Trafficking in cancer: from gene deregulation to altered organelles and emerging biophysical properties by Julie Patat, Kristine Schauer, Kristine Schauer, Hugo Lachuer

“…Here, we give an overview about trafficking proteins and highlight that in addition to their molecular functions, they contribute to the emergence of intracellular organelle landscapes. …”
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Molecular insights into a distinct class of terpenoid cyclases by Siyu Li, Jian-Wen Huang, Jian Min, Hao Li, Meidan Ning, Shuyu Zhou, Yu Yang, Chun-Chi Chen, Rey-Ting Guo

“…Here, we report the crystal structures of BcABA3, a closely related RuABA3 from Rutstroemia sp. and a bacterial SkABA3 from Shimazuella kribbensis. These ABA3 proteins adopt an all-α-helix fold and bind pyrophosphate moiety of farnesyl pyrophosphate by Glu-chelated Mg2+ ion cluster. …”
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A distant TANGO1 family member promotes vitellogenin export from the ER in C. elegans by Jimmy H. Mo, Chao Zhai, Kwangsek Jung, Yan Li, Yonghong Yan, Meng-Qiu Dong, Ho Yi Mak

“…In humans, the TANGO1 family of proteins generates membrane carriers to accommodate bulky ApoB-containing lipoprotein particles for their endoplasmic reticulum (ER) export. …”
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BIOCHEMICAL VALUES OF BLOOD SERA FROM FARM ANIMALS by D. S. Bolshakov, T. B. Nikeshina

“…The significanceof the main biochemical values (proteins, lipids, carbohydrates, colouring agents, low-molecular nitrogenous and mineral matters) in blood sera (plasm) from farm animals is described in the paper. …”
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MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer by Shamima Afrin Ruma, Rufus Vinod, Shruti Jain, Kaisa Huhtinen, Johanna Hynninen, Janne Leivo, Kim Pettersson, Karin Sundfeldt, Kamlesh Gidwani

“…Abstract Glycosylation changes of circulating proteins carrying the CA19-9 antigen may offer new targets for detection methods to be explored for the diagnosis of epithelial ovarian cancer (EOC). …”
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The expansion and loss of specific olfactory genes in relatives of parasitic lice, the stored-product psocids (Psocodea: Liposcelididae) by Jun Sun, Jian Wu, Sheng-Yuan Sun, Zhi-Dong Chen, Guy Smagghe, Jin-Jun Wang, Dan-Dan Wei

“…Result Using HMMER method and manual annotation, we have identified common gene families associated with olfactory processes, including odorant binding proteins (OBPs), chemosensory proteins (CSPs), odorant receptors (ORs), ionotropic receptors (IRs), and sensory neuron membrane proteins (SNMPs). …”
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HEDDI-Net: heterogeneous network embedding for drug-disease association prediction and drug repurposing, with application to Alzheimer’s disease by Yin-Yuan Su, Hsuan-Cheng Huang, Yu-Ting Lin, Yi-Fang Chuang, Sheh-Yi Sheu, Chen-Ching Lin

“…HEDDI-Net integrates graph and shallow learning techniques to extract representative diseases and proteins, respectively. These representative diseases and proteins are used to embed the input features, which are then utilized in a multilayer perceptron for predicting drug-disease associations. …”
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Calcitonin Gene-Related Peptide (Cgrp), Adrenomedullin (Am), Amylin, And Calcitonin (Ct) Receptors And Overlapping Biological Actions by J.A. Fischer, W. Born, R. Muff

“…The same proteins were specifically labeled with [125I]-hCGRP-I(1-37) and -(8-37). …”
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Role of the Notch signaling pathway in porcine oocyte maturation by Pil-Soo Jeong, Hyo-Gu Kang, Dabin Cha, Se-Been Jeon, Min Ju Kim, Bong-Seok Song, Bo-Woong Sim, Sanghoon Lee

“…Finally, the involvement of canonical Notch signaling in oocyte maturation was confirmed by the decreased expression of HES and HEY family transcripts and proteins in the RO-treated COCs. Conclusions It was first demonstrated that Notch signaling pathway-related transcripts and proteins were expressed during the meiotic maturation of porcine COCs. …”
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Phosphatidylinositol promoted the proliferation and invasion of pituitary adenoma cells by regulating POU1F1 expression by Tongjiang Xu, Xiaodong Zhai, RuiWei Wang, Xiaoben Wu, ZhiZhen Zhou, MiaoMiao Shang, Chongcheng Wang, Tengfei Qi, Wei Yang

“…Proteomic data showed that the top five up-regulated proteins were AD021, C2orf15, PLCXD3, HIST3H2BB and POU1F1, and the top five down-regulated proteins were AIPL1, CALB2, GLUD2, SLC4A10 and GTF2I. …”
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Simultaneous aerobic and anaerobic respiration in hot spring chemolithotrophic bacteria by Lisa M. Keller, Daniel R. Colman, Eric S. Boyd

“…Consumption of O2 measured via gas chromatography and detection of transcripts for proteins involved in S0 and O2 reduction in H2/S0/O2-grown cultures confirmed co-occurring aerobic and anaerobic metabolism. …”
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In silico evaluation, characterization, and in vitro anticancer activity of curcumin–nimbin loaded nanoformulation in HCT-116 cell lines by Arumugam Madeswaran, Selvam Tamilazhagan, Sellappan Mohan

“…In silico docking and ADMET analyses targeted proteins implicated in colorectal cancer, with doxorubicin as the standard. …”
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Interferon-gamma: A Potent Antiviral Agent Targeting Macrophages Infected with LP-BM5 Murine Leukemia Virus, the Causative Agent of 'AIDS' in Mice by Jens J Kort, Julie L Eiseman

“…Results indicate that the therapeutic effects of these single agents were dose-dependent and both agents were similarly effective in reducing the production of infectious virus determined by XC-plaque assay and by measurements of reverse transcriptase activity in culture supernatants; and AZT and IFN-γ reduced the production of virus proteins, quantified by laser densitometry of fluorographs from immunoprecipitated viral proteins using virus-specific antiserum. …”
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Therapies for Mitochondrial Disorders by Kayli Sousa Smyth, Anne Mulvihill

“…Mitochondria contain their own genome, mitochondrial DNA (mtDNA), which is maternally inherited from the oocyte. Mitochondrial proteins are encoded by either nuclear DNA (nDNA) or mtDNA, and both code for proteins forming the mitochondrial oxidative phosphorylation (OXPHOS) complexes of the respiratory chain. …”
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Nuclear Factor Erythroid 2-Related Factor 2 Intervenes the Release of Neutrophil Extracellular Traps during Lipopolysaccharide-Induced Acute Lung Injury in Mice by Junying Lu, Guilan Xiong, Hongxiang Li, Dong Zhang, Xiaohao Zhang

“…Results showed that DNase I improved lung function and lung tissue pathology and significantly reduced lung wet/dry ratio and proteins in the BALF. Besides, DNase I also attenuated the infiltration of inflammatory cells and the cytokines (TNF-α, IL-1β) production in the BALF and the activity of lung MPO. …”
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Polysaccharides of St. John’s Wort Herb Stimulate NHDF Proliferation and NEHK Differentiation via Influence on Extracellular Structures and Signal Pathways by S. Abakuks, A. M. Deters

“…Hp2, Hp3 and Hp4 contained pectic structures and arabinogalactan proteins varying in composition and quantity. Polysaccharides of Hp1 induced the keratinocyte differentiation by inhibiting the gene expression of the epidermal growth factor and insulin receptor. …”
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Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…These as well as fusion proteins and inhibitor proteins all share varying adverse event occurrence and severity. …”
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Gamisoyo-San Ameliorates Neuroinflammation in the Spinal Cord of hSOD1G93A Transgenic Mice by MuDan Cai, Eun Jin Yang

“…Moreover, we found that GSS inhibits the expression of proteins related to Toll-like receptor 4 signaling and oxidative stress, known to cause neuroinflammation. …”
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A Novel Paramagnetic Substrate for Detecting Myeloperoxidase Activity in Vivo by Mohammed S. Shazeeb, Yang Xie, Suresh Gupta, Alexei A. Bogdanov

“…Characterization of the resulting probe (bis-HTrp-DTPA(Gd)) in vitro using nuclear magnetic resonance spectroscopy and enzyme kinetic analysis showed that bis-HTrp-DTPA(Gd) (1) improves solubility in water; (2) acts as a substrate for both horseradish peroxidase and MPO enzymes; (3) induces cross-linking of proteins in the presence of MPO; (4) produces oxidation products, which bind to plasma proteins; and (5) unlike bis-5HT-DTPA(Gd), does not follow first-order reaction kinetics. …”
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Mechanistic study of the effect of a high-salt diet on the intestinal barrier by Li Chen, Junrui Tang, Yanglin Xia, Jie Wang, Li-na Xia

“…Expression levels of intestinal tight junction proteins and mucin-2 (MUC2) in SD rats were analyzed using immunofluorescence. …”
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