Nanosuspension Innovations: Expanding Horizons in Drug Delivery Techniques by Shery Jacob, Fathima Sheik Kather, Sai H. S. Boddu, Mahesh Attimarad, Anroop B. Nair

“…Rapid advances in the field of NS could resolve issues related to permeability-limited absorption and hepatic first-pass metabolism, offering promise for medications based on proteins and peptides. The evolution of novel stabilizers is essential to overcome the current limitations in NS formulations, enhancing their stability, bioavailability, targeting ability, and safety profile, which ultimately accelerates their clinical application and commercialization.…”
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Human Urine-Derived Stem Cells: Potential for Cell-Based Therapy of Cartilage Defects by Long Chen, Lang Li, Fei Xing, Jing Peng, Kun Peng, Yuanzheng Wang, Zhou Xiang

“…In this study, we revealed that induced hUSCs expressed chondrogenic-related proteins, including aggrecan and collagen II, and their gene expression levels were upregulated in vitro. …”
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ATG8 delipidation is not universally critical for autophagy in plants by Yong Zou, Jonas A. Ohlsson, Sanjana Holla, Igor Sabljić, Jia Xuan Leong, Florentine Ballhaus, Melanie Krebs, Karin Schumacher, Panagiotis N. Moschou, Simon Stael, Suayib Üstün, Yasin Dagdas, Peter V. Bozhkov, Elena A. Minina

“…Abstract Intracellular recycling via autophagy is governed by post-translational modifications of the autophagy-related (ATG) proteins. One notable example is ATG4-dependent delipidation of ATG8, a process that plays critical but distinct roles in autophagosome formation in yeast and mammals. …”
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Use of Immunostimulants in Shrimp Farming—A Bioeconomic Perspective by Héctor Rodrigo Nolasco-Alzaga, Elizabeth Monreal-Escalante, Mariel Gullian-Klanian, Juan Antonio de Anda-Montañez, Antonio Luna-González, Fernando Aranceta, Marcelo E. Araneda-Padilla, Carlos Angulo

“…In this regard, dietary immunostimulants have been tested at the farm level, such as carbohydrates and proteins known to enhance immunity and improve survival rates under experimental conditions. …”
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The Multifaceted Role of Extracellular Vesicles in Glioblastoma: microRNA Nanocarriers for Disease Progression and Gene Therapy by Natalia Simionescu, Radu Zonda, Anca Roxana Petrovici, Adriana Georgescu

“…Extracellular vesicles (EVs), a heterogeneous group of cell-derived vesicles, transport miRNAs, mRNAs and intracellular proteins, and have been shown to promote horizontal malignancy into adjacent tissue, as well as resistance to conventional therapies. …”
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Muscle-derived extracellular vesicles mediate crosstalk between skeletal muscle and other organs by Jiajie Jia, Jiajie Jia, Lu Wang, Lu Wang, Yue Zhou, Peng Zhang, Xiaoping Chen

“…Numerous bioactive molecules are secreted by SKM and transported by extracellular vesicles (EVs), a novel class of mediators of communication between cells and organs that contain various types of cargo molecules including lipids, proteins and nucleic acids. SKM-derived EVs (SKM-EVs) are intercellular communicators with significant roles in the crosstalk between SKM and other organs. …”
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Astragaloside IV attenuates cadmium induced nephrotoxicity in rats by activating Nrf2 by Yuchen Li, Jiayi Zhou, Tianxin Zhang, Xiaocong Li, Cheng Wu, Ziyi Zhao, Jianyuan Tang, Xiaoyu Tan, Qiongying Hu, Wenhao Liao

“…Expression of the mitochondria-associated apoptotic proteins Cleaved-Caspase3, Cleaved-Caspase9, and Cleaved-PARP was significantly reduced after AS-IV intervention. …”
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Resistance to Radiotherapy in Cancer by Almaz A. Akhunzianov, Elvira V. Rozhina, Yuliya V. Filina, Albert A. Rizvanov, Regina R. Miftakhova

“…These biomarkers mainly include proteins involved in metabolism and cell signaling pathways.…”
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Online Monitoring Oxidative Products and Metabolites of Nicotine by Free Radicals Generation with Fenton Reaction in Tandem Mass Spectrometry by Shih-Shin Liang, Yow-Ling Shiue, Chao-Jen Kuo, Su-Er Guo, Wei-Ting Liao, Eing-Mei Tsai

“…Fenton reaction generates free radicals via ferrous ion (Fe2+) and hydrogen peroxide (H2O2) to oxidize DNA and to degrade proteins in cells. In the EEO method, the oxidative products of nicotine including cotinine, cotinine-N-oxide, trans-3′-hydroxycotinine, nornicotine, norcotinine, 4-oxo-4-(3-pyridyl)-butanoic acid, 4-hydroxy-4-(3-pyridyl)-butanoic acid, and nicotine-N′-oxide were detected by tandem mass spectrometer to simulate the changes of nicotine and its derivatives in a time-dependent manner.…”
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Advanced Piezoelectric Materials, Devices, and Systems for Orthopedic Medicine by Jingkai Zhang, Chang Liu, Jun Li, Tao Yu, Jing Ruan, Fan Yang

“…Recent studies showed that piezoelectricity can impact microenvironments by regulating molecular sensors including ion channels, cytoskeletal elements, cell adhesion proteins, and other signaling pathways. This review thus focuses on discussing the pioneering applications of piezoelectricity in the diagnosis and treatment of orthopedic diseases, aiming to offer valuable insights for advancing next‐generation medical technologies. …”
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pVAXhsp65 Vaccination Primes for High IL-10 Production and Decreases Experimental Encephalomyelitis Severity by Sofia Fernanda Gonçalves Zorzella-Pezavento, Fernanda Chiuso-Minicucci, Thais Graziela Donegá França, Larissa Lumi Watanabe Ishikawa, Larissa Camargo da Rosa, Priscila Maria Colavite, Bianca Balbino, Camila Marques, Maura Rosane Valerio Ikoma, Ana Paula Masson, Célio Lopes Silva, Alexandrina Sartori

“…Considering the presence of an immune response directed to heat shock proteins (hsps) in autoimmune diseases and the immunoregulatory potential of these molecules, we evaluated the effect of a previous immunization with a genetic vaccine containing the mycobacterial hsp65 gene on EAE development. …”
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Anti-obesity effects of fucoidan from Sargassum thunbergii in adipocytes and high fat diet induced obese mice through inhibiting adipogenic specific transcription factor by Hyo-Geun Lee, H.H.A.C.K. Jayawardhana, Fengqi Yang, D.P. Nagahawaththa, N.M. Liyanage, Kyung-Mo Song, Yun-Sang Choi, Seung-Hong Lee, You-Jin Jeon, Min-Cheol Kang

“…According to the results, the STAF3, showed the highest xylose content and exhibited significant inhibitory effects on lipid accumulation by downregulating adipogenic and lipogenic proteins in 3T3-L1 cells. Furthermore, oral supplementation with STAC significantly declined gain in body weight and fat weight, and serum lipid contents in an HFD-induced obesity mouse model. …”
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Hydroxyapatite Chitosan Gradient Pore Scaffold Activates Oxidative Phosphorylation Pathway to Induce Bone Formation by Zeliang Zhang, Wei Shang, Lisong Lin

“…In vitro experiments indicated that the scaffolds had good biocompatibility, promoted the expression of osteogenesis-related genes and proteins, and activated the oxidative phosphorylation pathway to promote bone regeneration. …”
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It’s about TIME – Gal-9 as a potential immunotherapeutic target in pancreatic ductal adenocarcinoma by Christin Knickmeier, Gaetan Aime Noubissi Nzeteu, Bernhard F. Gibbs, Frederik J. H. Hoogwater, Maarten W. Nijkamp, Maximilian Bockhorn, N. Helge Meyer

“…Central to the progression and immune evasion of PDAC is the tumor (immune) microenvironment (TIME), where immune checkpoint proteins such as galectin-9 (Gal-9) play pivotal roles. …”
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Cas12e orthologs evolve variable structural elements to facilitate dsDNA cleavage by Danyuan Li, Shouyue Zhang, Shuo Lin, Wenjing Xing, Yun Yang, Fengxia Zhu, Dingding Su, Chunlai Chen, Jun-Jie Gogo Liu

“…Further structural comparisons reveal that the unique NTSB domain in PlmCas12e is beneficial to DNA unwinding at high salt concentrations, while some NTSB-lacking Cas12e proteins rely on positively charged loops for dsDNA unwinding. …”
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Mesenchymal Stem Cell-Derived Extracellular Vesicles: Roles in Tumor Growth, Progression, and Drug Resistance by Xiaoyan Zhang, Huaijun Tu, Yazhi Yang, Lijun Fang, Qiong Wu, Jian Li

“…Different studies have reported that MSC-EVs may exert various effects on the growth, metastasis, and drug response of different tumor cells by transferring proteins, messenger RNA, and microRNA to recipient cells. …”
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Drimartol B, a sesquiterpene coumarin of the edible powder of Artemisia sphaerocephala seed, induced apoptosis in NSCLC cells via PI3K/AKT/FoxO3a pathway inhibition by Jiwen Li, Zhongyu Li, Mengru Cui, Mei Sun, Lei Men, Xiaojie Gong, Keke Li

“…Molecular docking demonstrated favorable binding affinities between drimartol B and these proteins. Moreover, the regulatory role of drimartol B in NSCLC cells via PI3K/AKT/FoxO3a pathway was confirmed by co-treatment with SC-79 or JY-2. …”
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The Importance of Breakfast in Enhancing Students' Focus at School by Nurul Widad Fitri Muhammad, Nur Aina Mardhiah Che Rahim, Amrina Rasyada Kamaruzaman, Noor Fatimah Mujahid, Khairulnazrin Nasir

“…The results demonstrate that eating a healthy breakfast, a combination of carbohydrates, proteins and vegetables, does help students focus better in class. …”
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Targeting T-Cell Activation for Malaria Immunotherapy: Scoping Review by Balsa Nobility Gustifante, Shafia Khairani, Nisa Fauziah, Silvita Fitri Riswari, Afiat Berbudi

“…The genetic variability of <i>Plasmodium</i> proteins complicates the development of long-lasting immunity, as it impedes the human immune system’s ability to sustain effective responses. …”
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Effects of pollen enriched diet on hypopharyngeal glands’ morphology and morphometry and vitellogenin transcription levels in honey bees by Claudia D’Emilio, Viviana Valenzano, Paola Maiolino, Karen Power, Manuela Martano, Gennaro Di Prisco

“…Pollen proteins are necessary for the development of the hypopharyngeal glands (HPGs), and for Vitellogenin (VG) synthesis, responsible for producing royal jelly, essential for larval development and queen feeding. …”
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