PROTAC-based therapeutics for targeting HPV oncoproteins in head and neck cancers by Nobendu Mukerjee, Dattatreya Mukherjee

“…Proteolysis Targeting Chimeras (PROTACs) present a novel therapeutic strategy, leveraging the ubiquitin-proteasome system to specifically degrade the oncogenic HPV proteins E6 and E7. This targeted approach not only potentially reduces the side effects associated with conventional treatments but also directly interrupts the cancer-promoting activities of these proteins, offering a promising avenue for more effective and less invasive treatment of HPV-associated malignancies.…”
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Expanding the concept of ID conversion in TogoID by introducing multi-semantic and label features by Shuya Ikeda, Kiyoko F. Aoki-Kinoshita, Hirokazu Chiba, Susumu Goto, Masae Hosoda, Shuichi Kawashima, Jin-Dong Kim, Yuki Moriya, Tazro Ohta, Hiromasa Ono, Terue Takatsuki, Yasunori Yamamoto, Toshiaki Katayama

“…This enhancement enables TogoID to distinguish relationships such as "glycans bind to proteins" or "glycans are processed by proteins" between glycans and proteins. …”
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Elucidating the mechanism of phthalates induced osteoporosis through network toxicology and molecular docking by Xiao Zhang, Xi Zhu, Wenbo Gu, Xusheng Li, Tenyao Niu, Pengcheng Mao, Haifeng Yuan

“…And, we also investigated the binding of plasticizers to target proteins using network toxicology and molecular docking techniques. …”
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Multigenerational effects of cultivating transgenic maize straw on earthworms: A combined laboratory and field experiment by Li Zhang, Wenjing Shen, Zhixiang Fang, Laipan Liu, Ruizong Jia, Jingang Liang, Biao Liu

“…The cultivation of genetically modified (GM) maize has aroused notable public concern related to the potential risks to soil fauna caused by the release of foreign proteins. In this study, the potential effects of cultivating the GM maize variety DBN9936, which exhibits the expression of the Cry1Ab and EPSPS proteins, on earthworms (Eisenia fetida) were evaluated under laboratory and field conditions. …”
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Investigation of the Protective Effects of Phlorizin on Diabetic Cardiomyopathy in db/db Mice by Quantitative Proteomics by Qian Cai, Baoying Li, Fei Yu, Weida Lu, Zhen Zhang, Mei Yin, Haiqing Gao

“…Using isobaric tag for relative and absolute quantitation (iTRAQ) proteomics, we identified differentially expressed proteins involved in cardiac lipid metabolism, mitochondrial function, and cardiomyopathy, suggesting that phlorizin may prevent the development of diabetic cardiomyopathy by regulating the expression of key proteins in these processes. …”
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Paclitaxel-induced Hypersensitivity Reaction by Cyril Sajan, Elizabeth Jacob, Varunsingh Saggu, Rajesh Hadia, Hemraj Singh Rajput

“…Molecules present in Cremophor ELP are found to be similar in structure to certain nonionic block copolymers that activate complement proteins (the proteins involved in various immune processes).…”
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Exploring the buffalo whey: a look at nanotechnology in search of strategies for the modern nutraceutical industry by Franco E. Vasile

“… Buffalo whey is the most important by-product of the cheese industry. Whey proteins constitute the most exciting component from a technological and economic point of view. …”
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Allergic enteritis in children by Mieczysława Czerwionka-Szaflarska, Ewa Łoś-Rycharska, Julia Gawryjołek

“…The diagnosis of allergic enteritis is based on the clinical examination and the results of additional tests including an endoscopy of the lower digestive tract with histopathological assessment. Cow’s milk proteins are the most common nutrition proteins responsible for the development of the symptoms of allergic enteritis. …”
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Restoring bone healing potential by Inês Sequeira

“…A combination of intermittent fasting and administering Wnt3a proteins to a bone injury can rejuvenate bone repair in aged mice.…”
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MDM4 Isoform Expression in Melanoma Supports an Oncogenic Role for MDM4-A by Abdullah Alatawi, SoonJye Kho, Michael P. Markey

“…These changes in splicing must be considered in the design of therapeutic inhibitors of the MDM2/4 proteins for melanoma.…”
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An Insight into the Sialomes of Bloodsucking Heteroptera by José M. C. Ribeiro, Teresa C. Assumpção, Ivo M. B. Francischetti

“…Saliva of bloodsucking arthropods contains dozens or hundreds of proteins that affect their hosts' mechanisms against blood loss (hemostasis) and inflammation. …”
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Modulation of Toll-Like Receptor Activity by Leukocyte Ig-Like Receptors and Their Effects during Bacterial Infection by Louise E. Pilsbury, Rachel L. Allen, Martin Vordermeier

“…One family of immunoregulatory proteins which can provide a balancing effect on TLR activity are the Leukocyte Ig-like receptors (LILRs), which act as innate immune receptors for self-proteins. …”
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Thermal and morphological properties of human erythrocytes from patients afflicted with type 1 diabetes mellitus by Péter Gaszler, Dénes Lőrinczy, Dávid Szatmári, Beáta Bódis, Katalin Türmer

“…In diabetes, the primary influence is increased glucose levels in the blood plasma that can result in the oxidation of lipids and proteins and the glycation of proteins. The damage changes the conformation and organization of various lipids and proteins, which can result in the loss of function and decreased deformability. …”
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Utilizing the subtractive proteomics approach to design ensemble vaccine against Candida lusitaniae for immune response stimulation; a bioinformatics study. by Habiba Naz, Rimsha Timotheous, Muhammad Farhan Sarwar, Tariq Nadeem, Mudassar Fareed Awan, Sajed Ali, Sophia Awais, Irfan Ahmed

“…Notably, each of these proteins was non-homologous to human beings. This particular attribute of the selected proteins i.e., to be non-homologous, was made in order to possess the ability to trigger an immunological response in host (humans). …”
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Comparative Analysis on Single- and Multiherb Strategies in Coronary Artery Atherosclerosis Therapy by Yu Cao, Yang Liu, Tian Zhang, Wei Lei, Boli Zhang

“…The herbal strategy with multiherb not merely possesses more amounts and interactions of target proteins than the strategy with single-herb but also enlarges interaction partners of target proteins like PTPN11 and STAT3 in strategy II, III, and IV. …”
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HIF-1α Is Associated with Resistance to Hypoxia-Induced Apoptosis in Ameloblastoma by Katherine Julissa Palma Valladares, Karolyny Martins Balbinot, Antonia Taiane Lopes de Moraes, Maria Sueli da Silva Kataoka, Aline Maria Pereira Cruz Ramos, Rommel Thiago Jucá Ramos, Artur Luiz da Costa da Silva, Ricardo Alves Mesquita, David Normando, Sérgio de Melo Alves Júnior, João de Jesus Viana Pinheiro

“…AMB and DF expressed the studied proteins. These proteins showed significantly greater immunoexpression in AMB compared with the DF (p<0.05). …”
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Structural basis of THC analog activity at the Cannabinoid 1 receptor by Thor S. Thorsen, Yashraj Kulkarni, David A. Sykes, Andreas Bøggild, Taner Drace, Pattarin Hompluem, Christos Iliopoulos-Tsoutsouvas, Spyros P. Nikas, Henrik Daver, Alexandros Makriyannis, Poul Nissen, Michael Gajhede, Dmitry B. Veprintsev, Thomas Boesen, Jette S. Kastrup, David E. Gloriam

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Palovarotene Can Attenuate Heterotopic Ossification Induced by Tendon Stem Cells by Downregulating the Synergistic Effects of Smad and NF-κB Signaling Pathway following Stimulation... by Junchao Huang, Jialiang Lin, Congbin Li, Bo Tang, Haijun Xiao

“…The expression of osteogenic and inflammation-related proteins, as well as Smad proteins, was upregulated. …”
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CpG Oligodeoxynucleotides Inhibit RANKL-Induced Osteoclast Formation by Upregulating A20 Deubiquitinase in RAW 264.7 Cells by Seong-Kyu Kim, Jung-Yoon Choe, Ki-Yeun Park

“…RANKL-induced osteoclast-related genes and proteins, c-Fos, NFATc1, TRAP, cathepsin K, and carbonic anhydrase II were significantly inhibited in RAW 264.7 cells stimulated with CpG-ODN. …”
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Integrative transcriptome profiling for identifying ALS potential treatment using the drug repurposing approach by Navid Kashani, Amir Sabbaghian, Fatemeh EmamiPari, Mohammad Khalili Gorjimahalleh, Mahdi Aalikhani

“…Then, molecular docking was performed to repurpose drugs that have the potential to suppress upregulated proteins. Accordingly, three drugs including ketoprofen, thalitone, and cromolyn have been repurposed against CMPK2 and IFI44L proteins. …”
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