Melittin, a Potential Natural Toxin of Crude Bee Venom: Probable Future Arsenal in the Treatment of Diabetes Mellitus by Md. Sakib Hossen, Siew Hua Gan, Md. Ibrahim Khalil

“…Bee venom (BV) is a complex mixture of proteins, peptides, and low molecular components, and melittin is the main constituent. …”
Get full text

A conserved class of viral RNA structures regulates translation reinitiation through dynamic ribosome interactions by Madeline E. Sherlock, Conner J. Langeberg, Katherine E. Segar, Jeffrey S. Kieft

“…Summary: Certain viral RNAs encode proteins downstream of their main open reading frame, expressed through “termination-reinitiation” events. …”
Get full text

Fibrin and Collagen Differentially but Synergistically Regulate Sprout Angiogenesis of Human Dermal Microvascular Endothelial Cells in 3-Dimensional Matrix by Xiaodong Feng, Marcia G. Tonnesen, Shaker A. Mousa, Richard A. F. Clark

“…Angiogenesis is a highly regulated event involving complex, dynamic interactions between microvascular endothelial cells and extracellular matrix (ECM) proteins. Alteration of ECM composition and architecture is a hallmark feature of wound clot and tumor stroma. …”
Get full text

Free DNA in Cystic Fibrosis Airway Fluids Correlates with Airflow Obstruction by Veronica Marcos, Zhe Zhou-Suckow, Ali Önder Yildirim, Alexander Bohla, Andreas Hector, Ljubomir Vitkov, Wolf Dietrich Krautgartner, Walter Stoiber, Matthias Griese, Oliver Eickelberg, Marcus A. Mall, Dominik Hartl

“…After pathogen contact or prolonged activation, neutrophils release DNA fibres decorated with antimicrobial proteins, forming neutrophil extracellular traps (NETs). …”
Get full text

Chromosome-scale assembly and annotation of the wild wheat relative Aegilops comosa by Hongna Li, Shams ur Rehman, Rui Song, Liang Qiao, Xiaohua Hao, Jing Zhang, Kairong Li, Lifeng Hou, Wanyi Hu, Le Wang, Shisheng Chen

“…A total of 39,057 gene models were annotated through a combination of homoeologous proteins, Iso-seq, and RNA-seq data. Comparative genome analysis revealed a terminal intrachromosomal translocation on chromosome 2 M in Ae. comosa. …”
Get full text

Aging, cancer, and autophagy: connections and therapeutic perspectives by Begoña Zapatería, Esperanza Arias, Esperanza Arias

“…While autophagy acts as a tumor-suppressive mechanism by preventing the accumulation of damaged organelles and proteins, cancer cells often exploit it to survive under conditions of metabolic stress and treatment resistance. …”
Get full text

Green Tea Polyphenol Epigallocatechin Gallate Interactions with Copper-Serum Albumin by Meiling Fu, Liangliang Zhang, Rick Killeen, Kenneth E. Onugwu, Robert M. McCarrick, Ann E. Hagerman

“…Epigallocatechin gallate (EGCg), an abundant phytochemical in green tea, is an antioxidant that also binds proteins and complex metals. After gastrointestinal absorption, EGCg binds to serum albumin in the hydrophobic pocket between domains IIA and IIIA and overlaps with the Sudlow I site. …”
Get full text

Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering by Stefano Focaroli, Gabriella Teti, Viviana Salvatore, Isabella Orienti, Mirella Falconi

“…., transforming growth factor betas (TGF-βs) or bone morphogenetic proteins (BMPs)) to direct hADSC differentiation into cartilage-producing chondrocytes.…”
Get full text

Investigation of photophysical properties and potential biological applications of substituted tris(polypyridyl)ruthenium(II) complexes by T. Sumitha Celin, G. Allen Gnana Raj, T. S. Prathima, M. M. Balamurali

“…Following the above, the anticancer properties were evaluated against breast cancer-related proteins. The results revealed that the complex possesses comparable anticancer and antioxidant potential to that of [Ru(bpy)3]2+. …”
Get full text

Stem Cell-Derived Exosomes: A Potential Alternative Therapeutic Agent in Orthopaedics by John Burke, Ravindra Kolhe, Monte Hunter, Carlos Isales, Mark Hamrick, Sadanand Fulzele

“…Exosomal products can include miRNA, other genetic products, proteins, and various factors. They are released from cells in a paracrine fashion in order to combat local cellular stress. …”
Get full text

Alternanthera mosaic potexvirus: Several Features, Properties, and Application by Ekaterina Donchenko, Ekaterina Trifonova, Nikolai Nikitin, Joseph Atabekov, Olga Karpova

“…In this review, we discuss the features of AltMV virions, AltMV VLP assembly, and their structure and properties, as well as the characteristics of AltMV isolates, host plants, infection symptoms, AltMV isolation and purification, genome structure, viral proteins, and AltMV-based vectors.…”
Get full text

Mechanism for microbial population collapse in a fluctuating resource environment by Serdar Turkarslan, Arjun V Raman, Anne W Thompson, Christina E Arens, Mark A Gillespie, Frederick von Netzer, Kristina L Hillesland, Sergey Stolyar, Adrian López García de Lomana, David J Reiss, Drew Gorman‐Lewis, Grant M Zane, Jeffrey A Ranish, Judy D Wall, David A Stahl, Nitin S Baliga

“…We demonstrate that the collapse was caused by conditional gene regulation, which drove precipitous decline in intracellular abundance of essential transcripts and proteins, imposing greater energetic burden of regulation to restore function in a fluctuating environment.…”
Get full text

Properties of Edible Films Based on Oxidized Starch and Zein by Elizabeth Argüello-García, Javier Solorza-Feria, J. Rodolfo Rendón-Villalobos, Francisco Rodríguez-González, Alfredo Jiménez-Pérez, Emmanuel Flores-Huicochea

“…The oxidized starch showed differences from native starch due to the oxidation process, showing a decrease in lipids, proteins, and amylose. The increase of the sodium hypochlorite increased the content of carbonyl and carboxyl groups in the ranges 0.015–0.028% and 0.022–0.031%, respectively. …”
Get full text

Removal Efficiency of Cr6+ by Indigenous Pichia sp. Isolated from Textile Factory Effluent by Pablo M. Fernández, María M. Martorell, Julia I. Fariña, Lucia I. C. Figueroa

“…Chromate reductase activity could be related to cytosolic or membrane-associated proteins. The presence of a chromate reductase activity points out a possible role of an enzyme in Cr6+ reduction.…”
Get full text

Latent Inflammation and Insulin Resistance in Adipose Tissue by I. S. Stafeev, A. V. Vorotnikov, E. I. Ratner, M. Y. Menshikov, Ye. V. Parfyonova

“…It mostly develops as a result of dysregulated insulin signaling in insulin-sensitive cells, as compared to inactivating mutations in insulin receptor or signaling proteins that occur relatively rare. Here, we argue that inflammatory signaling provides a link between latent inflammation, obesity, insulin resistance, and metabolic disorders. …”
Get full text

Polymeric Scaffolds in Tissue Engineering Application: A Review by Brahatheeswaran Dhandayuthapani, Yasuhiko Yoshida, Toru Maekawa, D. Sakthi Kumar

“…Scaffolds have been used for tissue engineering such as bone, cartilage, ligament, skin, vascular tissues, neural tissues, and skeletal muscle and as vehicle for the controlled delivery of drugs, proteins, and DNA. Various technologies come together to construct porous scaffolds to regenerate the tissues/organs and also for controlled and targeted release of bioactive agents in tissue engineering applications. …”
Get full text

Exosomal lncRNAs as diagnostic and therapeutic targets in multiple myeloma by Hong Yan, Nan Jiang, Xiaoying Li, Chenyang Lin, Fang Wang, Juan Zhang, Lijuan Chen, Dan Li

“…Existing research indicates that exosomal long non-coding RNAs (lncRNAs) play a crucial regulatory role in the initiation and progression of tumors, involving various interactions such as lncRNA-miRNA, lncRNA-mRNA, and lncRNA-RNA binding proteins (RBP). Despite the significant clinical application potential of exosomal lncRNAs, research in this area still faces challenges due to their low abundance and technical limitations. …”
Get full text

Therapeutic application and potential mechanism of plant-derived extracellular vesicles in inflammatory bowel disease by Jinling Li, Ting Luo, Dou Wang, Yao Zhao, Yuanxiang Jin, Guiling Yang, Xin Zhang

“…Background: Plant-derived extracellular vesicles (PDEVs) are membrane vesicles characterized by a phospholipid bilayer as the basic skeleton that is wrapped by various functional components of proteins and nucleic acids. An increasing number of studies have confirmed that PDEVs can be a potential treatment of inflammatory bowel disease (IBD) and can, to some extent, compensate for the limitations of existing therapies. …”
Get full text

Gen inhibiting the Wnt/Ca2+ signaling pathway alleviates cerebral ischemia/reperfusion injury by Li Li, Saisai Liu, Mengzhe Wang, Mengjia Li, Yi Liu, Haili Chen, Jie Chen, Weiting Tao, Li Huang, Shidi Zhao

“…Further analysis revealed that Gen regulates key proteins in the Wnt/Ca2+ signaling pathway, including Wnt5a and Frizzled-2, effectively preventing intracellular calcium accumulation and subsequent damage. …”
Get full text

Molecular basis for the enzymatic inactivity of class III glutaredoxin ROXY9 on standard glutathionylated substrates by Pascal Mrozek, Stephan Grunewald, Katrin Treffon, Gereon Poschmann, Fabian Rabe von Pappenheim, Kai Tittmann, Christiane Gatz

“…Abstract Class I glutaredoxins (GRXs) are nearly ubiquitous proteins that catalyse the glutathione (GSH)-dependent reduction of mainly glutathionylated substrates. …”
Get full text