Phenogenetics of cortical granule dynamics during zebrafish oocyte-to-embryo transition by Priscila García-Castro, Isabella Giambó-Falian, Ingrid Carvacho, Ricardo Fuentes

“…The slow block, triggered by cortical granule (CG) exocytosis, involves the release of proteins that modify the zona pellucida to form a permanent barrier, avoiding the fertilization by additional sperm. …”
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COMPARATION OF EFFECTIVENESS OF SILVER SULFADIAZINE AND GENTAMICIN ON ABRASION WOUND HEALING by Mohan Mohan, Muhammad Jailani, Mirnasari Amirsyah

“…Conclusions: The use of SSD in abrasion wound treatment is believed to have advantages in proliferation phase where SSD is a sulfonamide class antibiotic that produces synergic effects along with silver which constantly absorbs exudates and bacteria, combines chloride tissue and several other proteins in the process of wound healing.…”
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Comparative Study of Angiotensin Convertase Enzyme (ACE2) Gene Expression in Patients with Covid-19 By Molecular Method by Behrooz Farzanegan, Naghmeh Bahrami, Mohammad Fathi, Saba Tahmasebi, Mehdi Kazem Pour Dizaji, Shadi Shafaghi, Farnaz Ahmadi, Farnoush Mohammadi, Seyedeh Zahra Fotook Kiaei, Mona Mohajeri Tehrani, Masoume Farhangiyan, Abdolreza Mohamadnia

“…This particular virus spreads rapidly likely because of the Spike proteins affinity, to the human ACE2 cell receptor causing harm to organs, like the lungs in type 2 pneumocytes that abundantly express this receptor. …”
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Exosomal MicroRNAs Derived from Human Amniotic Epithelial Cells Accelerate Wound Healing by Promoting the Proliferation and Migration of Fibroblasts by Bin Zhao, Xiaodong Li, Xiaomin Shi, Xueqin Shi, Wei Zhang, Gaofeng Wu, Xujie Wang, Linlin Su, Dahai Hu

“…It is reported that exosomes, which are carriers of the microRNAs (miRNAs) and proteins, play an important role in the regulation of cell-to-cell communication. …”
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Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPARγ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease by Merilin Al Sharif, Petko Alov, Vessela Vitcheva, Ilza Pajeva, Ivanka Tsakovska

“…A detailed analysis was performed regarding proteins which PPARγ-mediated expression changes had been confirmed to be prosteatotic by most experimental evidence. …”
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Synergistic effects of alginate oligosaccharide and cyanidin-3-O-glucoside on the amelioration of intestinal barrier function in mice by Jie Li, Yuanjie Guo, Liyuan Ma, Yixiang Liu, Chao Zou, Huiying Kuang, Bing Han, Yingliang Xiao, Yanbo Wang

“…The results show that, in comparison to their individual applications, the combination of AOS and C3G (mass ratio, 3:1) displayed a stronger ability to up-regulate the expression of tight junction proteins, while enhanced intestinal epithelial barrier was also observed and levels of mucin-2 and β-defensins were simultaneously increased in the intestinal mucus. …”
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Effects and Impact of Selenium on Human Health, A Review by Song Bai, Miaohe Zhang, Shouying Tang, Miao Li, Rong Wu, Suran Wan, Lijun Chen, Xian Wei, Shuang Feng

“…As a key component of various enzymes and proteins, selenium primarily exerts its biological functions in the form of selenoproteins within the body. …”
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Intrinsic interaction inferred oxidative stress and apoptosis by Biosurfactant-microplastic hybrid reduces coordinated in vivo biotoxicity in zebrafish (Danio rerio) by Utsa Saha, Aishee Ghosh, Adrija Sinha, Aditya Nandi, Sudakshya S. Lenka, Abha Gupta, Shalini Kumari, Anu Yadav, Mrutyunjay Suar, Nagendra Kumar Kaushik, Vishakha Raina, Suresh K. Verma

“…This effect was deduced as the intrinsic effects of hybridisation, which likely mitigated the bioavailability and toxicity of μP by reducing their molecular interaction with metabolic proteins like Sod1 and p53 through less accumulation and internalisation. …”
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Graphene nanomaterial-based electrochemical biosensors for salivary biomarker detection: A translational approach to oral cancer diagnostics by D. Mahalakshmi, J. Nandhini, G. Meenaloshini, E. Karthikeyan, KK Karthik, J. Sujaritha, Vandhana, V, C. Ragavendran

“…We discuss the unique advantages of saliva as a diagnostic medium and highlight the key salivary biomarkers associated with oral cancer, including proteins, DNA, and RNA. Various electrochemical detection techniques, such as cyclic voltammetry, differential pulse voltammetry, electrochemical impedance spectroscopy, field-effect transistors, amperometry, chronoamperometry, and photoelectrochemical methods, are explored in the context of graphene-based biosensors. …”
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Construction and Encapsulation of Colloidal Vesicles Based on Bovine Serum Albumin-Dextran Interfacial Assembly by Qianqian GUO, Dan LI, Yongli YANG, Li LI, Gaoyang YI, Xiaolin YAO

“…As colloidal structural components, the colloidal vesicles formed by the modified proteins and polysaccharides were a unique type of artificial cells with good membrane permeability, so they were widely used in cell engineering, biosensing, drug delivery and functional foods. …”
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Nature’s magic: how natural products work hand in hand with mitochondria to treat stroke by Lin Cheng, Shangbin Lv, Chengkai Wei, Sucheng Li, Hao Liu, Yong Chen, Zhaoliang Luo, Hongyan Cui

“…These compounds reduce neuronal apoptosis by modulating the expression of mitochondrial-associated apoptotic proteins. They inhibit the activation of the mitochondrial permeability transition pore (mPTP), thereby decreasing ROS production and cytochrome C release, which helps preserve mitochondrial function. …”
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An advanced 3D lymphatic system for assaying human cutaneous lymphangiogenesis in a microfluidic platform by Minseop Kim, Sieun Choi, Dong-Hee Choi, Jinchul Ahn, Dain Lee, Euijeong Song, Hyun Soo Kim, Mijin Kim, Sowoong Choi, Soojung Oh, Minsuh Kim, Seok Chung, Phil June Park

“…The lymphatic system plays important roles in removing cell waste, residual proteins, various antigens, and immune cells from tissues to maintain homeostasis and activate the immune system through the drainage of interstitial fluid1,2. …”
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Superficial Dsg2 Expression Limits Epidermal Blister Formation Mediated by Pemphigus Foliaceus Antibodies and Exfoliative Toxins by Donna Brennan, Ying Hu, Walid Medhat, Alicia Dowling, Mỹ G. Mahoney

“…Cell-cell adhesion mediated by desmosomes is crucial for maintaining proper epidermal structure and function, as evidenced by several severe and potentially fatal skin disorders involving impairment of desmosomal proteins. Pemphigus foliaceus (PF) and staphylococcal scalded skin syndrome (SSSS) are subcorneal blistering diseases resulting from loss of function of the desmosomal cadherin, desmoglein 1 (Dsg1). …”
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Nostoc commune Vauch. polysaccharide alleviates Pb-induced hepatorenal toxicity by changing gut bacteriome, mycobiome, and metabolome by Yue Liu, Ping Ren, Hailong Li, Yingying Liu, Yiting Yang, Wanting Wang, Jiaming Zhou, Ling Su, Lili Guan, Hongxia Ma

“…Moreover, the down-regulation of critical proteins of the Nrf2 pathway induced by Pb could be reversed after NCVP intervention. …”
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Guanidines Conjugated with Cell-Penetrating Peptides: A New Approach for the Development of Antileishmanial Molecules by João Victor Marcelino de Souza, Natalia C. S. Costa, Maria C. O. Arruda Brasil, Luana Ribeiro dos Anjos, Renata Priscila Barros de Menezes, Eduardo Henrique Zampieri, Jhonatan Santos de Lima, Angela Maria Arenas Velasquez, Luciana Scotti, Marcus Tullius Scotti, Marcia A. S. Graminha, Eduardo R. Pérez Gonzalez, Eduardo Maffud Cilli

“…Docking studies confirmed the higher interaction of the conjugate with CPP and suggested that other proteins, such as trypanothione reductase, could be targeted. …”
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Fabrication and evaluation of a portable and reproducible quartz crystal microbalance immunochip for label-free detection of β-lactoglobulin allergen in milk products by Mingfei Pan, Liping Hong, Jingying Yang, Xiaoqian Xie, Kaixin Liu, Shuo Wang

“…Additionally, this portable QCM immunochip had good stability, high specificity, and no obvious cross-reaction to three other milk proteins (α-casein, α-lactalbumin, and lactoferrin). …”
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Extracellular matrix re-normalization to improve cold tumor penetration by oncolytic viruses by Geofrey F. Soko, Geofrey F. Soko, Benson K. Kosgei, Stephene S. Meena, Stephene S. Meena, Ying Jing Ng, Huihui Liang, Bing Zhang, Qingjun Liu, Tielong Xu, Xinju Hou, Xinju Hou, Ray P. S. Han

“…Aberrant expressions of matrix proteins by cancer-associated fibroblasts (CAFs) alter the mechanical properties of the tumor extracellular matrix (ECM). …”
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Molecular Features and Methylation Status in Early Onset (≤40 Years) Colorectal Cancer: A Population Based, Case-Control Study by Giulia Magnani, Daniela Furlan, Nora Sahnane, Luca Reggiani Bonetti, Federica Domati, Monica Pedroni

“…Thirty-three patients ≤40 years with diagnosis of colorectal cancer and 41 patients with disease at >60 years of age were investigated for MSI, Mismatch Repair proteins expression, KRAS and BRAF mutations, hypermethylation, and LINE-1 hypomethylation. …”
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Enhancing foundation models for scientific discovery via multimodal knowledge graph representations by Vanessa Lopez, Lam Hoang, Marcos Martinez-Galindo, Raúl Fernández-Díaz, Marco Luca Sbodio, Rodrigo Ordonez-Hurtado, Mykhaylo Zayats, Natasha Mulligan, Joao Bettencourt-Silva

“…., unseen molecules and proteins, rear diseases). Finally, fostering openness and collaboration is key to accelerate scientific breakthroughs.…”
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Association of mitochondrial haplogroup F with physical performance in korean population by In Wook Hwang, Kicheol Kim, Eun Ji Choi, Han Jun Jin

“…Mitochondrial DNA (mtDNA) encodes essential proteins for oxidative phosphorylation, which is related to aerobic capacity. …”
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