Exploring the therapeutic potential of Asparagus africanus in polycystic ovarian syndrome: a computational analysis by Riaz Sania, Haider Fatima, ur-Rehman Rizwan-, Zafar Aqsa

“…The aim of this study is to investigate the potential therapeutic efficacy of A. africanus in the management of PCOS through molecular docking studies with Luteinizing Hormone Receptor and Follicle-Stimulating Hormone Receptor proteins. The identified compounds underwent molecular docking against key proteins associated with PCOS, namely Luteinizing Hormone Receptor and Follicle-Stimulating Hormone Receptor. …”
Get full text

Les dispersions de PVAC pour le collage des panneaux peints fragilisés by Gwendoline Firmery

“…Our study engages with the issues of stability and reversibility, both theoretical and practical, of PVAC dispersions, leading us to reconsider the advantages of their use over proteinic adhesives for opening damaged joints, in cases where swelling produced by the solvent could be problematic.…”
Get full text

 PVAC dispersions for the gluing of weakened panel paintings by Gwendoline Firmery

“…Our study engages with the issues of stability and reversibility, both theoretical and practical, of PVAC dispersions, leading us to reconsider the advantages of their use over proteinic adhesives for opening damaged joints, in cases where swelling produced by the solvent could be problematic.…”
Get full text

Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice by Alexandra O. Strohm, Sadie Oldfield, Eric Hernady, Carl J. Johnston, Brian Marples, M. Kerry O'Banion, Ania K. Majewska

“…Surprisingly, radiation exposure caused relatively smaller proteomic changes in glial and synaptic proteins, including Rgs10, Crybb1, C1qa, and Hexb. …”
Get full text

Assessment of Clinical Analgesic Levels and Serum Biomarkers in Patients with Rheumatoid Arthritis: A Randomized Controlled Trial Comparing the Efficacy of Diclofenac and Methotrex... by Mei Zhang, Zhongyuan Ma, Rinkiko Suguro, Menglin Zhu, Esther Xinyi Chen, Xin Dong, Meixiu Chen, Linling Cheng, Bolun Su, Yizhun Zhu

“…A statistical analysis was conducted on the levels of specific proteins and inflammatory factors before and after treatment to evaluate its impact. …”
Get full text

Integrated analysis of bioinformatics, mendelian randomization, and experimental validation reveals novel diagnostic and therapeutic targets for osteoarthritis: progesterone as a p... by Ziyu Weng, Chenzhong Wang, Bo Liu, Yi Yang, Yueqi Zhang, Chi Zhang

“…Screening with the Drug Signatures Database (DSigDB) identified progesterone as a small-molecule drug targeting these key proteins. Molecular docking analysis using AutoDock Vina revealed that progesterone exhibited binding energies of ≤ -7 kcal/mol with each of the key proteins, indicating strong binding affinity. …”
Get full text

Mechanistic insight into human milk extracellular vesicle‐intestinal barrier interactions by Xiang Luo, Yunyue Zhang, Ning Ding, Jana Javorovic, Bahijja Tolulope Raimi‐Abraham, Steven Lynham, Xiaoping Yang, Natalie Shenker, Driton Vllasaliu

“…Proteomic analysis of EVs transported across Caco‐2 monolayers identified 14 enriched EV proteins that may facilitate intestinal transport. …”
Get full text

Mutations in human prion-like domains: pathogenic but not always amyloidogenic by Andrea Bartolomé-Nafría, Javier García-Pardo, Salvador Ventura

“…Heterogeneous nuclear ribonucleoproteins (hnRNPs) are multifunctional proteins with integral roles in RNA metabolism and the regulation of alternative splicing. …”
Get full text

Effect of almond shell addition to substrates in Phaseolus vulgaris L. (cv. Saxa) growth, and physiological and biochemical characteristics by Ivo Oliveira, Anne Meyer, Rita Silva, Sílvia Afonso, Berta Gonçalves

“…Evaluated parameters included green bean pod production and characteristics and their biochemical parameters, namely pigments, total phenolics and antioxidant activity, and soluble sugars and proteins, but also leaf gas exchange parameters. Results The use of almond shell as a mulch resulted in unexpected higher crop growth rate, relative leaf growth rate, and leaf area index, with similar production and dimension of pods, when compared to the control assay, with comparable amounts of phenolic compounds, antioxidant capacity, and soluble sugars and proteins, even if gas exchange parameters were negatively affected. …”
Get full text

Betaine Treatment Attenuates Chronic Ethanol-Induced Hepatic Steatosis and Alterations to the Mitochondrial Respiratory Chain Proteome by Kusum K. Kharbanda, Sandra L. Todero, Adrienne L. King, Natalia A. Osna, Benita L. McVicker, Dean J. Tuma, James L. Wisecarver, Shannon M. Bailey

“…The alcohol-dependent loss in many of the low molecular weight oxidative phosphorylation proteins was prevented by betaine supplementation. …”
Get full text

Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and expe... by Yanggang Hong, Qichao Yuan, Yi Wang, Deqi Wang, Xiaoju Guan, Congde Chen

“…By integrating molecular docking, single-cell RNA sequencing, and in vivo experimentation, the study identified POLE and LRAT as critical proteins. These proteins were shown to interact strongly with busulfan, leading to genomic instability and increased germ cell apoptosis during spermatogenesis. …”
Get full text

Lipopolysaccharide affects metabolic processes and energy homeostasis in the corpus luteum by Karol Mierzejewski, Robert Stryiński, Iwona Bogacka, Monika Golubska, Mónica Carrera, Aleksandra Kurzynska

“…The CL slices were incubated in the presence of LPS for 24 h.ResultsWe identified 12 differentially regulated proteins after treatment with LPS (7 of them were upregulated, while 5 were downregulated). …”
Get full text

Characterizing the Contaminant-Adhesion of a Dibenzofuran Degrader <i>Rhodococcus</i> sp. by Yu Chen, Qingquan Wei, Xudi Wang, Yanan Wu, Changai Fu, Xu Wang, Hangzhou Xu, Li Li

“…Compared with sodium acetate as a carbon source, the percentages of glucose and proteins related to electron transfer, toxin–antitoxin, and stress responses were elevated, which were analyzed by polysaccharide composition and proteomics, and the contents of extracellular polysaccharides and proteins were increased. …”
Get full text

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs by Giuseppina Catanzaro, Zein Mersini Besharat, Neha Garg, Maurizio Ronci, Luisa Pieroni, Evelina Miele, Angela Mastronuzzi, Andrea Carai, Vincenzo Alfano, Agnese Po, Isabella Screpanti, Franco Locatelli, Andrea Urbani, Elisabetta Ferretti

“…Taken together, our findings highlight microRNAs, genes, and proteins that are significantly modulated in hMB-SLCs with respect to their RA-differentiated counterparts and could open new perspectives for prognostic and therapeutic intervention on MB.…”
Get full text

Evidence for Activation of Toll-Like Receptor and Receptor for Advanced Glycation End Products in Preterm Birth by Taketoshi Noguchi, Toshiyuki Sado, Katsuhiko Naruse, Hiroshi Shigetomi, Akira Onogi, Shoji Haruta, Ryuji Kawaguchi, Akira Nagai, Yasuhito Tanase, Shozo Yoshida, Takashi Kitanaka, Hidekazu Oi, Hiroshi Kobayashi

“…About half of the genes and proteins specifically present in preterm birth have the properties of endogenous ligands “alarmin” for receptor activation. …”
Get full text

Salivary biomarkers in cancer - A narrative review by R. Swaathi, Madhu Narayan, Rajkumar Krishnan

“…Antibodies, microorganisms, Deoxyribonucleic acid (DNA), Ribonucleic acid (RNA), lipids, metabolites and proteins are some of the many types of biomarkers. …”
Get full text

Polypeptide Expression in Prostate Hyperplasia and Prostate Adenocarcinoma by Ayodele Alaiya, Uwe Roblick, Lars Egevad, Adelaide Carlsson, Bo Franzén, Daniela Volz, Sören Huwendiek, Stig Linder, Gert Auer

“…The EST‐data base for prostate tumors available from NCI (CGAP) was searched for the expression of the mRNAs corresponding to proteins identified in our gels. Large differences in the relative expression of mRNAs and proteins were observed. …”
Get full text

Genome-wide analyses of the NAC transcription factor gene family in Acer palmatum provide valuable insights into the natural process of leaf senescence by Xin Meng, Chun Feng, Zhu Chen, Faheem Afzal Shah, Yue Zhao, Yuzhi Fei, Hongfei Zhao, Jie Ren

“…An analysis of the phylogenetic tree of Arabidopsis thaliana NAC family members revealed that ApNAC proteins could be divided into 16 subgroups. A comparison of ApNAC proteins with NAC genes from other species suggested their potential involvement in evolutionary processes. …”
Get full text

Rheology of Biopolymer Solutions and Gels by David R. Picout, Simon B. Ross-Murphy

“…This review concentrates on introducing the fundamentals of rheology and on discussing the rheological aspects and properties of the two major classes of biopolymers: polysaccharides and proteins. An overview of both their solution properties (dilute to semi-dilute) and gel properties is described.…”
Get full text

Aberrant Alternative Splicing Is Another Hallmark of Cancer by Michael Ladomery

“…Splice isoforms often encode proteins that have distinct and even antagonistic properties. …”
Get full text