Neutrophil extracellular traps in tumor metabolism and microenvironment by Zhanrui Liu, Yuanyao Dou, Conghua Lu, Rui Han, Yong He

“…Abstract Neutrophil extracellular traps (NETs) are intricate, web-like formations composed of DNA, histones, and antimicrobial proteins, released by neutrophils. These structures participate in a wide array of physiological and pathological activities, including immune rheumatic diseases and damage to target organs. …”
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A Review of Marine Bacterial Intracellular and Extracellular Bioactive Compounds as Novel Antibacterial and Anti-Inflammation Agents by Harningsih Karim, Arief Azis, Ananda Ramadani, Anita Anita, Ahyar Ahmad, Hasnah Natsir, Paulina Taba, Suriati Eka Putri, Sarlan Sarlan, Siti Halimah Larekeng, Rizal Irfandi

“…A crucial resource in the ongoing search for novel peptides, proteins, lipids, nucleosides, enzymes, alkaloids, polyketides, and terpenoids is the diversity of marine bacterium strains. …”
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Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling by Ying Cheng, Man Zhang, Chenguang Li, Long Su, Lingli Fu, Shi Wu, Chaofei Xu, Bei Sun, Liming Chen

“…AGGF1 upregulates the expression of cell cycle proteins by increasing the binding of tumour necrosis factor ligand superfamily member 12 (TNFSF12) to fibroblast -growth -factor-inducible 14 (FN14, TNFRSF12A). …”
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Characterization of Progenitor Cells during Canine Retinal Development by Mallely Ávila-García, Gustavo García-Sánchez, Esmeralda Lira-Romero, Norma Moreno-Mendoza

“…During the fetal stage, proteins were expressed in the inner neuroblastic layer (INL) as well as in the outer neuroblastic layer; BDNF, Thy1, and Brn3a were also expressed in the INL. …”
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Advances and Challenges in Antiviral Development for Respiratory Viruses by Luis Adrián De Jesús-González, Moisés León-Juárez, Flor Itzel Lira-Hernández, Bruno Rivas-Santiago, Manuel Adrián Velázquez-Cervantes, Iridiana Monserrat Méndez-Delgado, Daniela Itzel Macías-Guerrero, Jonathan Hernández-Castillo, Ximena Hernández-Rodríguez, Daniela Nahomi Calderón-Sandate, Willy Salvador Mata-Martínez, José Manuel Reyes-Ruíz, Juan Fidel Osuna-Ramos, Ana Cristina García-Herrera

“…In addition, innovative approaches such as inhibiting host cellular proteins to reduce viral resistance and repurposing existing drugs are explored, using advanced bioinformatics tools that optimize the identification of antiviral candidates. …”
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Buffalo Immune Competence Under Infectious and Non-Infectious Stressors by Maria Giovanna Ciliberti, Antonella Santillo, Mariangela Caroprese, Marzia Albenzio

“…In this condition, modulators of inflammatory responses are produced, including small proteins called cytokines, which exert a pro- or anti-inflammatory action in a context-dependent manner. …”
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Alteration of Sarcoplasmic Reticulum Ca2+ Release in Skeletal Muscle from Calpain 3-Deficient Mice by Govindan Dayanithi, Isabelle Richard, Cédric Viero, Elsa Mazuc, Sylvie Mallie, Jean Valmier, Nathalie Bourg, Muriel Herasse, Isabelle Marty, Gérard Lefranc, Paul Mangeat, Stephen Baghdiguian

“…We propose that calpain 3-dependent proteolysis plays a role in activating support proteins of intracellular Ca2+ signalling at a stage of cellular differentiation which is crucial for skeletal muscle regeneration.…”
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Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice by Haoyu Wang, Shengnan Yu, Kunyi Zhao, Tongyuan Hu, Zhinan Wu, Hewei Liang, Xiaoqian Lin, Luwen Cui, Jingtong Yao, Xiaomin Liu, Xin Tong, Ningning He, Liang Xiao, Karsten Kristiansen, Shangyong Li, Yuanqiang Zou

“…F. longum CM04–06 protected the intestinal epithelial barrier increasing the expression of tight junction proteins. Metagenomic sequencing indicated that F. longum supplementation did not change the overall composition of the gut microbiota in mice, but selectively increased the relative abundance of Staphylococcus xylosus and Staphylococcus nepalensis. …”
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TRAIL-Dependent Resolution of Pulmonary Fibrosis by David M. Habiel, Ana Paula Moreira, Ugur B. Ismailoglu, Michael P. Dunleavy, Karen A. Cavassani, Nico van Rooijen, Ana Lucia Coelho, Cory M. Hogaboam

“…Idiopathic pulmonary fibrosis (IPF) is the most common form of interstitial lung disease characterized by the persistence of activated myofibroblasts resulting in excessive deposition of extracellular matrix proteins and profound tissue remodeling. In the present study, the expression of tumor necrosis factor- (TNF-) related apoptosis-inducing ligand (TRAIL) was key to the resolution of bleomycin-induced pulmonary fibrosis. …”
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Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse by Pablo A. González, Leandro J. Carreño, Pablo F. Céspedes, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis

“…Such a structure involves massive redistribution of membrane proteins, including TCR/pMHC complexes, modulatory receptor pairs, and adhesion molecules. …”
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Opportunities for predictive proteogenomic biomarkers of drug treatment sensitivity in epithelial ovarian cancer by Trudy J. Philips, Britt K. Erickson, Stefani N. Thomas

“…An exclusive focus on the genome overlooks the significant insight that can be gained from other biological analytes, including proteins, which carry out cellular functions. Proteogenomics is the integration of genomics, transcriptomics, epigenomics and proteomics data. …”
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Paracrine activity of Smurf1-silenced mesenchymal stem cells enhances bone regeneration and reduces bone loss in postmenopausal osteoporosis by Alberto González-González, Itziar Álvarez-Iglesias, Daniel García-Sánchez, Monica Dotta, Ricardo Reyes, Ana Alfonso-Fernández, Alfonso Bolado-Carrancio, Patricia Díaz-Rodríguez, María Isabel Pérez-Núñez, José Carlos Rodríguez-Rey, Jesús Delgado-Calle, Flor M. Pérez-Campo

“…Proteomic analysis of the soluble and vesicular CM fractions identified key proteins involved in bone regeneration. Results CM from Smurf1-silenced MSCs significantly enhanced mineralization in vitro and bone formation in vivo. …”
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NUTRITIONAL AND OIL PROFILE OF THE SEEDS OF SESAMUM INDICUM L. AND VITELLARIA PARADOXA C. F. GAERTN. by Ibrahim Umar KARAYE, Sule Aliyu ANKA, Musa Tanko MUHAMMAD, Shafi’u Isma’ila ADILI, Muhammad Hannatu LAWAL

“…The seeds were found to contain appreciable amounts of crude proteins with 18.23% and 8.70% obtained in S. indicum and V. paradoxa respectively. …”
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Ascorbic acid-containing compound efficacy in ischemic brain damage by Rita M. Termulaeva, Konstantin Y. Belanov, Natalya D. Bunyatyan, Aleksander S. Pirozhkov, Dmitrii E. Timoshkin, Ekaterina V. Blinova, Olga V. Vasilkina, Kirill D. Blinov, Elena V. Semeleva, Aleksander A. Dmitriev, Dmitrii S. Blinov

“…Cell-protective effect of 3-EA involves changes in the basal and ischemia/reoxygenation-induced expression of genes encoding anti-apoptotic proteins and oxidative status proteins, which leads to inhibition of the late irreversible stages of apoptosis. …”
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Platelet-rich plasma combined with gypenosides for the treatment of psoriasis-like inflammation in mice by LI Dandan, WANG Bing, GE Yu, CHENG Hong, LI Mengxue, WANG Zhicheng, XIA Rong

“…The expression of skin tissue IL-17A (P<0.05) and TNF-α (P<0.05) decreased, along with the decreased expression of related signaling pathway proteins p-STAT3 and p-P38. [Conclusion] PRP combined with GPs can reduce the expression of IL-17A and TNF-α through the STAT3 and P38 signaling pathways, thereby alleviating inflammation and inhibiting the overproliferation of keratinocytes, thus improving psoriasis-like skin inflammation in BALB/c mice.…”
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Cardiac Function Remains Impaired Despite Reversible Cardiac Remodeling after Acute Experimental Viral Myocarditis by Peter Moritz Becher, Frauke Gotzhein, Karin Klingel, Felicitas Escher, Stefan Blankenberg, Dirk Westermann, Diana Lindner

“…Subsequently, we analyzed viral burden and viral replication in the cardiac tissue as well as the expression of cytokines and matrix proteins. Furthermore, cardiac fibroblasts were infected with virus to investigate if viral infection alone induces profibrotic signaling. …”
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Challenges and Innovations in Alveolar Bone Regeneration: A Narrative Review on Materials, Techniques, Clinical Outcomes, and Future Directions by Diana Marian, Giuseppe Toro, Giovanbattista D’Amico, Maria Consiglia Trotta, Michele D’Amico, Alexandru Petre, Ioana Lile, Anca Hermenean, Anca Fratila

“…Additionally, signaling molecules, like bone morphogenetic proteins, play a crucial role in guiding the process of bone formation and remodeling. …”
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Targeted Anticancer Immunotoxins and Cytotoxic Agents with Direct Killing Moieties by Koji Kawakami, Oumi Nakajima, Ryuichi Morishita, Ryozo Nagai

“…These conjugated or fused chimeric proteins are termed immunotoxins or cytotoxic agents. …”
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Advances in Fluorescence Techniques for the Detection of Hydroxyl Radicals near DNA and Within Organelles and Membranes by Eleanor C. Ransdell-Green, Janina Baranowska-Kortylewicz, Dong Wang

“…Hydroxyl radicals (^•OH), the most potent oxidants among reactive oxygen species (ROS), are a major contributor to oxidative damage of biomacromolecules, including DNA, lipids, and proteins. The overproduction of ^•OH is implicated in the pathogenesis of numerous diseases such as cancer, neurodegenerative disorders, and some cardiovascular pathologies. …”
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Energy metabolism and the intestinal barrier: implications for understanding and managing intestinal diseases by Shuai Chen, Caifei Shen, Xiaorui Zeng, Luqiang Sun, Fangli Luo, Renhong Wan, Yupeng Zhang, Xinyun Chen, Yujun Hou, Wen Wang, Qianhua Zheng, Ying Li

“…Disruptions in energy metabolism can compromise the integrity of the intestinal barrier; for example, inactivation of the AMPK pathway may lead to reduced expression of proteins associated with tight junctions. Conversely, impairment of the intestinal barrier can result in metabolic dysregulation, such as alterations in the gut microbiota that impede the production of short-chain fatty acids (SCFAs), which are essential substrates for energy metabolism. …”
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