Functional Stability of Plasminogen Activator Inhibitor-1 by Songul Yasar Yildiz, Pinar Kuru, Ebru Toksoy Oner, Mehmet Agirbasli

“…Environmental conditions, interaction with other proteins, mutations, and glycosylation are the main factors that have a significant impact on the stability of the PAI-1 structure. …”
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The Neuroprotective Disease-Modifying Potential of Psychotropics in Parkinson's Disease by Edward C. Lauterbach, Leonardo F. Fontenelle, Antonio L. Teixeira

“…The authors investigated the effects of psychotropics on pathobiological proteins, proteasomal activity, mitochondrial functions, apoptosis, neuroinflammation, trophic factors, stem cells, and neurogenesis. …”
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Integrated bioinformatic approach of Balur therapy for breast cancer subtypes by Aristyani Sherry, Subagjo Saraswati, Rahayu Tintrim, Sumitro Sutiman B.

“…The Cytoscape software was used to construct the network of Balur compounds and target proteins of breast cancer subtypes. Gene Ontology, pathway, docking, hub gene, and survival analysis were applied to investigate the detailed mechanism of Balur to breast cancer in each subtype. …”
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FOOD THERAPY AND EDUCATION NEXUS AGRONOMIC FRAMEWORK. EVIDENCE FROM MOUNTAIN BERRIES by R. Brejea, M. Covaci, B. Covaci, C. Selma

“…Methods: In this study, the authors delve into nutritional information, encompassing calories, fats, carbohydrates, fibres, and proteins, comparing values for regular berries (based on USDA values) and mountain berries (derived from their own research). …”
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Delayed drug hypersensitivity reactions: How p-i transforms pharmacology into immunology by Werner J. Pichler

“…P-i activation differs from classical antigen-driven immune reactions: a) drug binding induces structural changes in TCR-HLA proteins which make them look like allo-like TCR-HLA-complexes, able to elicit allo-like stimulations of T cells with cytotoxicity and IFNγ production, notably without the involvement of innate immunity; b) drug binding to TCR and/or HLA can increase the affinity of TCR-HLA interactions, which may affect signaling and IL-5 production by CD4+ T cells, and thus contribute to eosinophilia commonly found in dDHRs or induce oligoclonal T cell expansions; c) Both, antigen and p-i stimulations can induce eosinophil- or neutrophil-rich inflammations; but these stimulations should be distinguished as their underlying mechanism and development differ; and d) p-i stimulation can – like graft versus host reactions – result in long-lasting T-cell activations, which can lead to viremia, occasional autoimmunity, or a new syndrome characterized by multiple drug hypersensitivity (MDH).In summary, dDHRs are not allergic reactions but represent peculiar T-cell activations, similar to allo-like stimulations. …”
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The Pyrolytic Profile of Lyophilized and Deep-Frozen Compact Part of the Human Bone by Jolanta Lodowska, Daniel Wolny, Sławomir Kurkiewicz, Ludmiła Węglarz

“…The pyrolyzates were the most abundant in derivatives of pyrrole and nitriles originated from proteins. The predominant product in pyrolytic pattern of the investigated bone was pyrrolo[1,2-α]piperazine-3,6-dione derived from collagen. …”
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Antioxidant and Neuroproliferative Effects of THL-3-PTD5 Peptide Derived from Hydramacin-1 Antimicrobial Peptide by Ping-Chien Lee, Ching-Chun Lin, Hui-Hsuan Hsu, Feng-Di T. Lung

“…Notably, the macin family of proteins exhibits potent antimicrobial activity and nerve repair effects. …”
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Meta-Analysis of Pulmonary Transcriptomes from Differently Primed Mice Identifies Molecular Signatures to Differentiate Immune Responses following Bordetella pertussis Challenge by René H. M. Raeven, Jeroen L. A. Pennings, Elly van Riet, Gideon F. A. Kersten, Bernard Metz

“…Additionally, 46 genes encoding for secreted proteins may serve as markers in blood for the degree of protection (Cxcl9, Gp2, and Pla2g2d), intensity of infection (Retnla, Saa3, Il6, and Il1b), or adaptive recall responses (Ighg, C1qb). …”
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Methylated H3K4, a transcription-associated histone modification, is involved in the DNA damage response pathway. by David Faucher, Raymund J Wellinger

“…Eukaryotic genomes are associated with a number of proteins such as histones that constitute chromatin. …”
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The small GTPase MRAS is a broken switch by Gabriela Bernal Astrain, Regina Strakhova, Chang Hwa Jo, Emma Teszner, Ryan C. Killoran, Matthew J. Smith

“…Abstract Intense research on founding members of the RAS superfamily has defined our understanding of these critical signalling proteins, leading to the premise that small GTPases function as molecular switches dependent on differential nucleotide loading. …”
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Mitochondria of transformed cell as a target of antitumor influence by E. M. Frantsiyants, I. V. Neskubina, E. A. Sheiko

“…Mitochondria have the ability to control the activation of programmed cell death by regulating the translocation of proapoptotic proteins from the intermediate space of mitochondria to the cytosol. …”
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Morphine in Combination with Ketamine Improves Cervical Cancer Pain and Suppresses Immune Function via the JAK3/STAT5 Pathway by Yurong Jiang, Tong Li, Yi Qian, Xiaoming Zuo, Jinmei Liu

“…Western blotting was used for detection of JAK3/STAT5 pathway-related proteins after naltrexone treatment in vitro. Afterwards, all the patients were further divided into the morphine group and the Mor + Ket group in accordance with the principles of the randomized and double-blind method to assess pain intensity. …”
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A systematic review assessing the osseoincorporation potential of trabecular dental implants: A current evidence and future directions by Karuna S. Patwardhan, Nisha Puranik, Hema Kanathila, Santosh Yamanappa Nelogi, Vasanti P Jirge

“…Histologically, 2 studies showed upregulation of bone morphogenic proteins, collagens, and growth factors with respect to trabecular dental implants. …”
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In silico identification of switching nodes in metabolic networks by Mairet, Francis

“…Additionally, switch metabolites are deeply involved in post-translational modification of proteins, showing their importance in cellular regulation. …”
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Elucidation of peptide screen for targeted identification of Yersinia pestis by nano-liquid chromatography tandem mass spectrometry by Priya Rani, Syed Imteyaz Alam, Sandeep Singh, Subodh Kumar

“…Additionally, 148 peptides were discovered from proteins of Y. pestis-specific plasmids and chromosomal-associated virulence markers. …”
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The expression of different gene constructs in Escherichia coli SM lux biosensor after exposure to drugs by Grażyna Łaska, Marzena Matejczyk, Urszula Dauksza

“…In the analysis of the induction of the promoter (regulatory proteins) to the control (0 µg/ml), the highest biosensor response was shown in the case of kanamycin concentration equal to 0.625 µg/mL after 1-h incubation. …”
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High-Affinity Detection of Alpha-Synuclein by Aptamer-Gold Conjugates on an Amine-Modified Dielectric Surface by Xuemei You, Subash C. B. Gopinath, Thangavel Lakshmipriya, Dingan Li

“…Control experiments were performed with two closely related proteins, amyloid-beta and tau, to reveal the specificity; the results show that the aptamer only recognized alpha-synuclein. …”
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Prevalence of Helicobacter pylori Genes (CagA, BabA, and HomB) with Stem Cell Markers (LGR5 and CD133) in Severity of Gastric Disease by Safyia Khalid Abdullah, Wasan Abdul-elah Bakir, Mais Ibrahim Alsikafi

“…It adheres to the gastric epithelium, with an important aspect of the pathogenicity of the microorganism facilitating the transport of certain proteins such as CagA, BabA, and Hom into that epithelium. …”
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Factors associated with iron deficiency aneamia among pregnant women at Chuk hospital in Kigali, Rwanda by Mercy Nwankwo, Chinenye, Hashim Abdullahi, Fardosa

“…A balanced diet, rich in proteins, iron and vitamins from good sources like liver, meat, eggs, green peas, figs, beans, whole wheat and green bananas remains very critical in tackling iron deficiency anaemia problem among the pregnant women. …”
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Blood biomarker dynamics in people with relapsing multiple sclerosis treated with cladribine tablets: results of the 2-year MAGNIFY-MS study by Heinz Wiendl, Frederik Barkhof, Frederik Barkhof, Xavier Montalban, Anat Achiron, Anat Achiron, Tobias Derfuss, Andrew Chan, Suzanne Hodgkinson, Alexandre Prat, Letizia Leocani, Letizia Leocani, Letizia Leocani, Klaus Schmierer, Klaus Schmierer, Finn Sellebjerg, Finn Sellebjerg, Patrick Vermersch, Hulin Jin, Anita Chudecka, Andreas Kloetgen, Dongdong Lin, Lidia Gardner, Nicola De Stefano

“…In addition to lymphocyte kinetics, we studied intracellular cytokines serum proteins, and their associations with clinical outcomes. …”
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