Ensuring the Stability of the Genome: DNA Damage Checkpoints by Christine Latif, Susan H. Harvey, Susan J. O'Connell

“…An examination of this research, with emphasis on the function of checkpoint proteins, their relationship to DNA repair, and their involvement in oncogenesis is undertaken here.…”
Get full text

ICGenomics: A PROGRAM COMPLEX FOR ANALYSIS OF SYMBOL SEQUENCES IN GENOMICS by Y. L. Orlov, A. O. Bragin, I. V. Medvedeva, K. V. Gunbin, P. S. Demenkov, O. V. Vishnevsky, V. G. Levitsky, D. Y. Oshchepkov, N. L. Podkolodnyy, D. A. Afonnikov, I. Grosse, N. A. Kolchanov

“…Examples are: ChIP-seq analysis; functional annotation of gene regulatory regions in nucleotide and amino acid sequences; prediction of nucleosome positioning; and structural and functional annotation of proteins, including their allergenicity and evolution features. …”
Get full text

Mitochondrial disease and epilepsy in children by Xuan Zhang, Xuan Zhang, Xuan Zhang, Bo Zhang, Bo Zhang, Bo Zhang, Zhiming Tao, Zhiming Tao, Zhiming Tao, Jianmin Liang, Jianmin Liang, Jianmin Liang

“…Mitochondrial disease refers to a group of clinically heterogeneous disorders caused by dysfunction in the mitochondrial respiratory chain, often due to mutations in mitochondrial DNA (mtDNA) or nuclear DNA (nDNA) that encodes mitochondrial proteins. This dysfunction can lead to a variety of clinical phenotypes, particularly affecting organs with high energy demands, such as the brain and muscles. …”
Get full text

Deciphering the mechanisms of long non-coding RNAs in ferroptosis: insights into its clinical significance in cancer progression and immunology by Shengming Ou, Xiaoya Nie, Xiangyu Qiu, Xin Jin, Geyan Wu, Rongxin Zhang, Jinrong Zhu

“…Long non-coding RNAs (LncRNAs) are a group of functional RNA molecules that are not translated into proteins, which can regulate gene expression in various manners. …”
Get full text

DiffMAP-GP: Continuous 2D diffusion maps from particle trajectories without data binning using Gaussian processes by Vishesh Kumar, J. Shepard Bryan, IV, Alex Rojewski, Carlo Manzo, Steve Pressé

“…We analyze both synthetic data, where ground truth is known, as well as data drawn from live-cell single-molecule imaging of membrane proteins. The resulting tool provides an unsupervised method to rigorously map diffusion coefficients continuously across membranes without data binning.…”
Get full text

Epigenetic Regulations in Neural Stem Cells and Neurological Diseases by Hang Zhou, Bin Wang, Hao Sun, Xingshun Xu, Yongxiang Wang

“…The functions of 5hmC and TET proteins on neural stem cells and their roles in neurological diseases are discussed.…”
Get full text

Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy by Moisés Blanco Calvo, Angélica Figueroa, Enrique Grande Pulido, Rosario García Campelo, Luís Antón Aparicio

“…Because of their hydrophilic nature, cells use a number of transporter proteins to introduce sugars through their plasma membrane. …”
Get full text

Exploring Potential Complement Modulation Strategies for Ischemia–Reperfusion Injury in Kidney Transplantation by Dario Troise, Costanza Allegra, Luciana Antonia Cirolla, Silvia Mercuri, Barbara Infante, Giuseppe Castellano, Giovanni Stallone

“…In this review, we will explore drugs that target complement factors, complement receptors, and regulatory proteins, aiming to highlight their potential value in improving the management of renal IRI.…”
Get full text

Clinical, Biochemical, and ATR-FTIR Spectroscopic Parameters Associated with Death or Survival in Patients with Severe COVID-19 by Adriana Martinez-Cuazitl, Monica M. Mata-Miranda, Miguel Sanchez-Brito, Daniel Valencia-Trujillo, Amanda M. Avila-Trejo, Raul J. Delgado-Macuil, Consuelo Atriano-Colorado, Francisco Garibay-Gonzalez, Virginia Sanchez-Monroy, Gustavo J. Vazquez-Zapien

“…Herein, we demonstrate that ATR-FTIR spectroscopy allows the description of the events related to cell damage, such as lipids biogenesis and the secondary structure of proteins associated with lactate dehydrogenase and albumin levels. …”
Get full text

Dystrophic Epidermolysis Bullosa in Pregnancy: A Case Report of the Autosomal Dominant Subtype and Review of the Literature by Nicole Colgrove, Rayan Elkattah, Howard Herrell

“…This classification is based on the level of tissue separation within the basement membrane zone and this is attributed to abnormalities of individual or several anchoring proteins that form the interlocking network spanning from the epidermis to the dermis underneath. …”
Get full text

Macrophage-derived extracellular vesicles as new players in chronic non-communicable diseases by Fengjuan Lin, Huiyu Luo, Jiexian Wang, Qing Li, Longying Zha

“…Extracellular vesicles (EVs) are released by cells and transport their contents (micro RNAs, mRNA, proteins, and long noncoding RNAs) to nearby or distant cells for cell-to-cell communication. …”
Get full text

Insights into multiscale chemical characterisation for the understanding of berry maturation by Boulet, Emmanuelle Meudec, Marie-Agnes Ducasse, Elissa Abi-Habib, Sophie Le Gall, Xavier Falourd, Benedicte Bakan, Amidou Traore, Geraldine Lucchi, Karine Gourrat, Caroline Peltier, Céline Poncet-Legrand, Aude Vernhet, Veronique Cheynier

“…., polysaccharides and proteins. The aim of this work was to evaluate the potential of merging different analytical methods for identifying different compounds at different scales. …”
Get full text

Teaching an old dog new tricks: re-engineering IL-2 for immuno-oncology applications by Mario Sznol, Naiyer Rizvi

“…Interleukin-2 has become a prominent focus of preclinical and clinical investigation, because of its known clinical activity, the important role of this cytokine in immune biology, and the ability to engineer variant proteins with potentially improved antitumor immunomodulatory activity and reduced toxicity. …”
Get full text

Tumor-Related Exosomes Contribute to Tumor-Promoting Microenvironment: An Immunological Perspective by Wuzhen Chen, Jingxin Jiang, Wenjie Xia, Jian Huang

“…Exosomes are a kind of cell-released membrane-form structures which contain proteins, lipids, and nucleic acids. These vesicular organelles play a key role in intercellular communication. …”
Get full text

The Role of Exosomes in Cancer Progression and Therapy by Shynggys Sergazy, Roza Seydahmetova, Alexandr Gulyayev, Zarina Shulgau, Mohamad Aljofan

“…Interestingly, tumor-derived exosomes carry oncogenic molecules, such as proteins and microRNAs, which can reprogram recipient cells, promote angiogenesis, and stimulate cancer pre-metastatic niche, supporting cancer growth and metastasis. …”
Get full text

Postextractive Alveolar Ridge Preservation Using L-PRF: Clinical and Histological Evaluation by Giorgio Serafini, Marco Lollobrigida, Lorenzo Fortunato, Giulia Mazzucchi, Luca Lamazza, Dario Di Nardo, Iole Vozza, Mara Riminucci, Alberto De Biase

“…Leukocyte- and platelet-rich fibrin (L-PRF) is an autologous platelet concentrate rich in growth factors and plasma proteins, obtained by centrifugation of patient whole blood, and widely used in oral surgery. …”
Get full text

Impact of Excessive Nitrogen Fertilization on the Biochemical Quality, Phenolic Compounds, and Antioxidant Power of Sesamum indicum L Seeds by Laila Elhanafi, Mariame Houhou, Chaimae Rais, Ismail Mansouri, Lahsen Elghadraoui, Hassane Greche

“…In fact, N fertilizer promoted the accumulation of proteins until 57.16%, in detriment of oil and sugars that decreased with 49.43% and 16.27%, respectively. …”
Get full text

Functional large-conductance calcium and voltage-gated potassium channels in extracellular vesicles act as gatekeepers of structural and functional integrity by Shridhar Sanghvi, Divya Sridharan, Parker Evans, Julie Dougherty, Kalina Szteyn, Denis Gabrilovich, Mayukha Dyta, Jessica Weist, Sandrine V. Pierre, Shubha Gururaja Rao, Dan R. Halm, Tingting Chen, Panagiotis S. Athanasopoulos, Amalia M. Dolga, Lianbo Yu, Mahmood Khan, Harpreet Singh

“…Abstract Extracellular vesicles (EVs) are associated with intercellular communications, immune responses, viral pathogenicity, cardiovascular diseases, neurological disorders, and cancer progression. EVs deliver proteins, metabolites, and nucleic acids into recipient cells to effectively alter their physiological and biological response. …”
Get full text

Hyperresponsiveness in the Human Nasal Airway: New Targets for the Treatment of Allergic Airway Disease by P. J. Turner, J. C. Foreman

“…A number of different hypotheses have been proposed to explain the underlying mechanism of AHR, including a role for eosinophil-derived proteins, free radicals and neuropeptides. While there may be a number of independent pathways which can result in AHR, evidence obtained from both animal models and in vivo experiments in humans indicate that some mediators may interact with one another, resulting in AHR. …”
Get full text

Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease by Jiangyuan Jin, Mianzhi Zhang

“…Extracellular vesicles (EVs) contain cell-derived membrane proteins, nucleic acids (such as DNA and RNA) and other important cellular components and are involved in intercellular information and substance transmission. …”
Get full text