The EGFR-ADAM17 Axis in Chronic Obstructive Pulmonary Disease and Cystic Fibrosis Lung Pathology by Marta Stolarczyk, Bob J. Scholte

“…In airway epithelial cells, ADAM17 sheds multiple soluble signaling proteins by proteolysis, including EGFR ligands such as amphiregulin (AREG), and proinflammatory mediators such as the interleukin 6 coreceptor (IL-6R). …”
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Vesicles Generated during Storage of Red Blood Cells Enhance the Generation of Radical Oxygen Speciesin Activated Neutrophils by Herbert Jank, Ulrich Salzer

“…Vsto vesicles of blood transfusions have been shown to deliver glycosylphosphatidylinositol-linked proteins to recipient erythrocytes, to display prothrombotic activity, and to have an inhibitory effect on macrophages. …”
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A Review of the Prospective Effects of Spacing and Varieties on Onion Yield and Yield Components (Allium cepa L.) in Ethiopia by Yohannes Gelaye, Kelemu Nakachew, Solomon Ali

“…Countries around the world are producing onion for its nutritional value, medicinal properties, minerals, proteins, and carbohydrates. In terms of production, onion ranks second only after tomatoes. …”
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Inhibition of Glycogen Synthase Kinase and the Neuroprotective Function of Conjugated ZnO-Osthol Nanoparticles in Alzheimer’s Disease by Nahed S. Alharthi, Fahad M. Aldakheel, Abdulkarim S. Binshaya

“…Osthol treatment has also prevented synaptic proteins such as postsynaptic density-95 (PSD-95), synaptophysin (SYP), and synapsin-1 from decreasing in APP-induced BE (2)-M17 cells. …”
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A Comprehensive Review of the Development and Therapeutic Use of Antivirals in Flavivirus Infection by Aarti Tripathi, Shailendra Chauhan, Renu Khasa

“…Various approaches have been extensively utilized in clinical trials for antiviral development, targeting virus entry, replication, polyprotein synthesis and processing, and egress pathways exploiting virus as well as host proteins. However, to date, no licensed antiviral drug exists to treat the diseases caused by these viruses. …”
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ANRIL regulates retinoblastoma progression via targeting autophagy by miR-328-3p/TSC1/ULK signaling by Yang Yang, Yuezhi Zhang, Yanmei Fu, Shuanglian Li, Xiaolong Yin

“…Here, our data demonstrated that ANRIL overexpression inhibited miR-328-3p expression, but promoted expression of autophagy-related proteins (LC3B, ATG5, and BECN1). Then we predicted the binding sites for ANRIL with miR-328-3p, and for miR-328 3p with TSC1/ULK2 3′-UTR, and confirmed the combination of miR-328-3p and ANRIL and TSC1/ULK2 3′-UTR. …”
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Phytochemical, Antioxidant, Anti-Inflammatory, and Thrombolytic Properties of Cleisomeria lanatum (Lindl.) Lindl. ex G. Don by Minhajur Rahman, Abu Taleb Surag, Roxy Begum, Md. Shakhuat Hossain Tusher, Mohammed Kamrul Huda

“…In quantitative screening, a maximum of 106.02 ± 0.08 mg/g alkaloids (root), 179.67 ± 8.83 mg/g phenols (stem), 17.34 ± 0.88 mg/g flavonoids (stem), 73.67 ± 1.76 mg/g tannins (stem), and 180.04 ± 0.02 μg/mL proteins (root) were detected. Antioxidant, anti-inflammatory, and thrombolytic properties were investigated using a free-radical scavenging assay, heat-induced albumin denaturation assay, and blood clotting inhibition assay. …”
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Hijacking the Cellular Mail: Exosome Mediated Differentiation of Mesenchymal Stem Cells by Raghuvaran Narayanan, Chun-Chieh Huang, Sriram Ravindran

“…Additionally, exosomes can also bind to matrix proteins such as type I collagen and fibronectin enabling them to be tethered to biomaterials. …”
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Ribitol and ribose treatments differentially affect metabolism of muscle tissue in FKRP mutant mice by Marcela P. Cataldi, Qi L. Lu

“…Abstract Dystroglycanopathy is characterized by reduced or lack of matriglycan, a cellular receptor for laminin as well as other extracellular matrix proteins. Recent studies have delineated the glycan chain structure of the matriglycan and the pathway with key components identified. …”
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Ground Wheat Grain for Midlactation Cows: Challenging a Common Wisdom by A. Nikkhah, F. Amiri, H. Amanloo

“…GW at 10% versus 20% of diet DM decreased blood BHBA and increased blood concentrations of total proteins and albumin. Data provide novel evidence that both finely and coarsely ground WG can be safely fed up to 20% midlactation cows. …”
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Rereading of asian cuisine: bullfrog meat (Aquarana catesbeiana) enriching the flavor and nutritional value by José Teixeira de Seixas Filho, Laura Kiyoko Ide

“…The present work aimed to present ways of introducing frog meat into Asian cuisine, aiming to expand its enjoyment, mainly by people with food allergies to proteins of animal origin, as well as offering a healthy diet with low cholesterol and, finally, develop menus that make full use of the bullfrog carcass, with gastronomic and therapeutic recipes.…”
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A Systemic Network Triggered by Human Cytomegalovirus Entry by Anyou Wang, Li Ren, Hong Li

“…This network contains ten functional modules (i.e., groups of proteins) that coordinately respond to HCMV entry. …”
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Current Status of Plant-Based Bioactive Compounds as Therapeutics in Alzheimer’s Diseases by Dan Chen, Yun Sun

“…Numerous studies have shown that medicinal plants and their active ingredients can potentially mitigate AD by regulating various molecular mechanisms, including the production and aggregation of pathological proteins, oxidative stress, neuroinflammation, apoptosis, mitochondrial dysfunction, neurogenesis, neurotransmission, and the brain-gut microbiota axis. …”
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Effect of Tapuy (Philippine Rice Wine) Lees on the Gut Microbiota Profile and Lifespan under Normal and Stress Conditions in Drosophila melanogaster by Ma Carmela P. Dela Cruz, Paul Mark B. Medina

“…These lees have been reported to contain high concentrations of proteins and dietary fibers. However, studies showing the potential biological effects of consuming these lees are currently lacking. …”
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Millets as Future Grains: Need of Judicious Approach by Robin Badal, Arushi Saroch, Ankita Rai, Rohit Singh, Pramod Yadav, Shivakumar Harti, Pradeep Kumar Prajapati

“…In addition, to find unpublished information, a manual search was done in Ayurveda classical texts and college libraries.Review Methods:Millets are abundant in antioxidants, dietary fibers, polyphenols, phytochemicals, minerals, and proteins and are considered to be wholesome (Pathya) in specific disease conditions but also have some antinutritional properties. …”
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ISLRWR: A network diffusion algorithm for drug-target interactions prediction. by Lu Sun, Zhixiang Yin, Lin Lu

“…Moreover, after excluding the interference of homologous proteins (popular drugs or targets may lead to inflated prediction results), the ISLRWR algorithm still showed a significant performance improvement.…”
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Integrin-Linked Kinase: A Multi-functional Regulator Modulating Extracellular Pressure-Stimulated Cancer Cell Adhesion through Focal Adhesion Kinase and AKT by Shouye Wang, Marc D. Basson

“…Malignant cells in cancer patients may be exposed to physical forces such as extracellular pressure and shear, that stimulate their adhesion to matrix proteins, endothelium and surgical wounds. Pressure induces phosphorylation of AKT and focal adhesion kinase (FAK), which are required for pressure-stimulated cancer cell adhesion, but what mediates this effect is unknown. …”
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Chemigenetic Ca2+ indicators report elevated Ca2+ levels in endothelial Weibel-Palade bodies. by Julian Terglane, Nicole Mertes, Sarah Weischer, Thomas Zobel, Kai Johnsson, Volker Gerke

“…Weibel-Palade bodies (WPB) are secretory organelles exclusively found in endothelial cells and among other cargo proteins, contain the hemostatic von-Willebrand factor (VWF). …”
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Assessment of the nutritional constituents of Elaeis Guineensis Jacq exudates from different States of Nigeria by FI Obahiagbon, GE Ilori, JO Erhabor

“…The parameters determined were PH, taste, colour, relative density, alcohol, moisture, sucrose, proteins, acetic acid (acidity), thiamine, riboflavin, ascorbic acid and elemental constituents. …”
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Pathogenic role of lipids in non-alcoholic fatty liver disease by Yu. O. Shulpekova

“…According to modern concepts, at NAFLD stress of endoplasmic reticulum plays the central role in damage of liver cells which is accompanied by dysfunction of chaperone proteins. The subsequent biochemical changes cause disorders of cellular respiration, disorder of mitochondrial integrity, increase probability of hepatocyte death. …”
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