Multiomics approach identifies dysregulated lipidomic and proteomic networks in Parkinson’s disease patients mutated in TMEM175 by Federica Carrillo, Marco Ghirimoldi, Giorgio Fortunato, Nicole Piera Palomba, Laura Ianiro, Veronica De Giorgis, Shahzaib Khoso, Tiziana Giloni, Sara Pietracupa, Nicola Modugno, Elettra Barberis, Marcello Manfredi, Teresa Esposito

“…Interestingly, we quantified 43 lysosomal or lysosomal-related proteins, which were differentially modulated between TMEM175 patients and controls. …”
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The imprinted Igf2-Igf2r axis is critical for exosome biogenesis during the early development of bovine placenta by Kunhua ZHENG, Longfei XIAO, Naihan YUAN, Xihui SHENG, Xiaolong QI, Yingqiu WANG, Chang CHEN, Kaijun GUO, Lin YANG, Bingying LIU, Xiangguo WANG

“…The expressions of IGF2, IGF2R, and the exosomal marker proteins CD63, CD9, TSG101, and Rab11 showed a significant upward trend with increased gestation duration. …”
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Modeling extracellular matrix through histo-molecular gradient in NSCLC for clinical decisions by Camila Machado Baldavira, Tabatha Gutierrez Prieto, Juliana Machado-Rugolo, Juliana Machado-Rugolo, Jurandir Tomaz de Miranda, Lizandre Keren Ramos da Silveira, Ana Paula Pereira Velosa, Walcy Rosolia Teodoro, Alexandre Ab’Saber, Teresa Takagaki, Vera Luiza Capelozzi

“…Thus, this study aimed to explore the prognostic value of epithelial-to-mesenchymal transition (EMT), Wnt signaling, and ECM proteins expression in patients with non–small-cell lung carcinoma (NSCLC) with clinical stages I-IIIA. …”
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An analysis of observed and predicted extreme heat and precipitation trends across four pulse producing regions in North America: North Dakota, Montana, Saskatchewan, and Northeast... by Sophia Weiss, Erin Coughlan de Perez

“…The consumption of plant-based proteins in lieu of animal proteins is the most important dietary shift that would be needed to keep the world under 2 °C of warming, and this shift would require a dramatic increase in the percentage of cropland devoted to nuts and pulses (Peters et al 2016 Elementa 4 000116). …”
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circ-SIRT1 Promotes Colorectal Cancer Proliferation and EMT by Recruiting and Binding to eIF4A3 by Xiangjie Wang, Shuang Liu, Bin Xu, Yabin Liu, Peng Kong, Changlin Li, Binghui Li

“…We further found that EIF4A3 could bind to circ-SIRT1, and that overexpressing circ-SIRT1 decreased the abundance of EIF4A3 at the mRNAs of the EMT marker proteins N-cadherin and vimentin. Combined, our findings suggested that circ-SIRT1 regulates the expression of EMT-related proteins by preventing EIF4A3 recruitment to the respective mRNAs. …”
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Dexmedetomidine Attenuates Myocardial Ischemia-Reperfusion Injury in Diabetes Mellitus by Inhibiting Endoplasmic Reticulum Stress by Jinjie Li, Ying Zhao, Nan Zhou, Longyun Li, Kai Li

“…The apoptosis of heart tissue cells was also tested through the expressions of cleaved caspase-3, Bcl-2, and Bax proteins. The expression of endoplasmic reticulum stress-related proteins GRP78, CHOP, ERO1α, ERO1β, and PDI was examined. …”
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Mechanism of SET8 Activates the Nrf2-KEAP1-ARE Signaling Pathway to Promote the Recovery of Motor Function after Spinal Cord Injury by Xin Li, Yan Qian, Wanling Shen, Shiying Zhang, Hui Han, Yu Zhang, Shuangmei Liu, Shaokun Lv, Xiuying Zhang

“…Western blotting was used to assess the expression of signature proteins of astrocytes, proteins associated with autophagy, proteins associated with glial scar formation, reactive oxygen species (ROS) levels in cells using DHE staining, and astrocyte number, morphological alterations, and induction of glial scar formation processes using immunofluorescence. …”
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Exploring the functional diversity and metabolic activities of the human gut microbiome in Thai adults in response to a prebiotic diet by Amornthep Kingkaw, Preecha Patumcharoenpol, Narissara Suratannon, Massalin Nakphaichit, Sittiruk Roytrakul, Wanwipa Vongsangnak

“…Consistently, across 76,206 proteins assigned to the metabolism of the 255,964 annotated proteins, short-chain fatty acid (SCFA) biosynthesis, lipopolysaccharide (LPS) biosynthesis, and bile acid (BA) metabolism were positively associated with CMH. …”
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Transcriptome-Based Analysis of Dof Family Transcription Factors and Their Responses to Abiotic Stress in Tea Plant (Camellia sinensis) by Hui Li, Wei Huang, Zhi-Wei Liu, Yong-Xin Wang, Jing Zhuang

“…In this study, a total of 29 putative Dof TFs were identified based on transcriptome of tea plant, and the conserved domains and common motifs of these CsDof TFs were predicted and analyzed. The 29 CsDof proteins were divided into 7 groups (A, B1, B2, C1, C2.1, C2.2, and D2), and the interaction networks of Dof proteins in C. sinensis were established according to the data in Arabidopsis. …”
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Stem Cell-Derived Nanovesicles: A Novel Cell-Free Therapy for Wound Healing by Jianghong Huang, Jun Zhang, Jianyi Xiong, Shuqing Sun, Jiang Xia, Lei Yang, Yujie Liang

“…CDNs can shuttle various proteins, messenger RNAs, and microRNAs to regulate the activity of receptor cells, and they play important roles in skin wound healing. …”
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Nucleotide-Binding Oligomerization Domain-1 and -2 Play No Role in Controlling Brucella abortus Infection in Mice by Fernanda S. Oliveira, Natalia B. Carvalho, Dario S. Zamboni, Sergio C. Oliveira

“…Nucleotide-binding oligomerization domain proteins (NODs) are modular cytoplasmic proteins implicated in the recognition of peptidoglycan-derived molecules. …”
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CRMP2 and CRMP4 Are Differentially Required for Axon Guidance and Growth in Zebrafish Retinal Neurons by Zhi-Zhi Liu, Jian Zhu, Chang-Ling Wang, Xin Wang, Ying-Ying Han, Ling-Yan Liu, Hong A. Xu

“…Collapsin response mediator proteins (CRMPs) are a family of intracellular proteins that have been found to mediate growth cone behavior in vitro; however, their roles in vivo in axon development are much less explored. …”
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Improving polyketide biosynthesis by rescuing the translation of truncated mRNAs into functional polyketide synthase subunits by Yan Liu, Chaoyi Song, Qingwen Cui, Hongluan Sun, Chanjuan Jiang, Ruofei Guo, Ruoting He, Zhen Li, Ji Luan, Hailong Wang

“…The truncated mRNA translation rescue strategy will facilitate engineering of multi-domain proteins to enhance their functions.…”
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Perfusion Imaging in Autoimmune Encephalitis by Deepak Vallabhaneni, Muhammad Atif Naveed, Rajiv Mangla, Awss Zidan, Rashi I. Mehta

“…Autoimmune encephalitis is caused by antibodies against neuronal synaptic receptors, surface proteins, or intracellular proteins. In this case report, we present a 65-year-old female who presented with a fall and altered mental status. …”
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Engineering extracellular vesicles for ROS scavenging and tissue regeneration by Ahmed Abdal Dayem, Ellie Yan, Minjae Do, Yoojung Kim, Yeongseo Lee, Ssang-Goo Cho, Deok-Ho Kim

“…Additionally, we explore strategies to enhance EV therapeutic activity, including functionalization and incorporation of antioxidant defense proteins. Understanding these molecular mechanisms is crucial for optimizing EV-based regenerative therapies. …”
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Investigation on mussel periostracum, a viscoelastic-to-poro-gel graded material, as an interface between soft tissue and rigid materials by Hyungbin Kim, Heejin Lim, Sangsik Kim, Jun Mo Koo, Chanoong Lim, Hojung Kwak, Dongyeop X. Oh, Dong Soo Hwang

“…This process was facilitated by the slipping and reassembly of β-strands in the discovered major proteins, which we named periostracin proteins. On the shell end, the highly pigmented, mineralized, and porous segment of the periostracum provided stiffness and cushioned against compressive stresses exerted by the shell valves during closure. …”
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Pseudotyped Viruses: A Useful Platform for Pre-Clinical Studies Conducted in a BSL-2 Laboratory Setting by Sofiia N. Rizatdinova, Alina E. Ershova, Irina V. Astrakhantseva

“…In recent years, pseudoviruses, which consist of a backbone of one virus and envelope proteins of another virus, have become one of the most widely used tools for exploring the mechanisms of viruses binding to cells, membrane fusion and viral entry, as well as for screening the libraries of antiviral substances, evaluating the potential of neutralizing monoclonal antibodies, developing neutralization tests, and therapeutic platforms. …”
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MicroRNAs in the DNA Damage/Repair Network and Cancer by Alessandra Tessitore, Germana Cicciarelli, Filippo Del Vecchio, Agata Gaggiano, Daniela Verzella, Mariafausta Fischietti, Davide Vecchiotti, Daria Capece, Francesca Zazzeroni, Edoardo Alesse

“…Impairment in the DNA repair proteins, which physiologically protect cells from persistent DNA injury, can affect the efficacy of cancer therapies. …”
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Unveiling the benefit of germinated colored rice extract to decrease metastatic potential of colorectal cancer cells by Kittirat Saharat, Natthaphorn Paramee, N. Monique Paricharttanakul, Nuchanart Rangkadilok, Daranee Chokchaichamnankit, Chantragan Srisomsap, Kriengsak Lirdprapamongkol, Jisnuson Svasti, Jutamaad Satayavivad

“…This study aimed to explore the anti-metastatic potential of GCR extract in HT29 colorectal cancer cells through cell migration inhibition, and to identify target proteins by using proteomic approach. GCR extract at 4 mg/mL caused 87 % reduction in cell migration. …”
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Astaxanthin relieves HT22 cells from LPS-induced inflammation and apoptosis by inhibiting oxygen species and regulating the TLR4/MyD88/NFκB signaling pathway by Tan Wang, Rongrong Li, Ping Niu, Zhen Wei, Donge Xie, Huorong Huang, Jiayao Pan, Chunshu Rong

“…We found that LPS decreased the survival rate of HT22 cells, induced reactive oxygen species (ROS) accumulation and apoptosis, and increased the expression of inflammation-related proteins. Conversely, ATX diminished LPS-induced ROS accumulation and apoptosis, as well as the expression of inflammation-related proteins. …”
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