Advances in Corticosteroid Therapy for Ocular Inflammation: Loteprednol Etabonate by Timothy L. Comstock, Heleen H. DeCory

“…Elevations in IOP are infrequent with LE, and the absence of a C-20 ketone precludes formation of Schiff base intermediates with lens proteins, a common first step implicated in cataract formation with ketone steroids.…”
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NPM1/B23: A Multifunctional Chaperone in Ribosome Biogenesis and Chromatin Remodeling by Mikael S. Lindström

“…At a first glance, ribosome biogenesis and chromatin remodeling are quite different processes, but they share a common problem involving interactions between charged nucleic acids and small basic proteins that may result in unwanted intracellular aggregations. …”
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Biological Aging and Venous Thromboembolism: A Review of Telomeres and Beyond by Rafaela Vostatek, Cihan Ay

“…Techniques such as high-throughput genomics, epigenomics, transcriptomics, proteomics, and metabolomics analyses identified and quantified numerous epigenetic markers, transcripts, proteins, and metabolites. These methods have also revealed the molecular alterations organisms undergo as they age. …”
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Iron-regulatory liver hormone hepcidin and its place in the system of congenital immunity by O. A. Smirnov

“…Expression peptide mRNA in hepatocytes is induced by proinflammatory cytokines (IL-1α, IL-6 and TNF-α) similar to acute phase proteins of inflammation, and also by liver iron overload. …”
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Extracellular vesicles—a new player in the development of urinary bladder cancer by Damian Kasiński, Kamil Szeliski, Tomasz Drewa, Marta Pokrywczyńska

“…Extracellular vesicles (EVs) are nano-sized membranous structures secreted by all types of cells into the extracellular space. EVs can transport proteins, lipids, or nucleic acids to specific target cells. …”
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The hypoglycemic potential of phenolics from functional foods and their mechanisms by Oksana Golovinskaia, Chin-Kun Wang

“…Chronic hyperglycemia induces the glycation of proteins, oxidative stress, inflammation and increases plasma insulin and lipid concentrations. …”
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Drought Tolerance in Wheat by Arash Nezhadahmadi, Zakaria Hossain Prodhan, Golam Faruq

“…In wheat, there are several genes which are responsible for drought stress tolerance and produce different types of enzymes and proteins for instance, late embryogenesis abundant (lea), responsive to abscisic acid (Rab), rubisco, helicase, proline, glutathione-S-transferase (GST), and carbohydrates during drought stress. …”
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Classification, Mechanisms of Action, and Therapeutic Applications of Inhibitory Oligonucleotides for Toll-Like Receptors (TLR) 7 and 9 by Petar S. Lenert

“…The innate force acts as an alarm mechanism that senses changes in the microenvironment through the recognition of common microbial patterns by Toll-like receptors (TLR) and NOD proteins. It rapidly generates an inflammatory response aimed at neutralizing the intruder at the mucosal checkpoint. …”
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The ADF/Cofilin-Pathway and Actin Dynamics in Podocyte Injury by Beina Teng, Alexander Lukasz, Mario Schiffer

“…Recent studies suggest that cofilin-1 can be regulated through several extracellular signals and slit diaphragm proteins. Cofilin knockdown and knockout animal models show dysfunction of glomerular barrier and filtration with foot process effacement and loss of secondary foot processes. …”
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Risk factors and predictive model construction for lower extremity arterial disease in diabetic patients. by Yingjie Kuang, Zhixin Cheng, Jun Zhang, Chunxu Yang, Yue Zhang

“…Multivariate regression analysis indicated that male gender, atherosclerosis, carotid artery stenosis, fatty liver, hematologic diseases, endocrine disorders, and elevated glycosylated serum proteins were independent risk factors for LEAD. The risk prediction models constructed using Logistic regression and MLP algorithms achieved moderate discrimination performance, with AUCs of 0.73 and 0.72, respectively.…”
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PPAR𝜸 and Oxidative Stress: Con(𝜷) Catenating NRF2 and FOXO by Simone Polvani, Mirko Tarocchi, Andrea Galli

“…However, PPARγ does not act alone: indeed the nuclear receptor is at the point of interconnection of various pathways, such as the nuclear factor erythroid 2-related factor 2 (NRF2), Wnt/β-catenin, and forkhead box proteins O (FOXO) pathways. Here we reviewed the role of PPARγ in response to oxidative stress and its interaction with other signaling pathways implicated in this process, an interaction that emerged as a potential new therapeutic target for several oxidative-related diseases.…”
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Cavernous Nerve Injury Resulted Erectile Dysfunction and Regeneration by Nan Jiang, Cheng Wu, Xunrong Zhou, Guanghua Zhai, Jian Wu

“…In addition, such as neuromodulatory proteins, proimmune ligands, gene therapy, stem cell therapy, and the current cutting-edge low-energy shock wave therapy have shown advantages in basic research and limited clinical studies. …”
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Germ granule-mediated mRNA storage and translational control by Hoang-Anh Pham-Bui, Mihye Lee

“…These membrane-less organelles form through the condensation of RNA and proteins, governed by multivalent biomolecular interactions. …”
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Influencing immunity: role of extracellular vesicles in tumor immune checkpoint dynamics by Ziyang Ye, Genpeng Li, Jianyong Lei

“…Abstract Immune checkpoint proteins (ICPs) serve as critical regulators of the immune system, ensuring protection against damage due to overly activated immune responses. …”
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Alphaherpesvirus in Pets and Livestock by Shu-Hui Duan, Ze-Min Li, Xue-Jie Yu, Dan Li

“…During infection, herpesviruses not only stimulate innate immune responses in host cells but also interfere with signaling pathways through specific proteins to achieve immune evasion. These viruses can remain latent within the host for extended periods and reactivate under certain conditions to trigger disease recurrence. …”
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NTRK-rearranged spindle cell tumor with SPECC1L-NTRK3 fusion in the thoracic spine: a case report by Mi Zhou, Huaiyuan Xu, Jianxiong Niu, Qibing Yang, Anqi Wang, Hao Wu, Xiangqin Wang, Meng Yang, Jinxin Hu, Qinglian Tang, Jin Wang

“…The central feature of these tumors is the fusion of NTRK genes with other genes, resulting in abnormal expression and activation of tropomyosin receptor kinase proteins. In this report, we present the first documented case of an NTRK spindle cell tumor with SPECC1L-NTRK3 fusion located in the thoracic spine. …”
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Cloning, Structural Characterization, and Phylogenetic Analysis of Flower MADS-Box Genes from Crocus (Crocus sativus L.) by Athanasios S. Tsaftaris, Alexios N. Polidoros, Konstantinos Pasentsis, Apostolos Kalivas

“…In order to uncover and understand the molecular mechanisms controlling flower development in cultivated crocus and its relative wild progenitor species, and characterize a number of crocus flower mutants, we have cloned and characterized different, full-length, cDNA sequences encoding MADS-box transcription factor proteins involved in flower formation.…”
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Nature-inspired and medicinally relevant short peptides by Maria G. Ciulla, Monica Civera, Sara Sattin, Kamal Kumar

“…In comparison to their big counterparts, i.e. proteins, short peptides encompass several advantages, from the ease of synthesis to their physico-chemical properties. …”
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Sustainable Extraction Technology of Fruit and Vegetable Residues as Novel Food Ingredients by Shiqi Zheng, Zhoumei Huang, Li Dong, Daotong Li, Xiaosong Hu, Fang Chen, Chen Ma

“…It contains valuable compounds such as polysaccharides, polyphenols, proteins, vitamins, pigments, and fatty acids, which can be extracted for food applications. …”
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Modeling sacsin depletion in Danio Rerio offers new insight on retinal defects in ARSACS by Valentina Naef, Devid Damiani, Rosario Licitra, Maria Marchese, Stefania Della Vecchia, Matteo Baggiani, Letizia Brogi, Daniele Galatolo, Silvia Landi, Filippo Maria Santorelli

“…RNA-seq analysis in embryos revealed dysfunction in proteins related to fat-soluble vitamins (e.g., TTPA, RDH5, VKORC) and suggested a key role of neuroinflammation in driving the retinal defects. …”
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