Exploring Marine Cyanobacteria for Lead Compounds of Pharmaceutical Importance by Bushra Uzair, Sobia Tabassum, Madiha Rasheed, Saima Firdous Rehman

“…They are excellent source of vitamins and proteins vital for life. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immunodeficiency syndrome (AIDS), arthritis, and so forth, while other compounds have been developed as analgesics or to treat inflammation, and so forth. …”
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Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis by Ola Gutzeit, Aakanksha Gulati, Zohreh Izadifar, Anna Stejskalova, Hassan Rhbiny, Justin Cotton, Bogdan Budnik, Sanjid Shahriar, Girija Goyal, Abidemi Junaid, Donald E. Ingber

“…Proteomic analysis of the Vagina Chip, following exposure to mucus from the Cervix Chip, revealed differentially abundant proteins, suggesting potential biomarkers and therapeutic targets for BV management. …”
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The DEAD-Box RNA Helicase DDX3 Interacts with m6A RNA Demethylase ALKBH5 by Abdullah Shah, Farooq Rashid, Hassaan Mehboob Awan, Shanshan Hu, Xiaolin Wang, Liang Chen, Ge Shan

“…The dynamics of m6A RNA modification is still a field demanding further investigation, and here, we add a link by showing that RNA demethylation can be regulated by proteins such as DDX3.…”
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tRNA modifications: greasing the wheels of translation and beyond by Minjie Zhang, Zhipeng Lu

“…Transfer RNA (tRNA) is one of the most abundant RNA types in cells, acting as an adaptor to bridge the genetic information in mRNAs with the amino acid sequence in proteins. Both tRNAs and small fragments processed from them play many nonconventional roles in addition to translation. tRNA molecules undergo various types of chemical modifications to ensure the accuracy and efficiency of translation and regulate their diverse functions beyond translation. …”
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Influence of sulfate-reducing bacteria on the biocorrosion of mild steel coated with hybrid polyetherimide-ZnO or CuO bilayer composites by Rahali, Emna, El-Bassi, Leila, Bousselmi, Latifa, Alves, Marta M., Montemor, Maria de Fátima, Akrout, Hanene

“…Mild steel (MS) coated with protective bilayer hybrid coatings of polyetherimide, and ZnO/CuO was exposed to artificial treated wastewater (ATWW) inoculated with Desulfovibrio sp. (biotic system). Proteins from the extracellular polymeric substances (EPS) matrix of Desulfovibrio sp. responded to the coatings. …”
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Alternative Splicing and Its Impact as a Cancer Diagnostic Marker by Yun-Ji Kim, Heui-Soo Kim

“…It allows a limited number of genes to encode various proteins with intricate functions. Alternative splicing is regulated by genetic mutations in cis-regulatory factors and epigenetic events. …”
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Investigation of Splicing Quantitative Trait Loci in by Wonseok Yoo, Sungkyu Kyung, Seonggyun Han, Sangsoo Kim

“…The alteration of alternative splicing patterns has an effect on the quantification of functional proteins, leading to phenotype variation. The splicing quantitative trait locus (sQTL) is one of the main genetic elements affecting splicing patterns. …”
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Intravenous Immunoglobulins: Mode of Action and Indications in Autoimmune and Inflammatory Dermatoses by Lyubomir A. Dourmishev, Dimitrina V. Guleva, Ljubka G. Miteva

“…Intravenous immunoglobulins (IVIGs), a mixture of variable amounts of proteins (albumin, IgG, IgM, IgA, and IgE antibodies), as well as salt, sugar, solvents, and detergents, are successfully used to treat a variety of dermatological disorders. …”
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Inflammasomes in neurodegenerative diseases by Qianchen Wang, Songwei Yang, Xuan Zhang, Shanshan Zhang, Liping Chen, Wanxue Wang, Naihong Chen, Jiaqing Yan

“…In neurodegenerative diseases and neuroinflammation, the accumulation of misfolded proteins, such as beta-amyloid and alpha-synuclein, can lead to inflammasome activation, resulting in the release of interleukin (IL)-1β and IL-18. …”
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The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke by Nada H. Aljarba, Hayder M. Al-Kuraishy, Ali I. Al-Gareeb, Mustafa M. Shokr, Marios Papadakis, Athanasios Alexiou, Mubarak Alruwaili, Mohammed Alrouji, Mohammed S. Alshammari, Gaber El-Saber Batiha

“…The advanced glycation end-products (AGEs) are toxic molecules result from non-enzymatic interactions of sugar with lipids or proteins. AGEs promote the generation of reactive oxygen species that induce the release of pro-inflammatory cytokines, and alter the intracellular signaling leading to progressive biochemical and metabolic derangements. …”
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Natural products targeting RAS by multiple mechanisms and its therapeutic potential in cancer: An update since 2020 by Yanqing Liu, Jie Chen, Xiang Li, Yu Fan, Cheng Peng, Xiaochun Ye, Yingshuang Wang, Xin Xie

“…RAS proteins, as pivotal signal transduction molecules, are frequently mutated and hyperactivated in various human cancers, closely associated with tumor cell proliferation, survival, and metastasis. …”
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Incomplete divisions between sister germline cells require Usp8 function by Mathieu, Juliette, Huynh, Jean-René

“…First, we outline the molecular events of cytokinesis during both complete and delayed abscission, highlighting the role of the ESCRT-III proteins. We then focus on recent discoveries that reveal the molecular mechanisms blocking abscission in Drosophila germline cells. …”
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Pediatric RSV Infection During Two Winter Seasons in British Columbia: A Role for Subgroup Analysis in Young Children? by E Wilson, C Orvell, B Morrison, E Thomas

“…Using a panel of eight monoclonal antibodies directed against the G, F and NP proteins of respiratory syncytial virus, 167 virus isolates from nasopharyngeal washing cultures at British Columbia Children’s Hospital during two consecutive epidemics were subgrouped. …”
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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease by Kyeong-Ah Kwak, Seung-Pyo Lee, Jin-Young Yang, Young-Seok Park

“…Alzheimer’s disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins. Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease’s pathogenesis. …”
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IP3 Receptors, Mitochondria, and Ca2+ Signaling: Implications for Aging by Jean-Paul Decuypere, Giovanni Monaco, Ludwig Missiaen, Humbert De Smedt, Jan B. Parys, Geert Bultynck

“…The tight interplay between endoplasmic-reticulum-(ER-) and mitochondria-mediated Ca2+ signaling is a key determinant of cellular health and cellular fate through the control of apoptosis and autophagy. Proteins that prevent or promote apoptosis and autophagy can affect intracellular Ca2+ dynamics and homeostasis through binding and modulation of the intracellular Ca2+-release and Ca2+-uptake mechanisms. …”
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Roles of Inflammasomes in Inflammatory Kidney Diseases by Jinjin Fan, Kaifeng Xie, Liqin Wang, Nuoyan Zheng, Xueqing Yu

“…Inflammasomes are macromolecules consisting of multiple proteins, and their formation initiates the cleavage of procaspase-1, resulting in the activation of gasdermin D as well as the maturation and release of interleukin-1β and IL-18, leading to pyroptosis. …”
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The state of the art in anti-aging: plant-based phytochemicals for skin care by Merve Tomas, Deniz Günal-Köroğlu, Senem Kamiloglu, Tugba Ozdal, Esra Capanoglu

“…Recent research highlights that plant-based phytochemicals can improve skin elasticity, reduce hyperpigmentation, prevent the breakdown of important skin proteins, and support wound healing, making them valuable components for skin care and treatments. …”
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Molecular mimicry in the pathogenesis of autoimmune rheumatic diseases by Michaela Fehringer, Thomas Vogl

“…One prominent hypothesis for the initial breach of immune tolerance (leading to autoimmunity) is molecular mimicry, which describes structural or sequence similarities between human and microbial proteins (mimotopes). This similarity can lead to cross-reactive antibodies and T-cell receptors, resulting in an immune response against autoantigens. …”
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The Role of Chemokines in Breast Cancer Pathology and Its Possible Use as Therapeutic Targets by M. Isabel Palacios-Arreola, Karen E. Nava-Castro, Julieta I. Castro, Eduardo García-Zepeda, Julio C. Carrero, Jorge Morales-Montor

“…Chemokines are small proteins that primarily regulate the traffic of leukocytes under homeostatic conditions and during specific immune responses. …”
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Metal Complexes and Their Potential Therapeutic Role Against COVID-19: Recent Developments in Drug Designing by Kanwal Ashiq, Bushra Naureen, Sana Ashiq

“…Herein, metal complexes' therapeutic role and significance against treating SARS-CoV-2 or any of its target proteins are discussed. …”
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