The Biology and Function of Tissue Inhibitor of Metalloproteinase 2 in the Lungs by Louis Costanzo, Brian Soto, Richard Meier, Patrick Geraghty

“…Tissue inhibitors of matrix metalloproteinases (TIMP) are a family of four endogenous proteins that primarily function to inhibit the activities of proteases such as the matrix metalloproteinases (MMP). …”
Get full text

Prospects of Nanobiomaterials for Biosensing by Ravindra P. Singh

“…The biosensors using smart nanomaterials have applications for rapid, specific, sensitive, inexpensive, in-field, on-line and/or real-time detection of pesticides, antibiotics, pathogens, toxins, proteins, microbes, plants, animals, foods, soil, air, and water. …”
Get full text

Evidence for a Potential Role of Metallothioneins in Inflammatory Bowel Diseases by Anouk Waeytens, Martine De Vos, Debby Laukens

“…Metallothioneins (MTs) are a family of small proteins with a high and conserved cysteine content that are rapidly upregulated in response to an inflammatory stimulus. …”
Get full text

Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders by Clara Camaschella, Laura Silvestri

“…To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. …”
Get full text

PROTAC technology for prostate cancer treatment by Zhen Wang, Dingpeng Zhang, Hiroyuki Inuzuka, Wenyi Wei

“…This approach offers a novel means of degrading target proteins and we discuss how PROTAC holds potential as effective strategies to combat resistance mechanisms in CRPC.…”
Get full text

Determination of ramipril in human plasma and its fragmentation by UPLC-Q-TOF-MS with positive electrospray ionization by Szpot Paweł, Buszewicz Grzegorz

“…This report presents the application of ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry with positive electrospray ionization, to determine ramipril in human plasma. First, the proteins in human plasma were precipitated using acetonitrile, then the supernatant was extracted by ethyl acetate at pH 3 and finally, the extract was analyzed using a UPLC-QTOF- MS system. …”
Get full text

Time-resolved compositional and dynamics analysis of biofilm maturation and dispersal via solid-state NMR spectroscopy by Yi Xue, Xue Kang

“…The steepest decline of proteins precedes that of exopolysaccharides, likely reflecting their distinct spatial distribution. …”
Get full text

A review of gut microbiota as a therapeutic approach for Parkinson’s disease by Debosree Ghosh, Suvendu Ghosh, Madhurima Sharma, Sutapa Datta

“…This, in turn, activates the innate immune system, leading to systemic inflammation, whereas the adaptive immune system responds to bacterial proteins through cross-reactivity with human antigens. …”
Get full text

Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection by Rajnish Kumar Singh, Ramakrishna Vangala, Atharva S. Torne, Dipayan Bose, Erle S. Robertson

“…In this review, we describe the intricate processes by which these viruses interact with the epigenetic machinery, leading to alterations in DNA methylation, histone modifications, and the involvement of non-coding RNAs. The key viral proteins such as EBNA1 and LMP1 encoded by EBV; LANA and vGPCR encoded by KSHV; play pivotal roles in these modifications by interacting with host factors, and dysregulating signaling pathways. …”
Get full text

The Effect of Edible Mushroom on Health and Their Biochemistry by Anmut Assemie, Galana Abaya

“…They contain varying amounts of carbohydrates, proteins, nucleic acids, lipids, minerals, terpenoids, phenolic compounds, steroids, and lectins and vitamins, as well as lowering cholesterol levels in the body. …”
Get full text

A mitochondria-to-nucleus regulation mediated by the nuclear-translocated mitochondrial lncRNAs. by Jia Li, Ruoling Bai, Yulian Zhou, Xu Song, Ling Li

“…Mediated by HuR and PNPT1 proteins, the mtlncRNAs undergo a mitochondria-to-nucleus traveling and then regulate a network of nuclear genes. …”
Get full text

Rapid structural analysis of bacterial ribosomes in situ by Barrett M. Powell, Tyler S. Brant, Joseph H. Davis, Shyamal Mosalaganti

“…Abstract Rapid structural analysis of purified proteins and their complexes has become increasingly common thanks to key methodological advances in cryo-electron microscopy (cryo-EM) and associated data processing software packages. …”
Get full text

A Pilot Proteomic Analysis of Huntington’s Disease by Functional Capacity by Andrew McGarry, Ruin Moaddel

“…<b>Methods:</b> We assessed CSF proteomics from eight participants by their functional severity (TFC range 3–13), with 47 proteins having a minimum r-value of 0.7 and nominal <i>p</i>-values < 0.05. …”
Get full text

Research progress on Sertoli cell secretion during spermatogenesis by Yao Xiao, Jingyi Zhang, Yanxin Guan, Meijing Wang, Dehong Liu, Shengxi Xiong, Junjun Li, Xujun Yu

“…These cells secrete a diverse array of proteins and cytokines that interact with various targets, working in concert with mechanisms in the spermatogenesis pathway and contributing to each stage, from spermatogonial cell division to the maturation of spermatozoa. …”
Get full text

INTESTINAL MICROBIOME - A LEADING FACTOR IN HUMAN HEALTH AND DISEASES by E. Blum Hubert

“…On the other hand, high throughput array and other technologies made it possible to simultaneously analyze thousands of genes (DNA) or gene products (RNA and proteins), resulting in an individual gene or gene expression profile (‘signature’) or to characterize the individual microbiome and its pathogenetic potential. …”
Get full text

Colistin Resistance and Management of Drug Resistant Infections by Juhi Sharma, Divakar Sharma, Amit Singh, Kumari Sunita

“…Apart from mcr genes, some other intrinsic genes and proteins are also involved in colistin resistance. …”
Get full text

Calcium-mediated regulation of mitophagy: implications in neurodegenerative diseases by Fivos Borbolis, Christina Ploumi, Konstantinos Palikaras

“…Abstract Calcium signaling plays a pivotal role in diverse cellular processes through precise spatiotemporal regulation and interaction with effector proteins across distinct subcellular compartments. …”
Get full text

Hemin Augments Growth and Hemoglobinization of Erythroid Precursors from Patients with Diamond-Blackfan Anemia by Eitan Fibach, Memet Aker

“…The disease is commonly caused by mutations in genes for ribosomal proteins. Despite the identification of disease causal genes, the disease pathogenesis is not completely elucidated. …”
Get full text

Plasma Membrane Transporters in Modern Liver Pharmacology by Jose J. G. Marin

“…Several members of the superfamilies of solute carriers (SLC) and ATP-binding cassette (ABC) proteins, with a minor participation of other families of transporters, account for the uptake and efflux, respectively, of endobiotic and xenobiotic compounds across the basolateral and apical membranes of hepatocytes and cholangiocytes. …”
Get full text

UV-Excited Fluorescence on Riparian Insects except Hymenoptera Is Associated with Nitrogen Content by William D. Wiesenborn

“…Nitrogen concentrations in insect exoskeletons appear to increase as abundances of resilin and other fluorescent, elastic proteins increase. These structural compounds may be an important nitrogen source for insectivorous vertebrates.…”
Get full text