Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis by Mahvash Sadeghi, Jalil Tavakol Afshari, Afsane Fadaee, Mohammadreza Dashti, Fatemeh Kheradmand, Sajad Dehnavi, Mojgan Mohammadi

“…They facilitate communication and signalling between cells by transferring a variety of biological substances, such as proteins, lipids, and nucleic acids like mRNA and miRNA. …”
Get full text

Treatment of irritable bowel syndrome: the past, present and future by V. T. Ivashkin, Ye. A. Poluektova, O. S. Lyashenko, D. V. Reykhart

“…Considering new data on IBS pathogenesis (disorder of intestinal microbiome, functional and structural remodeling of proteins of cell membrane at the level of synapses of spinal cord posterior horns), prescription of probiotics and peripheral opioid receptors agonists is proven as well. …”
Get full text

An antifouling polydopamine-based fluorescent aptasensor for determination of arginine kinase by Yanbo Wang, Huan Li, Jinru Zhou, Fangting Wang, Yifan Qian, Linglin Fu

“…The aptasensor showed great stability and resistance to nonspecific interference of background proteins and had a limit of detection (LOD) of 0.298 μg/mL. …”
Get full text

CircRNAs in colorectal cancer: potential roles, clinical applications, and natural product-based regulation by Jingjing Yang, Jingjing Yang, Qiqi Fan, Yiyun Wang, Yuanyue Liu, Xiaoning Xu, Yeqi Liang, Jiakang Xie, Jiajie Li, Fengting Ai, Yong Cao, Shangzhen Yu, Jinman Liu

“…CircRNAs regulate tumor-related signaling pathways through interactions with microRNAs (miRNAs) and proteins, playing key roles in tumorigenesis, progression, invasion, metastasis, and chemoresistance. …”
Get full text

Gut-Heart Axis: Microbiome Involvement in Restrictive Cardiomyopathies by Samuel Jaimez-Alvarado, Itzel Ivonn López-Tenorio, Javier Barragán-De los Santos, Dannya Coral Bello-Vega, Francisco Javier Roldán Gómez, Amedeo Amedei, Enrique Alexander Berrios-Bárcenas, María Magdalena Aguirre-García

“…Recent reports highlight the potential role of microbiome in amyloidogenesis, as certain bacteria produce proteins that accelerate the formation of amyloid fibrils. …”
Get full text

Efficacy of Primate Humoral Passive Transfer in a Murine Model of Pneumonic Plague Is Mouse Strain-Dependent by V. A. Graham, G. J. Hatch, K. R. Bewley, K. Steeds, A. Lansley, S. R. Bate, S. G. P. Funnell

“…A new acellular plague vaccine composed of two separate recombinant proteins (rF1 and rV) has been developed and assessed for immunogenicity in humans. …”
Get full text

Stimulative Effects of Low Intensity He-Ne Laser Irradiation on the Proliferative Potential and Cell-Cycle Progression of Myoblasts in Culture by Cui-Ping Zhang, Shao-Dan Li, Yan Chen, Yan-Ming Jiang, Peng Chen, Chang-Zhen Wang, Xiao-Bing Fu, Hong-Xiang Kang, Ben-Jian Shen, Jie Liang

“…Meanwhile, the expressions of cell-cycle regulatory proteins in the laser-treated myoblasts were markedly upregulated as compared to the unirradiated cells, indicating that LILI could promote the reentry of quiescent myoblasts into the cell division cycle. …”
Get full text

Research Progress of ROS-Mitochondrial Pathway on Cardiovascular Protection of Tea Polyphenols by Tingting DENG, Jinchan PI, Xiaoping PENG, Yufei YAO, Yiquan LI, Wenjuan LI

“…From the perspective of ROS-mitochondrial pathway, the article elucidates how tea polyphenols behaved the beneficial effects against cardiovascular diseases by modulating the expression of mitochondrial fusion and fission proteins, reducing the opening of mitochondrial membrane permeability transition pore, maintaining cellular calcium homeostasis, mitigating mitochondrial DNA damage and regulating mitochondrial apoptosis signaling pathways. …”
Get full text

The Cotransplantation of Olfactory Ensheathing Cells with Bone Marrow Mesenchymal Stem Cells Exerts Antiapoptotic Effects in Adult Rats after Spinal Cord Injury by Shifeng Wu, Guanqun Cui, Hua Shao, Zhongjun Du, Jack C. Ng, Cheng Peng

“…We examined the changes in body weight, histopathological changes, apoptosis, and the expressions of apoptosis-related proteins after 14 days and 28 days after transplantation. …”
Get full text

Free radicals and their impact on health and antioxidant defenses: a review by Nisansala Chandimali, Seon Gyeong Bak, Eun Hyun Park, Hyung-Jin Lim, Yeong-Seon Won, Eun-Kyung Kim, Sang-Ik Park, Seung Jae Lee

“…Oxidative stress results in the damage of critical biomolecules like DNA, proteins, and lipids, contributing to the pathogenesis of various diseases. …”
Get full text

Concentration Kinetics of Serum MMP-9 and TIMP-1 after Blunt Multiple Injuries in the Early Posttraumatic Period by M. Brumann, T. Kusmenkov, L. Ney, K.-G. Kanz, B. A. Leidel, P. Biberthaler, W. Mutschler, V. Bogner

“…The aim of this paper was now to evaluate the posttraumatic serum levels and the time course of both proteins depending on distinct clinical parameters. 60 multiple traumatized patients (ISS > 16) were included. …”
Get full text

Identification and characterization of a novel tetrapeptide from enzymatic hydrolysates of Baijiu byproduct by Qiang Wu, Changqing Zhong, Guirong Zeng, Xu Zhang, Liping Xiang, Chang Wan, Yougui Yu

“…The peptide QGVP hydrolyzed from distilled spent grain proteins of Chinese strong-flavor Baijiu was expected to be used as a food ingredient to prevent or co-treat hypertension with other chemical drugs.…”
Get full text

Identification and analysis of immunological activity of two isoforms of tropomyosin in Alectryonella plicatula by Shiqiang Yang, Yexin Chen, Fei Huan, Xinrong He, Xiao Yun, Hong Liu, Guixia Chen, Guangming Liu

“…The sequences of 852 bp encoding 284 amino acids of TM-α/-β and 2 recombinant proteins were obtained, respectively. There were 12 amino acid differences between TM-α/-β. …”
Get full text

Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents by Benjamin Victoir, Océane Pertegaz, Elfi Ducrocq, Marion Polomski, Maxime Guéguinou, William Raoul, Cécile Croix, Gildas Prié

“…The involvement of STAT3/5 in the development of colorectal cancer is well established and has led to the development of new inhibitors of these proteins. This work was guided by the previous identification of a potent STAT5 inhibitor in the fight against myeloid leukemias. …”
Get full text

Importance diagnostique et prognostique des certains parametres sanguins et de liquide perltoneal chez les chevaux atteints de coliques by Veysi ASLAN, Kürşat TURGUT, Abdullah BAŞOĞLU, Mahmut OK

“…Les examens cliniques et laboratoires (proteine total, lacate, fibrtnogene et glucose sanguine et de liquide peritoneal) ont ete realises. …”
Get full text

Human microbiomes in cancer development and therapy by Chenglai Xia, Jiyan Su, Can Liu, Zhikai Mai, Shuanghong Yin, Chuansheng Yang, Liwu Fu

“…Abstract Colonies formed by bacteria, archaea, fungi, and viral groups and their genomes, metabolites, and expressed proteins constitute complex human microbiomes. An increasing evidences showed that carcinogenesis and disease progression were link to microbiomes. …”
Get full text

Endocan in Cancers: A Lesson from a Circulating Dermatan Sulfate Proteoglycan by Maryse Delehedde, Lucie Devenyns, Claude-Alain Maurage, Romain R. Vivès

“…Endocan is naturally expressed by endothelial cells, highly regulated in presence of proinflammatory and proangiogenic molecules, binds to matrix proteins, growth factors, integrin, and cells, and may be then considered as an accurate marker of endothelial activation. …”
Get full text

Co-Supplementation of Flos Sophorae Extract with Tremella fuciformis Polysaccharides Improves Physicochemical, Textural, Rheological, and Antioxidant Properties of Low-Fat Yogurts by Renyong Tang, Yurong Lu, Caiyun Hou, Jiaxuan Peng, Wei Wang, Xiulan Guo

“…Flos Sophorae extract (FSE) with abundant rutin and Tremella fuciformis polysaccharides (TP) could act as novel natural improvers of low-fat yogurt due to their health benefits and properties of interacting with proteins. This study attempted to understand how FSE or its combination with TP influences physicochemical, textural, and antioxidant properties of low-fat yogurts. …”
Get full text

Evidence for Directed Evolution of Larger Size Motif in Arabidopsis thaliana Genome by Rajesh Mehrotra, Amit Yadav, Purva Bhalothia, Ratna Karan, Sandhya Mehrotra

“…Transcription control of gene expression depends on a variety of interactions mediated by the core promoter region, sequence specific DNA-binding proteins, and their cognate promoter elements. The prominent group of cis acting elements in plants contains an ACGT core. …”
Get full text

An Improved Yolov10n for Detection of Bronchoalveolar Lavage Cells by Peihe Jiang, Shaoqi Li, Yanfen Lu, Xiaogang Song

“…Bronchoalveolar lavage fluid (BALF) is a liquid sample that reflects the biological status of lung tissues, containing a wealth of components such as cells and proteins. These components provide a non-invasive method to obtain pathological information about the lungs, serving as a powerful complement to traditional lung biopsies. …”
Get full text