shaun Moore, Pierre Billon, Zachary D. Nagel, Guy G. Poirier, Gareth J. Williams, Aaron A. Goodarzi

“…CHD6 displays direct PAR-binding, interacts with PARP-1 and other PAR-associated proteins, and combined DNA- and PAR-binding loss eliminates CHD6 relocalization to DNA damage. …”
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Folate alleviated skin inflammation and fibrosis resulting from impaired homocysteine metabolism by Jiefeng Huang, Wuyan Lu, Shenli Zhao, Zixin Cai, Linxiao Li, Zihao Hu, Yu Jiang, Jinyi Deng, Yiming Tang, Chenzhang Shi, Chen Wang, Guangpeng Liu, Shuaijun Li

“…Skin fibrosis, characterized by uncontrolled secretion of extracellular matrix (ECM) proteins such as collagen, can lead to excessive scarring and compromised tissue function. …”
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Targeted modulation of intestinal barrier and mucosal immune-related microbiota attenuates IgA nephropathy progression by Ran Zhang, Yuyan Tang, Xiangru Feng, Xiaoxuan Lu, Mengyao Zhao, Jiayang Jin, Xiaoguo Ji, Haidong He, Liming Zhao

“…There was also an imbalance in intestinal B-cell immunity and a decrease in the level of tight junction proteins (ZO-1 and Occludin). Intestinal barrier and mucosal immune-related microbiota (Clostridium leptum, unclassified Lachnospiraceae NK4Al36 group, unclassified Clostridia vadinBB60 group, unclassified Oscillospiraceae, and unclassified Roseburia) were enriched through targeted modulation with COS/COSF, enhancing intestinal ZO-1 expression and reducing APRIL/BAFF overexpression, thereby reducing renal damage in IgAN. …”
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Conditioned Media from Adipose-Tissue-Derived Mesenchymal Stem Cells Downregulate Degradative Mediators Induced by Interleukin-1β in Osteoarthritic Chondrocytes by Julia Platas, Maria Isabel Guillén, María Dolores Pérez del Caz, Francisco Gomar, Vicente Mirabet, Maria José Alcaraz

“…CM enhanced type II collagen expression in OA chondrocytes while decreasing matrix metalloproteinase (MMP) activity in cell supernatants as well as the levels of MMP-3 and MMP-13 proteins and mRNA in OA chondrocytes stimulated with interleukin- (IL-) 1β. …”
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A bivalent COVID-19 mRNA vaccine elicited broad immune responses and protection against Omicron subvariants infection by Jun Liu, Li Wang, Alexandra Kurtesi, Patrick Budylowski, Kyle G. Potts, Haritha Menon, Yilin Tan, Philip Samaan, Xinan Liu, Yisen Wang, Queenie Hu, Reuben Samson, Freda Qi, Danyel Evseev, Cini John, Kristofor K. Ellestad, Yue Fan, Frans Budiman, Ellaine Riczly Tohan, Suji Udayakumar, Jennifer Yang, Eric G. Marcusson, Anne-Claude Gingras, Douglas J. Mahoney, Mario A. Ostrowski, Natalia Martin-Orozco

“…Here, we report the immunogenicity and efficacy of a bivalent mRNA vaccine, PTX-COVID19-M1.2 (M1.2), which encodes native spike proteins from Wuhan-Hu-1 (D614G) and Omicron BA.2.12.1, in mouse and hamster models. …”
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Fungal and oomycete pathogens and heavy metals: an inglorious couple in the environment by Joanna Gajewska, Jolanta Floryszak-Wieczorek, Ewa Sobieszczuk-Nowicka, Autar Mattoo, Magdalena Arasimowicz-Jelonek

“…Such a network may include extracellular HMs immobilization, biosorption to cell wall, and/or their intracellular sequestration to proteins or other ligands. HMs may also induce a hormesis-like phenomenon allowing the pathogens to maintain or even increase fitness against chemical challenges. …”
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Nutrition before and during Surgery and the Inflammatory Response of the Heart: A Randomized Controlled Trial by Marlieke Visser, Hans W. M. Niessen, Wouter E. M. Kok, Riccardo Cocchieri, Willem Wisselink, Paul A. M. van Leeuwen, Bas A. J. M. de Mol

“…Both solutions included proteins or amino acids, glucose, vitamins, and minerals. …”
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Evolution of Alzheimer’s Disease Therapeutics: From Conventional Drugs to Medicinal Plants, Immunotherapy, Microbiotherapy and Nanotherapy by Emma Ortiz-Islas, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sánchez, Talía Sánchez-Barbosa, Diego Pichardo-Rojas, Cecilia Zavala-Tecuapetla, Karla Carvajal-Aguilera, Victoria Campos-Peña

“…Among the therapeutic alternatives, immunotherapy stands out, employing monoclonal antibodies to specifically target and eliminate toxic proteins implicated in AD. Additionally, the use of medicinal plants is examined, as their synergistic effects among components may confer neuroprotective properties. …”
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The Antibacterial Effect of Tinospora Cordifolia (Guduchi) and Its Role in Combating Antimicrobial Resistance by Kavitha EZHILARASU, Anand KASIRANJAN, Shanmuga PRIYA, Anand KAMARAJ

“…Phytochemical analysis of Tinospora cordifolia extract showed alkaloids, carbohydrates, phytosterols, saponins, tannins, proteins, flavonoids, and terpenoids. Conclusions: Our findings show that Tinospora cordifolia plays a potential role in combating the antimicrobial resistance of clinical isolates.…”
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Epilepsy and brain health: a large prospective cohort study by Dan-Dan Zhang, Zi-Yi Wang, Ya-Ru Zhang, Pei-Yang Gao, Wei Zhang, Yan Fu, Hao-Chen Chi, Li-Yun Ma, Yi-Jun Ge, Xiao-Yu He, Jia You, Wei Cheng, Jian-Feng Feng, Lan Tan, Jin-Tai Yu

“…Mediation analyses revealed mediating effects of peripheral markers and proteins (e.g., GGT, HDL, ACE2, and GDF15), suggesting that liver function and lipid metabolism may be involved in the development of other brain disorders in individuals with epilepsy. …”
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Genome-Wide Identification of the ABC Gene Family in Rosaceae and Its Evolution and Expression in Response to Valsa Canker by Chenglong Du, Hongqiang Yu, Huanhuan Hu, Zhiqi Dou, Cunwu Zuo, Junqiang Niu

“…Gene ontology (GO) enrichment analysis indicated the involvement of ABC proteins in transmembrane transport and signal transduction pathways. …”
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