The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier... by Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella

“…Although the exact mechanism of cell uptake is not fully deciphered, a series of naïve experiments indicates an energy-dependent, carrier-mediated transport: the organic cation transporters (OCTs) are the likely proteins involved.…”
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The 40S ribosomal subunit recycling complex modulates mitochondrial dynamics and endoplasmic reticulum - mitochondria tethering at mitochondrial fission/fusion hotspots by Foozhan Tahmasebinia, Yinglu Tang, Rushi Tang, Yi Zhang, Will Bonderer, Maisa de Oliveira, Bretton Laboret, Songjie Chen, Ruiqi Jian, Lihua Jiang, Michael Snyder, Chun-Hong Chen, Yawei Shen, Qing Liu, Boxiang Liu, Zhihao Wu

“…The complex binds to fission-fusion proteins located at mitochondrial hotspots, regulating the functional assembly of endoplasmic reticulum-mitochondria contact sites (ERMCSs). …”
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Recent Advances in Biosensors Using Enzyme-Stabilized Gold Nanoclusters by Myeong-Jun Lee, Jeong-Hyeop Shin, Seung-Hun Jung, Byung-Keun Oh

“…However, because they are unstable in solution, AuNCs require stabilization by using ligands such as dendrimers, peptides, DNA, and proteins. As a result, the properties of AuNCs and their formation are determined by the ligand, so the selection of the ligand is important. …”
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Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells by Jian-Xin Lin, Ning Du, Peng Li, Majid Kazemian, Tesfay Gebregiorgis, Rosanne Spolski, Warren J. Leonard

“…IL-15 activates STAT5 proteins, which can form dimers or tetramers. We previously found that NK cell numbers are decreased in Stat5a−Stat5b tetramer-deficient double knockin (DKI) mice, but the mechanism was not investigated. …”
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Cytokines and Chemokines at the Crossroads of Neuroinflammation, Neurodegeneration, and Neuropathic Pain by Geeta Ramesh, Andrew G. MacLean, Mario T. Philipp

“…Cytokines and chemokines are proteins that coordinate the immune response throughout the body. …”
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Enhanced proteomic profiling of human plasma‐derived extracellular vesicles through charge‐based fractionation to advance biomarker discovery potential by Xianyi Su, Getúlio Pereira de Oliveira Júnior, Anne‐Lise Marie, Michal Gregus, Amanda Figueroa‐Navedo, Ionita C. Ghiran, Alexander R. Ivanov

“…Abstract The study introduces a charge‐based fractionation method for fractionating plasma‐derived extracellular vesicles (EVs) into sub‐populations aimed at the improved purification from free plasma proteins to enhance the diagnostic potential of EV sub‐populations for specific pathophysiological states. …”
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Nose to brain strategy coupled to nano vesicular system for natural products delivery: Focus on synaptic plasticity in Alzheimer's disease by Nunzia Maisto, Dalila Mango

“…However, several compounds, administered parenterally and orally, are unable to reach the brain due to the presence of the blood-brain barrier (BBB) which prevents the passage of external substances, such as proteins, peptides, or phytocompounds, representing a limit to the development of treatment for neurodegenerative diseases, such as AD. …”
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INTEGRATION OF SPENT GRAIN INTO FOOD PRODUCTS by ERŞOVA, Svetlana, SAITAN, Olesea, TARNA, Ruslan, RUMEUS, Iurie, CODINĂ, Georgiana Gabriela, GHENDOV-MOSANU, Aliona

“…It is characterized by a diverse chemical composition, mainly composed of proteins and dietary fibers and, to a lesser extent, lipids, minerals, phenolic compounds, as well as B vitamins and vitamin E. …”
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From Cartilage to Matrix: Protocols for the Decellularization of Porcine Auricular Cartilage by Ana Caroline dos Santos, Livia Maria Barbosa de Andrade, Raí André Querino Candelária, Juliana Casanovas de Carvalho, Maria Carolina Miglino Valbão, Rodrigo da Silva Nunes Barreto, Marcelo Domingues de Faria, Rogerio Leone Buchaim, Daniela Vieira Buchaim, Maria Angelica Miglino

“…In order to be classified as an ideal scaffold, it must be acellular, preserving its proteins and physical characteristics necessary for cell adhesion. …”
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Quercetin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy by Inhibiting ERK/NF-κB Pathway by Liwei Wu, Qinghui Zhang, Weiqi Dai, Sainan Li, Jiao Feng, Jingjing Li, Tong Liu, Shizan Xu, Wenwen Wang, Xiya Lu, Qiang Yu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Xiaoming Fan, Chuanyong Guo

“…The expression levels of liver enzymes, inflammatory cytokines, and other marker proteins were determined at 2, 8, and 24 hours after IR. …”
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Analysis of Toll-Like Receptors in Human Milk: Detection of Membrane-Bound and Soluble Forms by Chiara Cattaneo, Alice Caramaschi, Elena Uga, Michela Braghin, Gianluca Cosi, Chiara Peila, Maria C. Strozzi, Miriam Sabatini, Diego Gazzolo, Marcello Manfredi, Maria Cavaletto

“…We demonstrated the presence of only TLR2 in the milk fat globule membrane, while the immunoreactivity of TLR1/4/6 was ascribed to crossreaction with some interesting milk proteins sharing leucine-rich repeat domains. These results will provide new insights into the definition of the role of TLRs in intestinal immune regulation of the newborns.…”
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Skeletal Muscle Mitochondria and Aging: A Review by Courtney M. Peterson, Darcy L. Johannsen, Eric Ravussin

“…Mitochondria are the major producers of reactive oxygen species, which damage DNA, proteins, and lipids if not rapidly quenched. Animal and human studies typically show that skeletal muscle mitochondria are altered with aging, including increased mutations in mitochondrial DNA, decreased activity of some mitochondrial enzymes, altered respiration with reduced maximal capacity at least in sedentary individuals, and reduced total mitochondrial content with increased morphological changes. …”
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Loss of Sirtuin 7 impairs cell motility and proliferation and enhances S-phase cell arrest after 5-fluorouracil treatment in head and neck cancer by Marta Halasa, Syeda Afshan, Anna Wawruszak, Agata Borkowska, Klaudia Brodaczewska, Alicja Przybyszewska-Podstawka, Joanna Kalafut, Marzena Baran, Adolfo Rivero-Müller, Andrzej Stepulak, Matthias Nees

“…Additionally, SIRT7 deletion reduces the expression of G1 phase-associated proteins, Cyclin D and CDK4. Altogether, our study highlights SIRT7 as a promising therapeutic target in HNSCC, enhancing the effectiveness of treatment modalities such as combinational treatment.…”
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Triple-negative breast cancer modifies the systemic immune landscape and alters neutrophil functionality by Noor A. M. Bakker, Hannah Garner, Ewald van Dyk, Elisa Champanhet, Chris Klaver, Maxime Duijst, Leonie Voorwerk, Iris Nederlof, Rosie Voorthuis, Marte C. Liefaard, Marja Nieuwland, Iris de Rink, Onno B. Bleijerveld, Hendrika M. Oosterkamp, Lodewyk F. A. Wessels, Marleen Kok, Karin E. de Visser

“…Transcriptional, proteomic, and functional analyses revealed that neutrophils in mTNBC exhibited enhanced migratory capacity, elevated granule proteins, and higher ROS production. Some immune changes, such as reduced non-switched B cells and heightened neutrophil migration, were evident in earlier TNBC stages. …”
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Fluorescein-based SynNotch adaptors for regulating gene expression responses to diverse extracellular and matrix-based cues by Jeremy C. Tran, Christopher J. Kuffner, Alexander M. Marzilli, Ryan Emily Miller, Zachary E. Silfen, Jeffrey B. McMahan, D. Christopher Sloas, Christopher S. Chen, John T. Ngo

“…Abstract Synthetic Notch (SynNotch) receptors function like natural Notch proteins and can be used to install customized sense-and-respond capabilities into mammalian cells. …”
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Osteoimmunology: Major and Costimulatory Pathway Expression Associated with Chronic Inflammatory Induced Bone Loss by Tania N. Crotti, Anak A. S. S. K. Dharmapatni, Ekram Alias, David R. Haynes

“…The importance of the balance of the RANKL-RANK-OPG axis is discussed as well as the more recently appreciated role that receptors and adaptor proteins involved in the immunoreceptor tyrosine-based activation motif (ITAM) signaling pathway play. …”
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Engineering spatially-confined conduits to tune nerve self-organization and allodynic responses via YAP-mediated mechanotransduction by Xiaobin Luo, Jia Yang, Yonggang Zhao, Toshitatsu Nagayasu, Junlin Chen, Peilun Hu, Zhi He, Zifan Li, Jun Wu, Zhe Zhao, Guman Duan, Xiaodan Sun, Lingyun Zhao, Yongwei Pan, Xiumei Wang

“…Meanwhile, the decelerating axons exhibit excellent alignment and remyelination, thereby helping to prevent failure modes in nerve self-organization, such as axonal twisting in congested regions and overgrowth beyond the conduit’s capacity. Additionally, proteins associated with mechanical allodynia, including TRPA1 and CGRP, exhibit a gradual reduction in expression as spatial constraints tighten, a trend inversely validated by the administration of the YAP-targeted inhibitor Verteporfin. …”
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Essential Role of Thioredoxin 2 in Mitigating Oxidative Stress in Retinal Epithelial Cells by Eriko Sugano, Namie Murayama, Maki Takahashi, Kitako Tabata, Makoto Tamai, Hiroshi Tomita

“…The protective effect of Trx2 against oxidative stress was investigated by assessing cell viability, the kinetics of cell death, mitochondrial metabolic activity, and expression of heat shock proteins (Hsps) in Trx2-overexpressing cell lines generated by transfecting ARPE cells with an adeno-associated virus vector encoding Trx2. …”
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Personalized statin therapy: Targeting metabolic processes to modulate the therapeutic and adverse effects of statins by Zhuangqi Shi, Shuxin Han

“…However, the therapeutic efficiency and adverse effects of statins vary among different patients, which numerous clinical and epidemiological studies have attributed to genetic polymorphisms in statin-metabolizing enzymes and transport proteins. The metabolic processes of statins are relatively complex, involving spontaneous or enzyme-catalyzed interconversion between more toxic lactone metabolites and active acid forms in the liver and bloodstream, influenced by multiple factors, including the expression levels of many metabolic enzymes and transporters. …”
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PPARγ as a Novel Therapeutic Target in Lung Cancer by Aravind T. Reddy, Sowmya P. Lakshmi, Raju C. Reddy

“…Angiogenesis and secretion of certain matrix metalloproteinases and extracellular matrix proteins within the tumor microenvironment are also regulated by PPARγ. …”
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