Synaptic Cell Adhesion Molecules in Alzheimer’s Disease by Iryna Leshchyns’ka, Vladimir Sytnyk

“…Synaptic cell adhesion molecules are cell surface glycoproteins which are expressed at the synaptic plasma membranes of neurons. These proteins play key roles in formation and maintenance of synapses and regulation of synaptic plasticity. …”
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The therapeutic agents that target ATP-sensitive potassium channels by Rubaiy Hussein N.

“…The allosteric communication pathways between these two heterologus proteins in KATP channels are still poorly understood. …”
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Harnessing Nature‐Derived Sustainable Materials for Electrochemical Energy Storage: Unveiling the Mechanism and Applications by Naman Sharma, Kirti Mishra, Nirankar Singh, Samarjeet Singh Siwal, Phil Hart, Vijay Kumar Thakur

“…Abstract Recently, research all over the world is being carried out to develop eco‐friendly supercapacitors (SCs) using biopolymeric materials like proteins or polysaccharides. These polymers offer these innovative energy storage devices' sustainability and recyclability, flexibility, lightweight, and steady cycling performance—all crucial for utilizations involving wearable electronics and others. …”
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Unveiling the wonders of bacteria-derived extracellular vesicles: From fundamental functions to beneficial applications by Mariam Rima, Mariam Dakramanji, Elie El Hayek, Tia El Khoury, Ziad Fajloun, Mohamad Rima

“…EVs manage numerous physiological processes by transferring bioactive molecules, including proteins, lipids, and nucleic acids, between cells. …”
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Influence of Aging and Immune Alterations on Susceptibility to Pneumococcal Pneumonia in the Elderly by Nathan Kang, Veedamali S. Subramanian, Anshu Agrawal

“…Management of <i>S. pneumoniae</i> infections in the elderly is challenging due to impaired antibody responses to polysaccharides and surface proteins, compounded by rising antibiotic resistance. …”
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SOCS1 deficiency—crossroads of autoimmunity and autoinflammation—two case reports by Kajetan Trojovsky, Maximilian Seidl, Florian Babor, Stephan Ehl, Stephan Ehl, Min Ae Lee-Kirsch, Michael Friedt, Hans-Juergen Laws, Nibras Naami, Prasad Thomas Oommen, Sujal Ghosh

“…Suppressors of cytokine signaling (SOCS) proteins play a critical role in regulating immune signaling pathways. …”
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Extreme plasticity in the photosystem composition of a low‐light Prochlorococcus ecotype in response to iron and light by Xin Zhang, William G. Sunda, Haizheng Hong, Dalin Shi

“…Abstract Light affects the cellular iron (Fe) requirement of phytoplankton because of its presence in major photosynthetic proteins. Thus, interactions between variable Fe concentrations and light intensities could restrict photosynthetic carbon fixation in the ocean. …”
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Clinical Significance and Pathogenic Mechanisms of Long Non-Coding RNA TRPM2-AS in Cancers by Shichen Huang MS, Bowen Li MS, Huanyu Chen MD, Cheng Rong, Zheng Yang MD, Xianqin Zhang PhD

“…Moreover, TRPM2-AS is involved in regulating the cell proliferation, migration, invasion, apoptosis, drug or radio resistance by serving as a competing endogenous RNA, directly bounding to proteins and regulating multiple signaling pathways. …”
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A new perspective on apoptosis: Its impact on meat and organoleptic quality in different animals by Boin Lee, Young Min Choi

“…The apoptotic potential, determined by the balance between apoptotic and anti-apoptotic molecules, such as Ca2+, cytochrome c, caspases, and heat shock proteins, varies among different species. A moderate to rapid apoptotic rate can improve textural properties in species with a higher proportion of type I fibers, such as cattle. …”
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Adenine, a key player in biology and medicinal chemistry by Fillion, Alexandra, Vichier-Guerre, Sophie, Arimondo, Paola Barbara

“…In addition of being one of the four nucleobases constituting DNA and RNA, adenine is also contained in many biological molecules (ATP, SAM, NAD, cAMP, coA ...) that have fundamental roles in the functioning of living systems, e.g. energy source, cofactors of enzymes and proteins. As such, the adenine has naturally become a privileged scaffold explored in medicinal chemistry for biomedical applications. …”
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Proteolysis targeting chimera (PROTAC)-driven antibody internalization of oncogenic cell surface receptors by Ezequiel J. Tolosa, Lin Yang, Jennifer Ayers-Ringler, Shinichiro Suzuki, Jayapal Reddy Mallareddy, Janet Schaefer-Klein, Mitesh Borad, Farhad Kosari, Amarnath Natarajan, Aaron S. Mansfield

“…We show that PROTACs improve internalization of antibodies or their derivative antibody drug conjugates when both agents target the same oncogenic cell surface proteins (EGFR, HER2 or MET) by 1.4-1.9 fold in most models. …”
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Discovery of Evolutionary Loss of the Ubiquitin-like Autophagy-Related ATG12 System in a Lineage of Apicomplexa by Xiaoxia X. Lin, Yun D. Bai, Sichang T. Wang, Akira Nozawa, Tatsuya Sawasaki, Tatsunori Masatani, Kenji Hikosaka, Masahito Asada, Hirokazu Sakamoto

“…However, our in vitro functional analysis using recombinant proteins demonstrated that ATG3 retained the ability to interact with ATG8 in <i>Babesia bovis</i>, a model species in piroplasmida. …”
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Identification of Potential Calorie Restriction-Mimicking Yeast Mutants with Increased Mitochondrial Respiratory Chain and Nitric Oxide Levels by Bin Li, Craig Skinner, Pablo R. Castello, Michiko Kato, Erin Easlon, Li Xie, Tianlin Li, Shu-Ping Lu, Chen Wang, Felicia Tsang, Robert O. Poyton, Su-Ju Lin

“…Our results suggest that CR may derepress some hypoxic genes for mitochondrial proteins that function to promote the production of NO and the extension of lifespan.…”
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Exploiting CRISPR/Cas system in controlling antibiotic resistance of bacteria by Pourya Gholizadeh, Elnaz Faghfuri, Khudaverdi Ganbarov, Hossein Samadi Kafil

“…Clustered Regularly interspaced Short Palindromic Repeats (CRISPR) and CRISPR-associated proteins (Cas) protect archaebacteria and eubacteria from potentially harmful foreign DNA such as plasmids, transposable elements, and phages. …”
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Metallothioneins in Inflammatory Bowel Diseases: Importance in Pathogenesis and Potential Therapy Target by Anna Socha-Banasiak, Patrycja Sputa-Grzegrzółka, Jędrzej Grzegrzółka, Krzysztof Pacześ, Piotr Dzięgiel, Beata Sordyl, Hanna Romanowicz, Elżbieta Czkwianianc

“…Metallothioneins (MTs) belong to the group of low molecular weight proteins, which, among others, regulate the inflammation and homeostasis of heavy metals as well as participating in the regulation of the intensity of oxidative stress. …”
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Clearance In Vivo of Instilled [H]Cholesterol from the Rat Lung by Michael A. Wyder, Shannon M. Griffin, D. Nicole Worsham, Edna S. Kaneshiro

“…Phospholipids and lung surfactant proteins are known to be recycled within the lung alveolus mainly by uptake into type II epithelial cells that secrete lipid-enriched lung surfactant. …”
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Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions by Minkyoung Sung, Yeon-Ji Lee, Soo-Eun Sung, Kyung-Ku Kang, Jae Woo Park, Yujeong Lee, Dongmin Kim, Sunjong Lee, Joo-Hee Choi, Sijoon Lee

“…In addition, the tight junction proteins, ZO-1 and Occludin, were significantly decreased, whereas MPO was significantly increased. …”
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Lipid Chaperones and Metabolic Inflammation by Masato Furuhashi, Shutaro Ishimura, Hideki Ota, Tetsuji Miura

“…On the other hand, inside the cell, fatty acid-binding proteins (FABPs), a family of lipid chaperones, as well as endoplasmic reticulum (ER) stress, and reactive oxygen species derived from mitochondria play significant roles in promotion of metabolically triggered inflammation. …”
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Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings by Raffaele Nuzzi, Paolo Caselgrandi, Alessandro Vercelli

“…Exosomes are microvesicles formed by a double layer of phospholipid membrane and carry proteins and RNA, through which they play a therapeutic role on target cells. …”
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Application of antisense oligonucleotide drugs in amyotrophic lateral sclerosis and Huntington’s disease by Kaili Ou, Qingqing Jia, Dandan Li, Shihua Li, Xiao-Jiang Li, Peng Yin

“…Gene therapy, which aims to modify or express specific proteins for neuroprotection or correction, is considered a powerful tool in managing neurodegenerative conditions. …”
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