Klebsiella pneumoniae derived outer membrane vesicles mediated bacterial virulence, antibiotic resistance, host immune responses and clinical applications by Lifeng Li, Xinxiu Xu, Ping Cheng, Zengyuan Yu, Mingchao Li, Zhidan Yu, Weyland Cheng, Wancun Zhang, Huiqing Sun, Xiaorui Song

“…Outer membrane vesicles (OMVs) are spherical vesicles containing bioactive substances including lipopolysaccharides, peptidoglycans, periplasmic and cytoplasmic proteins, and nucleic acids. Emerging studies have reported various roles of OMVs in bacterial virulence, antibiotic resistance, stress adaptation, and host interactions, whereas knowledge on their roles in K. pneumoniae is currently unclear. …”
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Advanced Glycation End Products Play Adverse Proinflammatory Activities in Osteoporosis by Roberta Sanguineti, Alessandra Puddu, François Mach, Fabrizio Montecucco, Giorgio Luciano Viviani

“…The accumulation of AGEs within the bone induces the formation of covalent cross-links with collagen and other bone proteins which affects the mechanical properties of tissue and disturbs bone remodelling and deterioration, underlying osteoporosis. …”
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Recent advances in L-Asparaginase enzyme production and formulation development for acrylamide reduction during food processing by Arindam Jana, Soumyajit Biswas, Ritu Ghosh, Rahul Modak

“…L-asparagine is an essential amino acid for cell growth and common constituent of all the proteins. During high temperature food processing it reacts with reducing sugars and leads to acrylamide production through a complex process known as Maillard reaction. …”
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Consequences of Hyperoxia and the Toxicity of Oxygen in the Lung by William J. Mach, Amanda R. Thimmesch, J. Thomas Pierce, Janet D. Pierce

“…Pathophysiological processes are associated with increased levels of hyperoxia-induced reactive O2 species (ROS) which may readily react with surrounding biological tissues, damaging lipids, proteins, and nucleic acids. Protective antioxidant defenses can become overwhelmed with ROS leading to oxidative stress. …”
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Challenges in classifying human chromosomal heteromorphisms using banding cytogenetics: From controversial guidelines to the need for a universal scoring system by Sílvia Pires, Paula Jorge, Thomas Liehr, Natália Oliva-Teles

“…Although not completely devoid of genes, these regions are typically not transcribed into proteins and lack obvious phenotypic impact. Nonetheless, their clinical importance is increasingly under scrutiny, with several studies aiming to assess their influence on human diseases and susceptibilities, especially as they are seemingly part of the long noncoding RNAs in certain tissues. …”
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Developmental Pathways Pervade Stem Cell Responses to Evolving Extracellular Matrices of 3D Bioprinted Microenvironments by Quyen A. Tran, Visar Ajeti, Brian T. Freeman, Paul J. Campagnola, Brenda M. Ogle

“…To this end, human mesenchymal stem cells (hMSCs) were cultured in 3D bioprinted prisms created from ECM proteins and associated controls. We found that exogenous ECM provided in 3D microenvironments at early time points impacts on the composition of microenvironments at later time points and that each evolving 3D microenvironment is uniquely poised to promote stem cell differentiation. …”
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Exploring the potential of some natural indoles as antiviral agents: quantum chemical analysis, inverse molecular docking, and affinity calculations by Amany Belal, Aly Abdou, Samar F. Miski, Mohamed A. M. Ali, Heba I. Ghamry, Ahmad J. Obaidullah, Ahmad J. Obaidullah, Mohamed Y. Zaky, Ahmed H. E. Hassan, Ahmed H. E. Hassan, Eun Joo Roh, Eun Joo Roh, Ahmed A. Al-Karmalawy, Ahmed A. Al-Karmalawy, Mona H. Ibrahim

“…We employed molecular docking, ADMET analysis, and computational techniques [frontier molecular orbital (FMO), natural bond orbital (NBO), and density functional theory (DFT)] to evaluate these compounds” potential as multi-target antiviral agents against HIV and HCV proteins.…”
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Evaluation of autophagic and apoptotic markers during infection with animal virus causing hemorrhagic fever in rabbits by Dominika Bębnowska, Dominika Bębnowska, Sylwia Rzeszotek, Agnieszka Kolasa, Karolina Wiśniewska, Karolina Wiśniewska, Magdalena Żabińska, Aneta Szulc, Zuzanna Cyske, Zuzanna Cyske, Karolina Pierzynowska, Karolina Pierzynowska, Aleksandra Wilk, Paulina Niedźwiedzka-Rystwej, Paulina Niedźwiedzka-Rystwej, Paulina Niedźwiedzka-Rystwej

“…This is particularly important because infection with different strains is associated with a different host immune response profile.MethodsIn this work, we analyzed the expression of selected genes and proteins involved in autophagic flux in the liver, spleen, kidney and peripheral blood, but also apoptotic cell death in the liver and peripheral blood of rabbits infected with the GI.2 strain.ResultsAs a result, we showed that autophagy is strongly activated in the liver, spleen and kidney of infected rabbits, and confirmed the activation of apoptosis in the liver.DiscussionThis study highlights the role of apoptosis and autophagy in the immune response in rabbits infected with Lagovirus europaeus/GI.2.…”
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Concurrent presentation of proliferative glomerulonephritis with monoclonal immunoglobulin deposits and light chain proximal tubulopathy: a case report and review of the literature by Jingdong Zhang, Yang Liu, Fengyan Jin, Jia Li, Hui Wang, Fuzhe Ma, Ye Jia, Jinyu Yu, Shan Wu, Shaojie Fu, Zhonggao Xu, Hao Wu

“…This case emphasizes the critical role of renal biopsy in the diagnosis, particularly in the absence of detectable monoclonal proteins, and demonstrates the efficacy of targeted therapy in managing such complex renal pathologies. …”
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Biosynthesis and Role of N-Linked Glycosylation in Cell Surface Structures of Archaea with a Focus on Flagella and S Layers by Ken F. Jarrell, Gareth M. Jones, Divya B. Nair

“…The genetics and biochemistry of the N-linked glycosylation system of Archaea have been investigated over the past 5 years using flagellins and S layers as reporter proteins in the model organisms, Methanococcus voltae, Methanococcus maripaludis, and Haloferax volcanii. …”
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IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection by Hsing-Chuan Tsai, Sharlene Velichko, Li-Yin Hung, Reen Wu

“…IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. Mice deficient in IL-17 receptor (IL-17R) expression are susceptible to infection by various pathogens. …”
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THE pH TRENDS OF BEEF MEAT DURING TWO AGING PROCESSES by Maria-Cristina Gliga (Colciar), Adriana Paula David, Giorgiana Mihaela Catunescu, Ioana Maria Bodea, Manuel León Camacho, Maria Tofana

“…Thus, the BA breed exhibited a greater decrease in pH compared to RS, which could indicate an advanced proteolysis of proteins.…”
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The PPAR Gamma Agonist Troglitazone Regulates Erk 1/2 Phosphorylation via a PPARγ-Independent, MEK-Dependent Pathway in Human Prostate Cancer Cells by Adrienne Bolden, Lynikka Bernard, Danielle Jones, Tunde Akinyeke, LaMonica V. Stewart

“…Pretreatment with U0126 did not alter the ability of troglitazone to regulate expression of two proteins that control cell cycle, p21, and c-Myc. Troglitazone was also still effective at reducing PC-3 proliferation in the presence of U0126. …”
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Role of MicroRNA in Governing Synaptic Plasticity by Yuqin Ye, Hongyu Xu, Xinhong Su, Xiaosheng He

“…Although synaptic plasticity in neural circuits is orchestrated by an ocean of genes, molecules, and proteins, the underlying mechanisms remain poorly understood. …”
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NHSL3 controls single and collective cell migration through two distinct mechanisms by Nikita M. Novikov, Jinmei Gao, Artem I. Fokin, Nathalie Rocques, Giovanni Chiappetta, Karina D. Rysenkova, Diego Javier Zea, Anna Polesskaya, Joelle Vinh, Raphael Guerois, Alexis M. Gautreau

“…Rescue with specific isoforms, and lack of rescue when relevant binding sites are mutated, establish that the interaction of a long isoform with MENA/VASP proteins is critical at cell-cell junctions for collective migration, while the interaction of a short one with 14-3-3θ in lamellipodia is critical for single cell migration. …”
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Age-Related Macular Degeneration: Insights into Inflammatory Genes by Raffaella Cascella, Michele Ragazzo, Claudia Strafella, Filippo Missiroli, Paola Borgiani, Francesco Angelucci, Luigi Tonino Marsella, Andrea Cusumano, Giuseppe Novelli, Federico Ricci, Emiliano Giardina

“…Several genetic and molecular studies have indicated the participation of inflammatory molecules (cytokines and chemokines), immune cells (macrophages), and complement proteins in the development and progression of the disease. …”
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Antioxidant Characterization of Oak Extracts Combining Spectrophotometric Assays and Chemometrics by Boris M. Popović, Dubravka Štajner, Ružica Ždero, Saša Orlović, Zoran Galić

“…Beside, mentioned parameters, soluble proteins, lipid peroxidation (LP), pigments and proline contents were also determined. …”
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Development of broadly protective influenza B vaccines by Chunyang Gu, Lavanya Babujee, David Pattinson, Shiho Chiba, Peter Jester, Tadashi Maemura, Gabriele Neumann, Yoshihiro Kawaoka

“…Notably, both recombinant HA proteins conferred enhanced protection against heterologous challenges compared to their respective wild-type antigens. …”
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Noncanonical roles of ATG5 and membrane atg8ylation in retromer assembly and function by Masroor Ahmad Paddar, Fulong Wang, Einar S Trosdal, Emily Hendrix, Yi He, Michelle R Salemi, Michal Mudd, Jingyue Jia, Thabata Duque, Ruheena Javed, Brett S Phinney, Vojo Deretic

“…ATG5 is one of the core autophagy proteins with additional functions such as noncanonical membrane atg8ylation, which among a growing number of biological outputs includes control of tuberculosis in animal models. …”
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Advances in RNA-Based Therapeutics: Challenges and Innovations in RNA Delivery Systems by Yuxuan Liu, Yaohui Ou, Linlin Hou

“…Among various types of nucleic acids, RNA offers greater versatility compared to DNA due to its single-stranded structure, ability to directly encode proteins, and high modifiability for targeted therapeutic and regulatory applications. …”
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