IS IT POSSIBLE TO PREDICT TUMOR PROGRESSION THROUGH GENOMIC CHARACTERIZATION OF MONOCLONAL GAMMOPATHY AND SMOLDERING MULTIPLE MYELOMA? by Ugo Testa, Giuseppe Leone, Elvira Pelosi, Germana Castelli, Valerio De Stefano

“… The study of monoclonal serum proteins has led to the generation of two major theories: one proposing that individuals who had monoclonal proteins without any symptoms or evidence of end-organ damage have a benign condition; the other one suggesting that some individuals with asymptomatic monoclonal proteins may progress to multiple myeloma and thus are affected by a monoclonal gammopathy of undetermined significance (MGUS). …”
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Eucalyptus grandis WRKY genes provide insight into the role of arbuscular mycorrhizal symbiosis in defense against Ralstonia solanacearum by Jianlang Zhang, Xinzhu Yang, Chunyu Huo, Xinyi Fan, Qiutong Liu, Zhihong Liu, Yu Su, Zujing Chen, Zujing Chen

“…Phylogenetic analysis divided the EgWRKY proteins into three groups: group I (21 proteins, 17.95%), group II (65 proteins, 55.56%), and group III (24 proteins, 20.51%). …”
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Temporal Changes in Gene Expression Profile during Mature Adipocyte Dedifferentiation by Julie Anne Côté, Frédéric Guénard, Julie Lessard, Marc Lapointe, Simon Biron, Marie-Claude Vohl, André Tchernof

“…Most of these genes coded for proteins involved in adipocyte functions (LIPE, PLIN1, DGAT2, PNPLA2, ADIPOQ, CEBPA, LPL, FABP4, SCD, INSR, and LEP). …”
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The role of ubiquitination and deubiquitination in cancer lipid metabolism by Yongkang Xu, Jiayu Zeng, Shumin Fu, Kan Liu, Ye Mao, Si Tao, Jianbing Wu

“…The ubiquitin-proteasome system (UPS) is one of the main degradation systems within cells, catalyzing the tagging of proteins for degradation by ubiquitin molecules, which are then recognized and degraded by the proteasome. …”
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Sticky organisms create underwater biological adhesives driven by interactions between EGF- and GlcNAc- containing polysaccharides by Jimin Choi, Seunghyeon Lee, Yongjin Lee, Dong Soo Hwang

“…EGF/EGF-like-domain-containing proteins demonstrate over three-fold superior underwater adhesion to chitosan compared to the well-known strongest wet-adhesive proteins, mefp-5, and suckerin, when adhering to mica in an surface forces apparatus-based measurement. …”
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Proteomic Analysis of Serum Opsonins Impacting Biodistribution and Cellular Association of Porous Silicon Microparticles by Rita E. Serda, Elvin Blanco, Aaron Mack, Susan J. Stafford, Sarah Amra, Qingpo Li, Anne van de Ven, Takemi Tanaka, Vladimir P. Torchilin, John E. Wiktorowicz, Mauro Ferrari

“…Mass transport of drug delivery vehicles is guided by particle properties, such as size, shape, composition, and surface chemistry, as well as biomolecules and serum proteins that adsorb to the particle surface. In an attempt to identify serum proteins influencing cellular associations and biodistribution of intravascularly injected particles, we used two-dimensional gel electrophoresis and mass spectrometry to identify proteins eluted from the surface of cationic and anionic silicon microparticles. …”
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Ingested house dust mite favors sensitization to egg white in mice independently of its proteinase activity by Sara Benedé, Leticia Pérez-Rodríguez, David Menchén-Martínez, Elena Molina, Rosina López-Fandiño

“…However, its role in promoting gastrointestinal sensitization and allergenicity to food proteins has been relatively unexplored.MethodsThis study investigates the immunostimulatory effects of HDM in a murine model of oral sensitization to egg white (EW) in the absence of exogenous adjuvants. …”
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Virulence and pathogenicity of group B Streptococcus: Virulence factors and their roles in perinatal infection by Christina J. Megli, Sophia M. Carlin, Elizabeth J. Giacobe, Gideon H. Hillebrand, Thomas A. Hooven

“…The paper also examines the molecular structures and functions of key GBS surface proteins, such as pili, serine-rich repeat proteins, and fibrinogen-binding proteins, which facilitate colonization and disease. …”
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Secretion and signaling activities of lipoprotein-associated hedgehog and non-sterol-modified hedgehog in flies and mammals. by Wilhelm Palm, Marta M Swierczynska, Veena Kumari, Monika Ehrhart-Bornstein, Stefan R Bornstein, Suzanne Eaton

“…Hedgehog (Hh) proteins control animal development and tissue homeostasis. …”
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Acetylation-enhanced Sp1 transcriptional activity suppresses Mlph expression by Chan Song Jo, Hairu Zhao, Jae Sung Hwang

“…Mutation of these proteins causes melanosome aggregation around the nucleus. …”
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Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney by Hui Zou, Jie Song, Xianzu Luo, Waseem Ali, Sifan Li, Ling Xiong, Yan Chen, Yan Yuan, Yonggang Ma, Xishuai Tong, Zongping Liu

“…Finally, we detected changes in apoptosis-related proteins and genes (Caspase-3, Caspase-9, Bax, Bcl-2, Cytc) and TUNEL staining, and after PVC-MPs+Cd treatment, apoptosis-related proteins/genes recovered and the apoptosis rate decreased compared with the Cd and PVC-MPs alone treatment. …”
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DIA-based quantitative proteomic analysis on porcine meat quality at different chilling rates by Yuqiang Bai, Tongjing Yan, Fei Fang, Xin Li, Su Wang, Juan Li, Chengli Hou, Dequan Zhang

“…Seventy-nine differential abundant proteins (fold change >1.5, P <0.05), including 46 up-regulated and 33 down-regulated proteins, were identified and mainly involved in carbon metabolism, pyruvate metabolism and proteasome pathways. …”
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Endophytic fungi related to the ash dieback causal agent encode signatures of pathogenicity on European ash by Maryam Rafiqi, Chatchai Kosawang, Jessica A. Peers, Lukas Jelonek, Hélène Yvanne, Mark McMullan, Lene R. Nielsen

“…Amongst shared secreted proteins are cell death-inducing effector candidates, such as necrosis, and ethylene-inducing peptide 1-like proteins, Nep1-like proteins, that are upregulated during in planta growth of all Hymenoscyphus species. …”
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Endopiriform neurons projecting to ventral CA1 are a critical node for recognition memory by Naoki Yamawaki, Hande Login, Solbjørg Østergaard Feld-Jakobsen, Bernadett Mercedesz Molnar, Mads Zippor Kirkegaard, Maria Moltesen, Aleksandra Okrasa, Jelena Radulovic, Asami Tanimura

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Notoginsenoside R1 Attenuates H/R Injury in H9c2 Cells by Maintaining Mitochondrial Homeostasis by Yuanbo Xu, Piao Wang, Ting Hu, Ke Ning, Yimin Bao

“…Further analysis indicated that NGR1 upregulated the expression of mitochondrial biogenesis-related proteins (PGC-1α, Nrf1, Nrf2) and mitochondrial fusion proteins (Opa1, Mfn1, Mfn2), while downregulating mitochondrial fission proteins (Fis1, Drp1) and reducing mitochondrial autophagy (mitophagy) levels, as well as the expression of mitophagy-related proteins (Pink1, Parkin, BNIP3) post-H/R. …”
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Biochemistry of the Thrombin-Like TLBpic and Its Purification from Bothrops pictus “Jergon de la Costa” (Reptilia: Viperidae) by Victor Ludgardo Álvarez Tohalino, Hugo Guillermo Jiménez Pacheco, Juan Raúl Jesús Zumaran Farfán, Pavel Kewin Delgado Sarmiento, Paulino Rodolfo Zegarra Panca

“…The ESI (electrospray ionisation), corresponding to the electrophoresis of proteins in polyacrylamide gels and to their denaturing solubilization in the presence of the SDS ionic detergent, uniting the proteins, breaking hydrophobic interactions, showing a molecular mass of ∼30 kDa, demonstrating high molecular homogeneity that exists in this family of proteins, is a soft ionization method, in which the samples were ionized by the addition or removal of a proton, with very little extra energy to cause fragmentation of the produced ions. …”
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An in vivo intermediate filament assembly model by Stéphanie Portet, Julien Arino

“…A model is developed to study the in vivo intermediate filament organization in terms of repartition between four different structural states: soluble proteins, particles, short, and long filaments. An analysis is conducted, showing that the system has a unique, globally asymptotically stable equilibrium. …”
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Small Bowel Review - Part I by ABR Thomson, G Wild

“…Part I of this two-part review of the small bowel examines carbohydrates, including brush border membrane hydrolysis and sugar transport; amino acids, dipeptides, proteins and food allergy, with a focus on glutamine, peptides and macromolecules, and nucleosides, nucleotides and polyamines; salt and water absorption, and diarrhea, including antidiarrheal therapy and oral rehydration treatment; lipids (digestion and absorption, fatty acid binding proteins, intracellular metabolism, lipoproteins and bile acids); and metals (eg, iron) and vitamins.…”
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Proteomic profiling of serum in cats with naturally occurring degenerative joint disease and co-morbid conditions by B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, B. Duncan X. Lascelles, Rakesh Ponnala, Steven G. Kamerling, Tracey Williams

“…With the added co-morbidity of CKD, similar pathways were identified, with the addition of IL-12 signaling and production in macrophages.DiscussionWe identified differentially abundant proteins associated with DJD, pain and CKD and future work should evaluate these proteins as potential biomarkers of disease (individually or as clusters). …”
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The Calicophoron daubneyi genome provides new insight into mechanisms of feeding, eggshell synthesis and parasite-microbe interactions by Shauna M. Clancy, Mark Whitehead, Nicola A. M. Oliver, Kathryn M. Huson, Jake Kyle, Daniel Demartini, Allister Irvine, Fernanda Godoy Santos, Paul-Emile Kajugu, Robert E. B. Hanna, Sharon A. Huws, Russell M. Morphew, J. Herbert Waite, Sam Haldenby, Mark W. Robinson

“…Results Several gene families have undergone specific expansion in C. daubneyi, including the peptidoglycan-recognition proteins (PGRPs) and DM9 domain-containing proteins, which function as pattern-recognition receptors, as well as the saposin-like proteins with putative antibacterial properties, and are upregulated upon arrival of the fluke in the microbe-rich rumen. …”
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