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14041
Biophysical aspects of mechanotransduction in cells and their physiological/biological implications in vocal fold vibration: a narrative review
Published 2025-01-01“…Recent studies have identified mechanosensitive proteins in vocal fold epithelia, supporting this hypothesis. …”
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14042
Disturbances in the Mechanism of Apoptosis as One of the Causes of the Development of Cancer Diseases
Published 2020-12-01“…New types of molecular therapies provide an opportunity to increase the effectiveness of anticancer treatment, aiming at deficient proteins and suppressing or eliminating their antiapoptotic effects.…”
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14043
Developments in Diagnosis and Antileishmanial Drugs
Published 2012-01-01“…This provides the promise that many of the parasite’s proteins should be sufficiently different from hosts and can be successfully exploited as drug targets. …”
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14044
In Vivo Pharmacodynamic Imaging of Proteasome Inhibition
Published 2009-05-01“…Toward this end, ectopic fusion of the destruction domain from ornithine decarboxylase (ODC) to reporter proteins is often used for assessing proteasome function. …”
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14045
The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models
Published 2012-01-01“…TGFβ1 is a member of a large growth factor family including activins/inhibins and bone morphogenic proteins (BMPs) that have a potent growth regulatory and immunomodulatory functions in normal skin homeostasis, regulation of epidermal stem cells, extracellular matrix production, angiogenesis, and inflammation. …”
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14046
Canonical and noncanonical autophagy: involvement in Parkinson’s disease
Published 2025-01-01“…On the other hand, recent studies have focused on the functions of autophagy proteins beyond intracellular degradation, including noncanonical autophagy, also known as the conjugation of ATG8 to single membranes (CASM), and autophagy-related extracellular secretion. …”
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14047
Role of gp91phox Homolog Nox1 in Induction of Premalignant Spindle Phenotypes of HPV 16 E6/E7—Immortalized Human Keratinocytes
Published 2010-01-01“…The NADPH oxidase (Nox) family of superoxide- and hydrogen peroxide—producing proteins has been recognized as important for signal transduction that regulates receptor-mediated functions, including cytoskeleton remodeling, cell proliferation, migration, differentiation, and cell death. …”
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14048
Mathematical modeling of liver fibrosis
Published 2017-01-01“…Fibrotic diseases are characterized by abnormal excessive deposition of fibrous proteins, such as collagen, and the disease is most commonly progressive, leading to organ disfunction and failure. …”
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14049
Usefulness of the Vitreous Fluid Analysis in the Translational Research of Diabetic Retinopathy
Published 2012-01-01“…However, several confounding factors such as vitreous haemorrhage and concentration of vitreous proteins should be considered in the analysis of the results. …”
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14050
Interplay between porin deficiency, fitness, and virulence in carbapenem-non-susceptible Pseudomonas aeruginosa and Enterobacteriaceae.
Published 2025-02-01“…Porins are outer membrane proteins, which play a key role in the bacterial permeability to allow nutrients to enter and toxic waste to leave. …”
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14051
Expression Profiling of Transglutaminase 2 and Inflammatory Host Response in Aspergillus Fumigatus After Treatment with Curcuma Extracts
Published 2021-12-01“…The current therapies are known for their limitations where they couldn’t target the proteins involved in undoing host response. Here we aimed to screen the possible antifungal role of Curcumin and its effect on the Transglutaminase 2 and Reactive Oxygen species response. …”
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14052
Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome.
Published 2011-03-01“…In this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype. …”
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14053
An Efficient Method for Immortalizing Mouse Embryonic Fibroblasts by CRISPR-mediated Deletion of the Tp53 Gene
Published 2025-01-01“…The MEF system can also be combined with rescue studies to characterize the function of mutant genes/proteins, such as disease-causing variants. However, primary MEFs undergo senescence soon after isolation and passaging, making long-term genetic manipulations difficult. …”
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14054
Hepatoprotective Effect of Mitochondria-Targeted Antioxidant Mito-TEMPO against Lipopolysaccharide-Induced Liver Injury in Mouse
Published 2022-01-01“…Finally, we found that the levels of pyroptosis-related proteins in the liver of LPS-treated mice were lower after pretreatment with Mito-TEMPO. …”
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14055
The Genetic Basis of Congenital Cataracts: Advances in Diagnostics and Therapeutics
Published 2025-02-01“…Genetic mutations in structural proteins such as crystallins and connexins account for over half of cases, emphasizing the critical role of early surgical intervention, particularly intraocular lens (IOL) implantation in children over two years old. …”
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14056
Organic Alternatives to Quantum Dots for Intraoperative Near-Infrared Fluorescent Sentinel Lymph Node Mapping
Published 2005-07-01“…We present robust methods for the covalent conjugation, purification, and characterization of proteins with tetra-sulfonated heptamethine indocyanines, including mass spectroscopic site mapping of highly substituted molecules. …”
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14057
Skin Matters: Identifying Pain Mechanisms and Predicting Treatment Outcomes
Published 2013-01-01“…Epidermal cells (such as keratinocytes, Langerhans cells, and Merkel cells) express sensor proteins and neuropeptides; these regulate the neuroimmunocutaneous system and participate in nociception and neurogenic inflammation. …”
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14058
Macrophage Polarization in the Osteoarthritis Pathogenesis and Treatment
Published 2025-01-01“…Additionally, this review discusses potential therapies targeting macrophage polarization, encompassing compounds, proteins, cells, and microRNAs, to offer insights into novel treatment strategies for OA.…”
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14059
Pulmonary Remodeling in Equine Asthma: What Do We Know about Mediators of Inflammation in the Horse?
Published 2016-01-01“…A systemic involvement has been shown for severe equine asthma by increased acute phase proteins like serum amyloid A and haptoglobin in peripheral blood during exacerbation. …”
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14060
Chemical Composition and Nutritional Value of Three Sonchus Species
Published 2022-01-01“…Statistically, fibers and ash presented the same proportions in S. asper and S. arvensis, as well as proteins in S. oleraceus and S. asper species. The availabilities of these vegetables together with their high nutritional value are important factors that contribute to ensuring food security for families that have these species in their diet.…”
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